65-86-1 | Orotic acid

Packsize	Purity	Availability	Price	Discounted Price
25g	98%	in stock	$8.00	$5.00
100g	98%	in stock	$13.00	$9.00
500g	98%	in stock	$55.00	$38.00

Description

• Catalog Number: AB46812
• Chemical Name: Orotic acid
• CAS Number: 65-86-1
• Molecular Formula: C5H4N2O4
• Molecular Weight: 156.0963
• MDL Number: MFCD00149398
• SMILES: O=c1[nH]c(=O)[nH]c(c1)C(=O)O

Computed Properties

• Complexity: 268
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 1
• XLogP3: -1.4

Upstream Synthesis Route

1,2,3,6-Tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid, also known as PTAD, is a versatile chemical compound widely utilized in chemical synthesis processes. This compound acts as a cyclic dienophile in Diels-Alder reactions, making it a valuable component in the formation of complex organic molecules. PTAD's ability to react with dienes under mild conditions facilitates the construction of intricate carbon frameworks with high regio- and stereo-selectivity. Additionally, PTAD can participate in cycloaddition reactions, enabling the rapid assembly of fused heterocyclic structures crucial for the development of pharmaceuticals, agrochemicals, and advanced materials. Its unique reactivity and functional groups make 1,2,3,6-Tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid a key building block in the synthesis of diverse chemical compounds with tailored properties and applications.

Literature

• Orotic acid induces hypertension associated with impaired endothelial nitric oxide synthesis.

  Toxicological sciences : an official journal of the Society of Toxicology 20150401

• Dehydroepiandrosterone sulfate and cytochrome P450 inducers alleviate fatty liver in male rats fed an orotic acid-supplemented diet.

  The Journal of toxicological sciences 20150401

• Benzoic acid and specific 2-oxo acids activate hepatic efflux of glutamate at OAT2.

  Biochimica et biophysica acta 20130201

• Solid state simulation of tetramer form of 5-aminoorotic acid: the vibrational spectra and molecular structure study by using MP2 and DFT calculations.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20121101

• EDTA disodium zinc has superior bioavailability compared to common inorganic or chelated zinc compounds in rats fed a high phytic acid diet.

  Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 20121001

• Selenium and zinc internalized by Lactobacillus buchneri Lb26 (DSM 16341) and Bifidobacterium lactis Bb1 (DSM 17850): improved bioavailability using a new biological approach.

  Journal of clinical gastroenterology 20121001

• Miller (Genee-Wiedemann) syndrome represents a clinically and biochemically distinct subgroup of postaxial acrofacial dysostosis associated with partial deficiency of DHODH.

  Human molecular genetics 20120915

• Ion-exclusion chromatography determination of organic acid in uridine 5'-monophosphate fermentation broth.

  Journal of chromatographic science 20120901

• D282, a non-nucleoside inhibitor of influenza virus infection that interferes with de novo pyrimidine biosynthesis.

  Antiviral chemistry & chemotherapy 20120821

• Crystal structure of dihydroorotate dehydrogenase from Leishmania major.

  Biochimie 20120801

• Biochemical and molecular characterization of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase from Toxoplasma gondii.

  Molecular and biochemical parasitology 20120801

• Pyrimidin-2(1H)-ones based inhibitors of Mycobacterium tuberculosis orotate phosphoribosyltransferase.

  European journal of medicinal chemistry 20120801

• Enhanced uridine 5'-monophosphate production by whole cell of Saccharomyces cerevisiae through rational redistribution of metabolic flux.

  Bioprocess and biosystems engineering 20120601

• Secondary processes in atmospheric pressure chemical ionization-ion trap mass spectrometry: a case study of orotic acid.

  Journal of mass spectrometry : JMS 20120601

• Hyperammonemia in a patient with late-onset ornithine carbamoyltransferase deficiency.

  Journal of Korean medical science 20120501

• Genetic dissection of pyrimidine biosynthesis and salvage in Leishmania donovani.

  The Journal of biological chemistry 20120413

• Improvement of the energy supply and contractile function in normal and ischemic rat hearts by dietary orotic acid.

  Life sciences 20120409

• Sustained correction of OTC deficiency in spf( ash) mice using optimized self-complementary AAV2/8 vectors.

  Gene therapy 20120401

• Current advances in detection and treatment of babesiosis.

  Current medicinal chemistry 20120401

• Stitching together multiple data dimensions reveals interacting metabolomic and transcriptomic networks that modulate cell regulation.

  PLoS biology 20120401

• Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression.

  The Journal of biological chemistry 20120323

• Preparation and chromatographic evaluation of a cysteine-bonded zwitterionic hydrophilic interaction liquid chromatography stationary phase.

  Journal of chromatography. A 20120309

• Path-integral calculations of heavy atom kinetic isotope effects in condensed phase reactions using higher-order Trotter factorizations.

  Journal of computational chemistry 20120205

• Reference intervals for orotic acid in urine, plasma and dried blood spot using hydrophilic interaction liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120201

• Growth and exopolysaccharide yield of Lactobacillus delbrueckii ssp. bulgaricus DSM 20081 in batch and continuous bioreactor experiments at constant pH.

  Journal of bioscience and bioengineering 20120201

• Molecular, kinetic and thermodynamic characterization of Mycobacterium tuberculosis orotate phosphoribosyltransferase.

  Molecular bioSystems 20120201

• Preclinical evaluation of a clinical candidate AAV8 vector for ornithine transcarbamylase (OTC) deficiency reveals functional enzyme from each persisting vector genome.

  Molecular genetics and metabolism 20120201

• Crystallization and preliminary X-ray diffraction analysis of orotate phosphoribosyltransferase from the human malaria parasite Plasmodium falciparum.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20120201

• Conformational studies of hydantoin-5-acetic acid and orotic acid.

  Acta crystallographica. Section C, Crystal structure communications 20120201

• [The ileocoecal valve changes in chronic constipation in children].

  Klinichna khirurhiia 20120201

• Mitochondria-ros crosstalk in the control of cell death and aging.

  Journal of signal transduction 20120101

• Functional Relationships between Lipid Metabolism and Liver Regeneration.

  International journal of hepatology 20120101

• Reconstruction and analysis of a genome-scale metabolic model for Scheffersomyces stipitis.

  Microbial cell factories 20120101

• Sex-specific mouse liver gene expression: genome-wide analysis of developmental changes from pre-pubertal period to young adulthood.

  Biology of sex differences 20120101

• Dietary sea cucumber cerebroside alleviates orotic acid-induced excess hepatic adipopexis in rats.

  Lipids in health and disease 20120101

• Cholesterol-lowering probiotics as potential biotherapeutics for metabolic diseases.

  Experimental diabetes research 20120101

• [Correction of a connective tissue dysplasia in the treatment of postoperative abdominal hernias].

  Klinichna khirurhiia 20120101

• Heteroduplex formation, mismatch resolution, and genetic sectoring during homologous recombination in the hyperthermophilic archaeon sulfolobus acidocaldarius.

  Frontiers in microbiology 20120101

• The association of dietary intake of purine-rich vegetables, sugar-sweetened beverages and dairy with plasma urate, in a cross-sectional study.

  PloS one 20120101

• Proliferating effect of orotic acid through mTORC1 activation mediated by negative regulation of AMPK in SK-Hep1 hepatocellular carcinoma cells.

  The Journal of toxicological sciences 20120101

• Carboxyamidotriazole-orotate inhibits the growth of imatinib-resistant chronic myeloid leukaemia cells and modulates exosomes-stimulated angiogenesis.

  PloS one 20120101

• Distinct fluctuations in nucleotide metabolism accompany the enhanced in vitro embryogenic capacity of Brassica cells over-expressing SHOOTMERISTEMLESS.

  Planta 20111201

• The major roles of DNA polymerases epsilon and delta at the eukaryotic replication fork are evolutionarily conserved.

  PLoS genetics 20111201

• Site directed spin labeling studies of Escherichia coli dihydroorotate dehydrogenase N-terminal extension.

