65141-46-0 | 2-(pyridin-3-ylformamido)ethyl nitrate

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$22.00	$15.00
5g	95%	in stock	$41.00	$29.00
25g	95%	in stock	$137.00	$96.00

Description

• Catalog Number: AB77483
• Chemical Name: 2-(pyridin-3-ylformamido)ethyl nitrate
• CAS Number: 65141-46-0
• Molecular Formula: C8H9N3O4
• Molecular Weight: 211.1748
• MDL Number: MFCD00186520
• SMILES: O=N(=O)OCCNC(=O)c1cccnc1

Computed Properties

• Complexity: 228
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 15
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 4
• XLogP3: 0.8

Literature

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  The British journal of dermatology 20121101

• Effect of sildenafil on ventricular arrhythmias in post-infarcted rat hearts.

  European journal of pharmacology 20120905

• Pharmacological preconditioning of ATP-sensitive potassium channel openers on acute urinary retention-induced bladder dysfunction in the rat.

  BJU international 20120901

• Update in pharmacological management of coronary no-reflow phenomenon.

  Cardiovascular & hematological agents in medicinal chemistry 20120901

• An unusual case of nicorandil-induced conjunctival erosions.

  Clinical and experimental dermatology 20120801

• Protective mechanism of nicorandil on rat myocardial ischemia-reperfusion.

  Journal of cardiovascular medicine (Hagerstown, Md.) 20120801

• Nicorandil, a K(atp) channel opener, alleviates chronic renal injury by targeting podocytes and macrophages.

  American journal of physiology. Renal physiology 20120801

• Nicorandil and ulcerations: the Trojan horse?

  Journal of the European Academy of Dermatology and Venereology : JEADV 20120701

• Treating stable angina - is there a NICE way towards an international consensus?

  International journal of clinical practice 20120701

• Effect of myocardial protection of intracoronary adenosine and nicorandil injection in patients undergoing non-urgent percutaneous coronary intervention: a randomized controlled trial.

  International journal of cardiology 20120628

• Nicorandil ameliorates hypertension-related bladder dysfunction in the rat.

  Neurourology and urodynamics 20120601

• Nicorandil induced ophthalmoplegic migraine.

  JRSM short reports 20120601

• Nicorandil as a novel therapy for advanced diabetic nephropathy in the eNOS-deficient mouse.

  American journal of physiology. Renal physiology 20120501

• K ATP channel agonists preserve connexin43 protein in infarcted rats by a protein kinase C-dependent pathway.

  Journal of cellular and molecular medicine 20120401

• The effect of nitric oxide on the pressure of the acutely obstructed ureter.

  Urological research 20120401

• Cerebral protective effect of nicorandil premedication on patients undergoing liver transplantation.

  Hepatobiliary & pancreatic diseases international : HBPD INT 20120401

• Nicorandil associated anal ulcers: an estimate of incidence.

  Annals of the Royal College of Surgeons of England 20120401

• Clinical applications of patient-specific induced pluripotent stem cells in cardiovascular medicine.

  Heart (British Cardiac Society) 20120315

• Conjunctival and corneal ulcerations: keep a sharp eye on nicorandil.

  The British journal of ophthalmology 20120301

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  Annales de dermatologie et de venereologie 20120301

• Role of antiischemic agents in the management of non-ST elevation acute coronary syndrome (NSTE-ACS).

  Cardiovascular therapeutics 20120201

• Reversible nicorandil induced perianal ulceration in acute myeloid leukemia.

  Leukemia & lymphoma 20120201

• Year in review in Intensive Care Medicine 2011: I. Nephrology, epidemiology, nutrition and therapeutics, neurology, ethical and legal issues, experimentals.

  Intensive care medicine 20120201

• Perianal actinomycosis: a case study of this rare infection associated with nicorandil usage.

  Scottish medical journal 20120201

• Enantioselective penetration enhancing effect of carvone on the in vitro transdermal permeation of nicorandil.

  Pharmaceutical development and technology 20120101

• Nicorandil-induced tongue ulceration with or without fungal infection.

  Odontology 20120101

• Mitochondrial calcium homeostasis as potential target for mitochondrial medicine.

  Mitochondrion 20120101

• Oral treatment with nicorandil at discharge is associated with reduced mortality after acute myocardial infarction.

  Journal of cardiology 20120101

• The involvement of adenosine triphosphate-sensitive potassium channels in the different effects of sevoflurane and propofol on glucose metabolism in fed rats.

  Anesthesia and analgesia 20120101

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  Biochemistry research international 20120101

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  Respiratory research 20120101

• Influence of skin thickness on the in vitro permeabilities of drugs through Sprague-Dawley rat or Yucatan micropig skin.

  Biological & pharmaceutical bulletin 20120101

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  Cardiovascular diabetology 20120101

• Effects of intravenous nicorandil on the mid-term prognosis of patients with acute heart failure syndrome.

  Circulation journal : official journal of the Japanese Circulation Society 20120101

• Nicorandil attenuates monocrotaline-induced vascular endothelial damage and pulmonary arterial hypertension.

  PloS one 20120101

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  International journal of hypertension 20120101

• Involvement of guanylate cyclase and K+ channels in relaxation evoked by ferulate nitrate in rat aorta artery.

  Journal of pharmacological sciences 20120101

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  International journal of nephrology 20120101

• Cardiac ryanodine receptor in metabolic syndrome: is JTV519 (K201) future therapy?

  Diabetes, metabolic syndrome and obesity : targets and therapy 20120101

• The relaxant action of nicorandil in bovine tracheal smooth muscle.

  Pharmacology 20120101

• Passive targeting of ischemic-reperfused myocardium with adenosine-loaded silica nanoparticles.

  International journal of nanomedicine 20120101

• Chest pain with ST-T changes on electrocardiogram and localized stenosis on coronary angiography could be a coronary vasospasm.

  Journal of cardiovascular disease research 20120101

• Cardioprotective effects of sarcolemmal and mitochondrial K-ATP channel openers in an experimental model of autoimmune myocarditis. Role of the reduction in calcium overload during acute heart failure.

  International heart journal 20120101

• Paclitaxel-induced endothelial dysfunction in living rats is prevented by nicorandil via reduction of oxidative stress.

  Journal of pharmacological sciences 20120101

• Nicorandil prevents right ventricular remodeling by inhibiting apoptosis and lowering pressure overload in rats with pulmonary arterial hypertension.

  PloS one 20120101

• Nicorandil-induced hyperkalemia in a uremic patient.

  Case reports in medicine 20120101

• Nicorandil-induced colonic ulceration: an unusually delayed presentation of a rare complication.

  International journal of colorectal disease 20111201

• Differential metabolism of organic nitrates by aldehyde dehydrogenase 1a1 and 2: substrate selectivity, enzyme inactivation, and active cysteine sites.

  The AAPS journal 20111201

• Effects of nicorandil on the reduction of BNP levels in patients with chronic kidney disease.

  Clinical and experimental nephrology 20111201

• Nicorandil-induced oral ulceration: report of 3 cases and review of the Japanese literature.

  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20111201

• Different K+ channels are involved in relaxation of arterial and venous graft induced by nicorandil.

  Journal of cardiovascular pharmacology 20111201

• Protection of human myocardium by bone marrow cells: role of long-term administration of the mitochondrial K(ATP) channel opener nicorandil.

  The Journal of surgical research 20111101

• Simultaneous quantitation of nicorandil and its denitrated metabolite in plasma by LC-MS/MS: application for a pharmacokinetic study.

  Journal of mass spectrometry : JMS 20111101

• Update on the medical treatment of stable angina.

  Archives of cardiovascular diseases 20111001

• N-(2-Nitro-oxyeth-yl)picolinamide.

  Acta crystallographica. Section E, Structure reports online 20111001

• Nicorandil attenuates cyclic strain-induced endothelin-1 expression via the induction of activating transcription factor 3 in human umbilical vein endothelial cells.

  European journal of pharmacology 20110930

• Nicorandil preserves myocardial function following brain death in rats by mitochondrial adenosine triphosphate-sensitive potassium channel-dependent mechanism.

  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20110901

• The effect of nicorandil on small intestinal ischemia-reperfusion injury in a canine model.

  Digestive diseases and sciences 20110801

• Nicorandil associated colonic ulceration: case series of an increasingly recognized complication.

  Digestive diseases and sciences 20110801

• A case of serious laryngeal edema unpredictably detected during laryngoscopy for orotracheal intubation following induction of anesthesia.

  Journal of anesthesia 20110801

• Pharmacological preconditioning with nicorandil and pioglitazone attenuates myocardial ischemia/reperfusion injury in rats.

  European journal of pharmacology 20110801

• Levosimendan attenuates pulmonary vascular remodeling.

  Intensive care medicine 20110801

• ATP-sensitive potassium (KATP) channel activation decreases intraocular pressure in the anterior chamber of the eye.

  Investigative ophthalmology & visual science 20110801

• Comparison of the effects of nitroprusside versus nicorandil on the slow/no-reflow phenomenon during coronary interventions for acute myocardial infarction.

  Heart and vessels 20110701

• The protective effect of mitochondrial ATP-sensitive K+ channel opener, nicorandil, combined with Na+/Ca2+ exchange blocker KB-R7943 on myocardial ischemia-reperfusion injury in rat.

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• Use of nicorandil in cardiovascular disease and its optimization.

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  International journal of cardiology 20110602

• Nicorandil-induced leg ulceration without mucosal involvement.

  Clinical and experimental dermatology 20110601

• Colonic and parastomal ulceration related to nicorandil.

  Surgical laparoscopy, endoscopy & percutaneous techniques 20110601

• The effect of nicorandil on ischemia-reperfusion injury in a porcine total hepatic vascular exclusion model.

  The Journal of surgical research 20110501

• Nicorandil ameliorates ischaemia-reperfusion injury in the rat kidney.

  British journal of pharmacology 20110501

• In vitro and in vivo evaluation of hydrophilic and hydrophobic polymers-based nicorandil-loaded peroral tablet compared with its once-daily commercial sustained-release tablet.

  Drug development and industrial pharmacy 20110401

• Nicorandil-induced rectovaginal fistula.

  American journal of obstetrics and gynecology 20110401

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  European heart journal 20110401

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  Allergy, asthma & immunology research 20110401

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  Chonnam medical journal 20110401

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  Intensive care medicine 20110301

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  Drug testing and analysis 20110301

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  Phytomedicine : international journal of phytotherapy and phytopharmacology 20110215

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  Research in veterinary science 20110201

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  Atherosclerosis 20110201

• Role of vascular K(ATP) channels in blood pressure variability after sinoaortic denervation in rats.

  Acta pharmacologica Sinica 20110201

• Nicorandil normalizes prolonged repolarisation in the first transgenic rabbit model with Long-QT syndrome 1 both in vitro and in vivo.

  European journal of pharmacology 20110110

• Nicorandil ameliorates impulse conduction disturbances during ischemia in isolated arterially perfused canine atria.

  International journal of cardiology 20110107

• HMC05, Herbal Formula, Inhibits TNF-α-Induced Inflammatory Response in Human Umbilical Vein Endothelial Cells.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Nicorandil-induced penile ulcerations: a case series.

  BJU international 20110101

• Nicorandil inhibits angiotensin-II-induced proliferation of cultured rat cardiac fibroblasts.

  Pharmacology 20110101

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  Masui. The Japanese journal of anesthesiology 20110101

• Variant angina and coronary artery spasm: the clinical spectrum, pathophysiology, and management.

  Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 20110101

• An alternative path to the cecum: nicorandil-associated diverticular sigmoido-cecal fistula.

  Endoscopy 20110101

• Variation assessment for in vitro permeabilities through Yucatan micropig skin.

