64461-82-1 | Tizanidine HCl

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$25.00	$17.00
5g	95%	in stock	$47.00	$33.00
25g	95%	in stock	$161.00	$113.00
100g	95%	in stock	$541.00	$379.00

Description

• Catalog Number: AI02234
• Chemical Name: Tizanidine HCl
• CAS Number: 64461-82-1
• Molecular Formula: C19H39N3O
• Molecular Weight: 325.5325
• MDL Number: MFCD00798231
• SMILES: OCCC1C2CCN(C1CNC(CCCN(CC)CC)C)CC2

Computed Properties

• Complexity: 300
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 17
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 2

Literature

• Eperisone versus tizanidine for treatment of chronic low back pain.

  Minerva medica 20120601

• [Pharmacological treatment of spasticity in multiple sclerosis].

  Revue neurologique 20120401

• Tizanidine (Zanaflex): a muscle relaxant that may prolong the QT interval by blocking IKr.

  Journal of cardiovascular pharmacology and therapeutics 20120301

• Medium-latency reflex response elicited from the flexor carpi radialis by radial nerve stimulation.

  Experimental brain research 20120301

• Improved transnasal transport and brain uptake of tizanidine HCl-loaded thiolated chitosan nanoparticles for alleviation of pain.

  Journal of pharmaceutical sciences 20120201

• Doxazosin versus tizanidine for treatment of dysfunctional voiding in children: a prospective randomized open-labeled trial.

  Urology 20120201

• Tizanidine and tizanidine hydrochloride: on the correct tautomeric form of tizanidine.

  Acta crystallographica. Section C, Crystal structure communications 20120101

• Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: an open-label pilot study.

  Audiology & neuro-otology 20120101

• Sensitive spectrofluorimetric determination of tizanidine in pharmaceutical preparations, human plasma and urine through derivatization with dansyl chloride.

  Luminescence : the journal of biological and chemical luminescence 20120101

• Potent suppression of stretch reflex activity after systemic or spinal delivery of tizanidine in rats with spinal ischemia-induced chronic spastic paraplegia.

  Neuroscience 20111027

• Tizanidine for alcohol withdrawal treatment.

  Medical hypotheses 20111001

• Formulation and evaluation of effervescent floating tablets of tizanidine hydrochloride.

  Acta pharmaceutica (Zagreb, Croatia) 20110601

• Pharmacotherapy of spasticity in children with cerebral palsy.

  Journal of the Formosan Medical Association = Taiwan yi zhi 20110401

• A case of delirium, motor disturbances, and autonomic dysfunction due to baclofen and tizanidine withdrawal: a review of the literature.

  General hospital psychiatry 20110101

• Development and validation of stability-indicating HPLC method for the simultaneous determination of paracetamol, tizanidine, and diclofenac in pharmaceuticals and human serum.

  Journal of AOAC International 20110101

• The effect of robot-assisted lokomotor training on gait recovery: a multivariate analysis.

  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 20110101

• Pharmacologic treatment of spasticity in children.

  Seminars in pediatric neurology 20101201

• Hypotension and bradycardia associated with concomitant tizanidine and lisinopril therapy.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20101001

• Cervical myelopathy from spinal sarcoidosis as the unexpected initial presentation for systemic sarcoidosis.

  Southern medical journal 20100901

• Managing spasticity with drugs.

  European journal of physical and rehabilitation medicine 20100901

• Pharmacological prophylaxis of chronic migraine: a review of double-blind placebo-controlled trials.

  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20100601

• Load rather than length sensitive feedback contributes to soleus muscle activity during human treadmill walking.

  Journal of neurophysiology 20100501

• Nightly sublingual tizanidine HCl in multiple sclerosis: clinical efficacy and safety.

  Clinical neuropharmacology 20100501

• Tizanidine does not affect the linear relation of stretch duration to the long latency M2 response of m. flexor carpi radialis.

  Experimental brain research 20100401

• Effects of mexiletine, a CYP1A2 inhibitor, on tizanidine pharmacokinetics and pharmacodynamics.

