6398-98-7 | 4-[(7-chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol dihydrate dihydrochloride

Packsize	Purity	Availability	Price	Discounted Price
250mg	98	in stock	$16.00	$11.00
5g	99%(HPLC)	in stock	$25.00	$18.00
25g	98%	in stock	$50.00	$35.00
100g	98%	in stock	$139.00	$97.00
500g	98%	in stock	$387.00	$271.00

Description

• Catalog Number: AB65599
• Chemical Name: 4-[(7-chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol dihydrate dihydrochloride
• CAS Number: 6398-98-7
• Molecular Formula: C20H28Cl3N3O3
• Molecular Weight: 464.8136
• MDL Number: MFCD00078857
• SMILES: CCN(Cc1cc(ccc1O)Nc1ccnc2c1ccc(c2)Cl)CC.Cl.Cl.O.O

Computed Properties

• Complexity: 406
• Covalently-Bonded Unit Count: 5
• Heavy Atom Count: 29
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 6
• Rotatable Bond Count: 6

Literature

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  Biomedica : revista del Instituto Nacional de Salud 20080601

• High efficacy of two artemisinin-based combinations (artemether-lumefantrine and artesunate plus amodiaquine) for acute uncomplicated malaria in Ibadan, Nigeria.

  Tropical medicine & international health : TM & IH 20080501

• Electrochemical generation of electrophilic drug metabolites: characterization of amodiaquine quinoneimine and cysteinyl conjugates by MS, IR, and NMR.

  Chemical research in toxicology 20080401

• Studies on antimalarial drug susceptibility in Colombia, in relation to Pfmdr1 and Pfcrt.

  Parasitology 20080401

• High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080401

• Disease and drug interactions: treating malaria with artesunate plus amodiaquine in patients also receiving treatment for concomitant HIV infection.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080401

• [Assessing the application of Rwanda's national protocol for uncomplicated malaria treatment in healthcare institutions in Kigali City, Rwanda].

  Medecine et maladies infectieuses 20080301

• Increased Plasmodium falciparum gametocyte production in mixed infections with P. malariae.

  The American journal of tropical medicine and hygiene 20080301

• Efficacy, safety, and selection of molecular markers of drug resistance by two ACTs in Mali.

  The American journal of tropical medicine and hygiene 20080301

• [Efficacy of the amodiaquine+sulfadoxine-pyrimethamine combination and of chloroquine for the treatment of malaria in Córdoba, Colombia, 2006].

  Biomedica : revista del Instituto Nacional de Salud 20080301

• Determination of N-desethylamodiaquine by hydrophilic interaction liquid chromatography with tandem mass spectrometry: application to in vitro drug metabolism studies.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080215

• Synthesis and antimalarial activity of new analogues of amodiaquine.

  European journal of medicinal chemistry 20080201

• Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20080201

• Antimalarial resistance and DHFR/DHPS genotypes of Plasmodium falciparum three years after introduction of sulfadoxine-pyrimethamine and amodiaquine in rural Tanzania.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20080201

• Chloroquine-resistance molecular markers (Pfcrt T76 and Pfmdr-1 Y86) and amodiaquine resistance in Burkina Faso.

  Tropical medicine & international health : TM & IH 20080201

• Chloroquine resistant Plasmodium falciparum malaria in Osogbo Nigeria: efficacy of amodiaquine + sulfadoxine-pyrimethamine and chloroquine + chlorpheniramine for treatment.

  Memorias do Instituto Oswaldo Cruz 20080201

• Feasibility and acceptability of artemisinin-based combination therapy for the home management of malaria in four African sites.

  Malaria journal 20080101

• Randomized, comparative study of the efficacy and safety of artesunate plus amodiaquine, administered as a single daily intake versus two daily intakes in the treatment of uncomplicated falciparum malaria.

  Malaria journal 20080101

• A trial of the efficacy, safety and impact on drug resistance of four drug regimens for seasonal intermittent preventive treatment for malaria in Senegalese children.

  PloS one 20080101

• Sulphadoxine/pyrimethamine versus amodiaquine for treating uncomplicated childhood malaria in Gabon: a randomized trial to guide national policy.

  Malaria journal 20080101

• Safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso.