  Biological & pharmaceutical bulletin 20110101

• Cardioprotective effect of nicorandil, a mitochondrial ATP-sensitive potassium channel opener, prolongs survival in HSPB5 R120G transgenic mice.

  PloS one 20110101

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  BMC anesthesiology 20110101

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  International heart journal 20110101

• Effect of long-term nitrate treatment on cardiac events in patients with vasospastic angina.

  Circulation journal : official journal of the Japanese Circulation Society 20110101

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  Indian journal of pharmacology 20110101

• Usefulness of rat skin as a substitute for human skin in the in vitro skin permeation study.

  Experimental animals 20110101

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• ATP-Sensitive Potassium Channel Currents in Eccentrically Hypertrophied Cardiac Myocytes of Volume-Overloaded Rats.

  International journal of cell biology 20110101

• Oral nicorandil for prevention of cardiac death in hemodialysis patients without obstructive coronary artery disease: a propensity-matched patient analysis.

  Nephron. Clinical practice 20110101

• Effect of the ATP-sensitive K⁺ channel opener nicorandil in a canine model of proarrhythmia.

  International heart journal 20110101

• A human TREK-1/HEK cell line: a highly efficient screening tool for drug development in neurological diseases.

  PloS one 20110101

• Cardioprotective effects of glycyrrhizic acid against isoproterenol-induced myocardial ischemia in rats.

  International journal of molecular sciences 20110101

• Nicorandil prevents endothelial dysfunction due to antioxidative effects via normalisation of NADPH oxidase and nitric oxide synthase in streptozotocin diabetic rats.

  Cardiovascular diabetology 20110101

• [The endogenous cardioprotection during reperfusion in acute myocardial infarction].

  Kardiologia polska 20110101

• Recurrent aphthous stomatitis.

  Journal of oral and maxillofacial pathology : JOMFP 20110101

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  Terapevticheskii arkhiv 20110101

• Formulation and evaluation of a sustained-release tablets of metformin hydrochloride using hydrophilic synthetic and hydrophobic natural polymers.

  Indian journal of pharmaceutical sciences 20110101

• Laparoscopic myomectomy with aquadissection and barbed sutures.

  Journal of gynecological endoscopy and surgery 20110101

• An unusual presentation of metastatic colon adenocarcinoma in the oral cavity.

  Case reports in dentistry 20110101

• Nicorandil-induced peristomal ulceration.

  International wound journal 20101201

• Acute, fatal postoperative myocardial infarction after laparoscopic cholecystectomy in a cardiac patient -A case report-.

  Korean journal of anesthesiology 20101201

• Acute effects of intravenous nicorandil on hemodynamics in patients hospitalized with acute decompensated heart failure.

  Journal of cardiology 20101101

• Efficacy and safety of nicorandil therapy in patients with acute heart failure.

  Journal of cardiology 20101101

• Translating novel strategies for cardioprotection: the Hatter Workshop Recommendations.

  Basic research in cardiology 20101101

• Nicorandil: a curable cause of anal ulceration to be known..

  Gastroenterologie clinique et biologique 20101101

• [Systematic review on the short-term efficacy and safety of nicorandil for stable angina pectoris in comparison with those of β-blockers, nitrates and calcium antagonists].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20101101

• Painful chronic ulceration linked with nicorandil: the vagina too.

  Prescrire international 20101101

• Mechanisms of the beneficial actions of ischemic preconditioning on subcellular remodeling in ischemic-reperfused heart.

  Current cardiology reviews 20101101

• Successful percutaneous coronary intervention for acute coronary syndrome in a patient with severe hemophilia a.

  Korean circulation journal 20101001

• Efficacy of Setarud (IMOD™), a novel electromagnetically-treated multi-herbal compound, in mouse immunogenic type-1 diabetes.

  Archives of medical science : AMS 20101001

• The role of Nicorandil in non-healing surgical wounds.

  Annals of the Royal College of Surgeons of England 20100901

• Life-threatening haemorrhage secondary to nicorandil-induced severe peri-anal ulceration.

  Annals of the Royal College of Surgeons of England 20100901

• Nicorandil ulcer: moves beyond the mucosa.

  Annals of the Royal College of Surgeons of England 20100901

• Diverticular fistulation is associated with nicorandil usage.

  Annals of the Royal College of Surgeons of England 20100901

• Nicorandil induced penile ulceration.

  The Ulster medical journal 20100901

• Endothelium-derived vasoactive factors and hypertension: possible roles in pathogenesis and as treatment targets.

  Current hypertension reports 20100801

• Conventional and novel drug therapeutics to relief myocardial ischemia.

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• Effects of ketamine on nicorandil induced ATP-sensitive potassium channel activity in cell line derived from rat aortic smooth muscle.

  The journal of medical investigation : JMI 20100801

• Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3.

  Cardiovascular research 20100701

• Percutaneous cardiopulmonary support in refractory no-reflow with cardiogenic shock after coronary stenting in acute myocardial infarction.

  Yonsei medical journal 20100701

• The role of ATP-sensitive potassium channel on acute urinary retention and subsequent catheterization in the rat.

  European journal of pharmacology 20100610

• Emerging medical treatment for angina pectoris.

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• Cardioprotection in the clinical setting-lessons from J-WIND studies.

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  Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20100601

• Effects of nicorandil on sympathetic neurotransmission in rat caudal artery.

  Clinical and experimental pharmacology & physiology 20100501

• Is there a Failure to Optimize theRapy in anGina pEcToris (FORGET) study?

  QJM : monthly journal of the Association of Physicians 20100501

• High index of microcirculatory resistance level after successful primary percutaneous coronary intervention can be improved by intracoronary administration of nicorandil.

  Circulation journal : official journal of the Japanese Circulation Society 20100501

• Anesthetic management of a patient undergoing liver transplantation who had previous coronary artery bypass grafting using an in situ right gastroepiploic artery.

  Journal of anesthesia 20100401

• Native coronary artery and grafted artery spasm just after coronary artery bypass grafting: a case report.

  Journal of Korean medical science 20100401

• Effects of nicorandil on cardiovascular events in patients with coronary artery disease in the Japanese Coronary Artery Disease (JCAD) study.

  Circulation journal : official journal of the Japanese Circulation Society 20100301

• Pathology, imaging and treatment of cardiac microvascular obstruction.

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• Angina in Women without Obstructive Coronary Artery Disease.

  Current cardiology reviews 20100201

• Differential DNA methylation correlates with differential expression of angiogenic factors in human heart failure.

  PloS one 20100101

• Assessment of ECG interval and restitution parameters in the canine model of short QT syndrome.

  Journal of pharmacological and toxicological methods 20100101

• Clinical application of ischemic preconditioning in the elderly.

  Dose-response : a publication of International Hormesis Society 20100101

• Effects of nicorandil on the cAMP-dependent Cl- current in guinea-pig ventricular cells.

  Journal of pharmacological sciences 20100101

• Novel approaches to treat experimental pulmonary arterial hypertension: a review.

  Journal of biomedicine & biotechnology 20100101

• Meta-analysis of the diagnostic performance of stress perfusion cardiovascular magnetic resonance for detection of coronary artery disease.

  Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20100101

• Acute effects of isosorbide dinitrate and nicorandil on the coronary slow flow phenomenon.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20100101

• Calcium-sensing receptors regulate cardiomyocyte Ca2+ signaling via the sarcoplasmic reticulum-mitochondrion interface during hypoxia/reoxygenation.

  Journal of biomedical science 20100101

• Rectal ulceration caused by the anti-anginal nicorandil: Case report of a preventable complication.

  Patient safety in surgery 20100101

• Cardiac cephalgia and cardiac migraine.

  The Journal of the Association of Physicians of India 20100101

• Role of amino acid infusion in delayed recovery from neuromuscular blockers.

  Indian journal of anaesthesia 20100101

• Dual role of nNOS in ischemic injury and preconditioning.

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• Comparative study of the binding characteristics to and inhibitory potencies towards PARP and in vivo antidiabetogenic potencies of taurine, 3-aminobenzamide and nicotinamide.

  Journal of biomedical science 20100101

• Recent advances in the management of chronic stable angina II. Anti-ischemic therapy, options for refractory angina, risk factor reduction, and revascularization.

  Vascular health and risk management 20100101

• Multifocal severe coronary artery vasospasm mistaken for diffuse atherosclerosis: a case report.

  Case reports in medicine 20100101

• General anaesthesia for insertion of an automated implantable cardioverter defibrillator in a child with Brugada and autism.

  Indian journal of anaesthesia 20100101

• Organic nitrates and nitrate resistance in diabetes: the role of vascular dysfunction and oxidative stress with emphasis on antioxidant properties of pentaerithrityl tetranitrate.

  Experimental diabetes research 20100101

• In vitro iontophoretic delivery of nicorandil.

  PDA journal of pharmaceutical science and technology 20100101

• Cardioprotective potential of Punica granatum extract in isoproterenol-induced myocardial infarction in Wistar rats.

  Journal of pharmacology & pharmacotherapeutics 20100101

• Nicorandil-induced terminal ileal ulceration--a probable link.

  BMJ case reports 20100101

• Vasodilators in the treatment of acute heart failure: what we know, what we don't.

  Heart failure reviews 20091201

• Supplementation of University of Wisconsin solution with Nitroglycerin and Nicorandil in long-term myocardial preservation: effects on the oxidative state, endothelial function and morphology.

  Histology and histopathology 20091201

• Vasospastic heart failure: multiple spasm may cause transient heart failure?

  Journal of cardiology 20091201

• Sorafenib-induced acute myocardial infarction due to coronary artery spasm.

  Journal of cardiology 20091201

• [Case of myocardial infarction during emergency clipping surgery of a cerebral aneurysm].

  Masui. The Japanese journal of anesthesiology 20091201

• Re: Perianal surgery in patients prescribed nicorandil may be hazardous.

  The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland 20091201

• Reverse rate dependency is an intrinsic property of canine cardiac preparations.

  Cardiovascular research 20091101

• Nicorandil protects ATP-sensitive potassium channels against oxidation-induced dysfunction in cardiomyocytes of aging rats.

  Biogerontology 20091001

• Effects of chronic treatment with a low dose of nicorandil on the function of the rat aorta during ageing.

  Clinical and experimental pharmacology & physiology 20091001

• Acute efficacy and safety of intravenous administration of nicorandil in patients with acute heart failure syndromes: usefulness of noninvasive echocardiographic hemodynamic evaluation.

  Journal of cardiovascular pharmacology 20091001

• Nicorandil associated vulval and inguinal ulceration.

  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20091001

• Clinical effects of hypertension on the mortality of patients with acute myocardial infarction.

  Journal of Korean medical science 20091001

• Second-generation sulfonylureas preserve inhibition of mitochondrial permeability transition by the mitochondrial K+(ATP) opener nicorandil in experimental myocardial infarction.

  Shock (Augusta, Ga.) 20090901

• Empirical correlation of triggered activity and spatial and temporal re-entrant substrates with arrhythmogenicity in a murine model for Jervell and Lange-Nielsen syndrome.

  Pflugers Archiv : European journal of physiology 20090901

• Vulval ulceration induced by the potassium-channel activator Nicorandil: a case series of five patients.

  BJOG : an international journal of obstetrics and gynaecology 20090901

• Vulvovaginal ulceration during prolonged treatment with nicorandil.

  BJOG : an international journal of obstetrics and gynaecology 20090901

• The effect of intracoronary nicorandil on coronary myocardial bridging.

  Journal of cardiovascular pharmacology and therapeutics 20090901

• Never forget medication as a cause: vaginal ulceration caused by nicorandil.

