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From the Cover: Fenretinide, Troglitazone, and Elmiron Add to Weight of Evidence Support for Hemangiosarcoma Mode-of-Action From Studies in Mice.
Toxicological sciences : an official journal of the Society of Toxicology 20180101
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Glycogen synthase kinase 3 regulates cell death and survival signaling in tumor cells under redox stress.
Neoplasia (New York, N.Y.) 20140901
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Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4.
Bioorganic & medicinal chemistry letters 20140701
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Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters 20130801
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N-(4-hydroxyphenyl)retinamide promotes apoptosis of resting and proliferating B-cell chronic lymphocytic leukemia cells and potentiates fludarabine and ABT-737 cytotoxicity.
Leukemia 20121001
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N-(4-hydroxyphenyl)retinamide inhibits breast cancer cell invasion through suppressing NF-KB activation and inhibiting matrix metalloproteinase-9 expression.
Journal of cellular biochemistry 20120901
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Identification of mammalian target of rapamycin as a direct target of fenretinide both in vitro and in vivo.
Carcinogenesis 20120901
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BCDO2 acts as a carotenoid scavenger and gatekeeper for the mitochondrial apoptotic pathway.
Development (Cambridge, England) 20120815
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Novel micelles based on amphiphilic branched PEG as carriers for fenretinide.
Nanomedicine : nanotechnology, biology, and medicine 20120801
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Two protein kinase C isoforms, δ and ε, regulate energy homeostasis in mitochondria by transmitting opposing signals to the pyruvate dehydrogenase complex.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120801
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Identification of drug modulators targeting gene-dosage disease CMT1A.
ACS chemical biology 20120720
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Fenretinide cytotoxicity is independent of both constitutive and pharmacologically modulated glutathione levels in pediatric acute lymphoblastic leukemia cells cultured at hypoxia.
Pediatric blood & cancer 20120601
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Fenretinide prevents lipid-induced insulin resistance by blocking ceramide biosynthesis.
The Journal of biological chemistry 20120518
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Alterations in expression of specific microRNAs by combination of 4-HPR and EGCG inhibited growth of human malignant neuroblastoma cells.
Brain research 20120515
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Evaluation of a mucoadhesive fenretinide patch for local intraoral delivery: a strategy to reintroduce fenretinide for oral cancer chemoprevention.
Carcinogenesis 20120501
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Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma.
Bioorganic & medicinal chemistry 20120415
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Mucoadhesive fenretinide patches for site-specific chemoprevention of oral cancer: enhancement of oral mucosal permeation of fenretinide by coincorporation of propylene glycol and menthol.
Molecular pharmaceutics 20120402
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Combinatorial chemotherapeutic efficacy in non-Hodgkin lymphoma can be predicted by a signaling model of CD20 pharmacodynamics.
Cancer research 20120401
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Dihydroceramide accumulation and reactive oxygen species are distinct and nonessential events in 4-HPR-mediated leukemia cell death.
Biochemistry and cell biology = Biochimie et biologie cellulaire 20120401
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Combined treatment with fenretinide and indomethacin induces AIF-mediated, non-classical cell death in human acute T-cell leukemia Jurkat cells.
Biochemical and biophysical research communications 20120316
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Detection and characterisation of multi-drug resistance protein 1 (MRP-1) in human mitochondria.
British journal of cancer 20120313
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Enhanced anti-neuroblastoma activity of a fenretinide complexed form after intravenous administration.
The Journal of pharmacy and pharmacology 20120201
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[Chemoprevention of oral cancer--clinical and experimental studies].
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20120201
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Adiponectin: a risk biomarker and attractive target for chemoprevention.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120110
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Prognostic effect of circulating adiponectin in a randomized 2 x 2 trial of low-dose tamoxifen and fenretinide in premenopausal women at risk for breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120110
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The impact of retinoic acid treatment on the sensitivity of neuroblastoma cells to fenretinide.
Oncology reports 20120101
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The mechanism of fenretinide (4-HPR) inhibition of β-carotene monooxygenase 1. New suspect for the visual side effects of fenretinide.
Advances in experimental medicine and biology 20120101
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Fenretinide ameliorates insulin resistance and fatty liver in obese mice.
Biological & pharmaceutical bulletin 20120101
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Fenretinide (4-HPR): a preventive chance for women at genetic and familial risk?
Journal of biomedicine & biotechnology 20120101
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Tetrathiomolybdate sensitizes ovarian cancer cells to anticancer drugs doxorubicin, fenretinide, 5-fluorouracil and mitomycin C.
BMC cancer 20120101
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AF1q: a novel mediator of basal and 4-HPR-induced apoptosis in ovarian cancer cells.
PloS one 20120101
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Phase III double-blind, placebo-controlled, prospective randomized trial of adjuvant tamoxifen vs. tamoxifen and fenretinide in postmenopausal women with positive receptors (EB193): an intergroup trial coordinated by the Eastern Cooperative Oncology Group.
Medical oncology (Northwood, London, England) 20111201
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Preclinical evaluation of lestaurtinib (CEP-701) in combination with retinoids for neuroblastoma.
Cancer chemotherapy and pharmacology 20111201
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4-Hydroxybenzyl modification of the highly teratogenic retinoid, 4-[(1E)-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)-1-propen-1-yl]benzoic acid (TTNPB), yields a compound that induces apoptosis in breast cancer cells and shows reduced teratogenicity.
Chemical research in toxicology 20111121
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Receptor tyrosine kinase inhibitors and cytotoxic drugs affect pleural mesothelioma cell proliferation: insight into EGFR and ERK1/2 as antitumor targets.
Biochemical pharmacology 20111115
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Synergistic activity of fenretinide and the Bcl-2 family protein inhibitor ABT-737 against human neuroblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 20111115
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Synergistic efficacy of a novel combination therapy controls growth of Bcl-x(L) bountiful neuroblastoma cells by increasing differentiation and apoptosis.
Cancer biology & therapy 20111101
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Phase II study of oral capsular 4-hydroxyphenylretinamide (4-HPR/fenretinide) in pediatric patients with refractory or recurrent neuroblastoma: a report from the Children's Oncology Group.
Clinical cancer research : an official journal of the American Association for Cancer Research 20111101
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TMEM14A inhibits N-(4-hydroxyphenyl)retinamide-induced apoptosis through the stabilization of mitochondrial membrane potential.
Cancer letters 20111028
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Development and in vitro-in vivo evaluation of fenretinide-loaded oral mucoadhesive patches for site-specific chemoprevention of oral cancer.
Pharmaceutical research 20111001
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Promising effects of the 4HPR-BSO combination in neuroblastoma monolayers and spheroids.
