632-85-9 | Wogonin

Packsize	Purity	Availability	Price	Discounted Price
5mg	≥98%	in stock	$83.00	$58.00
50mg	>98.0%(HPLC)	in stock	$150.00	$105.00

Description

• Catalog Number: AI54084
• Chemical Name: Wogonin
• CAS Number: 632-85-9
• Molecular Formula: C16H12O5
• Molecular Weight: 284.2635
• MDL Number: MFCD00017736
• SMILES: COc1c(O)cc(c2c1oc(cc2=O)c1ccccc1)O
• NSC Number: 717845

Computed Properties

• Complexity: 426
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 21
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 2
• XLogP3: 3

Literature

• Wogonin, a natural flavonoid, intercalates with genomic DNA and exhibits protective effects in IL-1β stimulated osteoarthritis chondrocytes.

  Chemico-biological interactions 20170825

• Protective effect of wogonin on endotoxin-induced acute lung injury via reduction of p38 MAPK and JNK phosphorylation.

  Environmental toxicology 20170201

• Endotoxin-induced acute lung injury in mice is protected by 5,7-dihydroxy-8-methoxyflavone via inhibition of oxidative stress and HIF-1α.

  Environmental toxicology 20161201

• BisGMA-induced cytotoxicity and genotoxicity in macrophages are attenuated by wogonin via reduction of intrinsic caspase pathway activation.

  Environmental toxicology 20160201

• In vitro effects of some flavones on human pyruvate kinase isoenzyme M2.

  Journal of biochemical and molecular toxicology 20150301

• Wogonin attenuates endotoxin-induced prostaglandin E2 and nitric oxide production via Src-ERK1/2-NFκB pathway in BV-2 microglial cells.

  Environmental toxicology 20141001

• GSK3β/β-catenin signaling is correlated with the differentiation of glioma cells induced by wogonin.

  Toxicology letters 20131024

• Wogonin attenuates etoposide-induced oxidative DNA damage and apoptosis via suppression of oxidative DNA stress and modulation of OGG1 expression.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20130901

• Wogonin inhibits H2O2-induced vascular permeability through suppressing the phosphorylation of caveolin-1.

  Toxicology 20130308

• A novel process related impurity and forced degradation study of synthetic wogonin: development of a liquid chromatographic method for purity control.

  Journal of pharmaceutical and biomedical analysis 20121201

• Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells.

  Molecular medicine reports 20121201

• Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

  Bioorganic & medicinal chemistry 20121115

• A novel local recycling mechanism that enhances enteric bioavailability of flavonoids and prolongs their residence time in the gut.

  Molecular pharmaceutics 20121105

• A simple isocratic HPLC method for the simultaneous determination of bioactive components of Scutellariae radix extract.

  Natural product research 20121101

• Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells.

  Journal of cellular biochemistry 20121101

• Simultaneous determination of baicalin, wogonoside, baicalein, wogonin, oroxylin A and chrysin of Radix scutellariae extract in rat plasma by liquid chromatography tandem mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20121101

• Wogonin induces apoptosis by activating the AMPK and p53 signaling pathways in human glioblastoma cells.

  Cellular signalling 20121101

• A new strategy for quality control and qualitative analysis of Yinhuang preparations by HPLC-DAD-MS/MS.

  Analytical and bioanalytical chemistry 20121001

• Enhanced accumulation of secondary metabolites in hairy root cultures of Scutellaria lateriflora following elicitation.

  Biotechnology letters 20120901

• Simultaneous determination of active flavonoids and alkaloids of Tang-Min-Ling-Pill in rat plasma by liquid chromatography tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120901

• 6-Shogaol, a ginger product, modulates neuroinflammation: a new approach to neuroprotection.

  Neuropharmacology 20120801

• Wogonin potentiates cisplatin-induced cancer cell apoptosis through accumulation of intracellular reactive oxygen species.

  Oncology reports 20120801

• Anti-atherosclerotic action of Ger-Gen-Chyn-Lian-Tang and AMPK-dependent lipid lowering effect in hepatocytes.

  Journal of ethnopharmacology 20120626

• Relaxant effect induced by wogonin from Scutellaria baicalensis on rat isolated uterine smooth muscle.

  Pharmaceutical biology 20120601

• Screening of anti-cancer agent using zebrafish: comparison with the MTT assay.

  Biochemical and biophysical research communications 20120525

• Scutellaria baicalensis alleviates cantharidin-induced rat hemorrhagic cystitis through inhibition of cyclooxygenase-2 overexpression.

  Molecules (Basel, Switzerland) 20120525

• The tetramethoxyflavone zapotin selectively activates protein kinase C epsilon, leading to its down-modulation accompanied by Bcl-2, c-Jun and c-Fos decrease.

  European journal of pharmacology 20120505

• Scutellaria extract and wogonin inhibit tumor-mediated induction of T(reg) cells via inhibition of TGF-β1 activity.

  Cancer immunology, immunotherapy : CII 20120501

• Detection of baicalin metabolites baicalein and oroxylin-a in mouse pancreas and pancreatic xenografts.

  Pancreas 20120501

• [Non-alkaloid chemical constituents from Coptis chinensis].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120501

• [Wogonin inhibits IGF-1-stimulated cell growth and estrogen receptor α expression in breast adenocarcinoma cell and angiogenesis of chick chorioallantoic membrane].

  Sheng li xue bao : [Acta physiologica Sinica] 20120425

• Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production.

  Bioorganic & medicinal chemistry letters 20120401

• Chemical constituents of the aerial parts of Scutellaria lateriflora and their alpha-glucosidase inhibitory activities.

  Natural product communications 20120401

• Screening active compounds acting on the epidermal growth factor receptor from Radix scutellariae via cell membrane chromatography online coupled with HPLC/MS.

  Journal of pharmaceutical and biomedical analysis 20120325

• Comparison of intestinal absorption and disposition of structurally similar bioactive flavones in Radix Scutellariae.

  The AAPS journal 20120301

• The molecular basis for the inhibition of human cytochrome P450 1A2 by oroxylin and wogonin.

  European biophysics journal : EBJ 20120301

• Studying on inclusion complexes of Wogonin with β-cyclodextrin and hydroxypropyl-cyclodextrin.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120215

• Phenolic compounds and antioxidant activities of Liriope muscari.

