62669-70-9 | Rhodamine 123

Packsize	Purity	Availability	Price	Discounted Price
5mg	95%	in stock	$42.00	$29.00
10mg	95%	in stock	$74.00	$52.00
25mg	95%	in stock	$116.00	$81.00
50mg	95%	in stock	$203.00	$142.00
100mg	95%	in stock	$355.00	$248.00
250mg	95%	in stock	$698.00	$488.00
1g	95%	in stock	$1,726.00	$1,208.00

Description

• Catalog Number: AI53948
• Chemical Name: Rhodamine 123
• CAS Number: 62669-70-9
• Molecular Formula: C21H17ClN2O3
• Molecular Weight: 380.82428
• MDL Number: MFCD00150072
• SMILES: COC(=O)c1ccccc1c1c2ccc(cc2[o+]c2c1ccc(c2)N)N.[Cl-]

Computed Properties

• Complexity: 706
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 27
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 3

Literature

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  Toxicology in vitro : an international journal published in association with BIBRA 20170601

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  Toxicology in vitro : an international journal published in association with BIBRA 20141201

• CEP-33779 antagonizes ATP-binding cassette subfamily B member 1 mediated multidrug resistance by inhibiting its transport function.

  Biochemical pharmacology 20140915

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  Toxicology and applied pharmacology 20140115

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  Phytomedicine : international journal of phytotherapy and phytopharmacology 20130515

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  International journal of pharmaceutics 20121101

• Amphiphilic HPMA-LMA copolymers increase the transport of Rhodamine 123 across a BBB model without harming its barrier integrity.

  Journal of controlled release : official journal of the Controlled Release Society 20121028

• Polyethylenimine-capped Ag nanoparticle film as a platform for detecting charged dye molecules by surface-enhanced Raman scattering and metal-enhanced fluorescence.

  ACS applied materials & interfaces 20121024

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  European journal of pharmacology 20120905

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  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120815

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• Determination of Rhodamine 123 in rat plasma utilizing liquid chromatography-tandem mass spectrometry.

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  Synapse (New York, N.Y.) 20110901

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  Biochimica et biophysica acta 20110901

• Characterization of rhodamine-123, calcein and 5(6)-carboxy-2',7'-dichlorofluorescein (CDCF) export via MRP2 (ABCC2) in MES-SA and A549 cells.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20110817

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  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20110101

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  Journal of biomedicine & biotechnology 20110101

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  The AAPS journal 20101201

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  Neuroscience letters 20100122

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  Journal of pharmaceutical sciences 20100101

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  The Journal of pharmacy and pharmacology 20091001

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  Die Pharmazie 20090901

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• Glutathione depletion upregulates P-glycoprotein expression at the blood-brain barrier in rats.

  The Journal of pharmacy and pharmacology 20090601

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  Toxicology in vitro : an international journal published in association with BIBRA 20090201

• Development and characterisation of a new model of rat trophoblasts.

  Toxicology in vitro : an international journal published in association with BIBRA 20090201

• Functionality of drug efflux pumps in antimonial resistant Leishmania donovani field isolates.

  Indian journal of biochemistry & biophysics 20090201

• Reversal of P-glycoprotein-mediated multidrug resistance by the murine double minute 2 antagonist nutlin-3.

  Cancer research 20090115

• 2-Methoxyestradiol and multidrug resistance: can 2-methoxyestradiol chemosensitize resistant breast cancer cells?

  Breast cancer research and treatment 20090101

• Inhibition of P-glycoprotein-mediated paclitaxel resistance by reversibly linked quinine homodimers.

  Molecular pharmacology 20090101

• From delocalized lipophilic cations to hypoxia: blocking tumor cell mitochondrial function leads to therapeutic gain with glycolytic inhibitors.

  Molecular nutrition & food research 20090101

• A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes.

  Neurochemistry international 20090101

• Effect of resveratrol on the pharmacokinetics of oral and intravenous nicardipine in rats: possible role of P-glycoprotein inhibition by resveratrol.

  Die Pharmazie 20090101

• Imatinib is a substrate for various multidrug resistance proteins.

  Neoplasma 20090101

• Antitumor activity of alkaloids derived from Amaryllidaceae species.

  In vivo (Athens, Greece) 20090101

• Live-cell imaging of the cytoskeleton and mitochondrial-cytoskeletal interactions in budding yeast.

  Methods in molecular biology (Clifton, N.J.) 20090101

• [P-glycoprotein functional activity in peripheral blood lymphocytes in ulcerative colitis].

  Medicina 20090101

• Paclitaxel-resistance conferred by altered expression of efflux and influx transporters for paclitaxel in the human hepatoma cell line, HepG2.

  Drug metabolism and pharmacokinetics 20090101

• Effects of intestinal ischemia/reperfusion on P-glycoprotein mediated biliary and renal excretion of rhodamine123 in rat.

  Drug metabolism and pharmacokinetics 20090101

• Differential effect of phenothiazines on MRP1 and P-glycoprotein activity.

  In vivo (Athens, Greece) 20090101

• Chemosensitizing effect of nordihydroguaiaretic acid and its tetra-acetylated derivative on parental and multiresistant TA3 mouse mammary adenocarcinoma cells.

  In vivo (Athens, Greece) 20090101

• Lymphocyte P-glycoprotein variability in healthy individuals.

  Medicina 20090101

• Different storing and processing conditions of human lymphocytes do not alter P-glycoprotein rhodamine 123 efflux.

  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20090101

• Down-regulation of P-glycoprotein expression by sustained intracellular acidification in K562/Dox cells.

  Biochemical and biophysical research communications 20081212

• Evaluation of carbamazepine pharmacokinetic profiles in mice with kainic acid-induced acute seizures.

  Biological & pharmaceutical bulletin 20081201

• Simple, fast and high-throughput single-cell analysis on PDMS microfluidic chips.

  Electrophoresis 20081201

• Quinoline derivative KB3-1 potentiates paclitaxel induced cytotoxicity and cycle arrest via multidrug resistance reversal in MES-SA/DX5 cancer cells.

  Life sciences 20081121

• Human pharmaceuticals modulate P-gp1 (ABCB1) transport activity in the fish cell line PLHC-1.

  Aquatic toxicology (Amsterdam, Netherlands) 20081121

• P-glycoprotein (Abcb1) is involved in absorptive drug transport in skin.

  Journal of controlled release : official journal of the Controlled Release Society 20081112

• [Effect of Glycyrrhiza inflata and Daphne genkwa on permeabilities of rhodamine 123, a P-glycoprotein substrate across rat jejunum membranes in vitro].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081101

• Solid lipid nanoparticles enhance the delivery of the HIV protease inhibitor, atazanavir, by a human brain endothelial cell line.

  Pharmaceutical research 20081001

• Delivery of nanoparticles to the brain detected by fluorescence microscopy.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20081001

• Reversal effect of tyroservatide (YSV) tripeptide on multi-drug resistance in resistant human hepatocellular carcinoma cell line BEL-7402/5-FU.

  Cancer letters 20080928

• Lobeline, a piperidine alkaloid from Lobelia can reverse P-gp dependent multidrug resistance in tumor cells.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20080901

• Interaction of coenzyme Q10 with the intestinal drug transporter P-glycoprotein.

  Journal of agricultural and food chemistry 20080827

• Rhodamine 123 efflux in human subpopulations of hematopoietic stem cells: comparison between bone marrow, umbilical cord blood and mobilized peripheral blood CD34+ cells.

  International journal of molecular medicine 20080801

• Enhanced oral bioavailability of paclitaxel by D-alpha-tocopheryl polyethylene glycol 400 succinate in mice.

  International journal of pharmaceutics 20080709

• Folate-functionalized polymeric micelles for tumor targeted delivery of a potent multidrug-resistance modulator FG020326.

  Journal of biomedical materials research. Part A 20080701

• Energy metabolism transition in multi-cellular human tumor spheroids.