Free radical biology & medicine 20110915
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Combination of N-(4-hydroxyphenyl) retinamide and apigenin suppressed starvation-induced autophagy and promoted apoptosis in malignant neuroblastoma cells.
Neuroscience letters 20110908
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Cytotoxic responses to N-(4-hydroxyphenyl)retinamide in human pancreatic cancer cells.
Cancer chemotherapy and pharmacology 20110801
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Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide.
The Journal of biological chemistry 20110715
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Fenretinide derivatives act as disrupters of interactions of serum retinol binding protein (sRBP) with transthyretin and the sRBP receptor.
Journal of medicinal chemistry 20110714
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Fenretinide metabolism in humans and mice: utilizing pharmacological modulation of its metabolic pathway to increase systemic exposure.
British journal of pharmacology 20110701
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Inhibition of acid ceramidase by a 2-substituted aminoethanol amide synergistically sensitizes prostate cancer cells to N-(4-hydroxyphenyl) retinamide.
The Prostate 20110701
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Preventive therapy for breast cancer: a consensus statement.
The Lancet. Oncology 20110501
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Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition.
Clinical cancer research : an official journal of the American Association for Cancer Research 20110415
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ERK1/2 deactivation enhances cytoplasmic Nur77 expression level and improves the apoptotic effect of fenretinide in human liver cancer cells.
Biochemical pharmacology 20110401
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Enrichment of Nur77 mediated by retinoic acid receptor β leads to apoptosis of human hepatocellular carcinoma cells induced by fenretinide and histone deacetylase inhibitors.
Hepatology (Baltimore, Md.) 20110301
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Phase I trial of fenretinide lym-x-sorb oral powder in adults with solid tumors and lymphomas.
Anticancer research 20110301
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Preferential involvement of both ROS and ceramide in fenretinide-induced apoptosis of HL60 rather than NB4 and U937 cells.
Biochemical and biophysical research communications 20110211
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Characterization of the metabolism of fenretinide by human liver microsomes, cytochrome P450 enzymes and UDP-glucuronosyltransferases.
British journal of pharmacology 20110201
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The expression of retinal cell markers in human retinal pigment epithelial cells and their augmentation by the synthetic retinoid fenretinide.
Molecular vision 20110101
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Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells.
BMC cancer 20110101
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Heterogeneous role of the glutathione antioxidant system in modulating the response of ESFT to fenretinide in normoxia and hypoxia.
PloS one 20110101
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The hydroxyl functional group of N-(4-hydroxyphenyl)retinamide mediates cellular uptake and cytotoxicity in premalignant and malignant human epithelial cells.
Free radical biology & medicine 20101215
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HIF-1α-dependent autophagy protects HeLa cells from fenretinide (4-HPR)-induced apoptosis in hypoxia.
Pharmacological research 20101101
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Survivin knockdown and concurrent 4-HPR treatment controlled human glioblastoma in vitro and in vivo.
Neuro-oncology 20101101
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Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry letters 20101101
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[Therapy approaches for geographic atrophy].
Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20101101
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Fenretinide-dependent upregulation of death receptors through ASK1 and p38α enhances death receptor ligand-induced cell death in Ewing's sarcoma family of tumours.
British journal of cancer 20101026
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A phase II study of fenretinide in patients with hormone refractory prostate cancer: a trial of the Cancer Therapeutics Research Group.
Cancer chemotherapy and pharmacology 20101001
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Relationship among pharmacokinetics and pharmacodynamics of fenretinide and plasma retinol reduction in neuroblastoma patients.
Cancer chemotherapy and pharmacology 20101001
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Targeting GRP78 to enhance melanoma cell death.
Pigment cell & melanoma research 20101001
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Development of PLGA-based injectable delivery systems for hydrophobic fenretinide.
Pharmaceutical research 20101001
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Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells.
The Journal of biological chemistry 20100917
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Targeting X-linked inhibitor of apoptosis protein to increase the efficacy of endoplasmic reticulum stress-induced apoptosis for melanoma therapy.
The Journal of investigative dermatology 20100901
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Decreased expression of insulin-like growth factor binding protein-5 during N-(4-hydroxyphenyl)retinamide-induced neuronal differentiation of ARPE-19 human retinal pigment epithelial cells: regulation by CCAAT/enhancer-binding protein.
Journal of cellular physiology 20100901
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Angioprevention with fenretinide: targeting angiogenesis in prevention and therapeutic strategies.
Critical reviews in oncology/hematology 20100701
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Sphingolipidomics of A2780 human ovarian carcinoma cells treated with synthetic retinoids.
Journal of lipid research 20100701
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Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis.
Free radical biology & medicine 20100701
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Sphingosine kinase mediates resistance to the synthetic retinoid N-(4-hydroxyphenyl)retinamide in human ovarian cancer cells.
The Journal of biological chemistry 20100611
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The peptidomimetic, 1-adamantyl-substituted, and flex-het classes of retinoid-derived molecules: structure-activity relationships and retinoid receptor-independent anticancer activities.
Mini reviews in medicinal chemistry 20100601
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Induction and intracellular localization of Nur77 dictate fenretinide-induced apoptosis of human liver cancer cells.
Biochemical pharmacology 20100401
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Fenretinide promotes functional recovery and tissue protection after spinal cord contusion injury in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100303
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Fenretinide induces mitochondrial ROS and inhibits the mitochondrial respiratory chain in neuroblastoma.
Cellular and molecular life sciences : CMLS 20100301
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Regulation of endoplasmic reticulum stress-induced cell death by ATF4 in neuroectodermal tumor cells.
The Journal of biological chemistry 20100226
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Oncology reports 20100201
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Zhonghua bing li xue za zhi = Chinese journal of pathology 20100201
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The binding of synthetic retinoids to lipocalin beta-lactoglobulins.
Journal of medicinal chemistry 20100114
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The chemopreventive retinoid 4HPR impairs prostate cancer cell migration and invasion by interfering with FAK/AKT/GSK3beta pathway and beta-catenin stability.
Molecular cancer 20100101
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Brg-1 mediates the constitutive and fenretinide-induced expression of SPARC in mammary carcinoma cells via its interaction with transcription factor Sp1.
Molecular cancer 20100101
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MicroRNA expression in human retinal pigment epithelial (ARPE-19) cells: increased expression of microRNA-9 by N-(4-hydroxyphenyl)retinamide.
Molecular vision 20100101
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4-oxo-N-(4-hydroxyphenyl)retinamide: two independent ways to kill cancer cells.
PloS one 20100101
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Fenretinide-associated multilayered retinal hemorrhage in a patient with hairy cell leukemia.
Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye 20100101
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Phase II trial of fenretinide (NSC 374551) in patients with recurrent small cell lung cancer.