  American journal of obstetrics and gynecology 20090901

• Nicorandil improves glomerular injury in rats with mesangioproliferative glomerulonephritis via inhibition of proproliferative and profibrotic growth factors.

  Journal of pharmacological sciences 20090901

• Refractory hypotension and ECG changes in a case of nicorandil and lisinopril overdose and role of vasopressor in management.

  Journal of cardiovascular medicine (Hagerstown, Md.) 20090801

• Oral nicorandil to reduce cardiac death after coronary revascularization in hemodialysis patients: a randomized trial.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20090801

• The no-reflow phenomenon in the coronary circulation.

  Cardiovascular & hematological agents in medicinal chemistry 20090701

• Effect of ATP-sensitive potassium channel agonists on sympathetic hyperinnervation in postinfarcted rat hearts.

  American journal of physiology. Heart and circulatory physiology 20090601

• Factors associated with myocardial salvage immediately after emergent percutaneous coronary intervention in patients with ST-elevation acute myocardial infarction.

  Annals of nuclear medicine 20090601

• Nicorandil-induced foreskin ulceration.

  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20090501

• Peri-stomal ulceration with nicorandil.

  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20090501

• Nicorandil treatment in patients with acute myocardial infarction: a meta-analysis.

  Circulation journal : official journal of the Japanese Circulation Society 20090501

• Pharmacological characteristics and clinical applications of K201.

  Current clinical pharmacology 20090501

• [Myocardial infarction remodeling in rats with dinitrosyl iron complex with glutathione].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20090501

• Intravenous administration of nicorandil immediately before percutaneous coronary intervention can prevent slow coronary flow phenomenon.

  European heart journal 20090401

• Pursuing the goal to improve downstream myocardial tissue perfusion.

  European heart journal 20090401

• Fatal muscle haemorrhage attributable to heparin administration in a patient with dermatomyositis.

  Clinical and experimental dermatology 20090401

• [Case of undiagnosed vasospastic angina first noted during anesthesia].

  Masui. The Japanese journal of anesthesiology 20090401

• Gastroprotective effect of nicorandil in indomethacin and alcohol-induced acute ulcers.

  Applied biochemistry and biotechnology 20090301

• Nicorandil attenuates FeCl(3)-induced thrombus formation through the inhibition of reactive oxygen species production.

  Circulation journal : official journal of the Japanese Circulation Society 20090301

• High incidence of repeat anginal attacks despite treatment with calcium-channel blockers in patients with coronary spastic angina.

  Circulation journal : official journal of the Japanese Circulation Society 20090301

• A new mechanism and strategy for inhibiting thrombus formation in the artery.

  Circulation journal : official journal of the Japanese Circulation Society 20090301

• Effect of nicorandil on proteinuria in well controlled hypertensive patients.

  Journal of hypertension 20090301

• [Use of cardiovascular drugs for cardiac surgery--based on recent studies].

  Masui. The Japanese journal of anesthesiology 20090301

• [Myocardial preconditioning in anesthesia: from bench to bedside].

  Masui. The Japanese journal of anesthesiology 20090301

• Peristomal ulceration caused by nicorandil.

  Clinical and experimental dermatology 20090101

• Therapeutic development in cardiac syndrome X: a need to target the underlying pathophysiology.

  Cardiovascular therapeutics 20090101

• Clinical potential of nicorandil to inhibit major cardiac events in hemodialysis patients with suspected myocardial ischemia.

  Nephron. Clinical practice 20090101

• Cardiac toxicity with capecitabine, vinorelbine and trastuzumab therapy: case report and review of fluoropyrimidine-related cardiotoxicity.

  Oncology 20090101

• Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons.

  PloS one 20090101

• Effect of antianginal drugs in stable angina on predicted mortality risk after surviving a myocardial infarction: a preliminary study (METRO).

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20090101

• Drugs associated with more suicidal ideations are also associated with more suicide attempts.

  PloS one 20090101

• Influence of non-nucleoside reverse transcriptase inhibitors (efavirenz and nevirapine) on the pharmacodynamic activity of gliclazide in animal models.

  Diabetology & metabolic syndrome 20090101

• Ulceration of the oral mucosa induced by antidepressant medication: a case report.

  Journal of medical case reports 20090101

• Persistent orocutaneous and anal fistulae induced by nicorandil: a case report.

  Journal of medical case reports 20090101

• Low use of statins and other coronary secondary prevention therapies in primary and secondary care in India.

  Vascular health and risk management 20090101

• Renin Angiotensin system as a regulator of cell volume. Implications to myocardial ischemia.

  Current cardiology reviews 20090101

• Formulation and evaluation of once daily minocycline hydrochloride extended release matrix tablets.

  Indian journal of pharmaceutical sciences 20090101

• Formulation and optimization of sustained release tablets of venlafaxine resinates using response surface methodology.

  Indian journal of pharmaceutical sciences 20090101

• Formulation and Evaluation of in situ Gels Containing Clotrimazole for Oral Candidiasis.

  Indian journal of pharmaceutical sciences 20090101

• Nicorandil induced perianal ulceration.

  JNMA; journal of the Nepal Medical Association 20090101

• In vitro controlled release of colon targeted mesalamine from compritol ATO 888 based matrix tablets using factorial design.

  Research in pharmaceutical sciences 20090101

• Nicorandil, an adenosine triphosphate-sensitive potassium channel opener, inhibits muscarinic acetylcholine receptor-mediated activation of extracellular signal-regulated kinases in PC12 cells.

  Anesthesia and analgesia 20081201

• Important factors for salvaging myocardium in patients with acute myocardial infarction.

  Journal of cardiology 20081201

• [Severe hypotension as a complication of intramyometrial injection of vasopressin: a case report].

  Masui. The Japanese journal of anesthesiology 20081201

• Advances in clinical applications of cardiovascular magnetic resonance imaging.

  Heart (British Cardiac Society) 20081101

• Preservation of myocardial viability within the risk area by intravenous nicorandil before primary coronary intervention in patients with acute myocardial infarction.

  Nuclear medicine communications 20081101

• Nicorandil, a potassium channel opener and nitric oxide donor, improves the frequent urination without changing the blood pressure in rats with partial bladder outlet obstruction.

  Biological & pharmaceutical bulletin 20081101

• Nicorandil-induced colonic ulceration: a new cause of colonic ulceration. Report of four cases.

  Diseases of the colon and rectum 20081001

• Prize sessions.

  Indian journal of pharmacology 20081001

• Unremitting anal ulceration following haemorrhoidectomy.

  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20080901

• Isolated cutaneous inguinal ulcerations induced by nicorandil.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20080901

• A comparative study on in vitro and in vivo effects of topical vasodilators in human internal mammary, radial artery and great saphenous vein.

  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20080901

• Effect of intra-coronary nicorandil administration prior to reperfusion in acute ST segment elevation myocardial infarction.

  Circulation journal : official journal of the Japanese Circulation Society 20080901

• Chronic stable angina pectoris.

  Disease-a-month : DM 20080901

• Potassium channel openers and improvement of toxic stress: do they have role in the management of inflammatory bowel disease?

  Inflammation & allergy drug targets 20080901

• Population pharmacokinetic and pharmacodynamic modelling of the effects of nicorandil in the treatment of acute heart failure.

  British journal of clinical pharmacology 20080901

• [Severe arrhythmia after gastrectomy in patients with history of coronary bypass graft surgery using right gastroepiploic artery].

  Masui. The Japanese journal of anesthesiology 20080901

• Reperfusion injury in acute myocardial infarction: from bench to cath lab. Part II: Clinical issues and therapeutic options.

  Archives of cardiovascular diseases 20080901

• Design and in vitro/in vivo evaluation of novel nicorandil extended release matrix tablets based on hydrophilic interpolymer complexes and a hydrophobic waxy polymer.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080801

• TNF-alpha gene promoter polymorphism at nucleotide -308 and the inflammatory response and oxidative stress induced by cardiac surgery: role of heart failure and medical treatment.

  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20080801

• Predicting drug-induced changes in QT interval and arrhythmias: QT-shortening drugs point to gaps in the ICHS7B Guidelines.

  British journal of pharmacology 20080801

• Cardioprotective effects of nicorandil in patients undergoing on-pump coronary artery bypass surgery.

  Journal of cardiothoracic and vascular anesthesia 20080801

• Pharmacological pre- and post- conditioning agents: reperfusion-injury of the heart revisited.

  Mini reviews in medicinal chemistry 20080801

• Utility of ranolazine in chronic stable angina patients.

  Vascular health and risk management 20080801

• Pharmacological prevention of peri-, and post-procedural myocardial injury in percutaneous coronary intervention.

  Current cardiology reviews 20080801

• Mechanisms of preventive effect of nicorandil on ischaemia-induced ventricular tachyarrhythmia in isolated arterially perfused canine left ventricular wedges.

  Basic & clinical pharmacology & toxicology 20080601

• Nicorandil: serious gastrointestinal ulceration.

  Prescrire international 20080601

• Inhibitory effect of nicorandil on the contraction of isolated human urinary bladder detrusor muscle.

  Methods and findings in experimental and clinical pharmacology 20080601

• Effects of potassium channel openers in the isolated perfused hypokalaemic murine heart.

  Acta physiologica (Oxford, England) 20080501

• Recent advances in cardiorespiratory medicine: management of pulmonary embolism and prevention of venous thromboembolism, recent treatment strategies in childhood asthma, and dermatological adverse reactions to cardiovascular drugs.

  Clinical and experimental dermatology 20080501

• Nicorandil and ulcerations: a NAD/NADP and nicotinic acid-dependent side-effect?

  The British journal of dermatology 20080501

• Nicorandil-induced colonic ulceration.

  Heart (British Cardiac Society) 20080501

• Design and synthesis of nitrate esters of aromatic heterocyclic compounds as pharmacological preconditioning agents.

  Bioorganic & medicinal chemistry 20080415

• Dual pathology: cervicofacial actinomycosis and nicorandil-induced oral ulceration.

  The Journal of laryngology and otology 20080401

• Effect of ATP-sensitive potassium channel agonists on ventricular remodeling in healed rat infarcts.

  Journal of the American College of Cardiology 20080401

• Formulation approach for nicorandil pulsatile release tablet.

  Chemical & pharmaceutical bulletin 20080401

• Nicorandil protects cardiac mitochondria against permeability transition induced by ischemia-reperfusion.

  Journal of bioenergetics and biomembranes 20080401

• Perianal fistula, colorectal surgery and nicorandil.

  Clinical and experimental dermatology 20080301

• Lichenoid drug eruption secondary to treatment with nicorandil?

  Clinical and experimental dermatology 20080301

• Nicorandil-induced ulceration of the penis.

  Clinical and experimental dermatology 20080301

• Effects of long-term nicorandil administration on endothelial function, inflammation, and oxidative stress in patients without coronary artery disease.

  Journal of cardiovascular pharmacology 20080301

• Percutaneous permeation enhancement by terpenes: mechanistic view.

  The AAPS journal 20080301

• Inhibitory effects of nicorandil, a K ATP channel opener and a nitric oxide donor, on overactive bladder in animal models.

  BJU international 20080201

• Intracoronary nicorandil relieves multiple coronary vasospasm with hemodynamic collapse.

  Circulation journal : official journal of the Japanese Circulation Society 20080201

• [Nicorandil-induced cutaneous ulceration on a pacemaker implantation wound].

  Annales de dermatologie et de venereologie 20080201

• p38-MAPK is involved in restoration of the lost protection of preconditioning by nicorandil in vivo.

  European journal of pharmacology 20080128

• Nicorandil enhances the effect of endothelial nitric oxide under hypoxia-reoxygenation: role of the KATP channel.