  Journal of cellular physiology 20080701

• Effect of the novel antipsychotic drug perospirone on P-glycoprotein function and expression in Caco-2 cells.

  European journal of clinical pharmacology 20080701

• Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum.

  Bioorganic & medicinal chemistry letters 20080701

• Curcuma drugs and curcumin regulate the expression and function of P-gp in Caco-2 cells in completely opposite ways.

  International journal of pharmaceutics 20080624

• Detection of de- and hyperpolarization of mitochondria of cultured astrocytes and neurons by the cationic fluorescent dye rhodamine 123.

  Journal of neuroscience methods 20080615

• Trans- and cis-stilbene polyphenols induced rapid perinuclear mitochondrial clustering and p53-independent apoptosis in cancer cells but not normal cells.

  European journal of pharmacology 20080610

• Apoptosis-inducing effects of two anthraquinones from Hedyotis diffusa WILLD.

  Biological & pharmaceutical bulletin 20080601

• Reversal of P-glycoprotein and multidrug resistance-associated protein 1 mediated multidrug resistance in cancer cells by HZ08 Isomers, tetrataisohydroquinolin derivatives.

  Biological & pharmaceutical bulletin 20080601

• Inhibitory activity of nuclear factor-kappaB potentiates cisplatin-induced apoptosis in A549 cells.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20080601

• In vitro and in vivo study of CJY, an isoflavone, on p-glycoprotein function in rats.

  Journal of chemotherapy (Florence, Italy) 20080601

• Functional evaluation of polymorphisms in the human ABCB1 gene and the impact on clinical responses of antiepileptic drugs.

  Pharmacogenetics and genomics 20080501

• Chitosan-N-acetyl cysteine conjugates: in vitro evaluation of permeation enhancing and P-glycoprotein inhibiting properties.

  Drug delivery 20080501

• Reversal effect of isotetrandrine, an isoquinoline alkaloid extracted from Caulis Mahoniae, on P-glycoprotein-mediated doxorubicin-resistance in human breast cancer (MCF-7/DOX) cells.

  Yao xue xue bao = Acta pharmaceutica Sinica 20080501

• Nitric oxide down-regulates the expression of organic cation transporters (OCT) 1 and 2 in rat kidney during endotoxemia.

  European journal of pharmacology 20080428

• Histone deacetylase inhibitor apicidin-mediated drug resistance: involvement of P-glycoprotein.

  Biochemical and biophysical research communications 20080418

• Reversal effect of a macrocyclic bisbibenzyl plagiochin E on multidrug resistance in adriamycin-resistant K562/A02 cells.

  European journal of pharmacology 20080414

• Increased P-glycoprotein function and level after long-term exposure of four antiepileptic drugs to rat brain microvascular endothelial cells in vitro.

  Neuroscience letters 20080404

• Casiopeína IIgly induced cytotoxicity to HeLa cells depletes the levels of reduced glutathione and is prevented by dimethyl sulfoxide.

  Toxicology in vitro : an international journal published in association with BIBRA 20080401

• Plasmodium falciparum: erythrocytic stages die by autophagic-like cell death under drug pressure.

  Experimental parasitology 20080401

• [Effect of Tween-80 on the permeability of rhodamine 123, a P-gp substrate across rat intestinal membranes in vitro].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20080401

• Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1((R)).

  Biochemical pharmacology 20080315

• Inhibitory effect of docosahexaenoic acid (DHA) on the intestinal metabolism of midazolam: in vitro and in vivo studies in rats.

  International journal of pharmaceutics 20080303

• Microcystin-RR induced apoptosis in tobacco BY-2 suspension cells is mediated by reactive oxygen species and mitochondrial permeability transition pore status.

  Toxicology in vitro : an international journal published in association with BIBRA 20080301

• Plagiochin E, a botanic-derived phenolic compound, reverses fungal resistance to fluconazole relating to the efflux pump.

  Journal of applied microbiology 20080301

• Polychlorinated biphenyl-induced oxidative stress in organotypic co-cultures: experimental dopamine depletion prevents reductions in GABA.

  Neurotoxicology 20080301

• Inhibition of multidrug resistance by adamantylgb3, a globotriaosylceramide analog.

  The Journal of biological chemistry 20080222

• Anti-Trypanosoma cruzi effects of cyclosporin A derivatives: possible role of a P-glycoprotein and parasite cyclophilins.

  Parasitology 20080201

• A comparative evaluation of corneal epithelial cell cultures for assessing ocular permeability.

  Alternatives to laboratory animals : ATLA 20080201

• Selective toxicity of ginsenoside Rg3 on multidrug resistant cells by membrane fluidity modulation.

  Archives of pharmacal research 20080201

• Interactions of attention-deficit/hyperactivity disorder therapeutic agents with the efflux transporter P-glycoprotein.

  European journal of pharmacology 20080114

• Biochemical study of idebenone effect on mitochondrial metabolism of yeast.

  Cell biology international 20080101

• Activity of drug efflux transporters in tumor cells under hypoxic conditions.

  Advances in experimental medicine and biology 20080101

• Role of P-glycoprotein in evolution of populations of chronic myeloid leukemia cells treated with imatinib.

  Biochemistry. Biokhimiia 20080101

• A new procedure for the quantitative assessment of p-glycoprotein efflux pump associated with human T lymphocytes.

  Ethnicity & disease 20080101

• Effects of monoglycerides on P-glycoprotein: modulation of the activity and expression in Caco-2 cell monolayers.

  Molecular pharmaceutics 20080101

• Effects of monoglycerides on rhodamine 123 accumulation, estradiol 17 beta-D-glucuronide bidirectional transport and MRP2 protein expression within Caco-2 cells.

  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20080101

• Assessment of ileal epithelial P-glycoprotein dysfunction induced by ischemia/reperfusion using in vivo animal model.

  Drug metabolism and pharmacokinetics 20080101

• Antitumour properties of acridone alkaloids on a murine lymphoma cell line.

  Anticancer research 20080101

• New functional assay of P-glycoprotein activity using Hoechst 33342.

  Bioorganic & medicinal chemistry 20071201

• Substituted tetrahydroisoquinoline compound B3 inhibited P-glycoprotein-mediated multidrug resistance in-vitro and in-vivo.

  The Journal of pharmacy and pharmacology 20071201

• In-vivo and in-vitro studies on the effect of Huang-Lian-Jie-Du-Tang on nimodipine transport across rat blood-brain barrier.

  The Journal of pharmacy and pharmacology 20071201

• [Interaction between (E)-2-(4-(diethylamino methyl) benzylidene)-5,6-dimethoxy-2,3-dihydroinden-one and P-glycoprotein].

  Yao xue xue bao = Acta pharmaceutica Sinica 20071201

• Biocompatibility of contact lens solutions using confocal laser scanning microscopy and the in vitro bovine cornea.

  Eye & contact lens 20071101

• ZD6474 reverses multidrug resistance by directly inhibiting the function of P-glycoprotein.

  British journal of cancer 20071008

• The effect of ABCB1 polymorphism on the pharmacokinetics of saquinavir alone and in combination with ritonavir.

  Clinical pharmacology and therapeutics 20071001

• Plasma LDL cholesterol has no impact on P-glycoprotein (MDR1/ABCB1) activity in human peripheral blood mononuclear cells.

  Naunyn-Schmiedeberg's archives of pharmacology 20071001

• Increased P-glycoprotein expression and decreased phenobarbital distribution in the brain of pentylenetetrazole-kindled rats.

  Neuropharmacology 20071001

• The characteristics of Hep-2 cell with multiple drug resistance induced by Taxol.

  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20071001

• Assessment of antiepileptic drugs as substrates for canine P-glycoprotein.

  American journal of veterinary research 20071001

• Effects of capsaicin on cellular damage and monolayer permeability in human intestinal Caco-2 cells.