  Biochemical and biophysical research communications 20111028

• Crystallographic snapshots of tyrosine phenol-lyase show that substrate strain plays a role in C-C bond cleavage.

  Journal of the American Chemical Society 20111019

• Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: importance of residues in the orotate binding site.

  Biochemistry 20111004

• Megaloblastic anemia--a rare cause.

  Indian journal of pediatrics 20111001

• Acute treatment of hyperammonemia by continuous renal replacement therapy in a newborn patient with ornithine transcarbamylase deficiency.

  Korean journal of pediatrics 20111001

• Type II Toxoplasma gondii KU80 knockout strains enable functional analysis of genes required for cyst development and latent infection.

  Eukaryotic cell 20110901

• The function of oxalic acid in the human metabolism.

  Clinical chemistry and laboratory medicine 20110901

• Role of the AMPK/SREBP-1 pathway in the development of orotic acid-induced fatty liver.

  Journal of lipid research 20110901

• Anti-tumor activity of liposome encapsulated fluoroorotic acid as a single agent and in combination with liposome irinotecan.

  Journal of controlled release : official journal of the Controlled Release Society 20110810

• Perinatal gene transfer to the liver.

  Current pharmaceutical design 20110801

• Plastid uridine salvage activity is required for photoassimilate allocation and partitioning in Arabidopsis.

  The Plant cell 20110801

• Development of pyrF-based gene knockout systems for genome-wide manipulation of the archaea Haloferax mediterranei and Haloarcula hispanica.

  Journal of genetics and genomics = Yi chuan xue bao 20110620

• A GC/MS-based metabolomic approach for diagnosing citrin deficiency.

  Analytical and bioanalytical chemistry 20110601

• OAT2 catalyses efflux of glutamate and uptake of orotic acid.

  The Biochemical journal 20110601

• Study on possible mechanism of orotic acid-induced fatty liver in rats.

  Nutrition (Burbank, Los Angeles County, Calif.) 20110501

• Human urate transporter 1 (hURAT1) mediates the transport of orotate.

  The journal of physiological sciences : JPS 20110501

• Identification of the UMP synthase gene by establishment of uracil auxotrophic mutants and the phenotypic complementation system in the marine diatom Phaeodactylum tricornutum.

  Plant physiology 20110501

• Induction and prevention of severe hyperammonemia in the spfash mouse model of ornithine transcarbamylase deficiency using shRNA and rAAV-mediated gene delivery.

  Molecular therapy : the journal of the American Society of Gene Therapy 20110501

• Analysis of the efficacy, safety, and regulatory status of novel forms of creatine.

  Amino acids 20110501

• [Analysis of clinical features, biochemical analysis and gene mutations in one Chinese pedigree with neonatal-onset ornithine transcarbamylase deficiency].

  Zhonghua er ke za zhi = Chinese journal of pediatrics 20110501

• Substrate binding and reactivity are not linked: grafting a proton-transfer network into a Class 1A dihydroorotate dehydrogenase.

  Biochemistry 20110412

• A common telomeric gene silencing assay is affected by nucleotide metabolism.

  Molecular cell 20110408

• Molecular recognition of melamine by vesicles spontaneously formed from orotic acid derived bolaamphiphiles.

  The journal of physical chemistry. B 20110303

• Quinolones: from antibiotics to autoinducers.

  FEMS microbiology reviews 20110301

• New insights into galactose metabolism by Schizosaccharomyces pombe: isolation and characterization of a galactose-assimilating mutant.

  Journal of bioscience and bioengineering 20110201

• Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20110201

• Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction.

  Molecular cell 20110121

• Brassinolide-improved development of Brassica napus microspore-derived embryos is associated with increased activities of purine and pyrimidine salvage pathways.

  Planta 20110101

• Metabolomic profiling for identification of novel potential biomarkers in cardiovascular diseases.

  Journal of biomedicine & biotechnology 20110101

• New developments in the treatment of hyperammonemia: emerging use of carglumic acid.

  International journal of general medicine 20110101

• Posterior reversible encephalopathy syndrome in a child with cyclical vomiting and hypertension: a case report.

  Journal of medical case reports 20110101

• The complete genome sequence of 'Candidatus Liberibacter solanacearum', the bacterium associated with potato zebra chip disease.

  PloS one 20110101

• The importance of mitochondrial DNA in aging and cancer.

  Journal of aging research 20110101

• Path finding methods accounting for stoichiometry in metabolic networks.

  Genome biology 20110101

• [Adrenoreactivity in patients with arrhythmic syndrome associated with connective tissue dysplasia at the background of intake of the magnezium orotate].

  Kardiologiia 20110101

• 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active metabolite of leflunomide.

  International journal of molecular sciences 20110101

• Resistance of a rodent malaria parasite to a thymidylate synthase inhibitor induces an apoptotic parasite death and imposes a huge cost of fitness.

  PloS one 20110101

• Complete genome sequence of the filamentous anoxygenic phototrophic bacterium Chloroflexus aurantiacus.

  BMC genomics 20110101

• Decrease of energy spilling in Escherichia coli continuous cultures with rising specific growth rate and carbon wasting.

  BMC systems biology 20110101

• Comparative genomics and transcriptomics of Propionibacterium acnes.

  PloS one 20110101

• Zinc lozenges may shorten the duration of colds: a systematic review.

  The open respiratory medicine journal 20110101

• Arginase I deficiency: severe infantile presentation with hyperammonemia: more common than reported?

  Molecular genetics and metabolism 20110101

• Efficient overproduction of membrane proteins in Lactococcus lactis requires the cell envelope stress sensor/regulator couple CesSR.

  PloS one 20110101

• Isolation and anti-fatty liver activity of a novel cerebroside from the sea cucumber Acaudina molpadioides.

  Bioscience, biotechnology, and biochemistry 20110101

• Copper modulation as a therapy for Alzheimer's disease?

  International journal of Alzheimer's disease 20110101

• [Fifteen years experience of the use of magnesium preparations in patients with mitral valve prolapse].

  Kardiologiia 20110101

• Issues raised involving the copper hypotheses in the causation of Alzheimer's disease.

  International journal of Alzheimer's disease 20110101

• Horizontal and vertical growth of S. cerevisiae metabolic network.

  BMC evolutionary biology 20110101

• Metabolomics of oxidative stress in recent studies of endogenous and exogenously administered intermediate metabolites.

  International journal of molecular sciences 20110101

• Manganese superoxide dismutase: guardian of the powerhouse.

  International journal of molecular sciences 20110101

• Serum metabolic profile in multiple sclerosis patients.

  Multiple sclerosis international 20110101

• Disturbed copper bioavailability in Alzheimer's disease.

  International journal of Alzheimer's disease 20110101

• Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery.

  European journal of medicinal chemistry 20101201

• Leaving group activation and pyrophosphate ionic state at the catalytic site of Plasmodium falciparum orotate phosphoribosyltransferase.

  Journal of the American Chemical Society 20101201

• Metabolism of [U-(13)C]aspartate by astroglial cultures: nuclear magnetic resonance analysis of the culture media.

  Neurochemical research 20101201

• Use of the pyrG gene as a food-grade selection marker in Monascus.

  Biotechnology letters 20101101

• [Ornithine transcarbamylase deficiency in adult].

  La Revue de medecine interne 20101001

• Perioperative metabolic therapy improves redox status and outcomes in cardiac surgery patients: a randomised trial.

  Heart, lung & circulation 20101001

• Controlling selectivity and enhancing yield of flavonoid glycosides in recombinant yeast.

  Bioprocess and biosystems engineering 20100901

• Acute effect of milk on serum urate concentrations: a randomised controlled crossover trial.

  Annals of the rheumatic diseases 20100901

• [Effect of sea cucumber cerebroside on lipid metabolism in fatty liver rats].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20100901

• Malaria gametocytogenesis.

