630420-16-5 | Asunaprevir

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$39.00	$27.00
5mg	95%	in stock	$91.00	$64.00
10mg	95%	in stock	$126.00	$88.00
50mg	95%	in stock	$180.00	$126.00
100mg	95%	in stock	$356.00	$249.00
250mg	95%	in stock	$605.00	$424.00
1g	95%	in stock	$2,061.00	$1,443.00

Description

• Catalog Number: AB52538
• Chemical Name: Asunaprevir
• CAS Number: 630420-16-5
• Molecular Formula: C35H46ClN5O9S
• Molecular Weight: 748.2858
• MDL Number: MFCD27987900
• SMILES: C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H](CN1C(=O)[C@H](C(C)(C)C)NC(=O)OC(C)(C)C)Oc1ncc(c2c1cc(Cl)cc2)OC)C(=O)NS(=O)(=O)C1CC1

Computed Properties

• Complexity: 1470
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 5
• Heavy Atom Count: 51
• Hydrogen Bond Acceptor Count: 10
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 14
• XLogP3: 4.9

Literature

• The discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection.

  Journal of medicinal chemistry 20140313

• Highly efficient infectious cell culture of three hepatitis C virus genotype 2b strains and sensitivity to lead protease, nonstructural protein 5A, and polymerase inhibitors.

  Hepatology (Baltimore, Md.) 20140201

• Combination treatment with hepatitis C virus protease and NS5A inhibitors is effective against recombinant genotype 1a, 2a, and 3a viruses.

  Antimicrobial agents and chemotherapy 20130301

• Combinations of lambda interferon with direct-acting antiviral agents are highly efficient in suppressing hepatitis C virus replication.

  Antimicrobial agents and chemotherapy 20130301