  Biological & pharmaceutical bulletin 20071001

• Targeting the central nervous system: in vivo experiments with peptide-derivatized nanoparticles loaded with Loperamide and Rhodamine-123.

  Journal of controlled release : official journal of the Controlled Release Society 20070911

• Effects of diosmin, a flavonoid glycoside in citrus fruits, on P-glycoprotein-mediated drug efflux in human intestinal Caco-2 cells.

  Journal of agricultural and food chemistry 20070905

• Effect of cell differentiation and passage number on the expression of efflux proteins in wild type and vinblastine-induced Caco-2 cell lines.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20070901

• Effects of benzo(e)pyrene and benzo(a)pyrene on P-glycoprotein-mediated transport in Caco-2 cell monolayer: a comparative approach.

  Toxicology in vitro : an international journal published in association with BIBRA 20070801

• Decreased intestinal CYP3A and P-glycoprotein activities in rats with adjuvant arthritis.

  Drug metabolism and pharmacokinetics 20070801

• Adaptive response to increased bile acids: induction of MDR1 gene expression and P-glycoprotein activity in renal epithelial cells.

  Pflugers Archiv : European journal of physiology 20070701

• Mitochondrial inner membrane electrophysiology assessed by rhodamine-123 transport and fluorescence.

  Annals of biomedical engineering 20070701

• Remodelling of the SUR-Kir6.2 interface of the KATP channel upon ATP binding revealed by the conformational blocker rhodamine 123.

  The Journal of physiology 20070701

• Effects of Labrasol and other pharmaceutical excipients on the intestinal transport and absorption of rhodamine123, a P-glycoprotein substrate, in rats.

  Biological & pharmaceutical bulletin 20070701

• Inhibition of the mitogen-activated protein kinase pathway results in the down-regulation of P-glycoprotein.

  Molecular cancer therapeutics 20070701

• Inhibition of P-glycoprotein function by tannic acid and pentagalloylglucose.

  The Journal of pharmacy and pharmacology 20070701

• CJY, an isoflavone, reverses P-glycoprotein-mediated multidrug-resistance in doxorubicin-resistant human myelogenous leukaemia (K562/DOX) cells.

  The Journal of pharmacy and pharmacology 20070701

• Delayed mitochondrial dysfunction in apoptotic hair cells in chinchilla cochleae following exposure to impulse noise.

  Apoptosis : an international journal on programmed cell death 20070601

• Stereoselective regulation of MDR1 expression in Caco-2 cells by cetirizine enantiomers.

  Chirality 20070601

• Role of hypoxia-inducible factor-alpha in hepatitis-B-virus X protein-mediated MDR1 activation.

  Biochemical and biophysical research communications 20070601

• Is steroid resistance related to multidrug resistance-I (MDR-I) in rheumatoid arthritis?

  International immunopharmacology 20070601

• Comparison of the inhibitory activity of anti-HIV drugs on P-glycoprotein.

  Biochemical pharmacology 20070515

• Differential subcellular distribution of mitoxantrone in relation to chemosensitization in two human breast cancer cell lines.

  Drug metabolism and disposition: the biological fate of chemicals 20070501

• An inhibitory role of nitric oxide in the dynamic regulation of the blood-brain barrier function.

  Cellular and molecular neurobiology 20070501

• SLIM: a new method for molecular imaging.

  Microscopy research and technique 20070501

• Ethanol induced mitochondria injury and permeability transition pore opening: role of mitochondria in alcoholic liver disease.

  World journal of gastroenterology 20070428

• Withanolide induces apoptosis in HL-60 leukemia cells via mitochondria mediated cytochrome c release and caspase activation.

  Chemico-biological interactions 20070405

• Risperidone and paliperidone inhibit p-glycoprotein activity in vitro.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070401

• P-glycoprotein (MDR1) functional activity in human alveolar epithelial cell monolayers.

  Cell and tissue research 20070401

• Morphological and functional changes in p-glycoprotein during dexamethasone-induced hepatomegaly.

  Clinical and experimental pharmacology & physiology 20070401

• Parallel separation of multiple samples with negative pressure sample injection on a 3-D microfluidic array chip.

  Electrophoresis 20070401

• Detection and functional characterization of Pgp1 (ABCB1) and MRP3 (ABCC3) efflux transporters in the PLHC-1 fish hepatoma cell line.

  Aquatic toxicology (Amsterdam, Netherlands) 20070330

• Characterization of WIF-B9/R cells as an in vitro model with hepatocyte-like polarity and enhanced expression of canalicular ABC transporters involved in phase III of hepatic detoxification.

  Toxicology 20070322

• Dialysis of boar semen prior to freezing-thawing: its effects on post-thaw sperm characteristics.

  Theriogenology 20070315

• Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts.

  Leukemia 20070301

• New noncellular fluorescence microplate screening assay for scavenging activity against singlet oxygen.

  Analytical and bioanalytical chemistry 20070301

• High-molecular-weight polyphenols from oolong tea and black tea: purification, some properties, and role in increasing mitochondrial membrane potential.

  Bioscience, biotechnology, and biochemistry 20070301

• Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin.

  Molecular and cellular biochemistry 20070201

• Air-liquid interface (ALI) culture of human bronchial epithelial cell monolayers as an in vitro model for airway drug transport studies.

  Journal of pharmaceutical sciences 20070201

• Expression of the MDR1 gene and P-glycoprotein in canine mast cell tumor cell lines.

  The Journal of veterinary medical science 20070201

• A 'silent' polymorphism in the MDR1 gene changes substrate specificity.

  Science (New York, N.Y.) 20070126

• Effects of Kaempferia parviflora extracts and their flavone constituents on P-glycoprotein function.

  Journal of pharmaceutical sciences 20070101

• Cobalamin potentiates vinblastine cytotoxicity through downregulation of mdr-1 gene expression in HepG2 cells.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101

• Assay for apoptosis using the mitochondrial probes, Rhodamine123 and 10-N-nonyl acridine orange.

  Nature protocols 20070101

• Field amplified sample stacking coupled with chip-based capillary electrophoresis using negative pressure sample injection technique.

  Journal of chromatography. A 20061229

• A novel MDR1 G1199T variant alters drug resistance and efflux transport activity of P-glycoprotein in recombinant Hek cells.

  Journal of pharmaceutical sciences 20061201

• In vivo comparison of various polymeric and low molecular mass inhibitors of intestinal P-glycoprotein.

  Biomaterials 20061201

• Down-regulation of ABCB1 transporter by atorvastatin in a human hepatoma cell line and in human peripheral blood mononuclear cells.

  Biochimica et biophysica acta 20061201

• The role of Leishmania enriettii multidrug resistance protein 1 (LeMDR1) in mediating drug resistance is iron-dependent.

  Molecular and biochemical parasitology 20061201

• Down-regulation of P-glycoprotein expression in MDR breast cancer cell MCF-7/ADR by honokiol.

  Cancer letters 20061118

• Development and characterization of multidrug resistant human hepatocarcinoma cell line in nude mice.

  World journal of gastroenterology 20061107

• Rhodamine 123 permeability through the catfish intestinal wall: Relationship to thermal acclimation and acute temperature change.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20061101

• Concomitant real-time monitoring of intracellular reactive oxygen species and mitochondrial membrane potential in individual living promonocytic cells.

  Journal of immunological methods 20061020

• A kinetic study of Rhodamine123 pumping by P-glycoprotein.

  Biochimica et biophysica acta 20061001

• Improvement of intestinal absorption of P-glycoprotein substrate by D-tartaric acid.

  Drug metabolism and pharmacokinetics 20061001

• Gomisin A alters substrate interaction and reverses P-glycoprotein-mediated multidrug resistance in HepG2-DR cells.

  Biochemical pharmacology 20060928

• Bivalent probes of the human multidrug transporter P-glycoprotein.