Investigational new drugs 20091201
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Langerhans cell histiocytosis in a patient with stage 4 neuroblastoma receiving oral fenretinide.
Pediatric blood & cancer 20091201
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American journal of physiology. Endocrinology and metabolism 20091201
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Antimitotic effect of the retinoid 4-oxo-fenretinide through inhibition of tubulin polymerization: a novel mechanism of retinoid growth-inhibitory activity.
Molecular cancer therapeutics 20091201
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Fenretinide inhibits myeloma cell growth, osteoclastogenesis and osteoclast viability.
Cancer letters 20091101
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N-Myc down regulation induced differentiation, early cell cycle exit, and apoptosis in human malignant neuroblastoma cells having wild type or mutant p53.
Biochemical pharmacology 20091101
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Improvement of aqueous solubility of fenretinide and other hydrophobic anti-tumor drugs by complexation with amphiphilic dextrins.
Drug delivery 20091001
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American Society of Clinical Oncology clinical practice guideline update on the use of pharmacologic interventions including tamoxifen, raloxifene, and aromatase inhibition for breast cancer risk reduction.
Gynecologic oncology 20091001
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nature chemical biology 20091001
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ROS-driven Akt dephosphorylation at Ser-473 is involved in 4-HPR-mediated apoptosis in NB4 cells.
Free radical biology & medicine 20090901
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Surrogate response biomarkers in prevention research: do they point the way or lead us astray?
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090810
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Randomized double-blind 2 x 2 trial of low-dose tamoxifen and fenretinide for breast cancer prevention in high-risk premenopausal women.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090810
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Cystic fibrosis fatty acid imbalance is linked to ceramide deficiency and corrected by fenretinide.
American journal of respiratory cell and molecular biology 20090701
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Selective apoptosis induction by the cancer chemopreventive agent N-(4-hydroxyphenyl)retinamide is achieved by modulating mitochondrial bioenergetics in premalignant and malignant human prostate epithelial cells.
Apoptosis : an international journal on programmed cell death 20090701
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Enhanced in vivo antitumor efficacy of fenretinide encapsulated in polymeric micelles.
International journal of pharmaceutics 20090521
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Brain research 20090501
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Carcinogenesis 20090501
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Identification of ADP-ribosylation factor 4 as a suppressor of N-(4-hydroxyphenyl)retinamide-induced cell death.
Cancer letters 20090408
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Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20090401
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Comment re: continuous rather than intermittent administration of fenretinide in leukoplakia.
Cancer prevention research (Philadelphia, Pa.) 20090301
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Combining the endoplasmic reticulum stress-inducing agents bortezomib and fenretinide as a novel therapeutic strategy for metastatic melanoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 20090215
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Clinical cancer research : an official journal of the American Association for Cancer Research 20090215
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Application of an allosteric model to describe the interactions among retinol binding protein 4, transthyretin, and small molecule retinol binding protein 4 ligands.
Analytical biochemistry 20090115
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Plasma retinol and prognosis of postmenopausal breast cancer patients.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20090101
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Cyclin D1 and cancer development in laryngeal premalignancy patients.
Cancer prevention research (Philadelphia, Pa.) 20090101
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High-dose fenretinide in oral leukoplakia.
Cancer prevention research (Philadelphia, Pa.) 20090101
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Anti-angiogenic properties of chemopreventive drugs: fenretinide as a prototype.
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 20090101
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Oral fenretinide in biochemically recurrent prostate cancer: a California cancer consortium phase II trial.
Clinical genitourinary cancer 20090101
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Fenretinide-induced caspase-8 activation and apoptosis in an established model of metastatic neuroblastoma.
BMC cancer 20090101
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Converting redox signaling to apoptotic activities by stress-responsive regulators HSF1 and NRF2 in fenretinide treated cancer cells.
PloS one 20090101
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Liposome-mediated therapy of neuroblastoma.
Methods in enzymology 20090101
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N-(4-hydroxyphenyl)all-trans-retinamide (4-HPR) high dose effect on DMBA-induced hamster oral cancer: a histomorphometric evaluation.
International journal of oral and maxillofacial surgery 20081201
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Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine alpha-hydroxylating monooxygenase (PHM).
Bioorganic & medicinal chemistry 20081201
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Effect of fenretinide and low-dose tamoxifen on insulin sensitivity in premenopausal women at high risk for breast cancer.
Cancer research 20081115
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Documenta ophthalmologica. Advances in ophthalmology 20081101
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Manipulation of oxidative stress to induce cell death in Ewing's sarcoma family of tumours.
European journal of cancer (Oxford, England : 1990) 20081001
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Pharmacokinetics of oral fenretinide in neuroblastoma patients: indications for optimal dose and dosing schedule also with respect to the active metabolite 4-oxo-fenretinide.
Cancer chemotherapy and pharmacology 20080901
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Selected natural and synthetic retinoids impair CCR7- and CXCR4-dependent cell migration in vitro and in vivo.
Journal of leukocyte biology 20080901
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N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing.
Molecular cancer therapeutics 20080901
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N-(4-Hydroxyphenyl) retinamide induced both differentiation and apoptosis in human glioblastoma T98G and U87MG cells.
Brain research 20080828
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Identification of cytochrome c oxidase subunit 6A1 as a suppressor of Bax-induced cell death by yeast-based functional screening.
Biochemical and biophysical research communications 20080815
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Design, synthesis of novel peptidomimetic derivatives of 4-HPR for rhabdoid tumors.
Bioorganic & medicinal chemistry letters 20080715
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Mitogen-activated protein kinase pathway mediates N-(4-hydroxyphenyl)retinamide-induced neuronal differentiation in the ARPE-19 human retinal pigment epithelial cell line.
Journal of neurochemistry 20080701
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Design and synthesis of 4-HPR derivatives for rhabdoid tumors.
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Increasing melanoma cell death using inhibitors of protein disulfide isomerases to abrogate survival responses to endoplasmic reticulum stress.
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Leukemia 20080601
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Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 20080501
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Autophagy 20080501
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Experimental cell research 20080501
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International journal of oncology 20080501
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Journal of the National Cancer Institute 20080416
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N-(4-Hydroxyphenyl)retinamide induced differentiation with repression of telomerase and cell cycle to increase interferon-gamma sensitivity for apoptosis in human glioblastoma cells.
Cancer letters 20080308
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Inhibition of N-(4-hydroxyphenyl)retinamide-induced autophagy at a lower dose enhances cell death in malignant glioma cells.
Carcinogenesis 20080301
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The Journal of steroid biochemistry and molecular biology 20080301
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N-(4-hydroxyphenyl) retinamide augments laser-induced choroidal neovascularization in mice.