  Molecules (Basel, Switzerland) 20120210

• Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathway.

  International immunopharmacology 20120201

• [Study on ingredients of Scutellaria Radix extract penetrable through placental barrier of pregnant rat].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120201

• Transcription factor NF-κB regulates expression of pore-forming Ca2+ channel unit, Orai1, and its activator, STIM1, to control Ca2+ entry and affect cellular functions.

  The Journal of biological chemistry 20120120

• Wogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression.

  The Journal of biological chemistry 20120102

• Bambusae caulis in Liquamen Suppresses the Expression of Thymus and Activation-Regulated Chemokine and Macrophage-Derived Chemokine in Human Keratinocytes due to Antioxidant Effect.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Effect of an Ethanol Extract of Scutellaria baicalensis on Relaxation in Corpus Cavernosum Smooth Muscle.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• A Herbal Composition of Scutellaria baicalensis and Eleutherococcus senticosus Shows Potent Anti-Inflammatory Effects in an Ex Vivo Human Mucosal Tissue Model.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Wogonin improves histological and functional outcomes, and reduces activation of TLR4/NF-κB signaling after experimental traumatic brain injury.

  PloS one 20120101

• Advances in the treatment of ovarian cancer: a potential role of antiinflammatory phytochemicals.

  Discovery medicine 20120101

• Enhanced effects of cigarette smoke extract on inflammatory cytokine expression in IL-1β-activated human mast cells were inhibited by Baicalein via regulation of the NF-κB pathway.

  Clinical and molecular allergy : CMA 20120101

• Aldo-Keto Reductase 1B10 and Its Role in Proliferation Capacity of Drug-Resistant Cancers.

  Frontiers in pharmacology 20120101

• Effect of magnetic nanoparticles on apoptosis and cell cycle induced by wogonin in Raji cells.

  International journal of nanomedicine 20120101

• Functional role of wogonin in anti-angiogenesis.

  The American journal of Chinese medicine 20120101

• Neuroprotective Effects of San-Huang-Xie-Xin-Tang in the MPP(+)/MPTP Models of Parkinson's Disease In Vitro and In Vivo.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Icariside II induces apoptosis in U937 acute myeloid leukemia cells: role of inactivation of STAT3-related signaling.

  PloS one 20120101

• [Simultaneous determination of five main index components and specific chromatograms analysis in Xiaochaihu granules].

  Yao xue xue bao = Acta pharmaceutica Sinica 20120101

• Comparative study of the effect of baicalin and its natural analogs on neurons with oxygen and glucose deprivation involving innate immune reaction of TLR2/TNFα.

  Journal of biomedicine & biotechnology 20120101

• Different effects of farrerol on an OVA-induced allergic asthma and LPS-induced acute lung injury.

  PloS one 20120101

• Reactive oxygen species and inhibitors of inflammatory enzymes, NADPH oxidase, and iNOS in experimental models of Parkinson's disease.

  Mediators of inflammation 20120101

• Baicalin improves survival in a murine model of polymicrobial sepsis via suppressing inflammatory response and lymphocyte apoptosis.

  PloS one 20120101

• Yang-Dan-Tang, Identified from 15 Chinese Herbal Formulae, Inhibits Human Lung Cancer Cell Proliferation via Cell Cycle Arrest.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects.

  Oxidative medicine and cellular longevity 20120101

• Effect of magnetic nanoparticles of Fe3O4 and wogonin on the reversal of multidrug resistance in K562/A02 cell line.

  International journal of nanomedicine 20120101

• Traditional Japanese herbal (kampo) medicines and treatment of ocular diseases: a review.

  The American journal of Chinese medicine 20120101

• Wogonin induces reactive oxygen species production and cell apoptosis in human glioma cancer cells.

  International journal of molecular sciences 20120101

• Scutellaria baicalensis Extracts and Flavonoids Protect Rat L6 Cells from Antimycin A-Induced Mitochondrial Dysfunction.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes.

  European journal of drug metabolism and pharmacokinetics 20111201

• Wogonin ameliorates lipotoxicity-induced apoptosis of cultured vascular smooth muscle cells via interfering with DAG-PKC pathway.

  Acta pharmacologica Sinica 20111201

• Polyphenols and neuroprotection against ischemia and neurodegeneration.

  Mini reviews in medicinal chemistry 20111201

• Wogonin promotes cholesterol efflux by increasing protein phosphatase 2B-dependent dephosphorylation at ATP-binding cassette transporter-A1 in macrophages.

  The Journal of nutritional biochemistry 20111101

• Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones.

  Biopharmaceutics & drug disposition 20111101

• Wogonin, an active ingredient of Chinese herb medicine Scutellaria baicalensis, inhibits the mobility and invasion of human gallbladder carcinoma GBC-SD cells by inducing the expression of maspin.

  Journal of ethnopharmacology 20111011

• Wogonin induced apoptosis in human nasopharyngeal carcinoma cells by targeting GSK-3β and ΔNp63.

  Cancer chemotherapy and pharmacology 20111001

• Simultaneous quantification of twelve active components in Yiqing granule by ultra-performance liquid chromatography: application to quality control study.

  Biomedical chromatography : BMC 20110901

• Enhancement of flavone levels through overexpression of chalcone isomerase in hairy root cultures of Scutellaria baicalensis.

  Functional & integrative genomics 20110901

• Development of a novel method combining HPLC fingerprint and multi-ingredients quantitative analysis for quality evaluation of traditional Chinese medicine preparation.

  Talanta 20110815

• Wogonin suppresses arrhythmias, inflammatory responses, and apoptosis induced by myocardial ischemia/reperfusion in rats.

  Journal of cardiovascular pharmacology 20110801

• The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells.

  Toxicology and applied pharmacology 20110801

• Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells.

  Biochimica et biophysica acta 20110801

• [Comparision of adsorption-desorption dynamics of huanglian jiedu decoction using different macroporous resins combinations].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110801

• Simultaneous quantification of multiple active components from Xiexin decoction in rat plasma by LC-ESI-MS/MS: application in pharmacokinetics.

  Biomedical chromatography : BMC 20110701

• Developmental toxicity and genotoxicity studies of wogonin.

  Regulatory toxicology and pharmacology : RTP 20110701

• Effects of baicalein and wogonin isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice.