  Biochemistry 20060926

• Indomethacin overcomes doxorubicin resistance with inhibiting multi-drug resistance protein 1 (MRP1).

  Cancer chemotherapy and pharmacology 20060901

• Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein.

  Psychopharmacology 20060901

• Up-regulation of P-glycoprotein expression by glutathione depletion-induced oxidative stress in rat brain microvessel endothelial cells.

  Journal of neurochemistry 20060901

• In vivo evaluation of an oral delivery system for P-gp substrates based on thiolated chitosan.

  Biomaterials 20060801

• Visceral leishmaniasis, or kala azar (KA): high incidence of refractoriness to antimony is contributed by anthroponotic transmission via post-KA dermal leishmaniasis.

  The Journal of infectious diseases 20060801

• [Determination of rhodamine 123 in cell lysate by high-performance liquid chromatography with visible wavelength detection].

  Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20060801

• Hyperspectral imaging system using acousto-optic tunable filter for flow cytometry applications.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060801

• The alpha-subunit of Leishmania F1 ATP synthase hydrolyzes ATP in presence of tRNA.

  The Journal of biological chemistry 20060714

• Apparent active transport of MDMA is not mediated by P-glycoprotein: a comparison with MDCK and Caco-2 monolayers.

  Biopharmaceutics & drug disposition 20060701

• Effect of benzo[a]pyrene on P-glycoprotein-mediated transport in Caco-2 cell monolayer.

  Toxicology 20060601

• Ischemia/reperfusion injury in the monolayers of human intestinal epithelial cell line caco-2 and its recovery by antioxidants.

  Drug metabolism and pharmacokinetics 20060601

• Thalidomide does not interact with P-glycoprotein.

  Cancer chemotherapy and pharmacology 20060501

• JC-1, a sensitive probe for a simultaneous detection of P-glycoprotein activity and apoptosis in leukemic cells.

  Cytometry. Part B, Clinical cytometry 20060501

• Modulation of intestinal P-glycoprotein function by polyethylene glycols and their derivatives by in vitro transport and in situ absorption studies.

  International journal of pharmaceutics 20060426

• CJZ3, a lomerizine derivative, modulates P-glycoprotein function in rat brain microvessel endothelial cells.

  Acta pharmacologica Sinica 20060401

• Glutathione and thiolated chitosan inhibit multidrug resistance P-glycoprotein activity in excised small intestine.

  Journal of controlled release : official journal of the Controlled Release Society 20060310

• Influence of vitamin E TPGS poly(ethylene glycol) chain length on apical efflux transporters in Caco-2 cell monolayers.

  Journal of controlled release : official journal of the Controlled Release Society 20060310

• Somatostatin inhibits oxidative respiration in pancreatic beta-cells.

  Endocrinology 20060301

• Carbonyl stress and NMDA receptor activation contribute to methylglyoxal neurotoxicity.

  Free radical biology & medicine 20060301

• In vivo and in vitro modulation of MDR molecules in murine thymocytes.

  International immunopharmacology 20060201

• Development of an on-line extraction turbulent flow chromatography tandem mass spectrometry method for cassette analysis of Caco-2 cell based bi-directional assay samples.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060118

• Improved synthesis and in vitro characterization of chitosan-thioethylamidine conjugate.

  Biomaterials 20060101

• Transport of glyburide by placental ABC transporters: implications in fetal drug exposure.

  Placenta 20060101

• Verapamil induces upregulation of P-glycoprotein expression on human monocyte derived dendritic cells.

  Immunological investigations 20060101

• Alteration of genomic responses to doxorubicin and prevention of MDR in breast cancer cells by a polymer excipient: pluronic P85.

  Molecular pharmaceutics 20060101

• Interaction between doxorubicin and the resistance modifier stilbene on multidrug resistant mouse lymphoma and human breast cancer cells.

  Anticancer research 20060101

• Involvement of oxidative stress response genes in redox homeostasis, the level of reactive oxygen species, and ageing in Saccharomyces cerevisiae.

  FEMS yeast research 20051201

• Photodynamic damages induced by a monocationic porphyrin derivative in a human carcinoma cell line.

  The international journal of biochemistry & cell biology 20051201

• Effect of a beta-lapachone-derived naphthoimidazole on Trypanosoma cruzi: identification of target organelles.

  The Journal of antimicrobial chemotherapy 20051201

• Simultaneous determination of glutathione and reactive oxygen species in individual cells by microchip electrophoresis.

  Electrophoresis 20051201

• Structure-activity relationships of the inhibitory effects of flavonoids on P-glycoprotein-mediated transport in KB-C2 cells.

  Biological & pharmaceutical bulletin 20051201

• Prediction of absorbability of poorly water-soluble drugs based on permeability obtained through modified in vitro chamber method.

  Drug metabolism and pharmacokinetics 20051201

• Acute glutathione depletion restricts mitochondrial ATP export in cerebellar granule neurons.

  The Journal of biological chemistry 20051118

• Cellular organisation in meiotic and early post-meiotic rice anthers.

  Cell biology international 20051101

• Canine mdr1 gene mutation in Japan.

  The Journal of veterinary medical science 20051101

• Ultrafast dynamics in a nanocage of enzymes: solvation and fluorescence resonance energy transfer in reverse micelles.

  Journal of colloid and interface science 20051015

• Metabolic dysfunction during neuronal activation in the ex vivo hippocampus from chronic epileptic rats and humans.

  Brain : a journal of neurology 20051001

• Transport characteristics of rutin deca (H-) sulfonate sodium across Caco-2 cell monolayers.

  The Journal of pharmacy and pharmacology 20051001

• Reversal of p-glycoprotein-mediated multidrug resistance by CJX1, an amlodipine derivative, in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells.

  Life sciences 20050916

• Gefitinib, an EGFR tyrosine kinase inhibitor, directly inhibits the function of P-glycoprotein in multidrug resistant cancer cells.

  Lung cancer (Amsterdam, Netherlands) 20050901

• Glutathione depletion renders rat hepatocytes sensitive to nitric oxide donor-mediated toxicity.

  Hepatology (Baltimore, Md.) 20050901

• Glucose-dependent changes in NAD(P)H-related fluorescence lifetime of adipocytes and fibroblasts in vitro: potential for non-invasive glucose sensing in diabetes mellitus.

  Journal of photochemistry and photobiology. B, Biology 20050801

• Effect of curcumin on multidrug resistance in resistant human gastric carcinoma cell line SGC7901/VCR.

  Acta pharmacologica Sinica 20050801

• Functional analysis of human hematopoietic stem cell gene expression using zebrafish.

  PLoS biology 20050801

• Preparation of nanoparticles composed of poly(gamma-glutamic acid)-poly(lactide) block copolymers and evaluation of their uptake by HepG2 cells.

  Journal of controlled release : official journal of the Controlled Release Society 20050720

• Change in mitochondrial membrane potential is the key mechanism in early warm hepatic ischemia-reperfusion injury.

  Microvascular research 20050701

• Identification of a multixenobiotic resistance mechanism in primary cultured epidermal cells from Oncorhynchus mykiss and the effects of environmental complex mixtures on its activity.

  Aquatic toxicology (Amsterdam, Netherlands) 20050615

• Biphasic accumulation kinetics of [99mTc]-hexakis-2-methoxyisobutyl isonitrile in tumour cells and its modulation by lipophilic P-glycoprotein ligands.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050601

• Ultraviolet damages sperm mitochondrial function and membrane integrity in the sea urchin Anthocidaris crassispina.

  Ecotoxicology and environmental safety 20050501

• Lamellarin D: a novel pro-apoptotic agent from marine origin insensitive to P-glycoprotein-mediated drug efflux.

  Cancer letters 20050428

• Zinc-induced anti-apoptotic effects in SH-SY5Y neuroblastoma cells via the extracellular signal-regulated kinase 1/2.

  Brain research. Molecular brain research 20050427

• A downstream role for protein kinase Calpha in the cytosolic phospholipase A2-dependent protective signalling mediated by peroxynitrite in U937 cells.