  Journal of clinical pharmacology 20100301

• Practice parameter: pharmacologic treatment of spasticity in children and adolescents with cerebral palsy (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society.

  Neurology 20100126

• Drug-induced QT prolongation and sudden death.

  Missouri medicine 20100101

• [Therapeutic blockades and reflexotherapy in the complex treatment of tension headache].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

• Formulation of two-drug controlled release non-biodegradable microparticles for potential treatment of muscles pain and spasm and their simultaneous spectrophotometeric estimation.

  Acta poloniae pharmaceutica 20100101

• Quantification of the effects of an alpha-2 adrenergic agonist on reflex properties in spinal cord injury using a system identification technique.

  Journal of neuroengineering and rehabilitation 20100101

• Spasticity: revisiting the role and the individual value of several pharmacological treatments.

  NeuroRehabilitation 20100101

• The addition of tramadol as a second opioid may improve pain relief in severe osteoarthritis: a prospective study.

  Pain practice : the official journal of World Institute of Pain 20100101

• [Clinical features of headache of tension type and principles of treatment].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

• [The use of sirdalud MR in patients with multiple sclerosis].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

• Aceclofenac-tizanidine in the treatment of acute low back pain: a double-blind, double-dummy, randomized, multicentric, comparative study against aceclofenac alone.

  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 20091201

• Drug treatments for spasticity.

  Annals of physical and rehabilitation medicine 20091201

• [New therapies for spastic movement disorders].

  MMW Fortschritte der Medizin 20091001

• Formulation and evaluation of bioadhesive buccal drug delivery of tizanidine hydrochloride tablets.

  AAPS PharmSciTech 20090601

• Botulinum neurotoxin versus tizanidine in upper limb spasticity: a placebo-controlled study.

  Journal of neurology, neurosurgery, and psychiatry 20090401

• Botulinum toxin should be first-line treatment for poststroke spasticity.

  Journal of neurology, neurosurgery, and psychiatry 20090401

• Effect of cold application and tizanidine on clonus: clinical and electrophysiological assessment.

  The journal of spinal cord medicine 20090401

• Medium-latency reflex response of soleus elicited by peroneal nerve stimulation.

  Experimental brain research 20090201

• Alpha-1-adrenergic receptor agonist activity of clinical alpha-adrenergic receptor agonists interferes with alpha-2-mediated analgesia.

  Anesthesiology 20090201

• A combined approach of chemical enhancers and sonophoresis for the transdermal delivery of tizanidine hydrochloride.

  Drug delivery 20090201

• Pediatric safety of tizanidine: clinical adverse event database and retrospective chart assessment.

  Paediatric drugs 20090101

• Prevention of intrathecal baclofen withdrawal syndrome: successful use of a temporary intrathecal catheter.

  Regional anesthesia and pain medicine 20090101

• Botulinum toxin type A with oral baclofen versus oral tizanidine: a nonrandomized pilot comparison in patients with cerebral palsy and spastic equinus foot deformity.

  Journal of child neurology 20081201

• Relative bioavailability of tizanidine hydrochloride capsule formulation compared with capsule contents administered in applesauce: a single-dose, open-label, randomized, two-way, crossover study in fasted healthy adult subjects.

  Clinical therapeutics 20081201

• [Effects of intrathecal ouabain and tizanidine injection for treatment of neuropathic pain in rats].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20081001

• Update on tizanidine for muscle spasticity and emerging indications.

  Expert opinion on pharmacotherapy 20080801

• Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease.

  European journal of pharmacology 20080728

• Tizanidine-induced hypotension in patients with liver cirrhosis.

  European journal of clinical pharmacology 20080601

• Treatment of postpartum depression with psychotic features in a patient with tropical spastic paraparesis.

  The Annals of pharmacotherapy 20080601

• Celecoxib is a CYP1A2 inhibitor in vitro but not in vivo.

  European journal of clinical pharmacology 20080501

• [Protocol for tizanidine use in infantile cerebral palsy].

  Anales de pediatria (Barcelona, Spain : 2003) 20080501

• Efficacy of thiocolchicoside in Indian patients suffering from low back pain associated with muscle spasm.