  Molecular and biochemical parasitology 20100801

• Electrophilic aromatic selenylation: new OPRT inhibitors.

  Organic letters 20100702

• New trends in nucleoside biotechnology.

  Acta naturae 20100701

• Pyrophosphate interactions at the transition states of Plasmodium falciparum and human orotate phosphoribosyltransferases.

  Journal of the American Chemical Society 20100630

• Nucleotides and nucleosides in ovine and caprine milk during lactation.

  Journal of dairy science 20100601

• Fatal hyperammonemia after renal transplant due to late-onset urea cycle deficiency: a case report.

  Transplantation proceedings 20100601

• Tetra-aqua-bis(orotato-κO)cobalt(II) dihydrate.

  Acta crystallographica. Section E, Structure reports online 20100601

• Conformational changes in orotidine 5'-monophosphate decarboxylase: 'remote' residues that stabilize the active conformation.

  Biochemistry 20100504

• Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes.

  Molecular bioSystems 20100501

• Kinetic mechanism and catalysis of Trypanosoma cruzi dihydroorotate dehydrogenase enzyme evaluated by isothermal titration calorimetry.

  Analytical biochemistry 20100401

• New classes of PDE7 inhibitors identified by a fission yeast-based HTS.

  Journal of biomolecular screening 20100401

• The mechanisms of citrate on regulating the distribution of carbon flux in the biosynthesis of uridine 5'-monophosphate by Saccharomyces cerevisiae.

  Applied microbiology and biotechnology 20100301

• A Caenorhabditis elegans model of orotic aciduria reveals enlarged lysosome-related organelles in embryos lacking umps-1 function.

  The FEBS journal 20100301

• Orotic acid quantification in dried blood spots and biological fluids by hydrophilic interaction liquid chromatography tandem mass spectrometry.

  Journal of separation science 20100301

• A trial of minimization of chromosome 7 in Aspergillus oryzae by multiple chromosomal deletions.

  Molecular genetics and genomics : MGG 20100101

• Quantitation of orotic acid in urine using isotope dilution-selected ion gas chromatography-mass spectrometry.

  Methods in molecular biology (Clifton, N.J.) 20100101

• Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARalpha and SREBP-1c signaling.

  Lipids in health and disease 20100101

• [Comparative study of magnesium salts bioavailability in rats fed a magnesium-deficient diet].

  Vestnik Rossiiskoi akademii meditsinskikh nauk 20100101

• Amino acid accumulation limits the overexpression of proteins in Lactococcus lactis.

  PloS one 20100101

• One-step metabolomics: carbohydrates, organic and amino acids quantified in a single procedure.

  Journal of visualized experiments : JoVE 20100101

• Comparison of koala LPCoLN and human strains of Chlamydia pneumoniae highlights extended genetic diversity in the species.

  BMC genomics 20100101

• Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis.

  BMC systems biology 20100101

• Promoter methylation and large intragenic rearrangements of DPYD are not implicated in severe toxicity to 5-fluorouracil-based chemotherapy in gastrointestinal cancer patients.

  BMC cancer 20100101

• Induction of erythroid differentiation in human erythroleukemia cells by depletion of malic enzyme 2.

  PloS one 20100101

• The genome of Geobacter bemidjiensis, exemplar for the subsurface clade of Geobacter species that predominate in Fe(III)-reducing subsurface environments.

  BMC genomics 20100101

• The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism.

  Journal of nucleic acids 20100101

• Screening for bovine leukocyte adhesion deficiency, deficiency of uridine monophosphate synthase, complex vertebral malformation, bovine citrullinaemia, and factor XI deficiency in Holstein cows reared in Turkey.

  Acta veterinaria Scandinavica 20100101

• Directly-observed therapy (DOT) for the radical 14-day primaquine treatment of Plasmodium vivax malaria on the Thai-Myanmar border.

  Malaria journal 20100101

• Female heterozygotes for the hypomorphic R40H mutation can have ornithine transcarbamylase deficiency and present in early adolescence: a case report and review of the literature.

  Journal of medical case reports 20100101

• Uridine metabolism in HIV-1-infected patients: effect of infection, of antiretroviral therapy and of HIV-1/ART-associated lipodystrophy syndrome.

  PloS one 20100101

• Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates.

  PloS one 20100101

• Disruption of the proton relay network in the class 2 dihydroorotate dehydrogenase from Escherichia coli.

  Biochemistry 20091020

• Early detection of steatohepatitis in fatty rat liver by using MR elastography.

  Radiology 20091001

• Experimental evidence that ornithine and homocitrulline disrupt energy metabolism in brain of young rats.

  Brain research 20090929

• Orotic acid decarboxylation in water and nonpolar solvents: a potential role for desolvation in the action of OMP decarboxylase.

  Biochemistry 20090915

• [Development of anti-trypanosome drugs targeting nucleotides biosynthesis and red-ox regulatory pathway].

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20090901

• Roles in binding and chemistry for conserved active site residues in the class 2 dihydroorotate dehydrogenase from Escherichia coli.

  Biochemistry 20090804

• AAV2/8-mediated correction of OTC deficiency is robust in adult but not neonatal Spf(ash) mice.

  Molecular therapy : the journal of the American Society of Gene Therapy 20090801

• Myocardial infarct size-limiting and anti-arrhythmic effects of mildronate orotate in the rat heart.

  Cardiovascular drugs and therapy 20090801

• A functional analysis of the pyrimidine catabolic pathway in Arabidopsis.

  The New phytologist 20090701

• Comparative in vitro toxicity of seven zinc-salts towards neuronal PC12 cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20090601

• In vivo assessment of mutations in OTC for dominant-negative effects following rAAV2/8-mediated gene delivery to the mouse liver.

  Gene therapy 20090601

• Marker-disruptive gene integration and URA3 recycling for multiple gene manipulation in Saccharomyces cerevisiae.

  Applied microbiology and biotechnology 20090601

• Changes in noninfarcted myocardium explain benefits of on-pump beating-heart coronary artery bypass grafting for acute myocardial infarction.

  The Journal of thoracic and cardiovascular surgery 20090601

• Magnesium orotate in severe congestive heart failure (MACH).

  International journal of cardiology 20090501

• Transition states of Plasmodium falciparum and human orotate phosphoribosyltransferases.

  Journal of the American Chemical Society 20090408

• Plasmodium berghei: efficacy of 5-fluoroorotate in combination with commonly used antimalarial drugs in a mouse model.

  Experimental parasitology 20090401

• Synthesis of amidine and amide derivatives and their evaluation for anti-inflammatory and analgesic activities.

  European journal of medicinal chemistry 20090301

• Babesia bovis: effect of Albumax II and orotic acid in a low-serum in vitro culture.

  Experimental parasitology 20090301

• Regulation of pyrimidine formation in Pseudomonas lundensis.

  Canadian journal of microbiology 20090301

• Dihydroorotase from the hyperthermophile Aquifex aeolicus is activated by stoichiometric association with aspartate transcarbamoylase and forms a one-pot reactor for pyrimidine biosynthesis.

  Biochemistry 20090203

• Efficient generation of recessive traits in diploid sake yeast by targeted gene disruption and loss of heterozygosity.

  Applied microbiology and biotechnology 20090201

• Magnesium orotate in severe congestive heart failure (MACH).

  International journal of cardiology 20090109

• How mitochondria produce reactive oxygen species.

  The Biochemical journal 20090101

• Genome sequence of the pathogenic intestinal spirochete brachyspira hyodysenteriae reveals adaptations to its lifestyle in the porcine large intestine.

  PloS one 20090101

• The role of relA and spoT in Yersinia pestis KIM5 pathogenicity.

  PloS one 20090101

• Mapping the landscape of potentially primordial informational oligomers: oligo-dipeptides tagged with orotic acid derivatives as recognition elements.

  Angewandte Chemie (International ed. in English) 20090101

• Stability of metabolic correlations under changing environmental conditions in Escherichia coli--a systems approach.