  Biochemical pharmacology 20050415

• Simultaneous release of hydrophobic and cationic solutes from thin-film 'plum-pudding' gels: a multifunctional platform for surface drug delivery?

  The journal of physical chemistry. B 20050407

• Effects of miltefosine on membrane permeability and accumulation of [99mTc]-hexakis-2-methoxyisobutyl isonitrile, 2-[18F]fluoro-2-deoxy-D-glucose, daunorubucin and rhodamine123 in multidrug-resistant and sensitive cells.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050401

• Expression and activity of multidrug resistance protein 1 in a murine thymoma cell line.

  Immunology 20050401

• Regional difference in P-glycoprotein function in rat intestine.

  Drug metabolism and pharmacokinetics 20050401

• Difference in propagation of Ca2+ release in atrial and ventricular myocytes.

  The Japanese journal of physiology 20050401

• Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production.

  Brain research 20050321

• Assessment of drug interactions in hepatobiliary transport using rhodamine 123 in sandwich-cultured rat hepatocytes.

  Drug metabolism and disposition: the biological fate of chemicals 20050301

• Effects of dietary chemopreventive phytochemicals on P-glycoprotein function.

  Biochemical and biophysical research communications 20050218

• Optical assessment of motoneuron function in a 'twenty-four-hour' acute spinal cord slice model from fetal rats.

  Journal of neuroscience methods 20050215

• Chemical modification of paclitaxel (Taxol) reduces P-glycoprotein interactions and increases permeation across the blood-brain barrier in vitro and in situ.

  Journal of medicinal chemistry 20050210

• Modulation of P-glycoprotein function by amlodipine derivatives in brain microvessel endothelial cells of rats.

  Acta pharmacologica Sinica 20050201

• Single amino acid (482) variants of the ABCG2 multidrug transporter: major differences in transport capacity and substrate recognition.

  Biochimica et biophysica acta 20050201

• Inhibition of P-glycoprotein function and expression by kaempferol and quercetin.

  Journal of chemotherapy (Florence, Italy) 20050201

• A comparison of hepatocyte cytotoxic mechanisms for chromate and arsenite.

  Toxicology 20050131

• Determination of Rhodamine 123 in cell lysate by HPLC with visible wavelength detection.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050125

• Interaction of LDS-751 with P-glycoprotein and mapping of the location of the R drug binding site.

  Biochemistry 20050118

• Cultured gill epithelial cells from tilapia (Oreochromis niloticus): a new in vitro assay for toxicants.

  Aquatic toxicology (Amsterdam, Netherlands) 20050118

• Arginine-482 is not essential for transport of antibiotics, primary bile acids and unconjugated sterols by the human breast cancer resistance protein (ABCG2).

  The Biochemical journal 20050115

• Impact of the cyclooxygenase system on doxorubicin-induced functional multidrug resistance 1 overexpression and doxorubicin sensitivity in acute myeloid leukemic HL-60 cells.

  The Journal of pharmacology and experimental therapeutics 20050101

• Cytoplasmic and mitochondrial Ca levels in brown adipocytes.

  Acta physiologica Scandinavica 20050101

• Comparative study on the effects of cyclosporin a in renal cells in culture.

  Nephron. Experimental nephrology 20050101

• Antileukemic activity and cellular metabolism of the aryl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07).

  Arzneimittel-Forschung 20050101

• A comparison of the sensitivity of photodamage assays in rat basophilic leukemia cells.

  Photochemistry and photobiology 20050101

• Effects of selected flavonoids and carotenoids on drug accumulation and apoptosis induction in multidrug-resistant colon cancer cells expressing MDR1/LRP.

  In vivo (Athens, Greece) 20050101

• [Changes in the distribution of mitochondria in mouse embryos blocked at the two-cell stage].

  Ontogenez 20050101

• Human sarcoma cell lines MES-SA and MES-SA/Dx5 as a model for multidrug resistance modulators screening.

  Anticancer research 20050101

• Flow cytometric monitoring of fluorescent drug retention and efflux.

  Methods in molecular medicine 20050101

• Reduced mitochondrial membrane potential and metabolism correspond to acute chloroform toxicity of in vitro hepatocytes.

  Journal of applied toxicology : JAT 20050101

• Photophysical, photochemical, and tumor-selectivity properties of bromine derivatives of rhodamine-123.

  Photochemistry and photobiology 20050101

• Effect of the modulation of the membrane lipid composition on the localization and function of P-glycoprotein in MDR1-MDCK cells.

  In vitro cellular & developmental biology. Animal 20050101

• The effects of jatrophane derivatives on the reversion of MDR1- and MRP-mediated multidrug resistance in the MDA-MB-231 (HTB-26) cell line.

  Anticancer research 20050101

• Mitochondrial dysfunction in mouse oocytes results in preimplantation embryo arrest in vitro.

  Biology of reproduction 20041201

• Mitochondrial metabolism reveals a functional architecture in intact islets of Langerhans from normal and diabetic Psammomys obesus.

  American journal of physiology. Endocrinology and metabolism 20041201

• Effect of p-glycoprotein inhibitor combinations on drug efflux from rat brain microvessel endothelial cells.

  Die Pharmazie 20041201

• Nitric oxide mediates cyclosporine-induced impairment of the blood-brain barrier in cocultures of mouse brain endothelial cells and rat astrocytes.

  European journal of pharmacology 20041128

• Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from Turmeric powder.

  Biochemical pharmacology 20041115

• Inhibitory effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells.

  British journal of pharmacology 20041001

• Effect of rabeprazole on MDR1-mediated transport of Rhodamine 123 in Caco-2 and Hvr100-6 cells.

  Biological & pharmaceutical bulletin 20041001

• Comparison of metabolic oscillations from mouse pancreatic beta cells and islets.

  Endocrine 20041001

• Arginine482 to threonine mutation in the breast cancer resistance protein ABCG2 inhibits rhodamine 123 transport while increasing binding.

  The Biochemical journal 20040901

• Possible harmful effects on central nervous system cells in the use of physiological saline as an irrigant during neurosurgical procedures.

  Surgical neurology 20040801

• Evidence for modulation of P-glycoprotein-mediated efflux by methoxypolyethylene glycol-block-Polycaprolactone amphiphilic diblock copolymers.

  Pharmaceutical research 20040801

• Isolation and characterization of the mitochondrion-like organelle from Blastocystis hominis.

  Journal of microbiological methods 20040701

• Apoptotic-like mitochondrial events associated to phosphatidylserine exposure in blood platelets induced by local anaesthetics.

  Thrombosis and haemostasis 20040701

• Insulin feedback alters mitochondrial activity through an ATP-sensitive K+ channel-dependent pathway in mouse islets and beta-cells.

  Diabetes 20040701

• Molecular cytotoxic mechanisms of anticancer hydroxychalcones.

  Chemico-biological interactions 20040630

• Avermectins inhibit multidrug resistance of tumor cells.

  European journal of pharmacology 20040616

• ABC transporter activities of murine hematopoietic stem cells vary according to their developmental and activation status.

  Blood 20040615

• Reversal of multidrug resistance in drug-resistant human gastric cancer cell line SGC7901/VCR by antiprogestin drug mifepristone.

  World journal of gastroenterology 20040615

• Evaluation and comparison of MRP1 activity with three fluorescent dyes and three modulators in leukemic cell lines.

  Leukemia research 20040601

• Flow cytometric measurement of neutrophil respiratory burst in whole bovine blood using live Staphylococcus aureus.

  Journal of immunological methods 20040601

• Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells.

  Journal of lipid research 20040501

• Fexofenadine does not affect omeprazole pharmacokinetics: both are putative P-glycoprotein substrates.

  Basic & clinical pharmacology & toxicology 20040501

• Cellular features of an apoptotic form of programmed cell death during the development of the ascidian, Boltenia villosa.