  European journal of pharmacology 20080128

• Nicorandil suppressed myocardial injury after percutaneous coronary intervention.

  International journal of cardiology 20080111

• The use of nicorandil in cardioplegia solution.

  European journal of anaesthesiology 20080101

• [The study of vasodilative and antiischemic function of nicorandil in regional ischemia and reperfusion of rat heart in vivo].

  Kardiologiia 20080101

• Clinical and cost-effectiveness analysis of an open label, single-centre, randomised trial of spinal cord stimulation (SCS) versus percutaneous myocardial laser revascularisation (PMR) in patients with refractory angina pectoris: The SPiRiT trial.

  Trials 20080101

• Nitric oxide and cardiovascular effects: new insights in the role of nitric oxide for the management of osteoarthritis.

  Arthritis research & therapy 20080101

• Alternative pharmacological interventions that limit myocardial infarction.

  Current medicinal chemistry 20080101

• Arrhythmogenic substrate and its modification by nicorandil in a murine model of long QT type 3 syndrome.

  Progress in biophysics and molecular biology 20080101

• Hypoglycemic activity of Hemidesmus indicus R. Br. on streptozotocin-induced diabetic rats.

  International journal of diabetes in developing countries 20080101

• Modulation of venlafaxine hydrochloride release from press coated matrix tablet.

  Indian journal of pharmaceutical sciences 20080101

• Herbal excipients in novel drug delivery systems.

  Indian journal of pharmaceutical sciences 20080101

• Long QT syndrome: A therapeutic challenge.

  Annals of pediatric cardiology 20080101

• An unusual cause of 'pleuritic' chest pain.

  Acute medicine 20080101

• Catheter ablation of a left free-wall accessory pathway via the radial artery approach.

  Yonsei medical journal 20071231

• Effect of pravastatin on sympathetic reinnervation in postinfarcted rats.

  American journal of physiology. Heart and circulatory physiology 20071201

• Nicorandil-induced severe perianal ulceration.

  Techniques in coloproctology 20071201

• Anal ulceration induced by nicorandil.

  BMJ (Clinical research ed.) 20071103

• Prevention of no-reflow/slow-flow phenomenon during rotational atherectomy--a prospective randomized study comparing intracoronary continuous infusion of verapamil and nicorandil.

  American heart journal 20071101

• Treating acute myocardial infarction: something in the wind?

  Lancet (London, England) 20071027

• Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction (J-WIND): two randomised trials.

  Lancet (London, England) 20071027

• Long-term nicorandil therapy improves cardiac sympathetic nerve activity after reperfusion therapy in patients with first acute myocardial infarction.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20071001

• Ischemic preconditioning: protection against myocardial necrosis and apoptosis.

  Vascular health and risk management 20071001

• A review of pioglitazone HCL and glimepiride in the treatment of type 2 diabetes.

  Vascular health and risk management 20071001

• [Coronary thrombotic angina].

  Nihon rinsho. Japanese journal of clinical medicine 20070928

• Comparative study of nicorandil and a spasmolytic cocktail in preventing radial artery spasm during transradial coronary angiography.

  International journal of cardiology 20070903

• A quantitative analysis of the effect of cycle length on arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts.

  Pflugers Archiv : European journal of physiology 20070901

• Nicorandil suppresses the increases in plasma level of matrix metalloproteinase activity and attenuates left ventricular remodeling in patients with acute myocardial infarction.

  Heart and vessels 20070901

• Effectiveness of intravenous administration of nicorandil in a patient with variant angina refractory to continuous intravenous nitroglycerin.

  International journal of cardiology 20070809

• The role of mitochondria in protection of the heart by preconditioning.

  Biochimica et biophysica acta 20070801

• Intravenous nicorandil preserves endothelial junctions by decreasing endothelin-1 via activation of ATP-sensitive K+ channel.

  VASA. Zeitschrift fur Gefasskrankheiten 20070801

• Vasodilator effect of nicorandil on retinal blood vessels in rats.

  Naunyn-Schmiedeberg's archives of pharmacology 20070701

• Double-blind, multicenter, active-controlled, randomized clinical trial to assess the safety and efficacy of orally administered nicorandil in patients with stable angina pectoris in China.

  Circulation journal : official journal of the Japanese Circulation Society 20070601

• Nicorandil attenuates reperfusion injury after long cardioplegic arrest.

  Asian cardiovascular & thoracic annals 20070601

• Nicorandil-associated ulcerations.

  European journal of gastroenterology & hepatology 20070501

• Perianal ulceration and other cutaneous ulcerations complicating nicorandil therapy.

  Journal of the American Academy of Dermatology 20070501

• Effect of intravenous nicorandil and preexisting angina pectoris on short- and long-term outcomes in patients with a first ST-segment elevation acute myocardial infarction.

  The American journal of cardiology 20070501

• [Nicorandil and ulceration: new sites].

  Annales de dermatologie et de venereologie 20070501

• Nicorandil preserves the function of the mitochondrial phosphorylative and oxidative system in an animal model of global ischemia-reperfusion.

  Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20070501

• Thrombosuction utilizing an export aspiration catheter during primary percutaneous coronary intervention in acute myocardial infarction.

  Yonsei medical journal 20070430

• Bupivacaine induced cardiac toxicity mimicking an acute non-ST segment elevation myocardial infarction.

  Yonsei medical journal 20070430

• Effects of pravastatin on ventricular remodeling by activation of myocardial KATP channels in infarcted rats: role of 70-kDa S6 kinase.

  Basic research in cardiology 20070301

• Nicorandil-induced peristomal ulcers: is nicorandil also associated with gastrointestinal fistula formation?

  The British journal of dermatology 20070301

• [Suppressive effect of nicorandil in ventricular arrhythmias after reperfusion therapy in patients with acute myocardial infarction].

  Journal of cardiology 20070301

• Relationship between radial and central arterial pulse wave and evaluation of central aortic pressure using the radial arterial pulse wave.

  Hypertension research : official journal of the Japanese Society of Hypertension 20070301

• Nicorandil-induced leg ulceration.

  The British journal of dermatology 20070201

• Quantitation of nicorandil in pharmaceutical formulations by spectrophotometry using N-(1-naphthyl) ethylenediamine dihydrochloride as coupling agent.

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070201

• Nicorandil decreases cardiac events during and after noncardiac surgery.

  Journal of clinical anesthesia 20070201

• Novel therapeutic approaches to treating chronic angina in the setting of chronic ischemic heart disease.

  Clinical cardiology 20070201

• Myocardial protection by nicorandil during open-heart surgery under cardiopulmonary bypass.

  European journal of anaesthesiology 20070101

• Nicorandil opens mitochondrial K(ATP) channels not only directly but also through a NO-PKG-dependent pathway.

  Basic research in cardiology 20070101

• Effects of sulfonylureas on left ventricular mass in type 2 diabetic patients.

  American journal of physiology. Heart and circulatory physiology 20070101

• Investigation of the mechanisms underlying the gastroprotective effect of nicorandil.

  Pharmacology 20070101

• Nicorandil elevates tissue cGMP levels in a nitric-oxide-independent manner.

  Journal of pharmacological sciences 20070101

• Insights in the mechanisms underlying the anti-ulcer activity of nicorandil.

  Die Pharmazie 20070101

• Simultaneous multivessel coronary spasm causing acute myocardial infarction: a case report.

  Angiology 20070101

• Efficacy of oral nicorandil in patients with end-stage renal disease: a retrospective chart review after coronary angioplasty in Japanese patients receiving hemodialysis.

  Clinical therapeutics 20070101

• [A rapid method to evaluate potential vasodilatory activity of organic nitrates].

  Prikladnaia biokhimiia i mikrobiologiia 20070101

• Acute pancreatitis related to therapeutic dosing with colchicine: a case report.

  Journal of medical case reports 20070101

• An estimation method of the half-life for a one-compartment model of a single bolus intravenous injection by a single sampling.

  Journal of biopharmaceutical statistics 20070101

• Multivessel coronary artery spasm refractory to intensive medical treatment.

  Angiology 20070101

• Coronary slow flow phenomenon caused by contrast-induced microvascular spasm.

  Internal medicine (Tokyo, Japan) 20070101

• Prevention of no flow/slow reflow phenomenon in primary PCI by Nicorandil.

  Indian heart journal 20070101

• Effect of pravastatin on left ventricular mass in the two-kidney, one-clip hypertensive rats.

  American journal of physiology. Heart and circulatory physiology 20061201

• Nicorandil reduces myocardial no-reflow by protection of endothelial function via the activation of KATP channel.

  Clinica chimica acta; international journal of clinical chemistry 20061201

• Nicorandil-associated para-stomal ulceration: Case series.

  European journal of gastroenterology & hepatology 20061201

• Nicorandil improves post-ischemic myocardial dysfunction in association with opening the mitochondrial K(ATP) channels and decreasing hydroxyl radicals in isolated rat hearts.

  Circulation journal : official journal of the Japanese Circulation Society 20061201

• Targeting nitric oxide with drug therapy.

  Journal of clinical hypertension (Greenwich, Conn.) 20061201

• [Survey of coronary spasm in Japan before the establishment of spasm guidelines: analysis of questionnaires throughout Japan].

  Journal of cardiology 20061201

• Oral administration of nicorandil enhances the survival of ischemic skin flaps in rats.

  European journal of pharmacology 20061121

• Comparison of the effects of nicorandil versus verapamil on the incidence of slow flow/no reflow during rotational atherectomy.

  The American journal of cardiology 20061115

• The changes of fractional flow reserve after intracoronary nitrate and Nicorandil injection in coronary artery ectasia.

  International journal of cardiology 20061110

• Effect of temperature on the activation of myocardial KATP channel in guinea pig ventricular myocytes: a pilot study by whole cell patch clamp recording.

  Chinese medical journal 20061020

• The effect of altering haemodynamics on the plasma concentrations of natriuretic peptides in heart failure.

  European journal of heart failure 20061001

• Influence of nicorandil on the pharmacodynamics and pharmacokinetics of gliclazide in rats and rabbits.

  Molecular and cellular biochemistry 20061001

• Anal ulceration associated with Nicorandil: case series and review of the literature.

  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20061001

• [Nicorandil-associated anal ulceration].

  Annales de dermatologie et de venereologie 20061001

• New insights in the treatment strategy for pulmonary arterial hypertension.

  Cardiovascular drugs and therapy 20061001

• Clinical testing of nicorandil supplemented normokalemic cardioplegic solution.

  Interactive cardiovascular and thoracic surgery 20061001

• Rapid and sensitive liquid chromatography-tandem mass spectrometry method for the estimation of nicorandil in human plasma.

  Biomedical chromatography : BMC 20060901

• Effects of nicorandil preconditioning on membrane dystrophin.

  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20060901

• Usefulness of myocardial contrast echocardiography with nicorandil stress for the detection of coronary artery stenosis.

  Heart (British Cardiac Society) 20060901

• Impact of nicorandil to prevent reperfusion injury in patients with acute myocardial infarction: Sigmart Multicenter Angioplasty Revascularization Trial (SMART).

  Circulation journal : official journal of the Japanese Circulation Society 20060901

• Contractile recovery of heart muscle after hypothermic hypoxia is improved by nicorandil via mitochondrial K(ATP) channels.

  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20060801

• Cutaneous, perivulvar and perianal ulcerations induced by nicorandil.

  The British journal of dermatology 20060801

• Goat ureter - an alternative model for measuring ureteral peristalsis.

  Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20060801

• Intracoronary nicorandil prior to reperfusion in acute myocardial infarction.

  EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20060801

• The effect of the K+ agonist nicorandil on peripheral vascular resistance.

  International journal of cardiology 20060728

• Nicorandil-associated anal ulceration.