Investigative ophthalmology & visual science 20080301
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Oncogene 20080207
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Breast (Edinburgh, Scotland) 20080201
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International journal of cancer 20080201
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A rapid, sensitive and selective liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry method for determination of fenretinide (4-HPR) in plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080201
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Neurochemical research 20080101
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Fenretinide corrects newly found ceramide deficiency in cystic fibrosis.
American journal of respiratory cell and molecular biology 20080101
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Clinical cancer research : an official journal of the American Association for Cancer Research 20080101
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Phase III prevention trial of fenretinide in patients with resected non-muscle-invasive bladder cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 20080101
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BMC immunology 20080101
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Antitumor activity of 4-(N-hydroxyphenyl)retinamide conjugated with poly(L-glutamic acid) against ovarian cancer xenografts.
Gynecologic oncology 20071201
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Flow cytometry analysis of single-strand DNA damage in neuroblastoma cell lines using the F7-26 monoclonal antibody.
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Oncogene 20071004
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Biomacromolecules 20071001
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Oncogene 20070607
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Investigational new drugs 20070601
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Cancer biology & therapy 20070501
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Free radical research 20070501
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Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20070501
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Novel retinoic acid metabolism blocking agents have potent inhibitory activities on human breast cancer cells and tumour growth.
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Expert review of anticancer therapy 20070401
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Apoptosis : an international journal on programmed cell death 20070301
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International journal of oncology 20070301
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A fluorescence microplate cytotoxicity assay with a 4-log dynamic range that identifies synergistic drug combinations.
Molecular cancer therapeutics 20070301
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Central European journal of public health 20070301
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Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines.
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Bioorganic & medicinal chemistry letters 20070201
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Leukemia 20070201
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Nature clinical practice. Oncology 20070201
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Frontiers in bioscience : a journal and virtual library 20070101
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Anti-cancer drugs 20070101
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Understanding interactions between and among apoptosis inducing pathways in tumor cells.
In vivo (Athens, Greece) 20070101
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BMC cancer 20070101
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International journal of cancer 20061215
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A generalized response surface model with varying relative potency for assessing drug interaction.
Biometrics 20061201
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Inhibition of IL-8 release from CFTR-deficient lung epithelial cells following pre-treatment with fenretinide.
International immunopharmacology 20061101
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Amphiphilic poly(vinyl alcohol) derivatives as complexing agents for fenretinide.
Biomacromolecules 20061101
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Fenretinide-induced neuronal differentiation of ARPE-19 human retinal pigment epithelial cells is associated with the differential expression of Hsp70, 14-3-3, pax-6, tubulin beta-III, NSE, and bag-1 proteins.
Molecular vision 20061101
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Structural relaxation made simple.
Physical review letters 20061027
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Hypoxia-mediated fenretinide (4-HPR) resistance in childhood acute lymphoblastic leukemia cells.
Cancer chemotherapy and pharmacology 20061001
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Regulation of lipocalin-2 gene by the cancer chemopreventive retinoid 4-HPR.
International journal of cancer 20061001
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Mechanism of 4-HPR-induced apoptosis in glioma cells: evidences suggesting role of mitochondrial-mediated pathway and endoplasmic reticulum stress.
Carcinogenesis 20061001
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Mechanisms of fenretinide-induced apoptosis.
Apoptosis : an international journal on programmed cell death 20061001
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Involvement of mitochondrial and Akt signaling pathways in augmented apoptosis induced by a combination of low doses of celecoxib and N-(4-hydroxyphenyl) retinamide in premalignant human bronchial epithelial cells.
Cancer research 20061001
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A phase I-II preoperative biomarker trial of fenretinide in ascitic ovarian cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20061001
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4-HPR modulates gene expression in ovarian cells.
International journal of cancer 20060901
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Comparing the effect of ATRA, 4-HPR, and CD437 in bladder cancer cells.
Frontiers in bioscience : a journal and virtual library 20060901
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Intravesical N-(4-hydroxyphenyl) retinamide and adriamycin induces apoptosis in bladder cancer.
Frontiers in bioscience : a journal and virtual library 20060901
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Microplate screening assay for binding of ligands to bovine or reindeer beta-lactoglobulins.
Journal of biochemical and biophysical methods 20060831
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Quality of life assessment in a chemoprevention trial: fenretinide and oral or transdermal HRT.
Maturitas 20060820
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N-all-trans-retinoyl-L-proline inhibits metastatic potential of hepatocellular carcinoma cells.
Cell biology international 20060801
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Phase I trial of oral fenretinide in children with high-risk solid tumors: a report from the Children's Oncology Group (CCG 09709).
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060720
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Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma cells.
Toxicological sciences : an official journal of the Society of Toxicology 20060701
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Fifteen-year results of a randomized phase III trial of fenretinide to prevent second breast cancer.
Annals of oncology : official journal of the European Society for Medical Oncology 20060701
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Fenretinide in the prevention of breast cancer in premenopausal women: fluke or fact?
Annals of oncology : official journal of the European Society for Medical Oncology 20060701
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Fenretinide activity in retinoid-resistant oral leukoplakia.
Clinical cancer research : an official journal of the American Association for Cancer Research 20060515
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N-(4-hydroxyphenyl)retinamide-induced apoptosis triggered by reactive oxygen species is mediated by activation of MAPKs in head and neck squamous carcinoma cells.
Oncogene 20060504
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Synthesis and preliminary chemotherapeutic evaluation of the fully C-linked glucuronide of N-(4-hydroxyphenyl)retinamide.
Bioorganic & medicinal chemistry 20060501
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Statistical analysis of combined dose effects for experiments with two agents.
Artificial intelligence in medicine 20060501
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Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
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Overexpression of RARgamma increases death of SH-SY5Y neuroblastoma cells in response to retinoic acid but not fenretinide.
Cell death and differentiation 20060401
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4-oxo-fenretinide, a recently identified fenretinide metabolite, induces marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitive and fenretinide-resistant cell lines.
Cancer research 20060315
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N-(4-Hydroxyphenyl)retinamide and nitric oxide pro-drugs exhibit apoptotic and anti-invasive effects against bone metastatic breast cancer cells.
Carcinogenesis 20060301
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Clinical trials with retinoids for breast cancer chemoprevention.
Endocrine-related cancer 20060301
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The CLN9 protein, a regulator of dihydroceramide synthase.
The Journal of biological chemistry 20060203
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Targeting cyclin D1, a downstream effector of INI1/hSNF5, in rhabdoid tumors.
Oncogene 20060202
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Fenretinide inhibits HIV infection by promoting viral endocytosis.
Antiviral research 20060201
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Chemoprevention of skin carcinogenesis by phenylretinamides: retinoid receptor-independent tumor suppression.