  Zoological science 20040501

• [Reversal of multidrug resistance by lomerizine in K562/ADM cells].

  Yao xue xue bao = Acta pharmaceutica Sinica 20040501

• Cholesterol modulates P-glycoprotein activity in human peripheral blood mononuclear cells.

  Biochemical and biophysical research communications 20040409

• Modulation of intestinal P-glycoprotein function by cremophor EL and other surfactants by an in vitro diffusion chamber method using the isolated rat intestinal membranes.

  Journal of pharmaceutical sciences 20040401

• Effect of heat preconditioning on the uptake and permeability of R123 in brain microvessel endothelial cells during mild heat treatment.

  Journal of pharmaceutical sciences 20040401

• Implication of mitochondrial involvement in apoptotic activity of fragile histidine triad gene: application of synchronous luminescence spectroscopy.

  Biopolymers 20040301

• Localization and activity of multidrug resistance protein 1 in the secretory pathway of Leishmania parasites.

  Molecular microbiology 20040301

• Mitochondrial polarisation status and [Ca2+]i signalling in rat cerebellar granule neurones aged in vitro.

  Neurobiology of aging 20040301

• Cadmium-induced mitochondrial membrane-potential dissipation does not necessarily require cytosolic oxidative stress: studies using rhodamine-123 fluorescence unquenching.

  Toxicological sciences : an official journal of the Society of Toxicology 20040201

• In vitro effect of manganese chloride exposure on reactive oxygen species generation and respiratory chain complexes activities of mitochondria isolated from rat brain.

  Toxicology in vitro : an international journal published in association with BIBRA 20040201

• UV dose-dependent caspase activation in a corneal epithelial cell line.

  Current eye research 20040201

• Morphine prevents glutamate-induced death of primary rat neonatal astrocytes through modulation of intracellular redox.

  Immunopharmacology and immunotoxicology 20040201

• Flow cytometry of apoptosis.

  Current protocols in cell biology 20040201

• The modulation of action potential generation by calcium-induced calcium release is enhanced by mitochondrial inhibitors in mudpuppy parasympathetic neurons.

  Neuroscience 20040101

• Mitochondria in tumor cells studied by laser scanning confocal microscopy.

  Journal of biomedical optics 20040101

• Modulation of multidrug resistance and apoptosis of cancer cells by selected carotenoids.

  In vivo (Athens, Greece) 20040101

• New silicon compounds as resistance modifiers against multidrug-resistant cancer cells.

  Anticancer research 20040101

• Inhibition of P-glycoprotein transport: a mechanism for endocrine disruption in the channel catfish?

  Marine environmental research 20040101

• Increasing of oxidative stress from mitochondria in type 2 diabetic patients.

  Diabetes/metabolism research and reviews 20040101

• Functional characterization of human breast cancer resistance protein (BCRP, ABCG2) expressed in the oocytes of Xenopus laevis.

  Molecular pharmacology 20031201

• Epifluorescence microscope methods for bacterial enumeration in a 4-chlorophenol degrading consortium.

  Biotechnology letters 20031201

• Evaluation of the immortalised mouse brain capillary endothelial cell line, b.End3, as an in vitro blood-brain barrier model for drug uptake and transport studies.

  Brain research 20031114

• Interaction of imatinib mesilate with human P-glycoprotein.

  The Journal of pharmacology and experimental therapeutics 20031101

• Spontaneous changes in mitochondrial membrane potential in single isolated brain mitochondria.

  Biophysical journal 20031101

• Cytokines alter the expression and activity of the multidrug resistance transporters in human hepatoma cell lines; analysis using RT-PCR and cDNA microarrays.

  Journal of pharmaceutical sciences 20031101

• Effect of E6, a novel calmodulin inhibitor, on activity of P-glycoprotein in purified primary cultured rat brain microvessel endothelial cells.

  Acta pharmacologica Sinica 20031101

• The expression of P-glycoprotein does influence the distribution of novel fluorescent compounds in solid tumour models.

  British journal of cancer 20031020

• Mechanism of granulosa cell death during follicular atresia depends on follicular size.

  Theriogenology 20031001

• P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells.

  Brain pathology (Zurich, Switzerland) 20031001

• Rhodamine 123 as a probe of mitochondrial membrane potential: evaluation of proton flux through F(0) during ATP synthesis.

  Biochimica et biophysica acta 20030930

• P-glycoprotein-like protein contributes to cadmium resistance in Euglena gracilis.

  Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20030901

• Kinetic analysis of rhodamines efflux mediated by the multidrug resistance protein (MRP1).

  Biophysical journal 20030901

• Quinine as a multidrug resistance inhibitor: a phase 3 multicentric randomized study in adult de novo acute myelogenous leukemia.

  Blood 20030815

• Enhancement of sensitivity to cisplatin by orobol is associated with increased mitochondrial cytochrome c release in human ovarian carcinoma cells.

  Gynecologic oncology 20030801

• MDR1 polymorphisms G2677T in exon 21 and C3435T in exon 26 fail to affect rhodamine 123 efflux in peripheral blood lymphocytes.

  Fundamental & clinical pharmacology 20030801

• Rapid assessment of P-glycoprotein inhibition and induction in vitro.

  Pharmaceutical research 20030801

• Rhodamine 123 requires carrier-mediated influx for its activity as a P-glycoprotein substrate in Caco-2 cells.

  Pharmaceutical research 20030801

• Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers.

  Pharmaceutical research 20030801

• Mitotracker green is a P-glycoprotein substrate.

  Bioscience reports 20030801

• Molecular evidence and functional expression of P-glycoprotein (MDR1) in human and rabbit cornea and corneal epithelial cell lines.

  Investigative ophthalmology & visual science 20030701

• Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis.

  The Journal of biological chemistry 20030606

• Examination of the functional activity of P-glycoprotein in the rat placental barrier using rhodamine 123.

  The Journal of pharmacology and experimental therapeutics 20030601

• Modulation of P-glycoprotein-mediated multidrug resistance by flavonoid derivatives and analogues.

  Journal of medicinal chemistry 20030522

• Lopinavir: acute exposure inhibits P-glycoprotein; extended exposure induces P-glycoprotein.

  AIDS (London, England) 20030502

• Mechanisms of ocular toxicity using the in vitro bovine lens and sodium dodecyl sulfate as a chemical model.

  Toxicological sciences : an official journal of the Society of Toxicology 20030501

• The multidrug resistance protein ABCC1 drug-binding domains show selective sensitivity to mild detergents.

  Biochemical and biophysical research communications 20030418

• Optimisation of cell-based assays for medium throughput screening of oxidative stress.

  Toxicology in vitro : an international journal published in association with BIBRA 20030401

• Age-related changes of P-glycoprotein-mediated rhodamine 123 efflux in normal human bone marrow hematopoietic stem cells.

  Leukemia 20030401

• Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites.

  Pharmaceutical research 20030401

• CPT-11-induced cell death in leukemic cells is not affected by the MDR phenotype.

  Leukemia research 20030301

• Effects of a series of dihydroanthracene derivatives on drug efflux in multidrug resistant cancer cells.

  European journal of medicinal chemistry 20030301

• Reversal of P-glycoprotein-mediated multidrug resistance by ginsenoside Rg(3).

  Biochemical pharmacology 20030101

• Synthesis of aza mono, bi and tricyclic compounds. Evaluation of their anti MDR activity.

  European journal of medicinal chemistry 20030101

• Decrease of intestinal P-glycoprotein activity by 2n-propylquinoline, a new oral treatment for visceral leishmaniasis.

  Experimental parasitology 20030101

• Tamoxifen, protein kinase C and rat sperm mitochondria.

  Cell biology international 20030101

• Overcoming the blood-brain barrier to taxane delivery for neurodegenerative diseases and brain tumors.