  Age and ageing 20060701

• The effect of a nicorandil congener on isolated human myometrium.

  European journal of obstetrics, gynecology, and reproductive biology 20060601

• Preconditioning, postconditioning and their application to clinical cardiology.

  Cardiovascular research 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Economic evaluation of the impact of nicorandil in angina (IONA) trial.

  Heart (British Cardiac Society) 20060501

• Non-healing anal ulcers associated with nicorandil.

  Journal of wound care 20060501

• Nicorandil but not ISDN upregulates endothelial nitric oxide synthase expression, preventing left ventricular remodeling and degradation of cardiac function in Dahl salt-sensitive hypertensive rats with congestive heart failure.

  Journal of cardiovascular pharmacology 20060501

• Myocardial protective effects of nicorandil, an opener of potassium channels on senile rat heart.

  Perfusion 20060501

• Continuous administration of nicorandil decreases QT dispersion during the chronic phase of acute myocardial infarction.

  International heart journal 20060501

• Nicorandil administration shows cardioprotective effects in patients with poor TIMI and collateral flow as well as good flow after AMI.

  Annals of nuclear medicine 20060501

• Nicorandil may be associated with gastrointestinal ulceration.

  BMJ (Clinical research ed.) 20060415

• Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment.

  International journal of cardiology 20060404

• Nicorandil regulates Bcl-2 family proteins and protects cardiac myocytes against hypoxia-induced apoptosis.

  Journal of molecular and cellular cardiology 20060401

• Intrathecal nicorandil and small-dose morphine can induce spastic paraparesis after a noninjurious interval of spinal cord ischemia in the rat.

  Anesthesia and analgesia 20060401

• Effect of nerodilol and carvone on in vitro permeation of nicorandil across rat epidermal membrane.

  Drug development and industrial pharmacy 20060401

• Comparison of the percutaneous absorption of hydrophilic and lipophilic compounds in shed snake skin and human skin.

  Die Pharmazie 20060401

• Nicorandil reduces the incidence of minor cardiac marker elevation after coronary stenting.

  International journal of cardiology 20060208

• Selection of optimal therapy for chronic stable angina.

  Current treatment options in cardiovascular medicine 20060201

• Effects of intravenous nicorandil before reperfusion for acute myocardial infarction in patients with stress hyperglycemia.

  Diabetes care 20060201

• Evolving treatment strategies for chronic refractory angina.

  Expert opinion on pharmacotherapy 20060201

• [Angina pectoris presenting with unusual form of coronary spasm: a case report].

  Journal of cardiology 20060201

• Nicorandil: anal ulcerations an additional concern.

  Prescrire international 20060201

• [Clinical usefulness of 1231I-BMIPP myocardial SPECT in patient with microvascular spasm: a case report].

  Kaku igaku. The Japanese journal of nuclear medicine 20060201

• Determination of inorganic nitrate impurity from nicorandil and its tablet dosage form by simple reversed phase liquid chromatographic method.

  Journal of chromatography. A 20060106

• Mucosal disease series. Number VI. Recurrent aphthous stomatitis.

  Oral diseases 20060101

• Controlled in vivo release of nicorandil from a carvone-based transdermal therapeutic system in human volunteers.

  Drug delivery 20060101

• Nicorandil-associated perianal ulceration: a case series of 10 patients.

  The British journal of dermatology 20060101

• [Effects of intra-coronary and intra-graft administration of nicorandil for coronary spasm after coronary artery bypass grafting].

  Kyobu geka. The Japanese journal of thoracic surgery 20060101

• Andersen-Tawil syndrome.

  Indian pacing and electrophysiology journal 20060101

• Nicorandil related anal ulcer.

  Irish journal of medical science 20060101

• No-reflow: a heterogeneous clinical phenomenon with multiple therapeutic strategies.

  Current pharmaceutical design 20060101

• Microvascular obstruction after successful fibrinolytic therapy in acute myocardial infarction. Comparison of reteplase vs reteplase+abciximab: A cardiovascular magnetic resonance study.

  Heart international 20060101

• Nicorandil inhibits serum starvation-induced apoptosis in vascular endothelial cells.

  Journal of cardiovascular pharmacology 20051201

• Hypoxia-reoxygenation, St. Thomas cardioplegic solution, and nicorandil on endothelium-derived hyperpolarizing factor in coronary microarteries.

  The Annals of thoracic surgery 20051101

• Reduction of myocardial infarct size by SM-197378, a novel Na+/H+ exchange inhibitor, in rabbits.

  European journal of pharmacology 20051003

• Therapeutic potential of nitric oxide donors in the prevention and treatment of atherosclerosis.

  European heart journal 20051001

• Comparison of the effects of nitric oxide donors and calcium channel blockers on the intrinsic myogenic tone of sheep isolated internal anal sphincter.

  The British journal of surgery 20051001

• Effects of nicorandil on monocrotaline-induced pulmonary arterial hypertension in rats.

  Journal of cardiovascular pharmacology 20051001

• Nicorandil: the drug that keeps on giving.

  Hypertension (Dallas, Tex. : 1979) 20051001

• Nicorandil promotes myocardial capillary and arteriolar growth in the failing heart of Dahl salt-sensitive hypertensive rats.

  Hypertension (Dallas, Tex. : 1979) 20051001

• Determinants of coronary events in patients with stable angina: results from the impact of nicorandil in angina study.

  American heart journal 20051001

• Effect of ischaemic preconditioning on regional release of inflammatory markers.

  Clinical science (London, England : 1979) 20050901

• Comparative effects of nicorandil with isosorbide mononitrate on cardiac sympathetic nerve activity and left ventricular function in patients with ischemic cardiomyopathy.

  American heart journal 20050901

• Impact of a single intravenous administration of nicorandil before reperfusion in patients with ST-segment-elevation myocardial infarction.

  Circulation 20050830

• Bioavailability of nerodilol-based transdermal therapeutic system of nicorandil in human volunteers.

  Journal of controlled release : official journal of the Controlled Release Society 20050818

• Gadomer-enhanced MR imaging in the detection of microvascular obstruction: alleviation with nicorandil therapy.

  Radiology 20050801

• Nicorandil attenuates NF-kappaB activation, adhesion molecule expression, and cytokine production in patients with coronary artery bypass surgery.

  Shock (Augusta, Ga.) 20050801

• [Evolution of secondary prevention medication prescriptions after myocardial revascularisation: the ANCOR survey].

  Annales de cardiologie et d'angeiologie 20050801

• Is the sarcolemmal or mitochondrial K(ATP) channel activation important in the antiarrhythmic and cardioprotective effects during acute ischemia/reperfusion in the intact anesthetized rabbit model?

  Life sciences 20050729

• Nicorandil and idiopathic anal ulceration.

  Diseases of the colon and rectum 20050701

• K(ATP) channel therapeutics at the bedside.

  Journal of molecular and cellular cardiology 20050701

• Effects of the long-term administration of nicorandil on vascular endothelial function and the progression of arteriosclerosis.

  Journal of cardiovascular pharmacology 20050701

• A functional role of the C-terminal 42 amino acids of SUR2A and SUR2B in the physiology and pharmacology of cardiovascular ATP-sensitive K(+) channels.

  Journal of molecular and cellular cardiology 20050701

• [Beneficial effects of nicorandil on myocardial no-reflow state in a mini-swine model of acute myocardial infarction and reperfusion].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20050701

• Cardiac KATP channels in health and disease.

  Journal of molecular and cellular cardiology 20050601

• Release of nitric oxide and endothelium-derived hyperpolarizing factor (EDHF) in porcine coronary arteries exposed to hyperkalemia: effect of nicorandil.

  The Annals of thoracic surgery 20050601

• Nicorandil-associated perianal ulceration with prominent elastophagocytosis and flexural ulceration.

  The British journal of dermatology 20050601

• Nicorandil induced oral ulceration.

  British dental journal 20050528

• The potassium-channel syndrome: does it exist?

  Lancet (London, England) 20050501

• Reversal of life-threatening, drug-related potassium-channel syndrome by glibenclamide.

  Lancet (London, England) 20050501

• [Assessment of microcirculation disturbance in patients with coronary ectasia by ATP-loading 99mTc-tetrofosmin myocardial SPECT].

  Kaku igaku. The Japanese journal of nuclear medicine 20050501

• Cardiac preconditioning during percutaneous coronary interventions.

  Cardiovascular drugs and therapy 20050501

• The nicorandil-induced vasodilation in humans is inhibited by miconazole.

  Journal of cardiovascular pharmacology 20050401

• Long-term oral treatment with nicorandil prevents the progression of left ventricular hypertrophy and preserves viability.

  Journal of cardiovascular pharmacology 20050401

• Hypoglycemic and antihyperglycemic effect of Gmelina asiatica LINN. in normal and in alloxan induced diabetic rats.

  Biological & pharmaceutical bulletin 20050401

• Chronic anal ulceration due to nicorandil.

  The British journal of dermatology 20050401

• KCNJ2 mutation in intractable ventricular arrhythmia with Andersen's syndrome.

  Pediatrics international : official journal of the Japan Pediatric Society 20050401

• [Effects of propofol and thiamylal on nicorandil induced ATP-sensitive potassium channel activities in cultured rat aortic smooth muscle cells].

  Masui. The Japanese journal of anesthesiology 20050401

• Re: King PM, Suttie SA, Jansen JO, Watson AJ. Perforation of the terminal ileum: a possible complication of nicorandil therapy. Surg J R Coll Surg Edinb Irel 2004; 1: 56-57.

  The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland 20050401

• Can nicorandil treat angina pectoris effectively?

  Nature clinical practice. Cardiovascular medicine 20050401

• The effect of an angiotensin-converting enzyme inhibitor and a K+(ATP) channel opener on warm up angina.

  European heart journal 20050301

• Myocardial protective effects of nicorandil during percutaneous coronary intervention in patients with unstable angina.

  Circulation journal : official journal of the Japanese Circulation Society 20050301

• [Cardioprotective effects of K(ATP) channel opener nicorandil during ischemia/ reperfusion in dogs].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20050301

• Insulin resistance relates to acetylcholine-induced microvascular vasoconstriction in a patient with vasospastic angina: potential implication of causalities between hyperinsulinemia and coronary microcirculation failure.

  Heart and vessels 20050301

• Effects of nicorandil on cardiac sympathetic nerve activity after reperfusion therapy in patients with first anterior acute myocardial infarction.

  European journal of nuclear medicine and molecular imaging 20050301

• Bilateral thoracoscopic cervical sympathectomy for the treatment of recurrent polymorphic ventricular tachycardia.

  Heart (British Cardiac Society) 20050101

• Positive inotropic effect of nicorandil in adult rats in situ.

  Journal of anesthesia 20050101

• Management of cardiogenic shock due to acute coronary syndromes.

  Angiology 20050101

• [Neuron-protective effect of ischemic preconditioning in a rabbit reperfusion model following spinal ischemia].

  [Hokkaido igaku zasshi] The Hokkaido journal of medical science 20050101

• Mitochondrial K(ATP) channel opener prevents ischemia-reperfusion injury in rat liver.

  Transplantation proceedings 20050101

• A case of recurrent chest pain with reversible left ventricular dysfunction and ST segment elevation on electrocardiogram.

  International heart journal 20050101

• Oxidized and ubiquitinated proteins may predict recovery of postischemic cardiac function: essential role of the proteasome.

  Antioxidants & redox signaling 20050101

• Specific therapy based on the genotype and cellular mechanism in inherited cardiac arrhythmias. Long QT syndrome and Brugada syndrome.

  Current pharmaceutical design 20050101

• The no-reflow phenomenon: epidemiology, pathophysiology, and therapeutic approach.