Clinical cancer research : an official journal of the American Association for Cancer Research 20060201
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Anticancer effects of fenretinide in human medulloblastoma.
Cancer letters 20060118
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Preliminary results on safety and activity of a randomized, double-blind, 2 x 2 trial of low-dose tamoxifen and fenretinide for breast cancer prevention in premenopausal women.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060101
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Cholecalciferol (vitamin D3) and the retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) are synergistic for chemoprevention of prostate cancer.
Journal of experimental therapeutics & oncology 20060101
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A phase I clinical and pharmacokinetic study of fenretinide combined with paclitaxel and cisplatin for refractory solid tumors.
Investigational new drugs 20051201
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BBC3 mediates fenretinide-induced cell death in neuroblastoma.
Oncogene 20051201
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Cervical chromosome 9 polysomy: validation and use as a surrogate endpoint biomarker in a 4-HPR chemoprevention trial.
Gynecologic oncology 20051201
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Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of lipofuscin-based retinal diseases.
Investigative ophthalmology & visual science 20051201
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[Mechanisms of fenretinide-triggered apoptosis in leukemic cells].
Zhongguo shi yan xue ye xue za zhi 20051201
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Human T-cell lymphotropic virus type I-transformed T-cells have a partial defect in ceramide synthesis in response to N-(4-hydroxyphenyl)retinamide.
The Biochemical journal 20051115
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Cyclooxygenase-2 protein reduces tamoxifen and N-(4-hydroxyphenyl)retinamide inhibitory effects in breast cancer cells.
Laboratory investigation; a journal of technical methods and pathology 20051101
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PPAR activation and decreased proliferation in oral carcinoma cells with 4-HPR.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20051101
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The role of gangliosides in fenretinide-induced apoptosis of neuroblastoma.
Cancer letters 20051018
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N-(4-hydroxyphenyl)retinamide inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of I(kappa)B(alpha) kinase and nuclear factor-kappaB-regulated gene products.
Cancer research 20051015
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Inhibitory effects of N-(4-hydrophenyl) retinamide on liver cancer and malignant melanoma cells.
World journal of gastroenterology 20051007
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Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists.
Investigational new drugs 20051001
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Increased level of the p67phox subunit of NADPH oxidase by 4HPR in head and neck squamous carcinoma cells.
International journal of oncology 20050901
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Retinamide-induced apoptosis in glioblastomas is associated with down-regulation of Bcl-xL and Bcl-2 proteins.
Journal of neuro-oncology 20050901
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IB1/JIP-1 controls JNK activation and increased during prostatic LNCaP cells neuroendocrine differentiation.
Cellular signalling 20050801
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In vitro model of normal, immortalized ovarian surface epithelial and ovarian cancer cells for chemoprevention of ovarian cancer.
Gynecologic oncology 20050801
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Sensitivity to DNA damage is a common component of hormone-based strategies for protection of the mammary gland.
Molecular cancer research : MCR 20050801
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Could the combination of celecoxib and 4HPR be an effective lung cancer treatment?
Cancer biology & therapy 20050801
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Randomized trial of fenretinide (4-HPR) to prevent recurrences, new localizations and carcinomas in patients operated on for oral leukoplakia: long-term results.
International journal of cancer 20050701
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ROS mediates 4HPR-induced posttranscriptional expression of the Gadd153 gene.
Free radical biology & medicine 20050615
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The transforming growth factor-beta family members bone morphogenetic protein-2 and macrophage inhibitory cytokine-1 as mediators of the antiangiogenic activity of N-(4-hydroxyphenyl)retinamide.
Clinical cancer research : an official journal of the American Association for Cancer Research 20050615
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Fenretinide: a p53-independent way to kill cancer cells.
Biochemical and biophysical research communications 20050610
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[The role of reactive oxygen species in N-[4-hydroxyphenyl] retinamide induced apoptosis in bladder cancer cell lineT24].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20050601
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N-(4-Hydroxyphenyl)retinamide is more potent than other phenylretinamides in inhibiting the growth of BRCA1-mutated breast cancer cells.
Carcinogenesis 20050501
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The NF-kappaB pathway mediates fenretinide-induced apoptosis in SH-SY5Y neuroblastoma cells.
Apoptosis : an international journal on programmed cell death 20050501
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p38MAPK-Dependent sensitivity of Ewing's sarcoma family of tumors to fenretinide-induced cell death.
Clinical cancer research : an official journal of the American Association for Cancer Research 20050415
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Identification of the genes involved in enhanced fenretinide-induced apoptosis by parthenolide in human hepatoma cells.
Cancer research 20050401
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Enhanced growth inhibition and apoptosis induction in NSCLC cell lines by combination of celecoxib and 4HPR at clinically relevant concentrations.
Cancer biology & therapy 20050401
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Expression of gastrointestinal glutathione peroxidase is inversely correlated to the presence of hepatitis C virus subgenomic RNA in human liver cells.
The Journal of biological chemistry 20050311
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Regulation of ultraviolet B radiation-mediated activation of AP1 signaling by retinoids in primary keratinocytes.
Radiation research 20050301
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Phase II trial of fenretinide in advanced renal carcinoma.
Investigational new drugs 20050301
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Effect of the synthetic retinoid fenretinide on circulating free prostate-specific antigen, insulin-like growth factor-I, and insulin-like growth factor binding protein-3 levels in men with superficial bladder cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 20050301
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Induction of apoptosis in primary meningioma cultures by fenretinide.
Cancer research 20050215
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Chemopreventive N-(4-hydroxyphenyl)retinamide (fenretinide) targets deregulated NF-{kappa}B and Mat1A genes in the early stages of rat liver carcinogenesis.
Carcinogenesis 20050201
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Aromatase inhibition by 15-deoxy-prostaglandin J(2) (15-dPGJ(2)) and N-(4-hydroxyphenyl)-retinamide (4HPR) is associated with enhanced ceramide production.
The Journal of steroid biochemistry and molecular biology 20050201
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Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis.
Oncogene 20050120
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Endogenous fluorescence spectroscopy of cell suspensions for chemopreventive drug monitoring.
Photochemistry and photobiology 20050101
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Action of fenretinide (4-HPR) on ovarian cancer and endothelial cells.
Anticancer research 20050101
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Inhibition of mammary tumor growth by a novel nontoxic retinoid: chemotherapeutic evaluation of a C-linked analog of 4-HPR-glucuronide.
Anticancer research 20050101
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Intracellular glutathione levels determine cell sensitivity to apoptosis induced by the antineoplasic agent N-(4-hydroxyphenyl) retinamide.
Anticancer research 20050101
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Different ways to induce apoptosis by fenretinide and all-trans-retinoic acid in human B lymphoma cells.
