6478-73-5 | 5,6-Dichlorobenzimidazole

Packsize	Purity	Availability	Price	Discounted Price
1g	97%	in stock	$20.00	$14.00
5g	97%	in stock	$92.00	$65.00
100g	97%	in stock	$1,226.00	$858.00

Description

• Catalog Number: AI54389
• Chemical Name: 5,6-Dichlorobenzimidazole
• CAS Number: 6478-73-5
• Molecular Formula: C7H4Cl2N2
• Molecular Weight: 187.0261
• MDL Number: MFCD00211325
• SMILES: Clc1cc2[nH]cnc2cc1Cl
• NSC Number: 326397

Computed Properties

• Complexity: 153
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 1
• Hydrogen Bond Donor Count: 1
• XLogP3: 2.7

Literature

• SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair.

  Nature communications 20120313

• Synthesis and biological evaluation of benzo[d]imidazole derivatives as potential anti-cancer agents.

  Bioorganic & medicinal chemistry letters 20120201

• Paraoxonases-2 and -3 Are Important Defense Enzymes against Pseudomonas aeruginosa Virulence Factors due to Their Anti-Oxidative and Anti-Inflammatory Properties.

  Journal of lipids 20120101

• Implication of the ERK pathway on the post-transcriptional regulation of VEGF mRNA stability.

  Methods in molecular biology (Clifton, N.J.) 20100101

• Rates of in situ transcription and splicing in large human genes.

  Nature structural & molecular biology 20091101

• Determination of benzimidazole- and bicyclic hydantoin-derived selective androgen receptor antagonists and agonists in human urine using LC-MS/MS.

  Analytical and bioanalytical chemistry 20080501

• The polyglutamine-expanded protein ataxin-3 decreases bcl-2 mRNA stability.

  Biochemical and biophysical research communications 20080111

• Identification of metabolites with anticancer properties by computational metabolomics.

  Molecular cancer 20080101

• Selective androgen receptor modulators in preclinical and clinical development.

  Nuclear receptor signaling 20080101

• Role of glucocorticoid receptor and CCAAT/enhancer-binding protein alpha in the feed-forward induction of 11beta-hydroxysteroid dehydrogenase type 1 expression by cortisol in human amnion fibroblasts.

  The Journal of endocrinology 20071101

• Synthesis and SAR of potent and selective androgen receptor antagonists: 5,6-Dichloro-benzimidazole derivatives.

  Bioorganic & medicinal chemistry letters 20070201

• Molecular modeling of some 1H-benzimidazole derivatives with biological activity against Entamoeba histolytica: a comparative molecular field analysis study.

  Bioorganic & medicinal chemistry 20070115

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Ligand-induced estrogen receptor alpha degradation by the proteasome: new actors?

  Nuclear receptor signaling 20060101

• Intergenic transcription is not required in Th2 cells to maintain histone acetylation and transcriptional permissiveness at the Il4-Il13 locus.

  Journal of immunology (Baltimore, Md. : 1950) 20051215

• Casein kinase II (CK2) enhances death-inducing signaling complex (DISC) activity in TRAIL-induced apoptosis in human colon carcinoma cell lines.

  Oncogene 20050317

• Influence of casein kinase II in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human rhabdomyosarcoma cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20041001

• Effects of macromolecule synthesis inhibitors on light-induced phase shift of the circadian rhythm in melatonin release from the cultured pineal organ of a teleost, ayu (Plecoglossus altivelis).

  Zoological science 20031101

• Synthesis of photoactivable inhibitors of osteoclast vacuolar ATPase.

  Bioorganic & medicinal chemistry 20030515

• Low density lipoproteins downregulate lysyl oxidase in vascular endothelial cells and the arterial wall.

  Arteriosclerosis, thrombosis, and vascular biology 20020901

• Synthesis and antiparasitic activity of 1H-benzimidazole derivatives.

  Bioorganic & medicinal chemistry letters 20020819

• Post-transcriptional regulation of the AT1 receptor mRNA. Identification of the mRNA binding motif and functional characterization.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010601

• Up-regulation of cyclooxygenase-1 in neuroblastoma cell lines by retinoic acid and corticosteroids.

  Journal of neurochemistry 20010401