  PloS one 20090101

• Zicam-induced damage to mouse and human nasal tissue.

  PloS one 20090101

• Neuromuscular electrical stimulation and dietary interventions to reduce oxidative stress in a secondary progressive multiple sclerosis patient leads to marked gains in function: a case report.

  Cases journal 20090101

• High-dose glycine treatment of refractory obsessive-compulsive disorder and body dysmorphic disorder in a 5-year period.

  Neural plasticity 20090101

• Interaction of cyanide with enzymes containing vanadium, manganese, non-heme iron, and zinc.

  Metal ions in life sciences 20090101

• Reliability of urine collection pads for routine and metabolic biochemistry in infants and young children.

  European journal of pediatrics 20081101

• New amides of 5-(4-chlorobenzoyl)aminoorotic acid: their synthesis and biological activity.

  Archiv der Pharmazie 20081101

• Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction.

  Biochemistry 20081014

• Mutations of RNA polymerase II activate key genes of the nucleoside triphosphate biosynthetic pathways.

  The EMBO journal 20080917

• The dihydroorotase inhibitor 5-aminoorotic acid inhibits the metabolism in the rat of the cardioprotective drug dexrazoxane and its one-ring open metabolites.

  Drug metabolism and disposition: the biological fate of chemicals 20080901

• Clinical applications of urinary organic acids. Part I: Detoxification markers.

  Alternative medicine review : a journal of clinical therapeutic 20080901

• Acute fatal presentation of ornithine transcarbamylase deficiency in a previously healthy male.

  Hepatology international 20080901

• The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites.

  Biochemistry 20080826

• Phenotypic correction of ornithine transcarbamylase deficiency using low dose helper-dependent adenoviral vectors.

  The journal of gene medicine 20080801

• Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial.

  Journal of neural transmission (Vienna, Austria : 1996) 20080801

• Surprisingly low aqueous acidity at the alpha-positions of pyridiniums and pyrimidinium: the role of solvation.

  Organic letters 20080703

• Targeting oxidative stress in surgery: effects of ageing and therapy.

  Experimental gerontology 20080701

• Changes in the de novo, salvage, and degradation pathways of pyrimidine nucleotides during tobacco shoot organogenesis.

  Plant physiology and biochemistry : PPB 20080701

• Ghrelin and orotic acid increased in subclinical mastitis.

  Archives of physiology and biochemistry 20080701

• New lanthanide complexes with antioxidant activity.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20080701

• Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase from Y strain.

  Biochemical and biophysical research communications 20080509

• Postchemotherapy hyperammonemic encephalopathy emulating ornithine transcarbamoylase (OTC) deficiency.

  Southern medical journal 20080501

• Fenofibrate prevents orotic acid--induced hepatic steatosis in rats.

  Life sciences 20080409

• Stochastic switching as a survival strategy in fluctuating environments.

  Nature genetics 20080401

• Redetermination of orotic acid monohydrate.

  Acta crystallographica. Section E, Structure reports online 20080401

• Defects in vesicle core induced by escherichia coli dihydroorotate dehydrogenase.

  Biophysical journal 20080301

• Diaqua-(2,6-dioxo-1,2,3,6-tetra-hydro-pyrimidin-3-ide-4-carboxyl-ato-κN,O)(1,10-phenanthroline-κN,N')manganese(II).

  Acta crystallographica. Section E, Structure reports online 20080301

• Dihydroorotase of human malarial parasite Plasmodium falciparum differs from host enzyme.

  Biochemical and biophysical research communications 20080215

• Control of 5-FOA and 5-FU resistance by Saccharomyces cerevisiae YJL055W.

  Yeast (Chichester, England) 20080201

• Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome with stroke-like imaging presentation: clinical, biochemical and molecular analysis.

  Journal of the neurological sciences 20080115

• Gene tagging and gene replacement using recombinase-mediated cassette exchange in Schizosaccharomyces pombe.

  Gene 20080115

• Nutritional therapies for mental disorders.

  Nutrition journal 20080101

• Investigation of a wide spectrum of inherited metabolic disorders by 13C NMR spectroscopy.

  Acta biochimica Polonica 20080101

• In vitro atovaquone/proguanil susceptibility and characterization of the cytochrome b gene of Plasmodium falciparum from different endemic regions of Thailand.

  Malaria journal 20080101

• Strain improvement of recombinant Escherichia coli for efficient production of plant flavonoids.

  Molecular pharmaceutics 20080101

• Differentiation of 2-alkylthioorotic acids, methyl and ethyl 2-alkylthioorotates and hydrazides of 2-alkylthioorotic acids by using electron ionization mass spectra.

  European journal of mass spectrometry (Chichester, England) 20080101

• Perceiving molecular evolution processes in Escherichia coli by comprehensive metabolite and gene expression profiling.

  Genome biology 20080101

• Transcription factor control of growth rate dependent genes in Saccharomyces cerevisiae: a three factor design.

  BMC genomics 20080101

• Remodeling of the Streptococcus agalactiae transcriptome in response to growth temperature.

  PloS one 20080101

• [Basic and metabolic therapy of hypertensive disease in pregnant women].

  Klinicheskaia meditsina 20080101

• An insight into the biochemistry of inborn errors of metabolism for a clinical neurologist.

  Annals of Indian Academy of Neurology 20080101

• [2,6-Dioxo-1,2,3,6-tetra-hydro-pyrim-idine-4-carboxyl-ato(2-)]bis(pyrazino[2,3-f][1,10]phenanthroline)cobalt(II) dihydrate.

  Acta crystallographica. Section E, Structure reports online 20080101

• Ternary complex formation and induced asymmetry in orotate phosphoribosyltransferase.

  Biochemistry 20071211

• [Late-onset type ornitine transcarbamirase deficiency (OTCD) with fulminant onset following a fatal prognosis].

  Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20071201

• Complete recovery from acute encephalopathy of late-onset ornithine transcarbamylase deficiency in a 3-year-old boy.

  Journal of inherited metabolic disease 20071101

• QM/MM metadynamics study of the direct decarboxylation mechanism for orotidine-5'-monophosphate decarboxylase using two different QM regions: acceleration too small to explain rate of enzyme catalysis.

  The journal of physical chemistry. B 20071101

• The orotate transporter encoded by oroP from Lactococcus lactis is required for orotate utilization and has utility as a food-grade selectable marker.

  Microbiology (Reading, England) 20071101

• Transformation by complementation of a uracil auxotroph of the hyper lignin-degrading basidiomycete Phanerochaete sordida YK-624.

  Applied microbiology and biotechnology 20071001

• [Urea cycle disorders in adult patients].

  Revue neurologique 20071001

• Diversity of crystal structure with different lanthanide ions involving in situ oxidation-hydrolysis reaction.

  Dalton transactions (Cambridge, England : 2003) 20070928

• The role of DNA mismatch repair in generating genetic diversity and drug resistance in malaria parasites.

  Molecular and biochemical parasitology 20070901

• Dihydroorotate dehydrogenase from Saccharomyces cerevisiae: spectroscopic investigations with the recombinant enzyme throw light on catalytic properties and metabolism of fumarate analogues.

  FEMS yeast research 20070901

• Determination of 5-aminoimidazole-4-carboxamide in human plasma by ion-pair extraction and LC-MS/MS.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070815

• Carbanions from decarboxylation of orotate analogs: stability and mechanistic implications.

  Bioorganic chemistry 20070801

• Production of uridine 5'-monophosphate by Corynebacterium ammoniagenes ATCC 6872 using a statistically improved biocatalytic process.

  Applied microbiology and biotechnology 20070801

• Impaired microsomal oxidation of the atypical antipsychotic agent clozapine in hepatic steatosis.

  The Journal of pharmacology and experimental therapeutics 20070801

• Mutations in yhiT enable utilization of exogenous pyrimidine intermediates in Salmonella enterica serovar Typhimurium.

  Microbiology (Reading, England) 20070801

• Structures of ligand-free and inhibitor complexes of dihydroorotase from Escherichia coli: implications for loop movement in inhibitor design.