  Reviews in cardiovascular medicine 20050101

• Effect of the degree of ischaemic injury and reoxygenation time on the type of myocardial cell death in man: role of caspases.

  BMC physiology 20050101

• In vivo evaluation of limonene-based transdermal therapeutic system of nicorandil in healthy human volunteers.

  Skin pharmacology and physiology 20050101

• Successful treatment of intraoperative heart failure caused by ampulla cardiomyopathy by intra-aortic balloon pumping and percutaneous cardiopulmonary support: report of a case.

  Surgery today 20050101

• Drugs to facilitate recovery of neuromuscular blockade and muscle strength.

  Journal of anesthesia 20050101

• Acute hemodynamic effects of nicorandil in patients with primary pulmonary arterial hypertension.

  Indian heart journal 20050101

• Comparative study of perioperative infusion of diltiazem and nicorandil on myocardial protection during OPCAB surgery.

  Annals of cardiac anaesthesia 20050101

• Impact of nicorandil in angina: subgroup analyses.

  Heart (British Cardiac Society) 20041201

• Effect of nicorandil, a K+ATP -channel opener, on coronary capillary architecture and volume after early myocardial ischemia-reperfusion--a 3-dimensional confocal laser microscopic study--.

  Circulation journal : official journal of the Japanese Circulation Society 20041201

• Chronic non-healing anal ulceration and Nicorandil: further evidence of an emerging problem.

  ANZ journal of surgery 20041201

• ATP-dependent potassium channels as a key target for the treatment of myocardial and vascular dysfunction.

  Current opinion in critical care 20041201

• Selective and validated spectrophotometric methods for the determination of nicorandil in pharmaceutical formulations.

  The AAPS journal 20041201

• Assessment of coronary artery disease with nicorandil stress magnetic resonance imaging.

  Osaka city medical journal 20041201

• Nicorandil associated anal ulceration.

  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20041101

• Mutation in nucleotide-binding domains of sulfonylurea receptor 2 evokes Na-ATP-dependent activation of ATP-sensitive K+ channels: implication for dimerization of nucleotide-binding domains to induce channel opening.

  Molecular pharmacology 20041001

• Effect of pravastatin on left ventricular mass by activation of myocardial K ATP channels in hypercholesterolemic rabbits.

  Atherosclerosis 20041001

• Prophylactic effect of intravenous nicorandil on perioperative myocardial damage in patients undergoing off-pump coronary artery bypass surgery.

  Journal of cardiovascular pharmacology 20041001

• Effect of combined intracoronary adenosine and nicorandil on no-reflow phenomenon during percutaneous coronary intervention.

  Circulation journal : official journal of the Japanese Circulation Society 20041001

• Nicorandil improves cardiac function and clinical outcome in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention: role of inhibitory effect on reactive oxygen species formation.

  American heart journal 20041001

• Current and future treatment strategies for refractory angina.

  Mayo Clinic proceedings 20041001

• A case of severe tongue ulceration and laryngeal inflammation induced by low-dose nicorandil therapy.

  The British journal of dermatology 20041001

• [Inhibition of Rho-kinase by fasudil preventing anginal attacks associated with spastic angina: a case report].

  Journal of cardiology 20041001

• Re: Perforation of the terminal ileum: a possible complication of nicrorandil therapy. Surg J R Coll Surg Edinb Irel. 2004: 56-57.

  The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland 20041001

• Re: Perforation of the terminal ileum: a possible complication of nicorandil therapy. Surg JR Coll Surg Edinb Irel., 2 February 2004, 56-57.

  The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland 20041001

• Left ventricular mechanoenergetics after hyperpolarized cardioplegic arrest by nicorandil and after depolarized cardioplegic arrest by KCl.

  American journal of physiology. Heart and circulatory physiology 20040901

• Nicorandil associated anal ulceration.

  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20040901

• Efficacy and safety of a metabolic modulator drug in chronic stable angina: review of evidence from clinical trials.

  Journal of cardiovascular pharmacology and therapeutics 20040901

• Intravenous nicorandil can reduce QT dispersion and prevent bradyarrhythmia during percutaneous transluminal coronary angioplasty of the right coronary artery.

  Journal of cardiovascular pharmacology and therapeutics 20040901

• Effect of potassium-channel opener therapy on reperfused infarction in hypertrophied hearts: demonstration of preconditioning by using functional and contrast-enhanced magnetic resonance imaging.

  Journal of cardiovascular pharmacology and therapeutics 20040901

• Usefulness of fasudil, a Rho-kinase inhibitor, to treat intractable severe coronary spasm after coronary artery bypass surgery.

  Journal of cardiovascular pharmacology 20040901

• Preconditioning protects by inhibiting the mitochondrial permeability transition.

  American journal of physiology. Heart and circulatory physiology 20040801

• In vitro effects of antihypertensive drugs on thromboxane agonist (U46619)-induced vasoconstriction in human internal mammary artery.

  British journal of anaesthesia 20040801

• Nicorandil improves diabetes and rat islet beta-cell damage induced by streptozotocin in vivo and in vitro.

  European journal of endocrinology 20040801

• ATP-sensitive potassium channels and endogenous adenosine are involved in spinal antinociception produced by locus coeruleus stimulation.

  The International journal of neuroscience 20040801

• NO donor-activated PKC-delta plays a pivotal role in ischemic myocardial protection through accelerated opening of mitochondrial K-ATP channels.

  Journal of cardiovascular pharmacology 20040701

• Preconditioning improves postischemic mitochondrial function and diminishes oxidation of mitochondrial proteins.

  Free radical biology & medicine 20040701

• Persistent nicorandil induced oral ulceration.

  Heart (British Cardiac Society) 20040701

• Optimized and validated spectrophotometric methods for the determination of nicorandil in drug formulations and biological fluids.

  Farmaco (Societa chimica italiana : 1989) 20040701

• Electrophysiologic effects of nicorandil on the guinea pig long QT1 syndrome model.

  Journal of cardiovascular electrophysiology 20040701

• Use of potassium channel openers for pharmacologic modulation of cardiac excitability.

  Journal of cardiovascular electrophysiology 20040701

• The inherent rhythmic contraction property of penile tissue in sexually active adult male rats and the effect of sildenafil citrate (Viagra): an in vitro pilot study.

  Pakistan journal of pharmaceutical sciences 20040701

• Diazoxide preconditioning protects against neuronal cell death by attenuation of oxidative stress upon glutamate stimulation.

  Journal of neuroscience research 20040601

• The nucleotide-binding domains of sulfonylurea receptor 2A and 2B play different functional roles in nicorandil-induced activation of ATP-sensitive K+ channels.

  Molecular pharmacology 20040501

• Intravenous nicorandil can reduce the occurrence of ventricular fibrillation and QT dispersion in patients with successful coronary angioplasty in acute myocardial infarction.

  The Canadian journal of cardiology 20040501

• Novel therapeutics for treatment of long-QT syndrome and torsade de pointes.

  International journal of cardiology 20040501

• [How to use the paradigm of ischemic preconditioning to protect the heart?].

  Medecine sciences : M/S 20040501

• Nicorandil induces late preconditioning against myocardial infarction in conscious rabbits.

  American journal of physiology. Heart and circulatory physiology 20040401

• Replacing potassium with nicorandil in cold St. Thomas' Hospital cardioplegia improves preservation of energetics and function in pig hearts.

  The Annals of thoracic surgery 20040401

• Clinical outcome of percutaneous coronary intervention with antecedent mutant t-PA administration for acute myocardial infarction.

  American heart journal 20040401

• Extracellular potassium dependent negative dromotropic action of nicorandil in guinea pig myocardium.

  Fukuoka igaku zasshi = Hukuoka acta medica 20040401

• Comparison between nicorandil and magnesium as an adjunct cardioprotective agent to percutaneous coronary intervention in acute anterior myocardial infarction.

  Circulation journal : official journal of the Japanese Circulation Society 20040301

• Effects of nicorandil on endogenous fibrinolytic capacity in patients with coronary artery disease.

  Circulation journal : official journal of the Japanese Circulation Society 20040301

• Intracoronary administration of nicorandil for the treatment of spontaneous microvascular spasm with ST segment elevation.

  Circulation journal : official journal of the Japanese Circulation Society 20040301

• Postnatal outcome of fetal bradycardia without significant cardiac abnormalities.

  American heart journal 20040301

• Myocardial protection from either ischaemic preconditioning or nicorandil is not blocked by gliclazide.

  Cardiovascular drugs and therapy 20040301

• Effects of cariporide (HOE642) on myocardial infarct size and ventricular arrhythmias in a rat ischemia/reperfusion model: comparison with other drugs.

  Pharmacology 20040201

• Nicorandil attenuates the mitochondrial Ca2+ overload with accompanying depolarization of the mitochondrial membrane in the heart.

  Naunyn-Schmiedeberg's archives of pharmacology 20040201

• Nicorandil versus isosorbide dinitrate as adjunctive treatment to direct balloon angioplasty in acute myocardial infarction.

  Heart (British Cardiac Society) 20040201

• Rationale and design of a large-scale trial using nicorandil as an adjunct to percutaneous coronary intervention for ST-segment elevation acute myocardial infarction: Japan-Working groups of acute myocardial infarction for the reduction of Necrotic Damage by a K-ATP channel opener (J-WIND-KATP).

  Circulation journal : official journal of the Japanese Circulation Society 20040201

• Chronic anal ulceration due to nicorandil.

  The British journal of dermatology 20040201

• Perforation of the terminal ileum: a possible complication of nicorandil therapy.

  The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland 20040201

• Possible mechanisms of insulin antinociception.

  Methods and findings in experimental and clinical pharmacology 20040101

• Nicorandil protects against lethal ischemic ventricular arrhythmias and up-regulates endothelial nitric oxide synthase expression and sulfonylurea receptor 2 mRNA in conscious rats with acute myocardial infarction.

  Cardiovascular drugs and therapy 20040101

• Cardiac syndrome X. Diagnosis, pathogenesis and management.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20040101

• Treatment of erectile dysfunction in patients with cardiovascular disease : guide to drug selection.

  Drugs 20040101

• Nicorandil: a review of its use in the management of stable angina pectoris, including high-risk patients.

  Drugs 20040101

• Formulation of an HPMC gel drug reservoir system with ethanol-water as a solvent system and limonene as a penetration enhancer for enhancing in vitro transdermal delivery of nicorandil.

  Skin pharmacology and physiology 20040101

• Nicorandil-induced severe oral ulceration.

  Journal of the Irish Dental Association 20040101

• [CREST syndrome and pulmonary hypertension: a dark prognosis].

  Acta medica portuguesa 20040101

• Biochemical changes on the cardioprotective effect of nicorandil and amlodipine during experimental myocardial infarction in rats.

  Pharmacological research 20031201

• Nicorandil inhibits oxidative stress-induced apoptosis in cardiac myocytes through activation of mitochondrial ATP-sensitive potassium channels and a nitrate-like effect.

  Journal of molecular and cellular cardiology 20031201

• The efficacy of nicorandil, calcium chloride and nitroglycerin in treatment of ropivacaine-induced cardiotoxicity.

  European journal of anaesthesiology 20031201

• Congenital Long QT Syndrome presenting as epilepsy.

  Indian pediatrics 20031201

• Once-daily sustained-release matrix tablets of nicorandil: formulation and in vitro evaluation.

  AAPS PharmSciTech 20031201

• Nicorandil prevents oxidative stress-induced apoptosis in neurons by activating mitochondrial ATP-sensitive potassium channels.

  Brain research 20031114

• Nicorandil inhibits the release of TNFalpha from a lymphocyte cell line and peripheral blood lymphocytes.