Anticancer research 20050101
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Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice.
Journal of medicinal chemistry 20041230
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Molecular mechanisms of fenretinide-induced apoptosis of neuroblastoma cells.
Annals of the New York Academy of Sciences 20041201
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Fenretinide stimulates redox-sensitive ceramide production in breast cancer cells: potential role in drug-induced cytotoxicity.
British journal of cancer 20041115
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Fenretinide induces sustained-activation of JNK/p38 MAPK and apoptosis in a reactive oxygen species-dependent manner in neuroblastoma cells.
International journal of cancer 20041101
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Phase II study of fenretinide (NSC 374551) in adults with recurrent malignant gliomas: A North American Brain Tumor Consortium study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20041101
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Breast cancer progression in MCF10A series of cell lines is associated with alterations in retinoic acid and retinoid X receptors and with differential response to retinoids.
International journal of oncology 20041001
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Synergistic growth-inhibitory effects of fenretinide with either cisplatin or paclitaxel on human epithelial ovarian cancer cell line (SKOV-3).
Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20041001
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Identification of the fenretinide metabolite 4-oxo-fenretinide present in human plasma and formed in human ovarian carcinoma cells through induction of cytochrome P450 26A1.
Clinical cancer research : an official journal of the American Association for Cancer Research 20040915
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Liquid chromatography method for quantifying N-(4-hydroxyphenyl)retinamide and N-(4-methoxyphenyl)retinamide in tissues.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040905
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Fenretinide activates a distinct apoptotic pathway.
Journal of the National Cancer Institute 20040901
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Gangliosides link the acidic sphingomyelinase-mediated induction of ceramide to 12-lipoxygenase-dependent apoptosis of neuroblastoma in response to fenretinide.
Journal of the National Cancer Institute 20040901
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Fenretinide cytotoxicity for Ewing's sarcoma and primitive neuroectodermal tumor cell lines is decreased by hypoxia and synergistically enhanced by ceramide modulators.
Cancer research 20040801
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Quantitative histopathology and chromosome 9 polysomy in a clinical trial of 4-HPR.
Gynecologic oncology 20040801
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A two-by-two factorial trial comparing oral with transdermal estrogen therapy and fenretinide with placebo on breast cancer biomarkers.
Clinical cancer research : an official journal of the American Association for Cancer Research 20040701
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Synthetic retinoids as inducers of apoptosis in ovarian carcinoma cell lines.
Journal of cellular physiology 20040601
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How retinoids regulate breast cancer cell proliferation and apoptosis.
Cellular and molecular life sciences : CMLS 20040601
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Fenretinide enhances rituximab-induced cytotoxicity against B-cell lymphoma xenografts through a caspase-dependent mechanism.
Blood 20040501
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N-(4-hydroxyphenyl) retinamide (4HPR) enhances TRAIL-mediated apoptosis through enhancement of a mitochondrial-dependent amplification loop in ovarian cancer cell lines.
Cell death and differentiation 20040501
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Stage-specific effect of N-(4-hydroxyphenyl)retinamide on cell growth in squamous cell carcinogenesis.
Molecular carcinogenesis 20040501
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Synthesis and biological activity of novel retinamide and retinoate derivatives.
Chemical & pharmaceutical bulletin 20040501
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[Recent advances in neuroblastoma research].
Seikagaku. The Journal of Japanese Biochemical Society 20040501
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Nuclear retinoid receptors are involved in N-(4-hydroxyphenyl) retinamide (Fenretinide)-induced gene expression and growth inhibition in HL-60 acute myeloid leukemia cells.
Leukemia & lymphoma 20040501
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Inhibition of N-(4-hydroxyphenyl)retinamide-induced apoptosis in breast cancer cells by galectin-3.
Cancer biology & therapy 20040501
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Re: Lanvers C et al. Pharmacology of all-trans-retinoic acid in children with acute promyelocytic leukemia. Med Pediatr Oncol 2003;40:293-301.
Pediatric blood & cancer 20040401
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Identification of retinoid-modulated proteins in squamous carcinoma cells using high-throughput immunoblotting.
Cancer research 20040401
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Involvement of c-Fos in fenretinide-induced apoptosis in human ovarian carcinoma cells.
Cell death and differentiation 20040301
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N-(4-hydroxyphenyl)retinamide induces growth arrest and apoptosis in HTLV-I-transformed cells.
Leukemia 20040301
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Potent effect of 5-HPBR, a butanoate derivative of 4-HPR, on cell growth and apoptosis in cancer cells.
International journal of cancer 20040301
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The chemopreventive agents 4-HPR and DFMO inhibit growth and induce apoptosis in uterine leiomyomas.
American journal of obstetrics and gynecology 20040301
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Cyclooxygenase-2 is essential for HER2/neu to suppress N- (4-hydroxyphenyl)retinamide apoptotic effects in breast cancer cells.
Cancer research 20040215
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Synthesis of flexible sulfur-containing heteroarotinoids that induce apoptosis and reactive oxygen species with discrimination between malignant and benign cells.
Journal of medicinal chemistry 20040212
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Efficacy of 9-cis-retinoic acid and N-(4-hydroxyphenyl) retinamide alone and in combination in mammary cancer prevention.
Oncology reports 20040201
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Progress in chemoprevention of breast cancer.
Critical reviews in oncology/hematology 20040201
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Antisense BAG-1 sensitizes HeLa cells to apoptosis by multiple pathways.
Biochemical and biophysical research communications 20031219
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Growth and DNA damage-inducible transcription factor 153 mediates apoptosis in response to fenretinide but not synergy between fenretinide and chemotherapeutic drugs in neuroblastoma.
Molecular pharmacology 20031201
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Heterogeneous role of caspase-8 in fenretinide-induced apoptosis in epithelial ovarian carcinoma cell lines.
Molecular pharmacology 20031201
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Pharmacological prevention of breast cancer: quo vadis?
Breast (Edinburgh, Scotland) 20031201
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Inhibition of Kaposi's sarcoma in vivo by fenretinide.
Clinical cancer research : an official journal of the American Association for Cancer Research 20031201
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[Inhibitory effects on hepatocarcinoma and B16 melanoma cells by N-(4-hydrophenyl) retinamide].
Shi yan sheng wu xue bao 20031201
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Hydrolysis of 4-HPR to atRA occurs in vivo but is not required for retinamide-induced apoptosis.
Archives of biochemistry and biophysics 20031115
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Fenretinide: a prototype cancer prevention drug.
Expert opinion on investigational drugs 20031101
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Bak: a downstream mediator of fenretinide-induced apoptosis of SH-SY5Y neuroblastoma cells.