  Journal of molecular biology 20070727

• Low citrulline may not be diagnostic of ornithine transcarbamylase deficiency: a case report.

  Journal of inherited metabolic disease 20070601

• mer-Diaquabis(1H-imidazole-kappaN3)[orotato(2-)]cobalt(II).

  Acta crystallographica. Section C, Crystal structure communications 20070601

• Lithium toxicity from an Internet dietary supplement.

  Journal of medical toxicology : official journal of the American College of Medical Toxicology 20070601

• Interaction of benzoate pyrimidine analogues with class 1A dihydroorotate dehydrogenase from Lactococcus lactis.

  Biochemistry 20070515

• The Escherichia coli protein YjjG is a house-cleaning nucleotidase in vivo.

  FEMS microbiology letters 20070501

• Mechanism of flavin reduction in the class 1A dihydroorotate dehydrogenase from Lactococcus lactis.

  Biochemistry 20070403

• Comparative studies on pyrimidine metabolism in excised cotyledons of Pinus radiata during shoot formation in vitro.

  Journal of plant physiology 20070401

• Potential of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) for differential diagnosis of nonalcoholic steatohepatitis and fatty liver in rats using magnetic resonance imaging.

  Investigative radiology 20070401

• Regulation of the pyrimidine biosynthetic pathway in a pyrD knockout mutant of Pseudomonas aeruginosa.

  Journal of basic microbiology 20070401

• Characterization of Treponema denticola pyrF encoding orotidine-5'-monophosphate decarboxylase.

  FEMS microbiology letters 20070301

• Structure of the T109S mutant of Escherichia coli dihydroorotase complexed with the inhibitor 5-fluoroorotate: catalytic activity is reflected by the crystal form.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20070301

• Citrin deficiency: a novel cause of failure to thrive that responds to a high-protein, low-carbohydrate diet.

  Pediatrics 20070301

• Japanese black cattle with orotic aciduria detected by gas-chromatography/mass-spectrometry.

  The Journal of veterinary medical science 20070301

• Two step derivatization for the analyses of organic, amino acids and glycines on filter paper plasma by GC-MS/SIM.

  Archives of pharmacal research 20070301

• Dicoumarol impairs mitochondrial electron transport and pyrimidine biosynthesis in human myeloid leukemia HL-60 cells.

  Biochemical pharmacology 20070201

• Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase.

  Journal of medicinal chemistry 20070125

• The influence of pharmacogenetics on fatty liver disease in the wistar and kyoto rats: a combined transcriptomic and metabonomic study.

  Journal of proteome research 20070101

• The clinical application of metabolic therapy for cardiovascular disease.

  Heart, lung & circulation 20070101

• Swainsonine reduces 5-fluorouracil tolerance in the multistage resistance of colorectal cancer cell lines.

  Molecular cancer 20070101

• The effects of short-term alpha-ketoisocaproic acid supplementation on exercise performance: a randomized controlled trial.

  Journal of the International Society of Sports Nutrition 20070101

• Interaction of 2-aminopyrimidine with dichloro-[I-alkyl-2-(naphthylazo) imidazole]palladium(II) complexes: kinetic and mechanistic studies.

  Chemistry Central journal 20070101

• Classical genetics.

  Methods in molecular biology (Clifton, N.J.) 20070101

• [Study of anti-inflammatory activity of some organic and inorganic magnesium salts in rats fed with magnesium-deficient diet].

  Voprosy pitaniia 20070101

• Improved protocols for functional analysis in the pathogenic fungus Aspergillus flavus.

  BMC microbiology 20070101

• The oncoprotein H-RasV12 increases mitochondrial metabolism.

  Molecular cancer 20070101

• Mechanism of flavin reduction in class 2 dihydroorotate dehydrogenases.

  Biochemistry 20061219

• New lanthanum (III) complex--synthesis, characterization, and cytotoxic activity.

  Archiv der Pharmazie 20061101

• catena-Poly[[[triaquacobalt(II)]-mu-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylato(2-)] 1.72-hydrate].

  Acta crystallographica. Section C, Crystal structure communications 20061101

• European Academy of Paediatrics, Barcelona, Spain, October 7-10, 2006. Abstracts.

  European journal of pediatrics 20061101

• Crystallization and preliminary X-ray diffraction analysis of Leishmania major dihydroorotate dehydrogenase.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20061001

• Effects of arginine treatment on nutrition, growth and urea cycle function in seven Japanese boys with late-onset ornithine transcarbamylase deficiency.

  European journal of pediatrics 20060901

• Endogenous ascorbic acid modulates meristem reactivation in white spruce somatic embryos and affects thymidine and uridine metabolism.

  Tree physiology 20060901

• Control of ribosome turnover during growth of the haloalkaliphilic archaeon Natronococcus occultus.

  Research in microbiology 20060901

• Changes of purine and pyrimidine nucleotide biosynthesis during shoot initiation from epicotyl explants of white spruce (Picea glauca).

  Plant science : an international journal of experimental plant biology 20060901

• Thermodynamic analysis of catalysis by the dihydroorotases from hamster and Bacillus caldolyticus, as compared with the uncatalyzed reaction.

  Biochemistry 20060711

• Cloning, expression, purification, and characterization of Leishmania major dihydroorotate dehydrogenase.

  Protein expression and purification 20060701

• Long-term correction of ammonia metabolism and prolonged survival in ornithine transcarbamylase-deficient mice following liver-directed treatment with adeno-associated viral vectors.

  Molecular therapy : the journal of the American Society of Gene Therapy 20060701

• Vector-related tumorigenesis not found in ornithine transcarbamylase-deficient mice.

  Molecular therapy : the journal of the American Society of Gene Therapy 20060701

• Lys-D48 is required for charge stabilization, rapid flavin reduction, and internal electron transfer in the catalytic cycle of dihydroorotate dehydrogenase B of Lactococcus lactis.

  The Journal of biological chemistry 20060630

• 13C and 15N isotope effects for conversion of L-dihydroorotate to N-carbamyl-L-aspartate using dihydroorotase from hamster and Bacillus caldolyticus.

  Biochemistry 20060613

• Pre-operative preparation for cardiac surgery utilising a combination of metabolic, physical and mental therapy.

  Heart, lung & circulation 20060601

• Micellar electrokinetic capillary chromatographic method for the quantitative analysis of uricosuric and antigout drugs in pharmaceutical preparations.

  Electrophoresis 20060601

• Half-of-sites binding of orotidine 5'-phosphate and alpha-D-5-phosphorylribose 1-diphosphate to orotate phosphoribosyltransferase from Saccharomyces cerevisiae supports a novel variant of the Theorell-Chance mechanism with alternating site catalysis.

  Biochemistry 20060425

• PCR-mediated seamless gene deletion and marker recycling in Saccharomyces cerevisiae.

  Yeast (Chichester, England) 20060415

• Stability of large segmental duplications in the yeast genome.

  Genetics 20060401

• Accelerated decarboxylation of 1,3-dimethylorotic acid in ionic liquid.

  Bioorganic chemistry 20060401

• Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase.

  Bioorganic & medicinal chemistry letters 20060315

• Electronic structure of orotic acid III geometric feature and thermal properties of some transition metal orotic acid complexes.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20060301

• Genetic diversity and kinetic properties of Trypanosoma cruzi dihydroorotate dehydrogenase isoforms.

  Parasitology international 20060301

• Metabolomic and bioinformatic analyses in asphyxiated neonates.

  Clinical biochemistry 20060301

• A new type of migrating zone boundary in electrophoresis: 3. The hybrid boundary and stacking criteria.

  Electrophoresis 20060301

• Pulsed electrochemical detection of orotic acid by an activated potential waveform at a gold working electrode following anion-exchange chromatography.

  Journal of chromatography. A 20060224

• Hazards associated with pregnancies and deliveries in lysinuric protein intolerance.