  International immunopharmacology 20031101

• Role of endothelium-derived hyperpolarizing factor in human forearm circulation.

  Hypertension (Dallas, Tex. : 1979) 20031101

• Myocardial perfusion during transient slow-flow in the patient with old vein graft intervention: assessment by serial measurement of pressure-derived fractional flow reserve and thermodilution-derived coronary flow reserve.

  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20031101

• Diazoxide induces delayed pre-conditioning in cultured rat cortical neurons.

  Journal of neurochemistry 20031101

• Nicorandil for angina--an update.

  Drug and therapeutics bulletin 20031101

• [Nicorandil reduces incidence and severity of pain on propofol injection].

  Masui. The Japanese journal of anesthesiology 20031101

• Nicorandil cardioplegia or procaine cardioplegia?

  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20031001

• Beneficial effects of betaxolol, a selective antagonist of beta-1 adrenoceptors, on exercise-induced myocardial ischemia in patients with coronary vasospasm.

  International journal of cardiology 20031001

• ATP-sensitive K+ channel openers: old drugs with new clinical benefits for the heart.

  Current vascular pharmacology 20031001

• Oral nicorandil-induced lesions are not aphthous ulcers.

  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20030901

• [Molecular and functional diversity of ATP-sensitive K+ channels: the pathophysiological roles and potential drug targets].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20030901

• Synergistic effect of nicorandil and amlodipine on lysosomal hydrolases during experimental myocardial infarction in rats.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20030901

• Nicorandil: a drug for many purposes: too good to be true?

  European heart journal 20030701

• Evidence of pharmacologic preconditioning during PTCA by intravenous pretreatment with ATP-sensitive K+ channel opener nicorandil.

  European heart journal 20030701

• Effect of nicorandil on left ventricular end-diastolic pressure during exercise in patients with hypertrophic cardiomyopathy.

  European heart journal 20030701

• [A case of coronary artery spasm during epidural anesthesia with continuous infusion of propofol].

  Masui. The Japanese journal of anesthesiology 20030701

• Mitochondrial K ATP channel activation is important in the antiarrhythmic and cardioprotective effects of non-hypotensive doses of nicorandil and cromakalim during ischemia/reperfusion: a study in an intact anesthetized rabbit model.

  Pharmacological research 20030601

• Nicorandil induced oral ulceration.

  Australian family physician 20030601

• In vitro comparison of glyceryl trinitrate-verapamil with other dilators of human saphenous vein.

  ANZ journal of surgery 20030501

• Superior myocardial protection with nicorandil cardioplegia.

  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20030501

• Binding and effect of K ATP channel openers in the absence of Mg2+.

  British journal of pharmacology 20030501

• Modulation of slow waves by hyperpolarization with potassium channel openers in antral smooth muscle of the guinea-pig stomach.

  The Journal of physiology 20030401

• Intravenous nicorandil in conjunction with coronary reperfusion therapy is associated with better clinical and functional outcomes in patients with acute myocardial infarction.

  Circulation journal : official journal of the Japanese Circulation Society 20030401

• Antihyperglycemic action of angiotensin II receptor antagonist, valsartan, in streptozotocin-induced diabetic rats.

  Journal of hypertension 20030401

• [Anti-ischemic tolerance and preconditioning].

  Nihon rinsho. Japanese journal of clinical medicine 20030401

• Argatroban as an alternative anticoagulant for patients with heparin allergy during coronary bypass surgery.

  Heart and vessels 20030301

• Oral nicorandil recaptures the waned protection from preconditioning in vivo.

  British journal of pharmacology 20030301

• Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion.

  Methods and findings in experimental and clinical pharmacology 20030301

• Impairment of myocardial protection in type 2 diabetic patients.

  The Journal of clinical endocrinology and metabolism 20030201

• Intravenous nicorandil prevents thiamylal-fentanyl-induced bronchoconstriction in humans.

  Critical care medicine 20030201

• Nicorandil: albuterol-like or cromolyn-like?

  Critical care medicine 20030201

• Usefulness of massive oral nicorandil in a patient with variant angina refractory to conventional treatment.

  Internal medicine (Tokyo, Japan) 20030201

• [Assessment of microcirculation disturbance with nuclear cardiology in a patient with coronary ectasia: a case report].

  Kaku igaku. The Japanese journal of nuclear medicine 20030201

• Ischaemic preconditioning and outcomes after angioplasty: effects of drug therapy.

  Drugs 20030101

• Haemodynamic and electrocardiographic consequences of severe nicorandil toxicity.

  Emergency medicine journal : EMJ 20030101

• [Opening of ATP-sensitive potassium channel attenuates cardiac remodeling induced by chronic inhibition of nitric oxide synthesis].

  Journal of cardiology 20030101

• [The best of clinical pharmacology in 2002].

  Archives des maladies du coeur et des vaisseaux 20030101

• Synergistic effect of Nicorandil and Amlodipine on tissue defense system during experimental myocardial infarction in rats.

  Molecular and cellular biochemistry 20030101

• Differential selectivity of insulin secretagogues: mechanisms, clinical implications, and drug interactions.

  Journal of diabetes and its complications 20030101

• Antiulcer activity of levcromakalim and nicorandil in albino rats: a comparative study.

  Polish journal of pharmacology 20030101

• Coronary artery flow reserve in diabetics with erectile dysfunction using sildenafil.

  Cardiovascular diabetology 20030101

• Cardiomyocyte mitochondrial KATP channels participate in the antiarrhythmic and antiinfarct effects of KATP activators during ischemia and reperfusion in an intact anesthetized rabbit model.

  Polish journal of pharmacology 20030101

• Effect of nicorandil and amlodipine on bio-chemical parameters during isoproterenol induced myocardial necrosis in rats.

  Indian journal of clinical biochemistry : IJCB 20030101

• Nicorandil-associated anal ulceration.

  Lancet (London, England) 20021214

• Role of nicorandil in ischaemic preconditioning.

  Lancet (London, England) 20021207

• Role of nicorandil in ischaemic preconditioning.

  Lancet (London, England) 20021207

• Role of nicorandil in ischaemic preconditioning.

  Lancet (London, England) 20021207

• Opening of potassium channels modulates mitochondrial function in rat skeletal muscle.

  Biochimica et biophysica acta 20021202

• The effects of vasodilators on the relaxation of guinea-pig aorta during acute recoil.

  International journal of cardiology 20021201

• Nicorandil prevents epinephrine-induced arrhythmias in halothane-anesthetized rats by nitric oxide-dependent mechanism.

  Naunyn-Schmiedeberg's archives of pharmacology 20021201

• K(ATP) channel activity is required for hatching in Xenopus embryos.

  Developmental dynamics : an official publication of the American Association of Anatomists 20021201

• Prenatal diagnosis and treatment of fetal long QT syndrome: a case report.

  Prenatal diagnosis 20021201

• 2-Nicotinamidoethyl nitrale (2-NN) protects myocardium in ischemia and reperfusion via the protein kinase C pathway.

  The Journal of cardiovascular surgery 20021201

• Effect of intracoronary nicorandil administration on preventing no-reflow/slow flow phenomenon during rotational atherectomy.

  Circulation journal : official journal of the Japanese Circulation Society 20021201

• Increasing myocardial 123I-BMIPP uptake in non-ischemic area in a patient with acute myocardial ischemia.

  Annals of nuclear medicine 20021201

• Nicorandil and leukocyte activation.

  Journal of cardiovascular pharmacology 20021101

• [Fast-disintegration oral tablets having sustained release property].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20021101

• Infarct size limitation by nicorandil: roles of mitochondrial K(ATP) channels, sarcolemmal K(ATP) channels, and protein kinase C.

  Journal of the American College of Cardiology 20021016

• K(ATP) channel opening is an endogenous mechanism of protection against the no-reflow phenomenon but its function is compromised by hypercholesterolemia.

  Journal of the American College of Cardiology 20021002

• Long-term administration of nicorandil abolishes ischemic and pharmacologic preconditioning of the human myocardium: role of mitochondrial adenosine triphosphate-dependent potassium channels.

  The Journal of thoracic and cardiovascular surgery 20021001

• Nicorandil infusion leads to good recovery from ischemia of left ventricular regional work in comparison with nitroglycerin.

  Circulation journal : official journal of the Japanese Circulation Society 20021001

• [A case of intraoperative repeated coronary artery spasm with ST-segment depression].

  Masui. The Japanese journal of anesthesiology 20021001

• Nicorandil ameliorates posttransplant dysfunction in cardiac allografts harvested from non-heart-beating donors.

  The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi 20021001

• Opening of the adenosine triphosphate-sensitive potassium channel attenuates cardiac remodeling induced by long-term inhibition of nitric oxide synthesis: role of 70-kDa S6 kinase and extracellular signal-regulated kinase.

  Journal of the American College of Cardiology 20020904

• Left ventricular remodeling after infarction: sequential MR imaging with oral nicorandil therapy in rat model.

  Radiology 20020901

• Nicorandil-induced preconditioning as evidenced by troponin T measurements after coronary angioplasty in patients with stable angina pectoris.

  Japanese heart journal 20020901

• Antiapoptotic effect of nicorandil mediated by mitochondrial atp-sensitive potassium channels in cultured cardiac myocytes.

  Journal of the American College of Cardiology 20020821

• Nicorandil associated anal ulceration.

  Lancet (London, England) 20020817

• Triggers of ventricular tachyarrhythmias and therapeutic effects of nicorandil in canine models of LQT2 and LQT3 syndromes.

  Journal of the American College of Cardiology 20020807

• Nicorandil improves myocardial high-energy phosphates in postinfarction porcine hearts.

  Clinical and experimental pharmacology & physiology 20020801

• Inhibition of human and pig ureter motility in vitro and in vivo by the K(+) channel openers PKF 217-744b and nicorandil.

  The Journal of pharmacology and experimental therapeutics 20020801

• [Microanalysis of tryptophan metabolites and suppressor factor of delayed-type hypersensitivity in mice].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20020701

• Nicorandil preserves mitochondrial function during ischemia in perfused rat heart.

  European journal of pharmacology 20020620

• Effect of potassium-channel openers on the release of endothelium-derived hyperpolarizing factor in porcine coronary arteries stored in cold hyperkalemic solution.

  The journal of extra-corporeal technology 20020601

• Blood pool contrast-enhanced MRI detects suppression of microvascular permeability in early postinfarction reperfusion after nicorandil therapy.

  Magnetic resonance in medicine 20020501

• Opening of K(ATP) channel attenuates the increase in QT dispersion produced by the first balloon inflation during coronary angioplasty.

  Circulation journal : official journal of the Japanese Circulation Society 20020501

• Promises kept and broken: new pharmaceuticals.

  The Canadian journal of cardiology 20020501

• [Adenosine production and its role in protection against ischemic and reperfusion injury of the myocardium].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20020501

• ATP-sensitive potassium channels and endogenous adenosine are involved in spinal antinociception produced by locus coeruleus stimulation.

  Sheng li xue bao : [Acta physiologica Sinica] 20020425

• The IONA study: preparing the myocardium for ischaemia?

  Lancet (London, England) 20020413

• Effect of nicorandil on coronary events in patients with stable angina: the Impact Of Nicorandil in Angina (IONA) randomised trial.

  Lancet (London, England) 20020413

• Nicorandil enhances myocardial tolerance to ischemia without progressive collateral recruitment during coronary angioplasty.

  Circulation journal : official journal of the Japanese Circulation Society 20020401

• Effect of ischemic preconditioning and mitochondrial KATP channel openers on chronic left ventricular remodeling in the ischemic-reperfused rat heart.

  Circulation journal : official journal of the Japanese Circulation Society 20020401

• Pharmacological modulation of K(ATP) channels.

