6339-87-3 | Thiophene-2-sulfonamide

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$16.00	$11.00
5g	95%	in stock	$17.00	$12.00
10g	95%	in stock	$27.00	$19.00
25g	95%	in stock	$57.00	$40.00
100g	95%	in stock	$223.00	$156.00

Description

• Catalog Number: AB63025
• Chemical Name: Thiophene-2-sulfonamide
• CAS Number: 6339-87-3
• Molecular Formula: C4H5NO2S2
• Molecular Weight: 163.218
• MDL Number: MFCD00185853
• SMILES: NS(=O)(=O)c1cccs1
• NSC Number: 42521

Computed Properties

• Complexity: 181
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• XLogP3: -0.3

Literature

• Synthesis of novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity.

  Journal of medicinal chemistry 20140522

• The mechanism of γ-Secretase dysfunction in familial Alzheimer disease.

  The EMBO journal 20120516

• Discovery and synthesis of hydronaphthoquinones as novel proteasome inhibitors.

  Journal of medicinal chemistry 20120308

• BACE-1 inhibition prevents the γ-secretase inhibitor evoked Aβ rise in human neuroblastoma SH-SY5Y cells.

  Journal of biomedical science 20110101

• Drug development for Alzheimer's disease: recent progress.

  Experimental neurobiology 20101201

• Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease.

  Alzheimer's research & therapy 20100101

• Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.

  The Journal of pharmacology and experimental therapeutics 20091101

• Tryptamine-based human beta3-adrenergic receptor agonists. Part 1: SAR studies of the 7-position of the indole ring.

  Bioorganic & medicinal chemistry letters 20041220