  Metabolism: clinical and experimental 20060201

• Influence of calcium and phosphorus, lactose, and salt-to-moisture ratio on Cheddar cheese quality: changes in residual sugars and water-soluble organic acids during ripening.

  Journal of dairy science 20060201

• Counter-selectable marker for bacterial-based interaction trap systems.

  BioTechniques 20060201

• An unusual clinical and biochemical presentation of ornithine transcarbamylase deficiency in a male patient.

  Journal of inherited metabolic disease 20060201

• An engineered nonsense URA3 allele provides a versatile system to detect the presence, absence and appearance of the [PSI+] prion in Saccharomyces cerevisiae.

  Yeast (Chichester, England) 20060130

• The diagnostic utility of a genetics evaluation in children with pervasive developmental disorders.

  Genetics in medicine : official journal of the American College of Medical Genetics 20060101

• Integration of genomic and metabonomic data in systems biology--are we 'there' yet?

  Current opinion in drug discovery & development 20060101

• Ineffectiveness of zinc gluconate nasal spray and zinc orotate lozenges in common-cold treatment: a double-blind, placebo-controlled clinical trial.

  Alternative therapies in health and medicine 20060101

• Effects of amlodipine orotate on hypertension-related complications in spontaneously hypertensive rats.

  Arzneimittel-Forschung 20060101

• Pyrimidine base supplementation effects curdlan production in Agrobacterium sp. ATCC 31749.

  Journal of basic microbiology 20060101

• PSC 833, an inhibitor of P-glycoprotein inhibits 1,2-dimethylhydrazine-induced colorectal carcinogenesis in male Fischer F344 rats.

  Anticancer research 20060101

• Nucleotide supplementation: a randomised double-blind placebo controlled trial of IntestAidIB in people with Irritable Bowel Syndrome [ISRCTN67764449].

  Nutrition journal 20060101

• Metabolic engineering of microbes for oligosaccharide and polysaccharide synthesis.

  Microbial cell factories 20060101

• A fluoroorotic acid-resistant mutant of Arabidopsis defective in the uptake of uracil.

  Journal of experimental botany 20060101

• 5-fluoro-orotic acid induces chromosome alterations in genetically manipulated strains of Candida albicans.

  Mycologia 20060101

• Analysis of pyrimidine synthesis de novo intermediates in urine during crisis of a patient with ornithine transcarbamylase deficiency.

  Nucleosides, nucleotides & nucleic acids 20060101

• Genomic reconstruction by serial mitotic recombination of yeast artificial chromosomes.

  Methods in molecular biology (Clifton, N.J.) 20060101

• The Elbs and Boyland-Sims peroxydisulfate oxidations.

  Beilstein journal of organic chemistry 20060101

• [Use of orotic acid and orotates].

  Journal de pharmacie de Belgique 20060101

• [The results of application of magnesium-bearing medications and different load doses of vitamins B1 and B2 in volunteers].

  Voprosy pitaniia 20060101

• Simultaneous high performance liquid chromatographic separation of purines, pyrimidines, N-acetylated amino acids, and dicarboxylic acids for the chemical diagnosis of inborn errors of metabolism.

  Clinical biochemistry 20051101

• Expression, purification and crystallization of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with orotate.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20051001

• Glutamine inhibits cytokine-induced apoptosis in human colonic epithelial cells via the pyrimidine pathway.

  American journal of physiology. Gastrointestinal and liver physiology 20050901

• A high-efficiency method to replace essential genes with mutant alleles in yeast.

  Yeast (Chichester, England) 20050730

• The influence of metals on the electronic system of biologically important ligands. Spectroscopic study of benzoates, salicylates, nicotinates and isoorotates. Review.

  Journal of inorganic biochemistry 20050701

• Inhibition of de novo pyrimidine synthesis in growing potato tubers leads to a compensatory stimulation of the pyrimidine salvage pathway and a subsequent increase in biosynthetic performance.

  The Plant cell 20050701

• Urinary uracil in female patients with ornithine transcarbamylase deficiency.

  Pediatrics international : official journal of the Japan Pediatric Society 20050601

• Dihydroorotase from Escherichia coli: loop movement and cooperativity between subunits.

  Journal of molecular biology 20050506

• Inhibitory action of marine algae extracts on the Trypanosoma cruzi dihydroorotate dehydrogenase activity and on the protozoan growth in mammalian cells.

  Parasitology international 20050301

• Pretranslational upregulation of microsomal CYP4A in rat liver by intake of a high-sucrose, lipid-devoid diet containing orotic acid.

  Biochemical pharmacology 20050215

• 5-Fluoro-orotic acid induces chromosome alterations in Candida albicans.

  Yeast (Chichester, England) 20050115

• Regulation of pyrimidine biosynthesis in Acidovorax delafieldii.

  Journal of basic microbiology 20050101

• [Clinical value of the use of magnesium orotate in adolescents with syndrome of cardiac connective tissue dysplasia].

  Kardiologiia 20050101

• Dietary phosphatidylcholine alleviates fatty liver induced by orotic acid.

  Nutrition (Burbank, Los Angeles County, Calif.) 20050101

• Dietary supplementation with orotate and uracil increases adaptive growth of jejunal mucosa after massive small bowel resection in rats.

  JPEN. Journal of parenteral and enteral nutrition 20050101

• Ornithine aminotransferase deficiency: diagnostic difficulties in neonatal presentation.

  Journal of inherited metabolic disease 20050101

• Synthesis and properties of PNA oligomers containing orotic acid derivatives.

  Nucleosides, nucleotides & nucleic acids 20050101

• Mechanism of the dihydroorotase reaction.

  Biochemistry 20041228

• The cyanobacterial toxin cylindrospermopsin inhibits pyrimidine nucleotide synthesis and alters cholesterol distribution in mice.

  Toxicological sciences : an official journal of the Society of Toxicology 20041201

• Alterations in pyrimidine nucleotide metabolism as an early signal during the execution of programmed cell death in tobacco BY-2 cells.

  Journal of experimental botany 20041201

• Analysis of pyrimidine synthesis 'de novo' intermediates in urine and dried urine filter- paper strips with HPLC-electrospray tandem mass spectrometry.

  Clinical chemistry 20041101

• mer-Diaquabis(1H-imidazole-kappaN3)(orotato-kappa2N3,O4nickel(II).

  Acta crystallographica. Section C, Crystal structure communications 20041101

• Comparison of ion-pair chromatography and capillary zone electrophoresis for the assay of organic acids as markers of abnormal metabolism.

  Journal of chromatography. A 20041008

• Adsorption of bile acid by chitosan-orotic acid salt and its application as an oral preparation.

  Chemical & pharmaceutical bulletin 20041001

• Alleviation of fatty liver by alpha-linolenic acid.

  Journal of nutritional science and vitaminology 20040801

• Interstitial deletion of chromosome 2q32-34 associated with multiple congenital anomalies and a urea cycle defect (CPS I deficiency).

  American journal of medical genetics. Part A 20040730

• Multiple states of the Tyr318Leu mutant of dihydroorotate dehydrogenase revealed by single-molecule kinetics.

  Journal of the American Chemical Society 20040609

• Thermodynamic basis of electron transfer in dihydroorotate dehydrogenase B from Lactococcus lactis: analysis by potentiometry, EPR spectroscopy, and ENDOR spectroscopy.

  Biochemistry 20040601

• Improvement of culture conditions and evidence for nuclear transformation by homologous recombination in a red alga, Cyanidioschyzon merolae 10D.

  Plant & cell physiology 20040601

• A suspected case of ornithine transcarbamylase deficiency in a cat.

  The Journal of veterinary medical science 20040601

• Response of the senescent heart to stress: clinical therapeutic strategies and quest for mitochondrial predictors of biological age.

  Annals of the New York Academy of Sciences 20040601

• Effect of NaCN on currents evoked by uremic retention solutes in dissociated mouse neurons.