  European journal of pharmacology 20110701

• Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways.

  International journal of oncology 20110701

• Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1.

  Cell death & disease 20110701

• [Comparative and correlational studies on contents of flavonoids in axial root and lateral root of Scutellaria baicalensis].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110701

• Baicalein and wogonin are activators of rat TREK-2 two-pore domain K+ channel.

  Acta physiologica (Oxford, England) 20110601

• Simultaneous determination of five flavonoids from Scutellaria Barbata extract in rat plasma by LC-MS/MS and its application to pharmacokinetic study.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110601

• Herbal extract THI improves metabolic abnormality in mice fed a high-fat diet.

  Nutrition research and practice 20110601

• Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3.

  Clinics (Sao Paulo, Brazil) 20110601

• The inhibitory activities of the components of Huang-Lian-Jie-Du-Tang (HLJDT) on eicosanoid generation via lipoxygenase pathway.

  Journal of ethnopharmacology 20110517

• Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects.

  Cancer chemotherapy and pharmacology 20110501

• Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells.

  Bioorganic & medicinal chemistry 20110501

• Wogonin induces apoptosis by activation of ERK and p38 MAPKs signaling pathways and generation of reactive oxygen species in human breast cancer cells.

  Molecules and cells 20110430

• Inhibitory effects of wogonin on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-9.

  Toxicology 20110411

• Combined activity of oridonin and wogonin in advanced-stage ovarian cancer cells: sensitivity of ovarian cancer cells to phyto-active chemicals.

  Cell biology and toxicology 20110401

• Catalase suppression-mediated H(2)O(2) accumulation in cancer cells by wogonin effectively blocks tumor necrosis factor-induced NF-κB activation and sensitizes apoptosis.

  Cancer science 20110401

• [Study on transportation of Xiaochaihu Tang in Caco-2 cell model].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110401

• Identification and quantification of baicalein, wogonin, oroxylin A and their major glucuronide conjugated metabolites in rat plasma after oral administration of Radix scutellariae product.

  Journal of pharmaceutical and biomedical analysis 20110325

• Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats.

  Planta medica 20110301

• Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration?

  CNS & neurological disorders drug targets 20110301

• Structure-metabolism relationships for the glucuronidation of flavonoids by UGT1A3 and UGT1A9.

  The Journal of pharmacy and pharmacology 20110201

• San-Huang-Xie-Xin-Tang Protects against Activated Microglia- and 6-OHDA-Induced Toxicity in Neuronal SH-SY5Y Cells.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Prescriptions of Chinese Herbal Medicines for Insomnia in Taiwan during 2002.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Maternal baicalin treatment increases fetal lung surfactant phospholipids in rats.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Metabolism and pharmacokinetics of san-huang-xie-xin-tang, a polyphenol-rich chinese medicine formula, in rats and ex-vivo antioxidant activity.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Analyzing Cytotoxic and Apoptogenic Properties of Scutellaria litwinowii Root Extract on Cancer Cell Lines.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Delayed growth of glioma by Scutellaria flavonoids involve inhibition of Akt, GSK-3 and NF-κB signaling.

  Journal of neuro-oncology 20110101

• The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease.

  International journal of molecular sciences 20110101

• The scavenging of superoxide radicals promotes apoptosis induced by a novel cell-permeable fusion protein, sTRAIL:FeSOD, in tumor necrosis factor-related apoptosis-inducing ligand-resistant leukemia cells.

  BMC biology 20110101

• Silibinin induces apoptosis via calpain-dependent AIF nuclear translocation in U87MG human glioma cell death.

  Journal of experimental & clinical cancer research : CR 20110101

• Effects of flavonoids on matrix metalloproteinase-13 expression of interleukin-1β-treated articular chondrocytes and their cellular mechanisms: inhibition of c-Fos/AP-1 and JAK/STAT signaling pathways.

  Journal of pharmacological sciences 20110101

• Anti-inflammatory effects of Chinese medicinal herbs on cerebral ischemia.

  Chinese medicine 20110101

• Anti-cancer natural products isolated from chinese medicinal herbs.

  Chinese medicine 20110101

• Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway.

  PloS one 20110101

• New perspectives on chinese herbal medicine (zhong-yao) research and development.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Herbal medicine and hepatocellular carcinoma: applications and challenges.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Grape seed proanthocyanidin extract inhibits glutamate-induced cell death through inhibition of calcium signals and nitric oxide formation in cultured rat hippocampal neurons.

  BMC neuroscience 20110101

• Comparative chemical and statistical analysis of cultivated and wild Radix Scutellariae.

  The American journal of Chinese medicine 20110101

• A 4-week Repeated Dose Oral Toxicity and Cytotoxicity Study of Gumiganghwaltang in Crl:CD (SD) Rats.

  Toxicology international 20110101

• Stuck at the bench: Potential natural neuroprotective compounds for concussion.

  Surgical neurology international 20110101

• Ex vivo effects of flavonoïds extracted from Artemisia herba alba on cytokines and nitric oxide production in Algerian patients with Adamantiades-Behçet's disease.

  Journal of inflammation (London, England) 20110101

• Baicalein mediates inhibition of migration and invasiveness of skin carcinoma through Ezrin in A431 cells.

  BMC cancer 20110101

• Different apoptotic effects of wogonin via induction of H(2)O(2) generation and Ca(2+) overload in malignant hepatoma and normal hepatic cells.

  Journal of cellular biochemistry 20101215

• Molecular cloning and characterization of phenylalanine ammonia-lyase, cinnamate 4-hydroxylase and genes involved in flavone biosynthesis in Scutellaria baicalensis.

  Bioresource technology 20101201

• Characterization of the multiple absorbed constituents in rats after oral administration of Chai-Huang decoction by liquid chromatography coupled with electrospray-ionization mass spectrometry.

  Chemistry & biodiversity 20101201

• [Bio-activity evaluation of Qinlian Siwu decoction on inhibiting mice uterine contraction in vitro and its components analysis].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101201

• Wogonin induces differentiation and neurite outgrowth of neural precursor cells.