  Journal of the Indian Medical Association 20080501

• Alpha-2 agonists decrease expression of morphine-induced conditioned place preference.

  Pharmacology, biochemistry, and behavior 20080201

• A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury.

  Current medical research and opinion 20080201

• A clinically relevant review of tizanidine hydrochloride dose relationships to pharmacokinetics, drug safety and effectiveness in healthy subjects and patients.

  International journal of clinical practice 20080201

• Effects of gender and moderate smoking on the pharmacokinetics and effects of the CYP1A2 substrate tizanidine.

  European journal of clinical pharmacology 20080101

• The effects of medical treatment and rehabilitation in a patient with adult tethered cord syndrome in the late postoperative period.

  Medical science monitor : international medical journal of experimental and clinical research 20071201

• Evaluation of a muscle relaxant on sequelae of third molar surgery: a pilot study.

  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20070901

• Tolfenamic acid is a potent CYP1A2 inhibitor in vitro but does not interact in vivo: correction for protein binding is needed for data interpretation.

  European journal of clinical pharmacology 20070901

• Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam--probes of CYP2C9, CYP1A2, and CYP3A4.

  Clinical pharmacology and therapeutics 20070601

• Efficacy of neuroprotectors in patients with tension headaches.

  Neuroscience and behavioral physiology 20070601

• Relative bioavailability of tizanidine 4-mg capsule and tablet formulations after a standardized high-fat meal: a single-dose, randomized, open-label, crossover study in healthy subjects.

  Clinical therapeutics 20070401

• Drug interaction of tizanidine and ciprofloxacin: case report.

  Clinical pharmacology and therapeutics 20061201

• The pharmacological management of spasticity.

  The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses 20061201

• Rofecoxib is a potent inhibitor of cytochrome P450 1A2: studies with tizanidine and caffeine in healthy subjects.

  British journal of clinical pharmacology 20060901

• Effects of food on the single-dose pharmacokinetics/pharmacodynamics of tizanidine capsules and tablets in healthy volunteers.

  Clinical therapeutics 20060901

• [The usefulness of tizanidine. A one-year follow-up of the treatment of spasticity in infantile cerebral palsy].

  Revista de neurologia 20060801

• Non-antiepileptic drugs for trigeminal neuralgia.

  The Cochrane database of systematic reviews 20060719

• In-vitro studies of tizanidine controlled-release microcapsular matrices.

  Pakistan journal of pharmaceutical sciences 20060701

• Rifampicin is only a weak inducer of CYP1A2-mediated presystemic and systemic metabolism: studies with tizanidine and caffeine.

  European journal of clinical pharmacology 20060601

• Tizanidine distribution in a postmortem case.

  Journal of analytical toxicology 20060601

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Mediation of late excitation from human hand muscles via parallel group II spinal and group I transcortical pathways.

  The Journal of physiology 20060415

• Pharmacological interventions for spasticity following spinal cord injury: results of a Cochrane systematic review.

  Europa medicophysica 20060301

• Combination of tizanidine and amitriptyline in the prophylaxis of chronic tension-type headache: evaluation of efficacy and impact on quality of life.

  The journal of headache and pain 20060201

• Quantification of tizanidine in human plasma by liquid chromatography coupled to tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20060101

• Oral contraceptives containing ethinyl estradiol and gestodene markedly increase plasma concentrations and effects of tizanidine by inhibiting cytochrome P450 1A2.

  Clinical pharmacology and therapeutics 20051001

• Pharmacologic interventions for reducing spasticity in cerebral palsy.

  Indian journal of pediatrics 20051001

• Involvement of supraspinal imidazoline receptors and descending monoaminergic pathways in tizanidine-induced inhibition of rat spinal reflexes.

  Journal of pharmacological sciences 20050901

• Assessment of efficacy and psychomotor performances of thiocolchicoside and tizanidine in patients with acute low back pain.

  International journal of clinical practice 20050701

• [Extreme sinus bradycardia (30/min) with acute right heart failure under tizanidine (Sirdalud). Possible pharmacological interaction with rofecoxib (Vioxx)].