  Brain research 20040515

• Acute hyperammonaemic encephalopathy in a female newborn caused by a novel, de novo mutation in the ornithine transcarbamylase gene.

  Acta paediatrica (Oslo, Norway : 1992) 20040501

• An integrated reverse functional genomic and metabolic approach to understanding orotic acid-induced fatty liver.

  Physiological genomics 20040413

• Modest catalysis of the decarboxylation of orotate by hydrogen bonding: a theoretical model for orotidine- 5' -monophosphate decarboxylase.

  Bioorganic chemistry 20040401

• Human malaria parasite orotate phosphoribosyltransferase: functional expression, characterization of kinetic reaction mechanism and inhibition profile.

  Molecular and biochemical parasitology 20040401

• Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain.

  Protein science : a publication of the Protein Society 20040401

• pdf1, a palmitoyl protein thioesterase 1 Ortholog in Schizosaccharomyces pombe: a yeast model of infantile Batten disease.

  Eukaryotic cell 20040401

• Analytical derivatization-a tool for determination of orotic acid.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040125

• Alanine : glyoxylate aminotransferase of Saccharomyces cerevisiae-encoding gene AGX1 and metabolic significance.

  Yeast (Chichester, England) 20040115

• Regulation of pyrimidine nucleotide formation in Pseudomonas reptilivora.

  Letters in applied microbiology 20040101

• Determination of orotic acid, uric acid, and creatinine in milk by liquid chromatography.

  Journal of AOAC International 20040101

• How reliable is the allopurinol load in detecting carriers for ornithine transcarbamylase deficiency?

  Journal of inherited metabolic disease 20040101

• [New derivatives of triazino- and imidazoindole with hepatoprotective activity].

  Biomeditsinskaia khimiia 20040101

• Orotic aciduria and plasma urea cycle-related amino acid alterations in short bowel syndrome, evoked by an arginine-free diet.

  JPEN. Journal of parenteral and enteral nutrition 20040101

• Acetate-mediated production of orotic acid by ura3 mutants of Candida albicans.

  Microbiology and immunology 20040101

• Magnesium orotate--experimental and clinical evidence.

  Romanian journal of internal medicine = Revue roumaine de medecine interne 20040101

• Effect of PSC 833, an inhibitor of P-glycoprotein, on 1,2-dimethylhydrazine-induced liver carcinogenesis in rats.

  Carcinogenesis 20031201

• Experimental evidence for the existence of the passive antitumor defense system formed by the synergistic action of certain small substances of the circulatory system.

  Cancer biotherapy & radiopharmaceuticals 20031201

• High-resolution diffusion and relaxation-edited magic angle spinning 1H NMR spectroscopy of intact liver tissue.

  Magnetic resonance in medicine 20031101

• Cloning and disruption of the PpURA5 gene and construction of a set of integration vectors for the stable genetic modification of Pichia pastoris.

  Yeast (Chichester, England) 20031101

• Both gene expression for orotate phosphoribosyltransferase and its ratio to dihydropyrimidine dehydrogenase influence outcome following fluoropyrimidine-based chemotherapy for metastatic colorectal cancer.

  British journal of cancer 20031020

• Purine and pyrimidine metabolites in children's urine.

  Clinica chimica acta; international journal of clinical chemistry 20030901

• Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function.

  The Journal of biological chemistry 20030801

• Concentration and purification of orotic acid directly from whey with an expanded bed adsorption system.

  Journal of chromatography. A 20030718

• Chemical diagnosis of Lesch-Nyhan syndrome using gas chromatography-mass spectrometry detection.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030715

• Quantification of non-protein nitrogen components of infant formulae and follow-up milks: comparison with cows' and human milk.

  The British journal of nutrition 20030701

• Crystallization and preliminary X-ray crystallographic analysis of orotate phosphoribosyltransferase from Helicobacter pylori.

  Molecules and cells 20030630

• Comprehensive study of the luminescent properties and lifetimes of Eu(3+) and Tb(3+) chelated with various ligands in aqueous solutions: influence of the synergic agent, the surfactant and the energy level of the ligand triplet.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20030601

• Influence of dietary arginine on sexual dimorphism of arginine metabolism in mice.

  The Journal of nutritional biochemistry 20030601

• Magnesium-orotate supplementation for idiopathic infertile male patients: a randomized, placebo-controlled clinical pilot study.

  Magnesium research 20030601

• Involvement of voltage- and ligand-gated Ca2+ channels in the neuroexcitatory and synergistic effects of putative uremic neurotoxins.

  Kidney international 20030501

• Functions of a chitosan-orotic acid salt in the gastrointestinal tract.

  Biological & pharmaceutical bulletin 20030501

• Hexaaquanickel diorotate(1-) dihydrate at 150 K.

  Acta crystallographica. Section C, Crystal structure communications 20030401

• Determination of orotic acid in urine by capillary zone electrophoresis in tandem-coupled columns with diode array detection.

  Journal of chromatography. A 20030321

• Rapid determination of orotic acid in urine by liquid chromatography-electrospray tandem mass spectrometry.

  Clinical chemistry 20030301

• Plasma urea-cycle-related amino acids, ammonium levels, and urinary orotic acid excretion in short-bowel patients managed with an oral diet.

  Clinical nutrition (Edinburgh, Scotland) 20030201

• Microarray analysis of orthologous genes: conservation of the translational machinery across species at the sequence and expression level.

  Genome biology 20030101

• Rapid determination of orotic acid in urine by a fast liquid chromatography/tandem mass spectrometric method.

  Rapid communications in mass spectrometry : RCM 20030101

• Allopurinol challenge tests performed before and after living-related donor liver transplantation in citrullinaemia.

  Journal of inherited metabolic disease 20030101

• [Mechanism of action of a novel antitumor preparation of chlofiden. Effect on RNA synthesis].

  Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20030101

• Influence of carbon source on pyrimidine synthesis in Pseudomonas mendocina.

  Journal of basic microbiology 20030101

• The principles of metabolic therapy for heart disease.

  Heart, lung & circulation 20030101

• Diagnostic value of urinary orotic acid levels: applicable separation methods.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021205

• N-acetylglutamate synthase deficiency and the treatment of hyperammonemic encephalopathy.

  Annals of neurology 20021201

• Control of pyrimidine formation in Pseudomonas putida ATCC 17536.

  Canadian journal of microbiology 20021201

• Mechanism of leflunomide-induced proliferation of mitochondria in mammalian cells.

  Mitochondrion 20021201

• Equilibrium of formation of the 6-carbanion of UMP, a potential intermediate in the action of OMP decarboxylase.

  Journal of the American Chemical Society 20021127

• Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity.

  The Journal of biological chemistry 20021101

• The dimeric dihydroorotate dehydrogenase A from Lactococcus lactis dissociates reversibly into inactive monomers.

  Protein science : a publication of the Protein Society 20021101

• Urine amino and organic acids analysis in developmental delay or intellectual disability.

  Journal of paediatrics and child health 20021001

• An investigation of orotic acid levels in the breastmilk of smoking and non-smoking mothers.

  European journal of clinical nutrition 20021001

• Profiles of pyrimidine biosynthesis, salvage and degradation in disks of potato (Solanum tuberosum L.) tubers.

  Planta 20020901

• Elevated incidence of loss of heterozygosity (LOH) in an sgs1 mutant of Saccharomyces cerevisiae: roles of yeast RecQ helicase in suppression of aneuploidy, interchromosomal rearrangement, and the simultaneous incidence of both events during mitotic growth.

  Mutation research 20020725

• Unexpected toxicity induced by magnesium orotate treatment in congenital hypomagnesemia.

  Journal of internal medicine 20020701

• Variation in organic acids content during ripening of pickled white cheese.

  Journal of dairy science 20020701

• A new type of dihydroorotate dehydrogenase, type 1S, from the thermoacidophilic archaeon Sulfolobus solfataricus.

  Extremophiles : life under extreme conditions 20020601

• Effects of fatty liver induced by niacin-free diet with orotic acid on the metabolism of tryptophan to niacin in rats.