  Journal of molecular neuroscience : MN 20030101

• Non-invasive glucose monitoring by NAD(P)H autofluorescence spectroscopy in fibroblasts and adipocytes: a model for skin glucose sensing.

  Diabetes technology & therapeutics 20030101

• Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis).

  Journal of medicinal chemistry 20021219

• Changes in mitochondrial status associated with altered Ca2+ homeostasis in aged cerebellar granule neurons in brain slices.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20021215

• Effects of P-glycoprotein inhibitors on cadmium accumulation in cultured renal epithelial cells, LLC-PK1, and OK.

  Toxicology and applied pharmacology 20021215

• Characterization of drug transport, ATP hydrolysis, and nucleotide trapping by the human ABCG2 multidrug transporter. Modulation of substrate specificity by a point mutation.

  The Journal of biological chemistry 20021213

• The spleen is a major site of megakaryopoiesis following transplantation of murine hematopoietic stem cells.

  Blood 20021201

• Effect of zolpidem on human cytochrome P450 activity, and on transport mediated by P-glycoprotein.

  Biopharmaceutics & drug disposition 20021201

• Hyperresistance to photosensitized lipid peroxidation and apoptotic killing in 5-aminolevulinate-treated tumor cells overexpressing mitochondrial GPX4.

  Free radical biology & medicine 20021115

• Properties of a fetal multipotent neural stem cell (NEP cell).

  Developmental biology 20021115

• Evaluation of cell viability by double-staining fluorescence assay.

  Gan to kagaku ryoho. Cancer & chemotherapy 20021101

• Differential regulation of doxorubicin-induced mitochondrial dysfunction and apoptosis by Bcl-2 in mammary adenocarcinoma (MTLn3) cells.

  The Journal of biological chemistry 20020927

• Elevation of P-glycoprotein function by a catechin in green tea.

  Biochemical and biophysical research communications 20020920

• Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20020901

• Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells.

  Biochemical pharmacology 20020815

• Effect of interleukin-2 on intestinal P-glycoprotein expression and functionality in mice.

  The Journal of pharmacology and experimental therapeutics 20020801

• Liver and marrow of adult mdr-1a/1b(-/-) mice show normal generation, function, and multi-tissue trafficking of primitive hematopoietic cells.

  Experimental hematology 20020801

• Effect of hr-IL2 treatment on intestinal P-glycoprotein expression and activity in Caco-2 cells.

  The Journal of pharmacy and pharmacology 20020801

• Reversal of P-glycoprotein-mediated multidrug resistance by 5,6,7,3',4'-pentamethoxyflavone (Sinensetin).

  Biochemical and biophysical research communications 20020726

• No evidence for a basal, retinoic, or superoxide-induced uncoupling activity of the uncoupling protein 2 present in spleen or lung mitochondria.

  The Journal of biological chemistry 20020719

• Effects of various principles from Chinese herbal medicine on rhodamine123 accumulation in brain capillary endothelial cells.

  Acta pharmacologica Sinica 20020701

• Nucleotide binding and nucleotide hydrolysis properties of the ABC transporter MRP6 (ABCC6).

  Biochemistry 20020625

• Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates.

  Pharmaceutical research 20020601

• MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine.

  British journal of clinical pharmacology 20020501

• Protective effect of L-carnosine against 12-O-tetradecanoylphorbol-13-acetate- or hydrogen peroxide-induced apoptosis on v-myc transformed rat liver epithelial cells.

  Cancer letters 20020408

• Apoptosis susceptibility of tumor cells to arsenic trioxide and the inherent cellular level of reactive oxygen species.

  Chinese medical journal 20020401

• The inhibition of calcium signaling in T lymphocytes from old mice results from enhanced activation of the mitochondrial permeability transition pore.

  Mechanisms of ageing and development 20020331

• Impact of BCRP/MXR, MRP1 and MDR1/P-Glycoprotein on thermoresistant variants of atypical and classical multidrug resistant cancer cells.

  International journal of cancer 20020220

• Evaluation of the clinical relevance of the expression and function of P-glycoprotein, multidrug resistance protein and lung resistance protein in patients with primary acute myelogenous leukemia.

  Leukemia research 20020201

• Bromocriptine reverses P-glycoprotein-mediated multidrug resistance in tumor cells.

  Japanese journal of cancer research : Gann 20020201

• Microplate screening of the differential effects of test agents on Hoechst 33342, rhodamine 123, and rhodamine 6G accumulation in breast cancer cells that overexpress P-glycoprotein.

  Journal of biomolecular screening 20020201

• Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols.

  Biochimica et biophysica acta 20020130

• Transport activity and surface expression of the Na+-Ca2+ exchanger NCX1 are inhibited by the immunosuppressive agent cyclosporin A and by the nonimmunosuppressive agent PSC833.

  The Journal of biological chemistry 20020125

• Nitric oxide induces apoptosis by activating K+ channels in pulmonary vascular smooth muscle cells.

  American journal of physiology. Heart and circulatory physiology 20020101

• Alternative metabolic pathways for energy supply and resistance to apoptosis in Fanconi anaemia.

  Mutagenesis 20020101

• Aluminum toxicity is associated with mitochondrial dysfunction and the production of reactive oxygen species in plant cells.

  Plant physiology 20020101

• Metabolic responses of cultured cells to oxygenated perfluorocarbon.

  Artificial cells, blood substitutes, and immobilization biotechnology 20020101

• In vivo use of all-trans retinoic acid prior to induction chemotherapy improves complete remission rate and increases rhodamine 123 uptake in patients with de novo acute myeloid leukemia.

  Medical oncology (Northwood, London, England) 20020101

• Overexpression of protein disulfide isomerase-like protein in a mouse leukemia L1210 cell line selected for resistance to 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone, a ribonucleotide reductase inhibitor.

  Advances in enzyme regulation 20020101

• Flow cytometric determination of cytoplasmic oxidants and mitochondrial membrane potential in neuronal cells.

  Methods in enzymology 20020101

• Characterization of tropane alkaloid aromatic esters that reverse the multidrug-resistance phenotype.

  Anticancer research 20020101

• Tumor sensitivity to anti-cancer drugs predicted by changes in fluorescence intensity and polarization in vitro.

  Anticancer research 20020101

• Increased reactive oxygen species production with antisense oligonucleotides directed against uncoupling protein 2 in murine endothelial cells.

  Biochemistry and cell biology = Biochimie et biologie cellulaire 20020101

• Photosensitizer accumulation in spontaneous multidrug resistant cells: a comparative study with Rhodamine 123, Rose Bengal acetate and Photofrine.

  Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20020101

• Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure.

  British journal of pharmacology 20011201

• Staining of cellular mitochondria with LDS-751.

  Journal of immunological methods 20011101

• Leishmanicidal, antiplasmodial, and cytotoxic activity of novel diterpenoid 1,2-quinones from Perovskia abrotanoides: new source of tanshinones.

  Journal of natural products 20011101

• The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein.

  Cancer research 20011015

• Inhibitors of mdr1-dependent transport activity delay accumulation of the mdr1 substrate rhodamine 123 in primary rat hepatocyte cultures.

  Toxicology 20011005

• Expression of MRP1 and related transporters in human lung cells in culture.

  Toxicology 20011005

• Augmented K(+) currents and mitochondrial membrane depolarization in pulmonary artery myocyte apoptosis.

  American journal of physiology. Lung cellular and molecular physiology 20011001

• Expression and functional activity of P-glycoprotein in cultured hepatocytes from Oncorhynchus mykiss.

  American journal of physiology. Regulatory, integrative and comparative physiology 20011001

• Intracellular levels of two cyclosporin derivatives valspodar (PSC 833) and cyclosporin a closely associated with multidrug resistance-modulating activity in sublines of human colorectal adenocarcinoma HCT-15.

  Japanese journal of cancer research : Gann 20011001

• Influence of multidrug resistance (MDR) proteins at the blood-brain barrier on the transport and brain distribution of enaminone anticonvulsants.