Cancer research 20031101
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All-trans retinoic acid- and N-(4-hydroxyphenil)-retinamide-induced growth arrest and apoptosis in orbital fibroblasts in Graves' disease.
Metabolism: clinical and experimental 20031101
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Relationships between plasma insulin-like growth factor-I and insulin-like growth factor binding protein-3 and second breast cancer risk in a prevention trial of fenretinide.
Clinical cancer research : an official journal of the American Association for Cancer Research 20031015
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HER2/neu reduces the apoptotic effects of N-(4-hydroxyphenyl)retinamide (4-HPR) in breast cancer cells by decreasing nitric oxide production.
Oncogene 20031002
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Retinoid receptor-dependent and independent biological activities of novel fenretinide analogues and metabolites.
Clinical cancer research : an official journal of the American Association for Cancer Research 20031001
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N-(4-Hydroxyphenyl)retinamide (4-HPR) induces leukemia cell death via generation of reactive oxygen species.
International journal of hematology 20031001
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The chemopreventive agent N-(4-hydroxyphenyl)retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl-2 family.
Oncogene 20030918
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Transcriptional regulation of the human transferrin gene by GADD153 in hepatoma cells.
Hepatology (Baltimore, Md.) 20030901
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Enhanced effectiveness of last generation antiblastic compounds vs. cisplatin on malignant pleural mesothelioma cell lines.
European journal of pharmacology 20030725
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Immunoliposomal fenretinide: a novel antitumoral drug for human neuroblastoma.
Cancer letters 20030718
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Induction of GADD153 and Bak: novel molecular targets of fenretinide-induced apoptosis of neuroblastoma.
Cancer letters 20030718
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Fenretinide as an anti-angiogenic agent in neuroblastoma.
Cancer letters 20030718
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Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells.
Cancer research 20030715
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Fenretinide induces cytochrome c release, caspase 9 activation and apoptosis in the absence of mitochondrial membrane depolarisation.
Cell death and differentiation 20030701
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Effects on M5076-hepatic metastasis of retinoic acid and N-(4-hydroxyphenyl) retinamide, fenretinide entrapped in SG-liposomes.
Biological & pharmaceutical bulletin 20030701
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Breast tissue accumulation of retinamides in a randomized short-term study of fenretinide.
Clinical cancer research : an official journal of the American Association for Cancer Research 20030701
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Mechanisms of free-radical induction in relation to fenretinide-induced apoptosis of neuroblastoma.
Journal of cellular biochemistry 20030701
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Phase I trial and pharmacokinetics of fenretinide in children with neuroblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 20030601
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Comparison of the mechanism of induction of apoptosis in ovarian carcinoma cells by the conformationally restricted synthetic retinoids CD437 and 4-HPR.
Journal of cellular biochemistry 20030515
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In vitro and in vivo antitumor activity of liposomal Fenretinide targeted to human neuroblastoma.
International journal of cancer 20030501
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Increasing intracellular ceramide: an approach that enhances the cytotoxic response in prostate cancer cells.
Urology 20030501
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Cyclin d1 overexpression sensitizes breast cancer cells to fenretinide.
Clinical cancer research : an official journal of the American Association for Cancer Research 20030501
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[Breakthrough in breast cancer chemoprevention].
Orvosi hetilap 20030330
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N-(4-Hydroxylphenyl)retinamide (fenretinide, 4-HPR), a retinoid compound with antileukemic and proapoptotic activity in acute lymphoblastic leukemia (ALL).
Leukemia research 20030301
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Differentiation of human retinal pigment epithelial cells into neuronal phenotype by N-(4-hydroxyphenyl)retinamide.
Journal of neurochemistry 20030301
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N-(4-hydroxyphenyl)retinamide inhibits retinoblastoma growth through reactive oxygen species-mediated cell death.
Molecular pharmacology 20030301
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Requirement of c-jun for testosterone-induced sensitization to N-(4-hydroxyphenyl)retinamide-induced apoptosis.
Molecular carcinogenesis 20030301
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Breast cancer chemoprevention: additional observations.
International journal of clinical practice 20030301
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Altered sphingolipid metabolism in N-(4-hydroxyphenyl)-retinamide-resistant A2780 human ovarian carcinoma cells.
The Journal of biological chemistry 20030221
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Retinoic acid receptor beta and telomerase catalytic subunit expression in bronchial epithelium of heavy smokers.
Journal of the National Cancer Institute 20030115
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Effect of 4-hydroxyphenylretinamide on human cervical epithelial and cancer cell lines.
Journal of the Society for Gynecologic Investigation 20030101
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Fenretinide breast cancer prevention trial: drug and retinol plasma levels in relation to age and disease outcome.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20030101
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Specific keynote: chemoprevention of ovarian cancer: the journey begins.
Gynecologic oncology 20030101
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Antiangiogenic activity of chemopreventive drugs.
The International journal of biological markers 20030101
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Induction of apoptosis by fenretinide in tumor cell lines correlates with DLX2, DLX3 and DLX4 gene expression.
Oncology reports 20030101
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Evaluation of anti-tumour effects of oral fenretinide (4-HPR) in rats with human neuroblastoma xenografts.
Oncology reports 20030101
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Breast cancer prevention trials using retinoids.
Journal of mammary gland biology and neoplasia 20030101
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Ceramide signaling in fenretinide-induced endothelial cell apoptosis.
The Journal of biological chemistry 20021220
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Elucidation of molecular events mediating induction of apoptosis by synthetic retinoids using a CD437-resistant ovarian carcinoma cell line.
The Journal of biological chemistry 20021122
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Upregulation of GADD153 expression in the apoptotic signaling of N-(4-hydroxyphenyl)retinamide (4HPR).
International journal of cancer 20021101
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Contributions of mitogen-activated protein kinase and nuclear factor kappa B to N-(4-hydroxyphenyl)retinamide-induced apoptosis in prostate cancer cells.
Molecular carcinogenesis 20021101
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Biological activity of p-methylaminophenol, an essential structural component of N-(4-hydroxyphenyl)retinamide, fenretinide.
Journal of biochemistry 20021101
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GADD153-mediated anticancer effects of N-(4-hydroxyphenyl)retinamide on human hepatoma cells.
The Journal of biological chemistry 20021011
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A novel mechanism by which N-(4-hydroxyphenyl)retinamide inhibits breast cancer cell growth: the production of nitric oxide.
Molecular cancer therapeutics 20021001
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Cyclosporin A enhances the apoptotic effects of N-(4-hydroxyphenyl)retinamide in breast cancer cells.
International journal of cancer 20020920
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GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma.
Cancer research 20020915
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9-cis-retinoic acid but not 4-(hydroxyphenyl)retinamide inhibits prostate intraepithelial neoplasia in Noble rats.