  Biochemical and biophysical research communications 20101105

• Simultaneous determination of baicalin, baicalein, wogonin, berberine, palmatine and jatrorrhizine in rat plasma by liquid chromatography-tandem mass spectrometry and application in pharmacokinetic studies after oral administration of traditional Chinese medicinal preparations containing scutellaria-coptis herb couple.

  Journal of pharmaceutical and biomedical analysis 20101102

• Secondary metabolite mapping identifies Scutellaria inhibitors of human lung cancer cells.

  Journal of pharmaceutical and biomedical analysis 20101102

• 12-O-tetradecanoylphorbol-13-acetate-induced invasion/migration of glioblastoma cells through activating PKCalpha/ERK/NF-kappaB-dependent MMP-9 expression.

  Journal of cellular physiology 20101101

• Wogonin potentiates the antitumor effects of low dose 5-fluorouracil against gastric cancer through induction of apoptosis by down-regulation of NF-kappaB and regulation of its metabolism.

  Toxicology letters 20100901

• Combinative method using HPLC fingerprint and quantitative analyses for quality consistency evaluation of an herbal medicinal preparation produced by different manufacturers.

  Journal of pharmaceutical and biomedical analysis 20100801

• Use of isoform-specific UGT metabolism to determine and describe rates and profiles of glucuronidation of wogonin and oroxylin A by human liver and intestinal microsomes.

  Pharmaceutical research 20100801

• Wogonin inhibits osteoclast formation induced by lipopolysaccharide.

  Phytotherapy research : PTR 20100701

• Plant Natural compounds with antibacterial activity towards common pathogens of pond-cultured channel catfish (Ictalurus punctatus).

  Toxins 20100701

• New inhibitors for expression of IgE receptor on human mast cell.

  Bioorganic & medicinal chemistry letters 20100401

• Baicalein and Wogonin inhibit collagen deposition in SHR and WKY cardiac fibroblast cultures.

  BMB reports 20100401

• Traditional Chinese medicine and related active compounds against hepatitis B virus infection.

  Bioscience trends 20100401

• Spectrometric study of the interaction between alpinetin and bovine serum albumin using chemometrics approaches.

  Analytica chimica acta 20100324

• On-line continuous flow ultrasonic extraction coupled with high performance liquid chromatographic separation for determination of the flavonoids from root of Scutellaria baicalensis Georgi.

  Journal of chromatography. A 20100319

• Effects of naturally occurring polymethyoxyflavonoids on cell growth, p-glycoprotein function, cell cycle, and apoptosis of daunorubicin-resistant T lymphoblastoid leukemia cells.

  Cancer investigation 20100301

• [Simultaneous determination of five active constitutents in Xiaochaihu Tang by HPLC].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100301

• Qualitative and quantitative analysis of traditional Chinese medicine Niu Huang Jie Du Pill using ultra performance liquid chromatography coupled with tunable UV detector and rapid resolution liquid chromatography coupled with time-of-flight tandem mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20100205

• [Simultaneous determination of 7 active ingredients in Scutellaria barbata D. Don by capillary micellar electrokinetic chromatography].

  Se pu = Chinese journal of chromatography 20100201

• In vitro anti-leukemic activity of the ethno-pharmacological plant Scutellaria orientalis ssp. carica endemic to western Turkey.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20100101

• Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20100101

• Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF-7 human breast cancer cells.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20100101

• Inhibition of prostaglandin E2 production by flavone and its related compounds.

  In vivo (Athens, Greece) 20100101

• MKEM: a Multi-level Knowledge Emergence Model for mining undiscovered public knowledge.

  BMC bioinformatics 20100101

• Stem cell-based neuroprotective and neurorestorative strategies.

  International journal of molecular sciences 20100101

• Apoptotic effects of chrysin in human cancer cell lines.

  International journal of molecular sciences 20100101

• A comprehensive platform for quality control of botanical drugs (PhytomicsQC): a case study of Huangqin Tang (HQT) and PHY906.

  Chinese medicine 20100101

• Effects of Various Flavonoids on the α-Synuclein Fibrillation Process.

  Parkinson's disease 20100101

• Chungsim-Yeunja-Tang decreases the inflammatory response in peripheral blood mononuclear cells from patients with cerebral infarction through an NF-κB dependent mechanism.

  Journal of neuroinflammation 20100101

• Traditional herbal medicine in far-west Nepal: a pharmacological appraisal.

  Journal of ethnobiology and ethnomedicine 20100101

• Interaction of bioactive coomassie brilliant blue g with protein: insights from spectroscopic methods.

  Scientia pharmaceutica 20100101

• Molecular cloning and expression profiling of a chalcone synthase gene from hairy root cultures of Scutellaria viscidula Bunge.

  Genetics and molecular biology 20100101

• Wogonin induces G1 phase arrest through inhibiting Cdk4 and cyclin D1 concomitant with an elevation in p21Cip1 in human cervical carcinoma HeLa cells.

  Biochemistry and cell biology = Biochimie et biologie cellulaire 20091201

• Cloning and expression of beta-glucuronidase from Lactobacillus brevis in E. coli and application in the bioconversion of baicalin and wogonoside.

  Journal of microbiology and biotechnology 20091201

• [A quantitative method for simultaneous assay of four flavones with one marker in Radix Scutellariae].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091201

• Arsenic accumulation in Scutellaria baicalensis Georgi and its effects on plant growth and pharmaceutical components.

  Journal of hazardous materials 20091115

• Inhibition of prostaglandin E2 production by synthetic wogonin analogs.

  Archives of pharmacal research 20091101

• [Analysis of main flavonoids contents of Scutellaria baicalensis].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091101

• [Flavonoids from Scutellaria baicalensis and their bioactivities].

  Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20091018

• Contents of major bioactive flavones in proprietary traditional Chinese medicine products and reference herb of radix Scutellariae.

  Journal of pharmaceutical and biomedical analysis 20091015

• Reactive oxygen species up-regulate p53 and Puma; a possible mechanism for apoptosis during combined treatment with TRAIL and wogonin.

  British journal of pharmacology 20090801

• Molecular crosstalk between TRAIL and natural antioxidants in the treatment of cancer.

  British journal of pharmacology 20090801

• Inhibition of P-glycoprotein by wogonin is involved with the potentiation of etoposide-induced apoptosis in cancer cells.

  Annals of the New York Academy of Sciences 20090801

• Subchronic toxicity and plasma pharmacokinetic studies on wogonin, a natural flavonoid, in Beagle dogs.