  PloS one 20080101

• Enhanced efficacy of amodiaquine and chlorpheniramine combination over amodiaquine alone in the treatment of acute uncomplicated Plasmodium falciparum malaria in children.

  Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20080101

• Efficacy of amodiaquine in the treatment of uncomplicated falciparum malaria in young children of rural north-western Burkina Faso.

  Malaria journal 20080101

• The usefulness of twenty-four molecular markers in predicting treatment outcome with combination therapy of amodiaquine plus sulphadoxine-pyrimethamine against falciparum malaria in Papua New Guinea.

  Malaria journal 20080101

• Safety and tolerability of combination antimalarial therapies for uncomplicated falciparum malaria in Ugandan children.

  Malaria journal 20080101

• Activities of artemether-lumefantrine and amodiaquine-sulfalene-pyrimethamine against sexual-stage parasites in falciparum malaria in children.

  Chemotherapy 20080101

• An open label, randomised trial of artesunate+amodiaquine, artesunate+chlorproguanil-dapsone and artemether-lumefantrine for the treatment of uncomplicated malaria.

  PloS one 20080101

• Amodiaquine-artesunate vs artemether-lumefantrine for uncomplicated malaria in Ghanaian children: a randomized efficacy and safety trial with one year follow-up.

  Malaria journal 20080101

• Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children.

  Malaria journal 20080101

• Plasmodium falciparum gametocyte sex ratios in children with acute, symptomatic, uncomplicated infections treated with amodiaquine.

  Malaria journal 20080101

• Effectiveness of artemisinin-based combination therapy used in the context of home management of malaria: a report from three study sites in sub-Saharan Africa.

  Malaria journal 20080101

• Trends in malaria morbidity following the introduction of artesunate plus amodiaquine combination in M'lomp village dispensary, south-western Senegal.

  Malaria journal 20080101

• Malariological baseline survey and in vitro antimalarial drug resistance in Gulu district, Northern Uganda.

  Wiener klinische Wochenschrift 20080101

• Pharmacodynamic interaction between 4-aminoquinolines and retinol in Plasmodium falciparum in vitro.

  Wiener klinische Wochenschrift 20080101

• Seasonal intermittent preventive treatment for the prevention of anaemia and malaria in Ghanaian children: a randomized, placebo controlled trial.

  PloS one 20080101

• A randomized trial on effectiveness of artemether-lumefantrine versus artesunate plus amodiaquine for unsupervised treatment of uncomplicated Plasmodium falciparum malaria in Ghanaian children.

  Malaria journal 20080101

• High risk of severe anaemia after chlorproguanil-dapsone+artesunate antimalarial treatment in patients with G6PD (A-) deficiency.

  PloS one 20080101

• The effect of administration of amodiaquine on some parameters of neurobehaviour of Wistar rats.

  Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria 20080101

• Randomized comparison of amodiaquine plus sulfadoxine-pyrimethamine, artemether-lumefantrine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Burkina Faso.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20071201

• Simultaneous determination of amodiaquine and its active metabolite in human blood by ion-pair liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071201

• Short report: polymorphisms in the pfcrt and pfmdr1 genes of Plasmodium falciparum and in vitro susceptibility to amodiaquine and desethylamodiaquine.

  The American journal of tropical medicine and hygiene 20071201

• Pharmacologic advances in the global control and treatment of malaria: combination therapy and resistance.

  Clinical pharmacology and therapeutics 20071101

• A field-adapted HPLC method for determination of amodiaquine and its metabolite in whole blood dried on filter paper.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071101

• The safety of amodiaquine use in pregnant women.

  Expert opinion on drug safety 20071101

• Low efficacy of amodiaquine or chloroquine plus sulfadoxine-pyrimethamine against Plasmodium falciparum and P. vivax malaria in Papua New Guinea.

  The American journal of tropical medicine and hygiene 20071101

• Clinical symptoms, treatment and outcome of highlands malaria in Eldoret (2420 m a.s.l.) and comparison to malaria in hyper-immune population in endemic region of Southern Sudan.

  Neuro endocrinology letters 20071101

• Population pharmacokinetics of amodiaquine and desethylamodiaquine in pediatric patients with uncomplicated falciparum malaria.