  Bioscience, biotechnology, and biochemistry 20020601

• Molecular identification of a renal urate anion exchanger that regulates blood urate levels.

  Nature 20020523

• Steatosis is not sufficient to cause an impaired regenerative response after partial hepatectomy in rats.

  Journal of hepatology 20020501

• The interaction of 5-fluoroorotic acid with transition metals: synthesis and characterisation of Ni(II), Cu(II) and Zn(II) complexes.

  Journal of inorganic biochemistry 20020428

• Transfer RNA gene-targeted retrotransposition of Dictyostelium TRE5-A into a chromosomal UMP synthase gene trap.

  Journal of molecular biology 20020426

• Development of a CE method to analyze organic acids in dairy products: application to study the metabolism of heat-shocked spores.

  Journal of agricultural and food chemistry 20020327

• Mapping the active site-ligand interactions of orotidine 5'-monophosphate decarboxylase by crystallography.

  Biochemistry 20020326

• Behavior of alginate gel beads containing chitosan salt prepared with water-soluble vitamins.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20020301

• Transcriptional cosuppression of yeast Ty1 retrotransposons.

  Genes & development 20020215

• Capillary electrophoresis for detection of inherited disorders of purine and pyrimidine metabolism: a selective approach.

  Electrophoresis 20020201

• The oral anti-volatile sulphur compound effects of zinc salts and their stability constants.

  European journal of oral sciences 20020201

• Dietary orotic acid increases 1 ,2-diacylglycerol level and lowers superoxide dismutase activity in rat liver.

  Journal of nutritional science and vitaminology 20020201

• Fluorescence sensing of ionic analytes in water: from transition metal ions to vitamin B13.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20020104

• A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency.

  Human gene therapy 20020101

• Flumazenil responsive ornithine transcarbamylase deficiency encephalopathy: clinical and radiographic features.

  Journal of neuroimaging : official journal of the American Society of Neuroimaging 20020101

• [Orotic acid as a metabolic agent].

  Vestnik Rossiiskoi akademii meditsinskikh nauk 20020101

• Regulation of pyrimidine synthesis in Pseudomonas mendocina.

  Journal of basic microbiology 20020101

• Neonatal presentation of ventricular tachycardia and a Reye-like syndrome episode associated with disturbed mitochondrial energy metabolism.

  BMC pediatrics 20020101

• A nonradioactive high-performance liquid chromatographic microassay for uridine 5'-monophosphate synthase, orotate phosphoribosyltransferase, and orotidine 5'-monophosphate decarboxylase.

  Analytical biochemistry 20011215

• Theoretical studies of mechanisms and kinetic isotope effects on the decarboxylation of orotic acid and derivatives.

  Journal of the American Chemical Society 20011205

• Evolution: constantly avoiding mutation.

  Current biology : CB 20011113

• Regulation of Cyp1a1 induction by dioxin as a function of cell cycle phase.

  The Journal of pharmacology and experimental therapeutics 20011101

• Isolation of mitochondria from Plasmodium falciparum showing dihydroorotate dependent respiration.

  Parasitology international 20011101

• Orotic acid added to casein, but not to egg protein, soy protein, or wheat gluten diets increases 1,2-diacylglycerol levels and lowers superoxide dismutase activities in rat liver.

  Bioscience, biotechnology, and biochemistry 20011001

• Specific inhibition of a family 1A dihydroorotate dehydrogenase by benzoate pyrimidine analogues.

  Journal of medicinal chemistry 20010830

• Pitfalls in the detection of heterozygosity by allopurinol in a variant form of ornithine carbamoyltransferase deficiency.

  Journal of inherited metabolic disease 20010801

• Dihydrooxonate is a substrate of dihydroorotate dehydrogenase (DHOD) providing evidence for involvement of cysteine and serine residues in base catalysis.

  Archives of biochemistry and biophysics 20010715

• Simple gas chromatographic-mass spectrometric procedure for diagnosing pyrimidine degradation defects for prevention of severe anticancer side effects.

  Journal of chromatography. B, Biomedical sciences and applications 20010705

• Contribution of the bacterial endosymbiont to the biosynthesis of pyrimidine nucleotides in the deep-sea tube worm Riftia pachyptila.

  The Journal of biological chemistry 20010629

• Molecular structure of dihydroorotase: a paradigm for catalysis through the use of a binuclear metal center.

  Biochemistry 20010619

• Crystal structures of nucleotide exchange intermediates in the eEF1A-eEF1Balpha complex.

  Nature structural biology 20010601

• Intra-day variations in urinary pyrimidines in ornithine carbamoyltransferase deficiency and healthy individuals.

  Clinica chimica acta; international journal of clinical chemistry 20010601

• Capillary zone electrophoresis of orotic acid in urine with on-line isotachophoresis sample pretreatment and diode array detection.

  Journal of chromatography. A 20010504

• Rapid selection against truncation mutants in yeast reverse two-hybrid screens.

  BioTechniques 20010501

• Extremely short small bowel induces focal tubulointerstitial fibrosis.

  Journal of pediatric gastroenterology and nutrition 20010501

• Insight into the chemistry of flavin reduction and oxidation in Escherichia coli dihydroorotate dehydrogenase obtained by rapid reaction studies.

  Biochemistry 20010410

• Successful living-donor liver transplantation from an asymptomatic carrier mother in ornithine transcarbamylase deficiency.

  The Journal of pediatrics 20010301

• Large-scale production of the carbohydrate portion of the sialyl-Tn epitope, alpha-Neup5Ac-(2-->6)-D-GalpNAc, through bacterial coupling.

  Carbohydrate research 20010227

• Multiple inhibitor analysis of the brequinar and leflunomide binding sites on human dihydroorotate dehydrogenase.

  Biochemistry 20010220

• Ornithine carbamoyltransferase deficiency: improved sensitivity of testing for protein tolerance in the diagnosis of heterozygotes.

  Journal of inherited metabolic disease 20010201

• Laboratory evaluation of urea cycle disorders.

  The Journal of pediatrics 20010101

• [Passive orthostatic test in evaluation of efficiency of medical rehabilitation of flying personnel].

  Voenno-meditsinskii zhurnal 20010101

• [Effectiveness of treating periodontitis in patients with thyroid dysfunction].

  Stomatologiia 20010101

• Media formulations for various two-hybrid systems.

  Methods in molecular biology (Clifton, N.J.) 20010101

• [Psychophysiological effects of combined administration of pantogam and potassium orotate in patients with neurotic disorders].

  Eksperimental'naia i klinicheskaia farmakologiia 20010101

• Effect of hesperetin, a citrus flavonoid, on the liver triacylglycerol content and phosphatidate phosphohydrolase activity in orotic acid-fed rats.

  Plant foods for human nutrition (Dordrecht, Netherlands) 20010101

• Pyrimidine nucleobase ligands of orotate phosphoribosyltransferase from Toxoplasma gondii.

  Biochemical pharmacology 19991101

• Effects of C-terminal deletion on the activity and thermostability of orotate phosphoribosyltransferase from Thermus thermophilus.

  Journal of biochemistry 19990101

• Magnesium orotate in myocardial and neuronal protection.

  Romanian journal of internal medicine = Revue roumaine de medecine interne 19990101

• Metabolic supplementation with orotic acid and magnesium orotate.

  Cardiovascular drugs and therapy 19980901

• In vitro and in vivo response of hepatocytes from hepatic nodules to the mitoinhibitory effects of phenobarbital.

  Carcinogenesis 19940901

• Structure-activity relationship of ligands of uracil phosphoribosyltransferase from Toxoplasma gondii.

  Biochemical pharmacology 19940817

• Increase of serum very low density lipoproteins in rats after administration of alpha-hexachlorocyclohexane.

  Naunyn-Schmiedeberg's archives of pharmacology 19770601

• Enzymic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydro-orotic dehydrogenase.

  Biochimica et biophysica acta 19530101