  Journal of ethnopharmacology 20090715

• Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling.

  Gut 20090701

• Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora.

  Journal of natural products 20090601

• Simultaneous determination of 11 active components in two well-known traditional Chinese medicines by HPLC coupled with diode array detection for quality control.

  Journal of pharmaceutical and biomedical analysis 20090501

• [Analysis of the 4th generation Scutellaria baicalensis Georgi with space mutagenesis via FTIR spectroscopy].

  Guang pu xue yu guang pu fen xi = Guang pu 20090501

• Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study.

  Bioorganic & medicinal chemistry letters 20090315

• Toxicological studies of wogonin in experimental animals.

  Phytotherapy research : PTR 20090301

• Mechanism of CYP2C9 inhibition by flavones and flavonols.

  Drug metabolism and disposition: the biological fate of chemicals 20090301

• Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography.

  Analytica chimica acta 20090202

• New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin.

  Cancer treatment reviews 20090201

• In vitro antitumor mechanisms of various Scutellaria extracts and constituent flavonoids.

  Planta medica 20090101

• Natural products as promising drug candidates for the treatment of hepatitis B and C.

  Acta pharmacologica Sinica 20090101

• Bear bile: dilemma of traditional medicinal use and animal protection.

  Journal of ethnobiology and ethnomedicine 20090101

• A new dawn for the use of traditional Chinese medicine in cancer therapy.

  Molecular cancer 20090101

• Simple and reliable methods for the determination of sixteen marker components for quality control of Daochi pill by HPLC coupled with diode array detection.

  Phytochemical analysis : PCA 20090101

• Effect of Scutellariae radix ingredients on prostaglandin E(2) production and COX-2 expression by LPS-activated macrophage.

  In vivo (Athens, Greece) 20090101

• An in vitro based investigation of the cytotoxic effect of water extracts of the Chinese herbal remedy LD on cancer cells.

  Chemistry Central journal 20090101

• Synergistic effect of magnetic nanoparticles of Fe(3)O(4) with gambogic acid on apoptosis of K562 leukemia cells.

  International journal of nanomedicine 20090101

• Wogonin inhibits microglial cell migration via suppression of nuclear factor-kappa B activity.

  International immunopharmacology 20081210

• Wogonin, a bioactive flavonoid in herbal tea, inhibits inflammatory cyclooxygenase-2 gene expression in human lung epithelial cancer cells.

  Molecular nutrition & food research 20081101

• Wogonin induced differentiation and G1 phase arrest of human U-937 leukemia cells via PKCdelta phosphorylation.

  European journal of pharmacology 20080904

• Cancer is a preventable disease that requires major lifestyle changes.

  Pharmaceutical research 20080901

• Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu- tang across human intestinal Caco-2 cell monolayers.

  Acta pharmacologica Sinica 20080901

• Production of cytokines and stimulation of resistance to viral infection in human leukocytes by Scutellaria baicalensis flavones.

  Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20080901

• [Studies on ethyl acetate soluble constituents of Huanglian Jiedutang].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901

• QSAR modeling of the interaction of flavonoids with GABA(A) receptor.

  European journal of medicinal chemistry 20080801

• Chemopreventive effect of selenium and Chinese medicinal herbs on N-nitrosobis(2-oxopropyl)amine-induced hepatocellular carcinoma in Syrian hamsters.

  Liver international : official journal of the International Association for the Study of the Liver 20080701

• Comparison of the major flavonoid content of S. baicalensis, S. lateriflora, and their commercial products.

  Journal of natural medicines 20080701

• Genetic characterization and phytochemical analysis of wild and cultivated populations of Scutellaria baicalensis.

  Chemistry & biodiversity 20080701

• [Comparative study on chemcial composition between cultivated and wild Scutellariae radix].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080601

• Assessment of luteolin (3',4',5,7-tetrahydroxyflavone) neuropharmacological activity.

  Behavioural brain research 20080516

• Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells.

  Biochemical pharmacology 20080515

• Blockade of the dioxin pathway by herbal medicine Formula Bupleuri Minor: identification of active entities for suppression of AhR activation.

  Biological & pharmaceutical bulletin 20080501

• Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2.

  Life sciences 20080423

• Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1alpha/2alpha is mediated through chelation of iron.

  Journal of cellular biochemistry 20080415

• Differential apoptotic effect of wogonin and nor-wogonin via stimulation of ROS production in human leukemia cells.

  Journal of cellular biochemistry 20080401

• Wogonin induces the granulocytic differentiation of human NB4 promyelocytic leukemia cells and up-regulates phospholipid scramblase 1 gene expression.

  Cancer science 20080401

• Comparisons of Scutellaria baicalensis, Scutellaria lateriflora and Scutellaria racemosa: genome size, antioxidant potential and phytochemistry.

  Planta medica 20080301

• Anticancer effects of wogonin in both estrogen receptor-positive and -negative human breast cancer cell lines in vitro and in nude mice xenografts.

  International journal of cancer 20080215

• Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis.

  Blood 20080215

• Down-regulation of androgen-receptor and PSA by phytochemicals.

  International journal of oncology 20080201

• Two new alkaloids from Capparis himalayensis.

  Chemical & pharmaceutical bulletin 20080201

• Rutoside decreases human macrophage-derived inflammatory mediators and improves clinical signs in adjuvant-induced arthritis.

  Arthritis research & therapy 20080101

• Validation of a HPLC method for flavonoid biomarkers in skullcap (Scutellaria) and its use to illustrate wide variability in the quality of commercial tinctures.

  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20080101

• Enhanced electrochemiluminescence of Ru(bpy)3(2+) by flavone compounds.

  Luminescence : the journal of biological and chemical luminescence 20080101

• Effects of baicalin and wogonin on mucin release from cultured airway epithelial cells.

  Phytotherapy research : PTR 20071201

• Anticonvulsant effect of wogonin isolated from Scutellaria baicalensis.

  European journal of pharmacology 20071128

• Inhibition of mammalian collagenase, matrix metalloproteinase-1, by naturally-occurring flavonoids.

  Planta medica 20071001

• Antitumor activity of chloroform fraction of Scutellaria barbata and its active constituents.