  Journal of pharmacokinetics and pharmacodynamics 20071001

• Selection of pfmdr1 mutations after amodiaquine monotherapy and amodiaquine plus artemisinin combination therapy in East Africa.

  Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20070901

• Efficacy of sulfadoxine-pyrimethamine, amodiaquine, and sulfadoxine-pyrimethamine-amodiaquine combination for the treatment of uncomplicated falciparum malaria in the urban and suburban areas of Brazzaville (Congo).

  Acta tropica 20070901

• Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa.

  Clinical pharmacology and therapeutics 20070801

• Therapeutic efficacy and effects of artemether-lumefantrine and amodiaquine-sulfalene-pyrimethamine on gametocyte carriage in children with uncomplicated Plasmodium falciparum malaria in southwestern Nigeria.

  The American journal of tropical medicine and hygiene 20070801

• A non-radiolabeled heme-GSH interaction test for the screening of antimalarial compounds.

  Experimental parasitology 20070701

• The in-vitro susceptibilities of Ghanaian Plasmodium falciparum to antimalarial drugs.

  Annals of tropical medicine and parasitology 20070701

• Artesunate-amodiaquine for the treatment of uncomplicated malaria.

  Expert opinion on investigational drugs 20070701

• Emergency liver transplantation in amodiaquine-induced fulminant hepatitis.

  The American journal of tropical medicine and hygiene 20070701

• Amodiaquine in future combination treatment of malaria in Ghana.

  Tropical doctor 20070701

• Prevalent pfmdr1 n86y mutant Plasmodium falciparum in Madagascar despite absence of pfcrt mutant strains.

  The American journal of tropical medicine and hygiene 20070601

• Efficacy of artesunate plus amodiaquine, artesunate plus sulfadoxine-pyrimethamine, and chloroquine plus sulfadoxine-pyrimethamine in patients with uncomplicated Plasmodium falciparum in the Comoros Union.

  Acta tropica 20070601

• Enhancement of the antimalarial efficacy of amodiaquine by chlorpheniramine in vivo.

  Memorias do Instituto Oswaldo Cruz 20070601

• [Polymorphisms of the pfmdr1 gene in field samples of Plasmodium falciparum and their association with therapeutic response to antimalarial drugs and severe malaria in Colombia].

  Biomedica : revista del Instituto Nacional de Salud 20070601

• [Tolerance of amodiaquine].

  Medecine tropicale : revue du Corps de sante colonial 20070601

• [Open radomized study comparing chloroquine and amodiaquine for treatment of uncomplicated plasmodium falciparum malaria in children in Aboisso, Cote d' Ivoire].

  Medecine tropicale : revue du Corps de sante colonial 20070601

• [A new, cheaper and simpler anti-malaria preparation].

  Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20070531

• Antimalarial drugs--here and on the horizon.

  JAMA 20070523

• Combination therapy for uncomplicated falciparum malaria in Ugandan children: a randomized trial.

  JAMA 20070523

• Plasmodium falciparum genotypes associated with chloroquine and amodiaquine resistance in Guinea-Bissau.

  The American journal of tropical medicine and hygiene 20070501

• Dihydroartemisinin-piperaquine versus artesunate-amodiaquine: superior efficacy and posttreatment prophylaxis against multidrug-resistant Plasmodium falciparum and Plasmodium vivax malaria.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070415

• A randomised trial to assess the safety and efficacy of artemether-lumefantrine (Coartem) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwanda.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20070401

• Effects of prior administration of amodiaquine on the disposition of halofantrine in healthy volunteers.

  Therapeutic drug monitoring 20070401

• [ASAQ, a breakthrough in the fight against malaria].

  Medecine tropicale : revue du Corps de sante colonial 20070401

• Hepatotoxicity due to a drug interaction between amodiaquine plus artesunate and efavirenz.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070315

• [Against malaria: ASAQ, one dollar per box].

  Revue medicale suisse 20070314

• Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice.

  European journal of pharmacology 20070308

• New once a day, fixed dose antimalarial is now available for adults and children.

  BMJ (Clinical research ed.) 20070303

• Correlations between treatment outcome and both anti-MSP119 antibody response and erythrocyte-related genetic factors in Plasmodium falciparum malaria.

  Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20070301

• Different doses of amodiaquine and chloroquine for treatment of uncomplicated malaria in children in Guinea-Bissau: implications for future treatment recommendations.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20070301

• Practical HPLC methods for the quantitative determination of common antimalarials in Africa.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070301

• In vitro assessment of artesunate, artemether and amodiaquine susceptibility and molecular analysis of putative resistance-associated mutations of Plasmodium falciparum from São Tomé and Príncipe.

  Tropical medicine & international health : TM & IH 20070301

• The comparative efficacies of malartin, with and without amodiaquine, in the treatment of Plasmodium falciparum malaria in the Buea district of Cameroon.

  Annals of tropical medicine and parasitology 20070301

• [Assessment of the efficacy of antimalarial drugs in Tarapacá, in the Colombian Amazon basin].

  Biomedica : revista del Instituto Nacional de Salud 20070301

• Chloroquine-resistant malaria in Malawi.

  The New England journal of medicine 20070222

• Antimalarial drug combinations in vastly different settings.

  Lancet (London, England) 20070210

• Artemether-lumefantrine versus amodiaquine plus sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Burkina Faso: a randomised non-inferiority trial.

  Lancet (London, England) 20070210

• Antischistosomal efficacy of artesunate combination therapies administered as curative treatments for malaria attacks.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20070201

• Amodiaquine combined with sulfadoxine/pyrimethamine versus artemisinin-based combinations for the treatment of uncomplicated falciparum malaria in Africa: a meta-analysis.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20070201

• The effects of artemether-lumefantrine vs amodiaquine-sulfalene-pyrimethamine on the hepatomegaly associated with Plasmodium falciparum malaria in children.

  Parasitology research 20070201

• [Benzo[c][2,7]naphthyridine-5-yl-arylamines-phenol Mannich bases of the amodiaquine-, cycloquine- and pyronaridine-type].

  Die Pharmazie 20070201

• In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin.

  The Journal of biological chemistry 20070126

• Efficacies of artesunate plus either sulfadoxine-pyrimethamine or amodiaquine, for the treatment of uncomplicated, Plasmodium falciparum malaria in eastern Sudan.

  Annals of tropical medicine and parasitology 20070101

• Artemisinin-based combination therapy for uncomplicated Plasmodium falciparum malaria in Colombia.

  Malaria journal 20070101

• Artesunate--amodiaquine combination therapy for falciparum malaria in young Gabonese children.

  Malaria journal 20070101

• Exploration of rate-limiting conformational state for 5-[(7-chloro-4-quinolinyl)amino]-3-[(alkylamino)methyl][1,1'-biphenyl]-2-ols and N(omega)-oxides (tebuquine analogues) for antimalarial activity using molecular shape analysis and molecular field analysis studies.

  Journal of chemical information and modeling 20070101

• Amodiaquine failure associated with erythrocytic glutathione in Plasmodium falciparum malaria.

  Malaria journal 20070101

• Efficacy of antimalarial treatment in Guinea: in vivo study of two artemisinin combination therapies in Dabola and molecular markers of resistance to sulphadoxine-pyrimethamine in N'Zérékoré.

  Malaria journal 20070101

• Randomized clinical trial of artemisinin versus non-artemisinin combination therapy for uncomplicated falciparum malaria in Madagascar.

  Malaria journal 20070101

• Efficacy and tolerability of four antimalarial combinations in the treatment of uncomplicated Plasmodium falciparum malaria in Senegal.

  Malaria journal 20070101

• [Place of artemisinin derivatives as anti-malarial drugs in paediatric hospitalization in Abidjan].

  Therapie 20070101

• Community coverage of an antimalarial combination of artesunate and amodiaquine in Makamba Province, Burundi, nine months after its introduction.

  Malaria journal 20070101

• [Therapeutic efficacy of amodiaquine against uncomplicated malaria in Madagascar].

  Sante (Montrouge, France) 20070101

• Efficacy and safety of artemisinin-based antimalarial in the treatment of uncomplicated malaria in children in southern Tanzania.

  Malaria journal 20070101

• Efficacy and safety of artesunate plus amodiaquine in routine use for the treatment of uncomplicated malaria in Casamance, southern Sénégal.

