627536-09-8 | SD-208

Packsize	Purity	Availability	Price	Discounted Price
1mg	99%	in stock	$11.00	$8.00
5mg	99%	in stock	$22.00	$16.00
10mg	99%	in stock	$33.00	$23.00
50mg	99%	in stock	$81.00	$57.00
100mg	99%	in stock	$121.00	$85.00
250mg	99%	in stock	$191.00	$134.00
1g	99%	in stock	$485.00	$340.00

Description

• Catalog Number: AG69063
• Chemical Name: SD-208
• CAS Number: 627536-09-8
• Molecular Formula: C17H10ClFN6
• Molecular Weight: 352.7529
• MDL Number: MFCD11519969
• SMILES: Clc1ccc(c(c1)c1nc(Nc2ccncc2)c2c(n1)nccn2)F

Computed Properties

• Complexity: 437
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 25
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 3
• XLogP3: 3

Literature

• Didecyldimethylammonium chloride induces pulmonary fibrosis in association with TGF-β signaling in mice.

  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20131101

• Hypoxia influences stem cell-like properties in multidrug resistant K562 leukemic cells.

  Blood cells, molecules & diseases 20131001

• Identification of potent Yes1 kinase inhibitors using a library screening approach.

  Bioorganic & medicinal chemistry letters 20130801

• TGF-β regulates sclerostin expression via the ECR5 enhancer.

  Bone 20120301

• TGF-β1 mediates sirolimus and cyclosporine A-induced alteration of barrier function in renal epithelial cells via a noncanonical ERK1/2 signaling pathway.

  American journal of physiology. Renal physiology 20111201

• Differential TGF-{beta} signaling in retinal vascular cells: a role in diabetic retinopathy?

  Investigative ophthalmology & visual science 20100401

• Inhibition of transforming growth factor beta signaling reduces pancreatic adenocarcinoma growth and invasiveness.

  Molecular pharmacology 20070701

• Evaluation of the anti-hepatitis C virus effect of novel potent, selective, and orally bioavailable JNK and VEGFR kinase inhibitors.

  Bioorganic & medicinal chemistry letters 20070401

• Potential involvement of BMP receptor type IB activation in a synergistic effect of chondrogenic promotion between rhTGFbeta3 and rhGDF5 or rhBMP7 in human mesenchymal stem cells.

  Growth factors (Chur, Switzerland) 20061201

• Effect of transforming growth factor-beta receptor I kinase inhibitor 2,4-disubstituted pteridine (SD-208) in chronic allergic airway inflammation and remodeling.

  The Journal of pharmacology and experimental therapeutics 20061101

• Transforming growth factor-beta receptor type 1 (TGFbetaRI) kinase activity but not p38 activation is required for TGFbetaRI-induced myofibroblast differentiation and profibrotic gene expression.

  Molecular pharmacology 20060801

• Progressive transforming growth factor beta1-induced lung fibrosis is blocked by an orally active ALK5 kinase inhibitor.

  American journal of respiratory and critical care medicine 20050415