  Phytotherapy research : PTR 20070901

• Wogonin but not Nor-wogonin inhibits lipopolysaccharide and lipoteichoic acid-induced iNOS gene expression and NO production in macrophages.

  International immunopharmacology 20070801

• Wogonin prevents glucocorticoid-induced thymocyte apoptosis without diminishing its anti-inflammatory action.

  Journal of pharmacological sciences 20070801

• [HPLC fingerprint of flavonoids of Kushen Tang and its correlation to Scutellaria baicalensis and Sophora flavescens].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070801

• [Effects of processing and extracting methods on active components in Radix Scutellariae by HPLC analysis].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070801

• Comparative effects of flavonoids on oxidant scavenging and ischemia-reperfusion injury in cardiomyocytes.

  European journal of pharmacology 20070702

• [Pharmacokinetics of flavonoids from xiexin decoction in rats].

  Yao xue xue bao = Acta pharmaceutica Sinica 20070701

• [Enzymatic extraction of baicalein and wogonin from radix scutellariae].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070701

• Reversal of inflammation-associated dihydrodiol dehydrogenases (AKR1C1 and AKR1C2) overexpression and drug resistance in nonsmall cell lung cancer cells by wogonin and chrysin.

  International journal of cancer 20070501

• Anti-hepatitis B virus activity of wogonin in vitro and in vivo.

  Antiviral research 20070401

• Wogonin suppresses TARC expression induced by mite antigen via heme oxygenase 1 in human keratinocytes. Suppressive effect of wogonin on mite antigen-induced TARC expression.

  Journal of dermatological science 20070401

• Pharmacokinetics of baicalein, baicalin and wogonin after oral administration of a standardized extract of Scutellaria baicalensis, PF-2405 in rats.

  Archives of pharmacal research 20070201

• Quantitative analysis and chromatographic fingerprinting for the quality evaluation of Scutellaria baicalensis Georgi using capillary electrophoresis.

  Journal of pharmaceutical and biomedical analysis 20070117

• Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell.

  Cancer letters 20070108

• Simultaneous determination of eight active components in Chinese medicine 'YIQING' capsule using high-performance liquid chromatography.

  Journal of pharmaceutical and biomedical analysis 20070104

• Changes in mitochondrial membrane potential and reactive oxygen species during wogonin-induced cell death in human hepatoma cells.

  Hepatology research : the official journal of the Japan Society of Hepatology 20070101

• Wogonin prevents immunosuppressive action but not anti-inflammatory effect induced by glucocorticoid.

  Annals of the New York Academy of Sciences 20070101

• Wogonin, a plant flavone, potentiates etoposide-induced apoptosis in cancer cells.

  Annals of the New York Academy of Sciences 20070101

• Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels.

  Arthritis research & therapy 20070101

• [Antiatherosclerotic properties of flavones from the roots of Scutellaria baicalensis Georgi].

  Wiadomosci lekarskie (Warsaw, Poland : 1960) 20070101

• Gene expression profiling of cancer stem cell in human lung adenocarcinoma A549 cells.

  Molecular cancer 20070101

• Baicalein inhibits IL-1beta- and TNF-alpha-induced inflammatory cytokine production from human mast cells via regulation of the NF-kappaB pathway.

  Clinical and molecular allergy : CMA 20070101

• Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages.

  Mediators of inflammation 20070101

• Saikokeishito Extract Exerts a Therapeutic Effect on alpha-Naphthylisothiocyanate-Induced Liver Injury in Rats through Attenuation of Enhanced Neutrophil Infiltration and Oxidative Stress in the Liver Tissue.

  Journal of clinical biochemistry and nutrition 20070101

• Oroxylin A induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its antitumor activity.

  Biochemical and biophysical research communications 20061215

• Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells.

  Biochemical and biophysical research communications 20061208

• Liquid chromatography with tandem mass spectrometry for the simultaneous determination of baicalein, baicalin, oroxylin A and wogonin in rat plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061205

• Wogonin sensitizes resistant malignant cells to TNFalpha- and TRAIL-induced apoptosis.

  Blood 20061201

• Acacetin suppressed LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice.

  Biochemical pharmacology 20061115

• Protective role of wogonin against lipopolysaccharide-induced angiogenesis via VEGFR-2, not VEGFR-1.

  International immunopharmacology 20061101

• Wogonin inhibits IL-6-induced angiogenesis via down-regulation of VEGF and VEGFR-1, not VEGFR-2.

  Planta medica 20061101

• Analysis of baicalein, baicalin and wogonin in Scutellariae radix and its preparation by microemulsion electrokinetic chromatography with 1-butyl-3-methylimizolium tetrafluoborate ionic liquid as additive.

  Journal of chromatography. A 20061006

• Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI.

  Bioscience, biotechnology, and biochemistry 20061001

• Involvement of bax/bcl-2 in wogonin-induced apoptosis of human hepatoma cell line SMMC-7721.

  Anti-cancer drugs 20060801

• Retention behavior of silica-bonded and novel polymeric reversed-phase sorbents in studies on flavones as chemotaxonomic markers of Scutellaria L. genus.

  Journal of chromatography. A 20060707

• Lipopolysaccharide plus 12-o-tetradecanoylphorbol 13-acetate induction of migration and invasion of glioma cells in vitro and in vivo: Differential inhibitory effects of flavonoids.

  Neuroscience 20060630

• The anticancer activities of wogonin in murine sarcoma S180 both in vitro and in vivo.

  Biological & pharmaceutical bulletin 20060601

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Effects of flavonoids extracted from Scutellaria baicalensis Georgi on hemin-nitrite-H2O2 induced liver injury.

  European journal of pharmacology 20060424

• [Qualitative and quantitative determination of the main components of huanglianjiedu decoction by HPLC-UV/MS].

  Yao xue xue bao = Acta pharmaceutica Sinica 20060401

• Analysis of the interactions of botanical extract combinations against the viability of prostate cancer cell lines.

  Evidence-based complementary and alternative medicine : eCAM 20060301

• [Simultaneous determination of three kinds of components in sanhuang tablets by high-performance liquid chromatography].

  Yao xue xue bao = Acta pharmaceutica Sinica 20060301

• Micellar electrokinetic chromatography for separation of a mixture of coptis alkaloids, scute flavonoids, and rhubarb anthraquinones and bianthrones.