  Malaria journal 20070101

• Potential impact of host immunity on malaria treatment outcome in Tanzanian children infected with Plasmodium falciparum.

  Malaria journal 20070101

• Photophysical properties and photobiological behavior of amodiaquine, primaquine and chloroquine.

  Photochemistry and photobiology 20070101

• Amodiaquine resistance is not related to rare findings of pfmdr1 gene amplifications in Kenya.

  Tropical medicine & international health : TM & IH 20061201

• Use of weight-for-age-data to optimize tablet strength and dosing regimens for a new fixed-dose artesunate-amodiaquine combination for treating falciparum malaria.

  Bulletin of the World Health Organization 20061201

• Effects of pyrimethamine-sulphadoxine, chloroquine plus chlorpheniramine, and amodiaquine plus pyrimethamine-sulphadoxine on gametocytes during and after treatment of acute, uncomplicated malaria in children.

  Memorias do Instituto Oswaldo Cruz 20061201

• Improved efficacy with amodiaquine instead of chloroquine in sulfadoxine/pyrimethamine combination treatment of falciparum malaria in Uganda: experience with fixed-dose formulation.

  Acta tropica 20061101

• Amodiaquine, malaria, pregnancy: the old new drug.

  Lancet (London, England) 20061014

• Efficacy, safety, and tolerability of amodiaquine plus sulphadoxine-pyrimethamine used alone or in combination for malaria treatment in pregnancy: a randomised trial.

  Lancet (London, England) 20061014

• Artesunate + amodiaquine and artesunate + sulphadoxine-pyrimethamine for treatment of uncomplicated malaria in Democratic Republic of Congo: a clinical trial with determination of sulphadoxine and pyrimethamine-resistant haplotypes.

  Tropical medicine & international health : TM & IH 20061001

• Cost-effectiveness study of three antimalarial drug combinations in Tanzania.

  PLoS medicine 20061001

• Molecular epidemiology of malaria in Cameroon. XXI. Baseline therapeutic efficacy of chloroquine, amodiaquine, and sulfadoxine-pyrimethamine monotherapies in children before national drug policy change.

  The American journal of tropical medicine and hygiene 20060901

• A simple technique for the detection of anti-malarial drug formulations and their presence in human urine.

  Tanzania health research bulletin 20060901

• Heterotropic and homotropic cooperativity by a drug-metabolising mutant of cytochrome P450 BM3.

  Biochemical and biophysical research communications 20060804

• Factors contributing to the development of anaemia in Plasmodium falciparum malaria: what about drug-resistant parasites?

  Journal of tropical pediatrics 20060801

• High reinfection rate and treatment failures in children treated with amodiaquine for falciparum malaria in Muheza villages, Northeastern Tanzania.

  The American journal of tropical medicine and hygiene 20060801

• Amodiaquine resistant Plasmodium falciparum malaria in vivo is associated with selection of pfcrt 76T and pfmdr1 86Y.

  Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20060701

• Amodiaquine, its desethylated metabolite, or both, inhibit the metabolism of debrisoquine (CYP2D6) and losartan (CYP2C9) in vivo.

  European journal of clinical pharmacology 20060701

• Low efficacy of the combination artesunate plus amodiaquine for uncomplicated falciparum malaria among children under 5 years in Kailahun, Sierra Leone.

  Tropical medicine & international health : TM & IH 20060701

• High efficacy of two artemisinin-based combinations (artesunate + amodiaquine and artemether + lumefantrine) in Caala, Central Angola.

  The American journal of tropical medicine and hygiene 20060701

• Association between mutations in Plasmodium falciparum chloroquine resistance transporter and P. falciparum multidrug resistance 1 genes and in vivo amodiaquine resistance in P. falciparum malaria-infected children in Nigeria.

  The American journal of tropical medicine and hygiene 20060701

• Roles of specific Plasmodium falciparum mutations in resistance to amodiaquine and sulfadoxine-pyrimethamine in Burkina Faso.

  The American journal of tropical medicine and hygiene 20060701

• Occurrence of the Southeast Asian/South American SVMNT haplotype of the chloroquine-resistance transporter gene in Plasmodium falciparum in Tanzania.