  Biochemical Society transactions 20020401

• Nicorandil inhibits degranulation and TNF-alpha release from RBL-2H3 cells.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20020401

• Noninvasive assessment of the effects of nicorandil on left ventricular volumes and function in reperfused myocardial infarction.

  Cardiovascular research 20020401

• Angina, diabetes and SUR.

  Diabetes, obesity & metabolism 20020301

• Interactions of sildenafil with various coronary vasodilators in isolated porcine coronary artery.

  European journal of pharmacology 20020222

• Selective mitochondrial K(ATP) channel activation results in antiarrhythmic effect during experimental myocardial ischemia/reperfusion in anesthetized rabbits.

  European journal of pharmacology 20020222

• Potassium channel openers protect cardiac mitochondria by attenuating oxidant stress at reoxygenation.

  American journal of physiology. Heart and circulatory physiology 20020201

• Effect of an orally active Na+/H+ exchange inhibitor, SMP-300, on experimental angina and myocardial infarction models in rats.

  Journal of cardiovascular pharmacology 20020201

• Vasorelaxant properties of isolated human radial arteries: comparison with internal mammary arteries.

  Atherosclerosis 20020201

• [Anesthetic management of MIDCAB with high dose diltiazem].

  Masui. The Japanese journal of anesthesiology 20020201

• Loss of preconditioning by attenuated activation of myocardial ATP-sensitive potassium channels in elderly patients undergoing coronary angioplasty.

  Circulation 20020122

• [Possibility of gene-specific treatment for hereditary arrhythmic diseases].

  Nihon rinsho. Japanese journal of clinical medicine 20020101

• Clinical trials update: The Heart Protection Study, IONA, CARISA, ENRICHD, ACUTE, ALIVE, MADIT II and REMATCH. Impact Of Nicorandil on Angina. Combination Assessment of Ranolazine In Stable Angina. ENhancing Recovery In Coronary Heart Disease patients. Assessment of Cardioversion Using Transoesophageal Echocardiography. AzimiLide post-Infarct surVival Evaluation. Randomised Evaluation of Mechanical Assistance for Treatment of Chronic Heart failure.

  European journal of heart failure 20020101

• Synergistic effect of nicorandil and amlodipine on mitochondrial function during isoproterenol-induced myocardial infarction in rats.

  The Journal of pharmacy and pharmacology 20020101

• [Protective effect of nicorandil (ATP-sensitive potassium channel opener) on ischemic rabbit spinal cord].

  [Hokkaido igaku zasshi] The Hokkaido journal of medical science 20020101

• Effects of nicorandil on myocardial function and metabolism in the post-ischaemic reperfused heart with or without inhalation anaesthetics.

  Acta anaesthesiologica Scandinavica 20020101

• Highly protective effects of chronic oral administration of nicorandil on the heart of ageing rats.

  Clinical and experimental pharmacology & physiology 20020101

• Formulation optimization and stability study of transdermal therapeutic system of nicorandil.

  Pharmaceutical development and technology 20020101

• Arrhythmogenic peroxynitrite-induced alterations in mammalian heart contractility and its prevention with quercetin-filled liposomes.

  Cardiovascular toxicology 20020101

• Nicorandil reduced coronary events in stable angina.

  ACP journal club 20020101

• [The no-reflow phenomenon and its clinical significance].

  Kardiologiia 20020101

• Assessment of nicorandil therapy in ischemic myocardial injury by using contrast-enhanced and functional MR imaging.

  Radiology 20011201

• Involvement of potassium channels in spinal antinociceptions induced by fentanyl, clonidine and bethanechol in rats.

  Japanese journal of pharmacology 20011201

• Safety of oral nicorandil before coronary artery bypass graft surgery.

  British journal of anaesthesia 20011201

• [Mouth ulcers in patients receiving tacrolimus].

  Annales de dermatologie et de venereologie 20011201

• Cardiovascular news.

  Circulation 20011127

• Effects of administration of nicorandil or bimakalim prior to and during ischemia or reperfusion on survival rate, ischemia/reperfusion-induced arrhythmias and infarct size in anesthetized rabbits.

  Naunyn-Schmiedeberg's archives of pharmacology 20011101

• Effect of mild hypothermia on nicorandil-induced vasodilation of pial arterioles in cats.

  Critical care medicine 20011101

• Structural basis for the interference between nicorandil and sulfonylurea action.

  Diabetes 20011001

• The adenosine triphosphate-sensitive potassium channel opener nicorandil protects the ischemic rabbit spinal cord.

  The Journal of thoracic and cardiovascular surgery 20011001

• [Improvement in oxygenation by alpha stimulant].

  Masui. The Japanese journal of anesthesiology 20011001

• Nicorandil decreases postischemic actin oxidation.

  Free radical biology & medicine 20010901

• [Activation of ATP-sensitive K+ channels by ADP and K+ channel openers: homology model of sulfonylurea receptor carboxyl-termini].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20010901

• Ischemic preconditioning attenuates cardiac sympathetic nerve injury via ATP-sensitive potassium channels during myocardial ischemia.

  Circulation 20010828

• Nicorandil enhances cardiac endothelial nitric oxide synthase expression via activation of adenosine triphosphate-sensitive K channel in rat.

  Journal of cardiovascular pharmacology 20010801

• Combination of miglitol, an anti-diabetic drug, and nicorandil markedly reduces myocardial infarct size through opening the mitochondrial K(ATP) channels in rabbits.

  British journal of pharmacology 20010801

• Dual mechanism of action of nicorandil on rabbit corpus cavernosal smooth muscle tone.

  International journal of impotence research 20010801

• Assessment of ampulla (Takotsubo) cardiomyopathy with coronary angiography, two-dimensional echocardiography and 99mTc-tetrofosmin myocardial single photon emission computed tomography.

  Annals of nuclear medicine 20010801

• Controlled nicorandil administration for myocardial protection during coronary artery bypass grafting under cardiopulmonary bypass.

  Journal of cardiovascular pharmacology 20010701

• Ischemic preconditioning and nicorandil pretreatment improve donor heart preservation.

  Japanese circulation journal 20010701

• Nicorandil and oral ulceration.

  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20010701

• [Pharmaceutical evaluation of fast-disintegrant tablet containing nicorandil-loaded particles].

  Yao xue xue bao = Acta pharmaceutica Sinica 20010701

• Helicobacter pylori induces pepsinogen secretion by rat gastric cells in culture via a cAMP signal pathway.

  International journal of molecular medicine 20010601

• Trial to show the impact of nicorandil in angina (IONA): design, methodology, and management.

  Heart (British Cardiac Society) 20010601

• Nicorandil, a potent cardioprotective agent, reduces QT dispersion during coronary angioplasty.

  American heart journal 20010601

• Nicorandil, a hybrid between nitrate and ATP-sensitive potassium channel opener, preconditions human heart to ischemia during percutaneous transluminal coronary angioplasty.

  Japanese circulation journal 20010601

• ATP-Sensitive potassium channels modulate glucose transport in cultured human skeletal muscle cells.

  Endocrine journal 20010601

• The role of nicorandil in the treatment of myocardial ischaemia.

  Expert opinion on pharmacotherapy 20010501

• [The role of ischemic preconditioning in off-pump CABG: is it really necessary to accomplish scrupulous ischemic preconditioning?].

  Kyobu geka. The Japanese journal of thoracic surgery 20010401

• On the mechanism of the protective effects of nitroglycerin and nicorandil in cardiac anaphylaxis.

  Naunyn-Schmiedeberg's archives of pharmacology 20010401

• Nicorandil--induced ATP release in endothelial cells of rat caudal artery is associated with increase in intracellular Ca(2+).

  European journal of pharmacology 20010330

• The effect of K(atp)channel activation on myocardial cationic and energetic status during ischemia and reperfusion: role in cardioprotection.

  Journal of molecular and cellular cardiology 20010301

• Effects of KRN2391 on ionic currents in rabbit femoral arterial myocytes.

  British journal of pharmacology 20010301

• Inhibitory effects of nicorandil on rat mesangial cell proliferation via the protein kinase G pathway.

  Nephron 20010301

• Beneficial effects of nicorandil versus enalapril in chronic rheumatic severe mitral regurgitation: six months follow up echocardiographic study.

  The Journal of heart valve disease 20010301

• Dose-dependent prophylactic effect of nicorandil, an ATP-sensitive potassium channel opener, on intra-operative myocardial ischaemia in patients undergoing major abdominal surgery.

  British journal of anaesthesia 20010301

• Additive effects of nicorandil on coronary blood flow during continuous administration of nitroglycerin.

  Journal of the American College of Cardiology 20010301

• Acute effects of nicorandil on glucose tolerance in subjects with borderline fasting blood glucose levels.

  Wiener klinische Wochenschrift 20010215

• Therapeutic options for the management of patients with cardiac syndrome X.

  European heart journal 20010201

• Nicorandil can induce severe oral ulceration.

  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20010201

• Role of mitochondrial and sarcolemmal K(ATP) channels in ischemic preconditioning of the canine heart.

  American journal of physiology. Heart and circulatory physiology 20010101

• Nicorandil accelerates recovery of neuromuscular block caused by vecuronium.

  Canadian journal of anaesthesia = Journal canadien d'anesthesie 20010101

• [WHen interrogation permits appraisal of the mouth...].

  La Revue de medecine interne 20010101

• Major aphthous ulcers induced by nicorandil.

  Age and ageing 20010101

• No reflow phenomenon in coronary heart disease.

  Journal of cardiology 20010101

• Effects of nicorandil administration on survival rate and arrhythmias during reperfusion in anesthetized rabbits.

  Pharmacology 20010101

• Evaluation of the effects of nicorandil on experimentally induced gastric ulcers.

  Pharmacology 20010101

• Potassium channel openers in myocardial ischaemia: therapeutic potential of nicorandil.

  Drugs 20010101

• Lack of antagonism between nicorandil and sulfonylurea in stable angina pectoris.

  International journal of clinical pharmacology research 20010101

• Mechanisms of the effects of nicorandil in the isolated rat heart during ischemia and reperfusion: a 31P-nuclear magnetic resonance study.

  Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20010101

• Original method for nicorandil synthesis.

  Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20010101

• Hypotensive interaction of sildenafil and nicorandil in rats through the cGMP pathway but not by K(ATP) channel activation.

  Japanese journal of pharmacology 20001101

• Effects of intravenous nicorandil on coronary circulation in humans: plasma concentration and action mechanism.

  Journal of cardiovascular pharmacology 20000601

• Effects of nicorandil, a potassium channel opener, on idiopathic ventricular tachycardia.

  Journal of the American College of Cardiology 19981101

• Role of potassium channels in halothane-epinephrine arrhythmias.

  Research communications in molecular pathology and pharmacology 19980601

• Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel.

  The Journal of physiology 19970315

• Analysis of relaxation and repolarization mechanisms of nicorandil in rat mesenteric artery.

  British journal of pharmacology 19961201

• Effect of four potassium channel agonists on bupivacaine-induced toxicity in mice.

  Life sciences 19950101

• Effect of KRN2391, a novel vasodilator, on various experimental anginal models in rats.

  Japanese journal of pharmacology 19930901

• Protection by nicorandil against the dysfunction of the central vagal baroreflex system following transient global cerebral ischaemia in dogs.

  British journal of pharmacology 19930801

• Nicorandil. A review of its pharmacology and therapeutic efficacy in angina pectoris.

  Drugs 19921001

• Molecular mechanism of action of nicorandil.

  Journal of cardiovascular pharmacology 19920101

• Pharmacokinetic profile of nicorandil in humans: an overview.

  Journal of cardiovascular pharmacology 19920101