  Medizinische Klinik (Munich, Germany : 1983) 20050415

• Application of HPLC and HPTLC for the simultaneous determination of tizanidine and rofecoxib in pharmaceutical dosage form.

  Journal of pharmaceutical and biomedical analysis 20050207

• Simultaneous LC determination of tizanidine and rofecoxib in tablets.

  Journal of pharmaceutical and biomedical analysis 20050207

• Symptomatic bradycardia probably due to tizanidine hydrochloride in a chronic hemodialysis patient.

  Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20050201

• Involuntary jerking of lower half of the body (spinal myoclonus).

  The Journal of the Association of Physicians of India 20050201

• Ciprofloxacin greatly increases concentrations and hypotensive effect of tizanidine by inhibiting its cytochrome P450 1A2-mediated presystemic metabolism.

  Clinical pharmacology and therapeutics 20041201

• Hypotension due to interaction between lisinopril and tizanidine.

  The Annals of pharmacotherapy 20041101

• Drug interaction of tizanidine and fluvoxamine.

  Clinical pharmacology and therapeutics 20041101

• [Effects of tizanidine for refractory sleep disturbance in disabled children with spastic quadriplegia].

  No to hattatsu = Brain and development 20041101

• [Pharmacology and upper limb poststroke spasticity: a review. International Society of Prosthetics and Orthotics].

  Annales de readaptation et de medecine physique : revue scientifique de la Societe francaise de reeducation fonctionnelle de readaptation et de medecine physique 20041001

• [Progressive encephalomyelitis with rigidity responsive to gabapentin: a pharmacological update].

  Neurologia (Barcelona, Spain) 20041001

• Alpha2-adrenergic receptor subtype specificity of intrathecally administered tizanidine used for analgesia for neuropathic pain.

  Journal of neurosurgery 20041001

• Preventive migraine therapy: what is new.

  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20041001

• Tizanidine for the treatment of intention myoclonus: a case series.

  Archives of physical medicine and rehabilitation 20040701

• Muscle relaxants in the treatment of myofascial face pain. A literature review.

  Minerva stomatologica 20040601

• Fluvoxamine drastically increases concentrations and effects of tizanidine: a potentially hazardous interaction.

  Clinical pharmacology and therapeutics 20040401

• Effect of oral tizanidine on local-anesthetic infiltration pain during epidural catheterization.

  Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 20040401

• Efficacy of tizanidine hydrochloride in the treatment of myofascial face pain.

  Minerva medica 20040401

• Tizanidine is mainly metabolized by cytochrome p450 1A2 in vitro.

  British journal of clinical pharmacology 20040301

• Modulation of the transmission in group II heteronymous pathways by tizanidine in spastic hemiplegic patients.

  Journal of neurology, neurosurgery, and psychiatry 20040101

• Retrospective review of Tizanidine (Zanaflex) overdose.

  Journal of toxicology. Clinical toxicology 20040101

• Stability-indicating HPTLC determination of tizanidine hydrochloride in bulk drug and pharmaceutical formulations.

  Journal of pharmaceutical and biomedical analysis 20031124

• Antihyperalgesic and side effects of intrathecal clonidine and tizanidine in a rat model of neuropathic pain.

  Anesthesiology 20030601

• Continuous intrathecal clonidine and tizanidine in conscious dogs: analgesic and hemodynamic effects.

  Anesthesia and analgesia 20030301

• Tizanidine is not a cure for chronic daily headache.

  Headache 20030301

• Effects of intrathecally administered dexmedetomidine, MPV-2426 and tizanidine on EMG in rats.

  Acta anaesthesiologica Scandinavica 20030301

• Eosinophilic exudative pleural effusion after initiation of tizanidine treatment: a case report.

  Pain medicine (Malden, Mass.) 20030301

• Modulatory effects of alpha1-,alpha2-, and beta -receptor agonists on feline spinal interneurons with monosynaptic input from group I muscle afferents.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030101

• Anti-spasticity medications.

  Saudi medical journal 20030101

• Preventative treatment for migraine and tension-type headaches : do drugs having effects on muscle spasm and tone have a role?