  The Journal of infectious diseases 20060615

• In-vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, dihydroartemisinin and quinine in an area of high chloroquine resistance in Rwanda.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20060601

• Resisting resistance: dealing with the irrepressible problem of malaria.

  British journal of clinical pharmacology 20060601

• Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for uncomplicated malaria: a systematic review.

  Tropical medicine & international health : TM & IH 20060601

• [Knowledge and practice among health workers from the Thiès region with regard to new malaria treatment policies].

  Sante publique (Vandoeuvre-les-Nancy, France) 20060601

• Efficacy of chloroquine, sulfadoxine-pyrimethamine and amodiaquine for treatment of uncomplicated Plasmodium falciparum malaria among children under five in Bongor and Koumra, Chad.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20060501

• Tolerability of amodiaquine and sulphadoxine-pyrimethamine, alone or in combination for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan adults.

  Tropical medicine & international health : TM & IH 20060501

• Susceptibility of Colombian Plasmodium falciparum isolates to 4-aminoquinolines and the definition of amodiaquine resistance in vitro.

  Memorias do Instituto Oswaldo Cruz 20060501

• Amodiaquine polymeric membrane electrode.

  Journal of pharmaceutical and biomedical analysis 20060411

• A new approach to evaluate stability of amodiaquine and its metabolite in blood and plasma.

  Journal of pharmaceutical and biomedical analysis 20060411

• Geographic differences in antimalarial drug efficacy in Uganda are explained by differences in endemicity and not by known molecular markers of drug resistance.

  The Journal of infectious diseases 20060401

• Operational response to malaria epidemics: are rapid diagnostic tests cost-effective?

  Tropical medicine & international health : TM & IH 20060401

• Microscopy and outpatient malaria case management among older children and adults in Kenya.

  Tropical medicine & international health : TM & IH 20060401

• Prevalence of malaria parasitemia among clients seeking treatment for fever or malaria at drug stores in rural Tanzania 2004.

  Tropical medicine & international health : TM & IH 20060401

• The costs of changing national policy: lessons from malaria treatment policy guidelines in Tanzania.

  Tropical medicine & international health : TM & IH 20060401

• Sulfadoxine-pyrimethamine plus artesunate versus sulfadoxine-pyrimethamine plus amodiaquine for treating uncomplicated malaria.

  The Cochrane database of systematic reviews 20060125

• [Cytochrome P-450 and the response to antimalarial drugs].

  Revista panamericana de salud publica = Pan American journal of public health 20060101

• Artemether-lumefantrine versus artesunate plus amodiaquine for treating uncomplicated childhood malaria in Nigeria: randomized controlled trial.

  Malaria journal 20060101

• A medicinal chemistry perspective on 4-aminoquinoline antimalarial drugs.

  Current topics in medicinal chemistry 20060101

• Efficacy of three artemisinin combination therapies for the treatment of uncomplicated Plasmodium falciparum malaria in the Republic of Congo.

  Malaria journal 20060101

• The quality of sulphadoxine-pyrimethamine and amodiaquine products in the Kenyan retail sector.

  Journal of clinical pharmacy and therapeutics 20051201

• Short communication: high prevalence of the cytochrome P450 2C8*2 mutation in Northern Ghana.

  Tropical medicine & international health : TM & IH 20051201

• Open randomized study of artesunate-amodiaquine vs. chloroquine-pyrimethamine-sulfadoxine for the treatment of uncomplicated Plasmodium falciparum malaria in Nigerian children.

  Tropical medicine & international health : TM & IH 20051101

• Amodiaquine and combination chemotherapy for malaria.

  The American journal of tropical medicine and hygiene 20051101

• Amodiaquine, sulfadoxine-pyrimethamine, and combination therapy for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso.

  The American journal of tropical medicine and hygiene 20051101

• Structural basis for inhibition of histamine N-methyltransferase by diverse drugs.

  Journal of molecular biology 20051021

• Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for treating uncomplicated malaria.

  The Cochrane database of systematic reviews 20051019

• Efficacy of artesunate plus amodiaquine versus that of artemether-lumefantrine for the treatment of uncomplicated childhood Plasmodium falciparum malaria in Zanzibar, Tanzania.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20051015

• Therapeutic efficacy of sulfadoxine-pyrimethamine and amodiaquine among children with uncomplicated Plasmodium falciparum malaria in Zanzibar, Tanzania.