  Journal of pharmaceutical and biomedical analysis 20060123

• Application of LC/MS and ICP/MS for establishing the fingerprint spectrum of the traditional Chinese medicinal preparation Gan-Lu-Yin.

  Journal of separation science 20060101

• [Determination of contents of the effective ingredients in root of Scutellaria baicalensis by HPLC-ECD].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060101

• Cardioprotective effects of grape seed proanthocyanidins, baicalin and wogonin: comparison between acute and chronic treatments.

  The American journal of Chinese medicine 20060101

• Effects of wogonin on the levels of cytokines and functions of leukocytes associated with NF-kappa B expression in Sprague-Dawley rats.

  In vivo (Athens, Greece) 20060101

• [Studies on chemical constituents in bark of dictamnus dasycarpus].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20051101

• Molecular targets of dietary polyphenols with anti-inflammatory properties.

  Yonsei medical journal 20051031

• Binding of wogonin to human gammaglobulin.

  International journal of biological macromolecules 20051030

• Inhibitory effects of a chemically standardized extract from Scutellaria barbata in human colon cancer cell lines, LoVo.

  Journal of agricultural and food chemistry 20051019

• Synthesis and inhibition of PGE2 production of 6,8-disubstituted chrysin derivatives.

  European journal of medicinal chemistry 20050901

• Skullcapflavone I from Scutellaria baicalensis induces apoptosis in activated rat hepatic stellate cells.

  Planta medica 20050901

• Inhibition of prostaglandin production by a structurally-optimized flavonoid derivative, 2',4',7-trimethoxyflavone and cellular action mechanism.

  Biological & pharmaceutical bulletin 20050801

• Structure and antiinflammatory activity relationships of wogonin derivatives.

  Archives of pharmacal research 20050801

• Interaction of wogonin with bovine serum albumin.

  Bioorganic & medicinal chemistry 20050602

• Non-aqueous capillary electrophoresis for simultaneous separation and determination of three major active components in traditional medicinal preparations.

  Biomedical chromatography : BMC 20050601

• Synthesis and iNOS inhibitory activities of thioflavones.

  Archives of pharmacal research 20050601

• Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20050515

• Isolation and purification of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatography.

  Journal of chromatography. A 20050513

• Enhancing effects of Scutellaria baicalensis and some of its constituents on TGF-beta1 gene expression in RAW 264.7 murine macrophage cell line.

  Planta medica 20050501

• Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells.

  Blood 20050415

• Synthetic wogonin derivatives suppress lipopolysaccharide-induced nitric oxide production and hydrogen peroxide-induced cytotoxicity.

  Archives of pharmacal research 20050201

• The herbal medicine Sho-saiko-to selectively inhibits CD8+ T-cell proliferation.

  European journal of pharmacology 20050110

• Suppression of cyclooxygenase-2 expression of skin fibroblasts by wogonin, a plant flavone from Scutellaria radix.

  Prostaglandins, leukotrienes, and essential fatty acids 20050101

• Wogonin inhibits N-acetyltransferase activity and gene expression in human leukemia HL-60 cells.

  Anticancer research 20050101

• Therapeutic potential of wogonin: a naturally occurring flavonoid.

  CNS drug reviews 20050101

• Melatonin, a potent agent in antioxidative defense: actions as a natural food constituent, gastrointestinal factor, drug and prodrug.

  Nutrition & metabolism 20050101

• Scutellaria baicalensis decreases ritonavir-induced nausea.

  AIDS research and therapy 20050101

• Separation methods used for Scutellaria baicalensis active components.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041205

• Efficacy of wogonin in the production of immunoglobulins and cytokines by mesenteric lymph node lymphocytes in mouse colitis induced with dextran sulfate sodium.

  Bioscience, biotechnology, and biochemistry 20041201

• A metabolomic analysis of medicinal diversity in Huang-qin (Scutellaria baicalensis Georgi) genotypes: discovery of novel compounds.

  Plant cell reports 20041101

• Wogonin inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion.

  Biological & pharmaceutical bulletin 20041001

• Neuroprotective effect of wogonin: potential roles of inflammatory cytokines.

  Archives of pharmacal research 20040901

• [Isolation and elucidation of antioxidant constituents from acetone extract in root of Scutellaria rehderiana].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040901

• Neuroprotective effect of wogonin in hippocampal slice culture exposed to oxygen and glucose deprivation.

  European journal of pharmacology 20040616

• Neuroprotective effects of flavones on hydrogen peroxide-induced apoptosis in SH-SY5Y neuroblostoma cells.

  Bioorganic & medicinal chemistry letters 20040503

• Inhibition of contact dermatitis in animal models and suppression of proinflammatory gene expression by topically applied flavonoid, wogonin.

  Archives of pharmacal research 20040401

• Binding of wogonin to human serum albumin: a common binding site of wogonin in subdomain IIA.

  Journal of photochemistry and photobiology. B, Biology 20040319

• Synthesis and inhibitory activity against COX-2 catalyzed prostaglandin production of chrysin derivatives.

  Bioorganic & medicinal chemistry letters 20040308

• Cytotoxic activities of flavonoids from two Scutellaria plants in Chinese medicine.

  Journal of ethnopharmacology 20040301

• Synthesis and biological activities of 8-arylflavones.

  Archives of pharmacal research 20040301

• Preventive effect of the flavonoid, wogonin, against ethanol-induced gastric mucosal damage in rats.

  Digestive diseases and sciences 20040301

• Lipopolysaccharide enhancement of 12-o-tetradecanoylphorbol 13-acetate-mediated transformation in rat glioma C6, accompanied by induction of inducible nitric oxide synthase.

  Toxicology letters 20040227

• Wogonin inhibits excitotoxic and oxidative neuronal damage in primary cultured rat cortical cells.

  European journal of pharmacology 20040206

• Phytotoxic and antimicrobial constituents of Bacopa monnieri and Holmskioldia sanguinea.

  Phytotherapy research : PTR 20040201

• Antimutagenic and antiradical properties of flavones from the roots of Scutellaria baicalensis georgi.

  Die Nahrung 20040201

• Suppression of nitric oxide production in mouse macrophages by soybean flavonoids accumulated in response to nitroprusside and fungal elicitation.