  Journal of pharmaceutical sciences 20011001

• Purification and some properties of an inhibitor for a yeast pleiotropic drug resistant pump from Kitasatospora sp. E-420.

  Bioscience, biotechnology, and biochemistry 20011001

• Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.

  Cancer research 20010915

• Glucose-induced oscillations in cytoplasmic free Ca2+ concentration precede oscillations in mitochondrial membrane potential in the pancreatic beta-cell.

  The Journal of biological chemistry 20010914

• Quercetin modifies reactive oxygen levels but exerts only partial protection against oxidative stress within HL-60 cells.

  Biochimica et biophysica acta 20010903

• Cells from chronic myelogenous leukaemia patients at presentation exhibit multidrug resistance not mediated by either MDR1 or MRP1.

  British journal of haematology 20010901

• Ultrasound-Induced hyperthermia increases cellular uptake and cytotoxicity of P-glycoprotein substrates in multi-drug resistant cells.

  Pharmaceutical research 20010901

• HIV-protease inhibitors contribute to P-glycoprotein efflux function defect in peripheral blood lymphocytes from HIV-positive patients receiving HAART.

  Journal of acquired immune deficiency syndromes (1999) 20010801

• Mechanisms of taxotere-related drug resistance in pancreatic carcinoma.

  The Journal of surgical research 20010801

• Effect of chronic renal failure on the expression and function of rat intestinal P-glycoprotein in drug excretion.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20010801

• Functional expression of multidrug resistance protein 1 in Pichia pastoris.

  Biochemistry 20010727

• Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells.

  Biochemical and biophysical research communications 20010706

• Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells.

  Advanced drug delivery reviews 20010702

• Methadone inhibits rhodamine123 transport in Caco-2 cells.

  Drug metabolism and disposition: the biological fate of chemicals 20010701

• Permeability of the peptidic GH secretagogues hexarelin and EP 51389, across rat jejunum.

  Peptides 20010701

• Apoptosis induced by doxorubicin and cinchonine in P388 multidrug-resistant cells.

  The Journal of pharmacy and pharmacology 20010701

• Decreased expression of P-glycoprotein in interleukin-1beta and interleukin-6 treated rat hepatocytes.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20010701

• Effect of P-glycoprotein modulators on the human extraneuronal monoamine transporter.

  European journal of pharmacology 20010622

• Modulation by LY335979 of P-glycoprotein function in multidrug-resistant cell lines and human natural killer cells.

  Biochemical pharmacology 20010601

• A decrease in intracellular zinc level precedes the detection of early indicators of apoptosis in HL-60 cells.

  Apoptosis : an international journal on programmed cell death 20010601

• Protein kinase C and phosphatidylinositol 3-kinase independently contribute to P-glycoprotein-mediated drug secretion in the mouse proximal tubule.

  Pflugers Archiv : European journal of physiology 20010601

• Interactions between P-glycoprotein and drugs used in the supportive care of acute myeloid leukemia patients.

  Leukemia & lymphoma 20010601

• The relative quiescence of hematopoietic stem cells in nonhuman primates.

  Blood 20010515

• Hypersensitization of tumor cells to glycolytic inhibitors.

  Biochemistry 20010508

• P-glycoprotein efflux pump expression and activity in Calu-3 cells.

  Journal of pharmaceutical sciences 20010501

• Two rhodamine derivatives: 9-[2-(ethoxycarbonyl)phenyl]-3,6-bis-(ethylamino)-2,7-dimethylxanthylium chloride monohydrate and 3,6-diamino-9-[2-(methoxycarbonyl)-phenyl]xanthylium chloride trihydrate.

  Acta crystallographica. Section C, Crystal structure communications 20010501

• Increase in doxorubicin cytotoxicity by inhibition of P-glycoprotein activity with lomerizine.

  Biological & pharmaceutical bulletin 20010501

• Nuclear shrinkage in live mouse hippocampal slices.

  Acta neuropathologica 20010501

• Activation of K+ channels induces apoptosis in vascular smooth muscle cells.

  American journal of physiology. Cell physiology 20010401

• Overcoming multi-drug resistance using an intracellular anti-MDR1 sFv.

  International journal of cancer 20010401

• Ca2+ signalling and changes of mitochondrial function during low-Mg2+-induced epileptiform activity in organotypic hippocampal slice cultures.

  The European journal of neuroscience 20010401

• In vitro and in vivo tracer characteristics of an established multidrug-resistant human colon cancer cell line.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20010401

• Fixation and permanent mounting of fluorescent probes after vital labelling of cultured cells.

  Acta histochemica 20010401

• [The leading role of mitochondrial depolarization in the mechanism of glutamate-induced disorder in Ca(2+)-homeostasis].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20010401

• Apoptosis and adaptive responses to oxidative stress in human endothelial cells exposed to cyclosporin A correlate with BCL-2 expression levels.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010301

• Effects of Taxotere on invasive potential and multidrug resistance phenotype in pancreatic carcinoma cell line SUIT-2.

  World journal of gastroenterology 20010215

• Pharmacokinetic interaction of cytochrome P450 3A-related compounds with rhodamine 123, a P-glycoprotein substrate, in rats pretreated with dexamethasone.

  Drug metabolism and disposition: the biological fate of chemicals 20010201

• Differential sensitization by orobol in proliferating and quiescent human ovarian carcinoma cells.

  International journal of oncology 20010201

• Monitoring of cellular resistance to cancer chemotherapy: drug retention and efflux.

  Methods in cell biology 20010101

• P-glycoprotein-mediated drug secretion in mouse proximal tubule perfused in vitro.

  Journal of the American Society of Nephrology : JASN 20010101

• Regulation of cyclosporin A sensitive mitochondrial permeability transition by the redox state of pyridine nucleotides.

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20010101

• A human lymphocyte based ex vivo assay to study the effect of drugs on P-glycoprotein (P-gp) function.

  Pharmaceutical research 20010101

• P-glycoprotein in HK-2 proximal tubule cell line.

  Renal failure 20010101

• Impact of proliferative activity and tumorigenic conversion on mitochondrial function of fibroblasts in 2D and 3D culture.

  Cell biology international 20010101

• Optical detection of mitochondrial NADH content in intact human myotubes.

  Cellular and molecular biology (Noisy-le-Grand, France) 20010101

• [Multidrug resistance of leukemia cells to cytostatics--the functional fluorescent dye efflux assay evaluated by flow cytometry].

  Vnitrni lekarstvi 20010101

• Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein.

  Molecular pharmacology 20000101

• Prostate apoptosis response-4 mediates trophic factor withdrawal-induced apoptosis of hippocampal neurons: actions prior to mitochondrial dysfunction and caspase activation.

  Journal of neurochemistry 19990801

• Contribution of mdr1b-type P-glycoprotein to okadaic acid resistance in rat pituitary GH3 cells.

  Naunyn-Schmiedeberg's archives of pharmacology 19990801

• Characterization of anti-Toxoplasma activity of SDZ 215-918, a cyclosporin derivative lacking immunosuppressive and peptidyl-prolyl-isomerase-inhibiting activity: possible role of a P glycoprotein in Toxoplasma physiology.

  Antimicrobial agents and chemotherapy 19970901

• Rapid loss in the mitochondrial membrane potential during geranylgeranoic acid-induced apoptosis.

  Biochemical and biophysical research communications 19970103

• Combined cytotoxic effects of tamoxifen and chemotherapeutic agents on bladder cancer cells: a potential use in intravesical chemotherapy.

  British journal of urology 19960101

• Toxicity of the mitochondrial poison dequalinium chloride in a murine model system.

  Journal of pharmaceutical sciences 19930301

• Dequalinium, a topical antimicrobial agent, displays anticarcinoma activity based on selective mitochondrial accumulation.

  Proceedings of the National Academy of Sciences of the United States of America 19870801