  The American journal of tropical medicine and hygiene 20051001

• Rapid increase in resistance of Plasmodium falciparum to chloroquine-Fansidar in Uganda and the potential of amodiaquine-Fansidar as a better alternative.

  Acta tropica 20050901

• Comparative efficacy of antimalarial drugs including ACTs in the treatment of uncomplicated malaria among children under 5 years in Ghana.

  Acta tropica 20050901

• Economic evaluation of a policy change from single-agent treatment for suspected malaria to artesunate-amodiaquine for microscopically confirmed uncomplicated falciparum malaria in the Oussouye District of south-western Senegal.

  Tropical medicine & international health : TM & IH 20050901

• [Evaluation of the therapeutic efficacy of amodiaquine versus chloroquine in the treatment of uncomplicated malaria in Abie, Côte-d'Ivoire].

  Bulletin de la Societe de pathologie exotique (1990) 20050901

• Malaria in the Nuba Mountains of Sudan: baseline genotypic resistance and efficacy of the artesunate plus sulfadoxine-pyrimethamine and artesunate plus amodiaquine combinations.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20050701

• Antimalarial efficacy of chloroquine, amodiaquine, sulfadoxine-pyrimethamine, and the combinations of amodiaquine + artesunate and sulfadoxine-pyrimethamine + artesunate in Huambo and Bie provinces, central Angola.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20050701

• Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda.

  PLoS medicine 20050701

• New malaria combination cheaper and easier to take.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20050607

• Efficacy of amodiaquine in uncomplicated falciparum malaria in Nigeria in an area with high-level resistance to chloroquine and sulphadoxine/pyrimethamine.

  Parasitology research 20050601

• A randomized, placebo-controlled, double-blind trial on sulfadoxine-pyrimethamine alone or combined with artesunate or amodiaquine in uncomplicated malaria.

  Tropical medicine & international health : TM & IH 20050601

• Efficacy of combination therapy with artesunate plus amodiaquine compared to monotherapy with chloroquine, amodiaquine or sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum in Afghanistan.

  Tropical medicine & international health : TM & IH 20050601

• Malaria: uncomplicated, caused by Plasmodium falciparum.

  Clinical evidence 20050601

• New combination drug to treat malaria.

  The Lancet. Infectious diseases 20050501

• Sulfadoxine-pyrimethamine plus chloroquine or amodiaquine for uncomplicated falciparum malaria: a randomized, multisite trial to guide national policy in Uganda.

  The American journal of tropical medicine and hygiene 20050501

• Antimalarial drugs: QT prolongation and cardiac arrhythmias.

  Expert opinion on drug safety 20050501

• Efficacy of chloroquine, amodiaquine, sulfadoxine-pyrimethamine, chloroquine-sulfadoxine-pyrimethamine combination, and amodiaquine-sulfadoxine-pyrimethamine combination in Central African children with noncomplicated malaria.

  The American journal of tropical medicine and hygiene 20050501

• Effectiveness trials in African children with malaria?

  Lancet (London, England) 20050401

• Amodiaquine alone, amodiaquine+sulfadoxine-pyrimethamine, amodiaquine+artesunate, and artemether-lumefantrine for outpatient treatment of malaria in Tanzanian children: a four-arm randomised effectiveness trial.

  Lancet (London, England) 20050401

• Selective inhibition of human cytochrome P4502C8 by montelukast.

  Drug metabolism and disposition: the biological fate of chemicals 20050301

• Pharmacodynamic interactions of amodiaquine and its major metabolite desethylamodiaquine with artemisinin, quinine and atovaquone in Plasmodium falciparum in vitro.

  Acta tropica 20050301

• A randomized comparative study of chloroquine, amodiaquine and sulphadoxine-pyrimethamine for the treatment of uncomplicated malaria in Ghana.

  Tropical medicine & international health : TM & IH 20050301

• The disposition of oral amodiaquine in Papua New Guinean children with falciparum malaria.

  British journal of clinical pharmacology 20050301

• CYP2C8 polymorphism frequencies among malaria patients in Zanzibar.

  European journal of clinical pharmacology 20050301

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