  CNS drugs 20030101

• [Spastic syndrome and main directions of its treatment].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20030101

• High-dose tizanidine abuse.

  Psychopharmacology bulletin 20030101

• Protective effects of dextromethorphan and tizanidine on ouabain-induced arrhythmias.

  Methods and findings in experimental and clinical pharmacology 20020901

• Oral tizanidine, an alpha2-adrenoceptor agonist, reduces the minimum alveolar concentration of sevoflurane in human adults.

  Anesthesia and analgesia 20020801

• Determination of tizanidine in human plasma by gas chromatography-mass spectrometry.

  The Analyst 20020701

• Involvement of imidazoline receptors in the centrally acting muscle-relaxant effects of tizanidine.

  European journal of pharmacology 20020612

• Treatment of spasticity.

  Spinal cord 20020601

• Chronic daily headache prophylaxis with tizanidine: a double-blind, placebo-controlled, multicenter outcome study.

  Headache 20020601

• Modulation of NSAID-induced antinociceptive and anti-inflammatory effects by alpha2-adrenoceptor agonists with gastroprotective effects.

  Life sciences 20020503

• Low-dose tizanidine with nonsteroidal anti-inflammatory drugs for detoxification from analgesic rebound headache.

  Headache 20020301

• Cost-effectiveness comparison of tizanidine and baclofen in the management of spasticity.

  PharmacoEconomics 20020101

• Systemic tizanidine hydrochloride (Zanaflex) partially decreases experimental postoperative pain in rats.

  Anesthesia and analgesia 20011101

• Systemic tizanidine hydrochloride (Zanaflex) relieves thermal hyperalgesia in rats with an experimental mononeuropathy.

  Anesthesia and analgesia 20011101

• Alpha adrenergic and serotonergic agents in the treatment of spastic hypertonia.

  Physical medicine and rehabilitation clinics of North America 20011101

• Prospective assessment of tizanidine for spasticity due to acquired brain injury.

  Archives of physical medicine and rehabilitation 20010901

• Group II muscle afferents probably contribute to the medium latency soleus stretch reflex during walking in humans.

  The Journal of physiology 20010801

• Open-label dose-titration safety and efficacy study of tizanidine hydrochloride in the treatment of spasticity associated with chronic stroke.

  Stroke 20010801

• Management of spasticity, pain, and paroxysmal phenomena in multiple sclerosis.

  Current neurology and neuroscience reports 20010501

• An open-label dose-titration study of the efficacy and tolerability of tizanidine hydrochloride tablets in the prophylaxis of chronic daily headache.

  Headache 20010401

• Antagonistic effects of selective alpha1-adrenoceptor antagonists MDL73005EF and tamsulosin and partial agonists clonidine and tizanidine in rat thoracic aorta and rabbit iliac artery.

  The Journal of pharmacy and pharmacology 20010101

• Hypotension following the initiation of tizanidine in a patient treated with an angiotensin converting enzyme inhibitor for chronic hypertension.

  Journal of child neurology 20001201

• Scopolamine-induced convulsions in food given fasted mice: effects of clonidine and tizanidine.

  Epilepsy research 19990601

• Tizanidine protects mice against convulsions induced by lidocaine: involvement of alpha 2-adrenoceptors.

  Pharmacology & toxicology 19990101

• Intrathecal clonidine and tizanidine in conscious dogs: comparison of analgesic and hemodynamic effects.

  Anesthesia and analgesia 19960301

• A clinical and experimental investigation of the effects of tizanidine in trigeminal neuralgia.

  Pain 19930601

• Development of a simple spasticity quantification method: effects of tizanidine on spasticity in patients with sequelae of cerebrovascular disease.

  The Journal of international medical research 19920201

• Inhibitory effects of clonidine and tizanidine on release of substance P from slices of rat spinal cord and antagonism by alpha-adrenergic receptor antagonists.

  Neuropharmacology 19910601

• Antagonists of adenosine and alpha-2-adrenoceptors reverse the anticonvulsant effects of tizanidine in DBA/2 mice.

  Neuropharmacology 19890301