  BMC biochemistry 20040101

• Proteomic analysis of mouse liver for the evaluation of effects of Scutellariae radix by liquid chromatography with tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20040101

• Antifungal activity of wogonin.

  Phytotherapy research : PTR 20031201

• Wogonin suppresses cellular proliferation and expression of monocyte chemoattractant protein 1 in Peyronie's plaque-derived cells.

  BJU international 20031101

• Differential effects of natural polyphenols on neuronal survival in primary cultured central neurons against glutamate- and glucose deprivation-induced neuronal death.

  Brain research 20031003

• Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20031001

• Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression.

  Biochemical pharmacology 20031001

• Effects of baicalin, baicalein, and wogonin on interleukin-6 and interleukin-8 expression, and nuclear factor-kappab binding activities induced by interleukin-1beta in human retinal pigment epithelial cell line.

  Experimental eye research 20030801

• [Effects of wogonin on inducing apoptosis of human ovarian cancer A2780 cells and telomerase activity].

  Ai zheng = Aizheng = Chinese journal of cancer 20030801

• Pharmacokinetic study on the multi-constituents of Huangqin-Tang decoction in rats.

  Biological & pharmaceutical bulletin 20030701

• [Studies on flavonoids of Anaphalis sinica].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20030601

• Degradation of flavonoid aglycones by rabbit, rat and human fecal flora.

  Biological & pharmaceutical bulletin 20030501

• Effect of the flavonoid components obtained from Scutellaria radix on the histamine, immunoglobulin E and lipid peroxidation of spleen lymphocytes of Sprague-Dawley rats.

  Bioscience, biotechnology, and biochemistry 20030501

• Inhibition of [3H]-LSD binding to 5-HT7 receptors by flavonoids from Scutellaria lateriflora.

  Journal of natural products 20030401

• Novel synthesis of flavonoids of Scutellaria baicalensis Georgi.

  Chemical & pharmaceutical bulletin 20030301

• Insect antifeedant activity of flavones and chromones against Spodoptera litura.

  Journal of agricultural and food chemistry 20030115

• Effects of wogonin, wogonoside, and 3,5,7,2',6'-pentahydroxyflavone on chemical mediator production in peritoneal exduate cells and immunoglobulin E of rat mesenteric lymph node lymphocytes.

  Journal of ethnopharmacology 20030101

• Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of Scutellariae Radix in humans.

  Biological & pharmaceutical bulletin 20030101

• Effects of topical instillation of traditional herbal medicines, herbal extracts, and their components on prostaglandin E2-induced aqueous flare elevation in pigmented rabbits.

  Japanese journal of ophthalmology 20030101

• Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi.

  Biochemical pharmacology 20021101

• Tumor necrosis factor-producing activity of wogonin in RAW 264.7 murine macrophage cell line.

  Planta medica 20021101

• [Studies on chemical constituents of Sorbaria sorbifolia].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20021101

• Quantitation of the flavonoid wogonin and its major metabolite wogonin-7 beta-D-glucuronide in rat plasma by liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020805

• [A novel approach to quality evaluation of root of Scutellaria baicalensis by DPPH free radical scavenging].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20020801

• Evaluation of variation of acteoside and three major flavonoids in wild and cultivated Scutellaria baicalensis roots by micellar electrokinetic chromatography.

  Chemical & pharmaceutical bulletin 20020701

• In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E(2) production.

  European journal of pharmacology 20020620

• Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1.

  Archives of toxicology 20020601

• Metabolism of constituents in Huangqin-Tang, a prescription in traditional Chinese medicine, by human intestinal flora.

  Biological & pharmaceutical bulletin 20020501

• [Determination of wogonin in rat plasma by liquid chromatography-tandem mass spectrometry].

  Yao xue xue bao = Acta pharmaceutica Sinica 20020501

• [Antibacterial constituents against Helicobacter pylori of Brazilian medicinal plant, Pariparoba].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20020401

• Evaluation of the anti-inflammatory effect of baicalein on dextran sulfate sodium-induced colitis in mice.

  Planta medica 20020301

• [Determination of flavone for Scutellaria baicalensis from different areas by HPLC].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20020301

• Antiviral Chinese medicinal herbs against respiratory syncytial virus.

  Journal of ethnopharmacology 20020201

• Different effects of baicalein, baicalin and wogonin on mitochondrial function, glutathione content and cell cycle progression in human hepatoma cell lines.

  Planta medica 20020201

• Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease.

  Biochemical pharmacology 20020115

• Induction of apoptosis in human lung fibroblasts and peripheral lymphocytes in vitro by Shosaiko-to derived phenolic metabolites.

  Biological & pharmaceutical bulletin 20020101

• Protective effects of baicalein and wogonin against benzo[a]pyrene- and aflatoxin B(1)-induced genotoxicities.

  Biochemical pharmacology 20011215

• Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells.

  Molecular pharmacology 20010901

• The plant flavonoid wogonin suppresses death of activated C6 rat glial cells by inhibiting nitric oxide production.

  Neuroscience letters 20010817

• Inhibition of TPA-induced cyclooxygenase-2 expression and skin inflammation in mice by wogonin, a plant flavone from Scutellaria radix.

  European journal of pharmacology 20010810

• Effect of an extract of the root of Scutellaria baicalensis and its flavonoids on aflatoxin B1 oxidizing cytochrome P450 enzymes.

  Planta medica 20010701

• 3D-QSAR model of flavonoids binding at benzodiazepine site in GABAA receptors.

  Journal of medicinal chemistry 20010607

• Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide.

  Biochemical pharmacology 20010601

• Determination of 14 chemical constituents in the traditional Chinese medicinal preparation Huangqin-Tang by high performance liquid chromatography.

  Biological & pharmaceutical bulletin 20010601

• Effect of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells.

  Biochemical pharmacology 20010515

• Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cells.

  Pharmacological research 20010201

• Effects of scutellariae radix extract and its components (baicalein, baicalin, and wogonin) on the experimental elevation of aqueous flare in pigmented rabbits.

  Japanese journal of ophthalmology 20010101

• Protective effect of wogonin on endotoxin-induced lethal shock in D-galactosamine-sensitized mice.

  Microbiology and immunology 20010101

• Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis.

  Planta medica 20001201

• Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases.

  European journal of biochemistry 19900705