Cancer research 20020915
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Distinct patterns of mitochondrial changes precede induction of apoptosis by all-trans-retinoic acid and N-(4-hydroxyphenyl)retinamide in MCF7 breast cancer cells.
Experimental cell research 20020910
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Effect of transdermal estradiol and oral conjugated estrogen on C-reactive protein in retinoid-placebo trial in healthy women.
Circulation 20020903
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An improved synthesis of the C-linked glucuronide of N-(4-hydroxyphenyl)retinamide.
Bioorganic & medicinal chemistry letters 20020902
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Phase II clinical trial of N-(4-Hydroxyphenyl)retinamide and tamoxifen administration before definitive surgery for breast neoplasia.
Clinical cancer research : an official journal of the American Association for Cancer Research 20020901
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Is growth inhibition and induction of apoptosis in lung cancer cell lines by fenretinide [N-(4-hydroxyphenyl)retinamide] sufficient for cancer therapy?
International journal of cancer 20020810
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Effect of fenretinide on ovarian carcinoma occurrence.
Gynecologic oncology 20020701
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N-(4-hydroxyphenyl)retinamide (4-HPR) modulates GADD45 expression in radiosensitive bladder cancer cell lines.
Cancer letters 20020628
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Re: Effects of N-(4-hydroxy-phenyl)retinamide on hTERT expression in the bronchial epithelium of cigarette smokers.
Journal of the National Cancer Institute 20020619
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Implication of mitochondria-derived ROS and cardiolipin peroxidation in N-(4-hydroxyphenyl)retinamide-induced apoptosis.
British journal of cancer 20020617
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Tissue transglutaminase protects against apoptosis by modifying the tumor suppressor protein p110 Rb.
The Journal of biological chemistry 20020607
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OVCA2 is downregulated and degraded during retinoid-induced apoptosis.
International journal of cancer 20020510
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N-(4-hydroxyphenyl)retinamide increases ceramide and is cytotoxic to acute lymphoblastic leukemia cell lines, but not to non-malignant lymphocytes.
Leukemia 20020501
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Correspondence re: M. Follen et al., a randomized clinical trial of 4-hydroxyphenylretinamide for high-grade squamous intraepithelial lesions of the cervix.
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[Telomere and telomerase in lung cancer].
Nihon rinsho. Japanese journal of clinical medicine 20020501
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Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
The Journal of biological chemistry 20020419
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Retinoids enhance cisplatin-based chemoradiation in cervical cancer cells in vitro.
Gynecologic oncology 20020401
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Classical and novel retinoids: their targets in cancer therapy.
Leukemia 20020401
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Apoptosis of squamous cells at different stages of carcinogenesis following 4-HPR treatment.
Carcinogenesis 20020301
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Cytochrome c oxidase subunit III: a molecular marker for N-(4-hydroxyphenyl)retinamise-induced oxidative stress in hepatoma cells.
The Journal of biological chemistry 20020208
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Modulation of cyclophilin gene expression by N-4-(hydroxyphenyl)retinamide: association with reactive oxygen species generation and apoptosis.
Molecular carcinogenesis 20020101
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Fluorescence spectroscopy as a biomarker in a cell culture and in a nonhuman primate model for ovarian cancer chemopreventive agents.
Journal of biomedical optics 20020101
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Selective estrogen receptor modulators (SERMs) and retinoids in breast cancer chemoprevention.
Environmental and molecular mutagenesis 20020101
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[Are mitochondria targets of anticancer drugs responsible for apoptosis?].
Annales de biologie clinique 20020101
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Retinoid-induced growth arrest of breast carcinoma cells involves co-activation of multiple growth-inhibitory genes.
Cancer biology & therapy 20020101
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How much do we know about retinoid-regulated genes?
Cancer biology & therapy 20020101
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Experimental studies on the effects of the combined use of N-(4-hydroxyphenyl)retinamide (4-HPR) and tamoxifen (TAM) for estrogen receptor (ER)-negative breast cancer.
The Kurume medical journal 20020101
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Effects of body weight gain reduction resulting from chemopreventive agent treatment on mammary gland morphology.
Nutrition and cancer 20020101
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N-(4-hydroxyphenyl)-retinamide selectively increases All-TRANS retinoic acid inhibitory effects in HER2/NEU-overexpressing breast cancer cells.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20020101
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Antiproliferative mechanism of retinoid derivatives in ovarian cancer cells.
Cancer letters 20011228
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Mitochondrial respiration is uniquely associated with the prooxidant and apoptotic effects of N-(4-hydroxyphenyl)retinamide.
The Journal of biological chemistry 20011207
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Activation of caspase-8 during N-(4-hydroxyphenyl)retinamide-induced apoptosis in Fas-defective hepatoma cells.
Hepatology (Baltimore, Md.) 20011201
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Clinical trials referral resource. Current clinical trials of fenretinide.
Oncology (Williston Park, N.Y.) 20011201
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Beyond tamoxifen new endpoints for breast cancer chemoprevention, new drugs for breast cancer prevention.
Annals of the New York Academy of Sciences 20011201
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A randomized clinical trial of 4-hydroxyphenylretinamide for high-grade squamous intraepithelial lesions of the cervix.
Clinical cancer research : an official journal of the American Association for Cancer Research 20011101
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Inhibition of neuroblastoma-induced angiogenesis by fenretinide.
International journal of cancer 20011101
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Mechanism of fenretinide (4-HPR)-induced cell death.
Apoptosis : an international journal on programmed cell death 20011001
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Long-term effects of fenretinide, a retinoic acid derivative, on the insulin-like growth factor system in women with early breast cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20011001
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Sequential tumor biopsies in early phase clinical trials of anticancer agents for pharmacodynamic evaluation.
Clinical cancer research : an official journal of the American Association for Cancer Research 20011001
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Retinoid therapy of childhood cancer.
Hematology/oncology clinics of North America 20011001
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Rhesus macaque model for ovarian cancer chemoprevention.
Comparative medicine 20011001
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N-(4-hydroxyphenyl)retinamide (4-HPR) decreases neoplastic properties of human prostate cells: an agent for prevention.
Mutation research 20010920
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Effects of tissue transglutaminase on retinoic acid-induced cellular differentiation and protection against apoptosis.
The Journal of biological chemistry 20010907
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Effects of N-(4-hydroxyphenyl)retinamide on hTERT expression in the bronchial epithelium of cigarette smokers.
Journal of the National Cancer Institute 20010815
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Biomarker modulation in a nonhuman rhesus primate model for ovarian cancer chemoprevention.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20010801
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Synergistic effects of the fenretinide (4-HPR) and anti-CD20 monoclonal antibodies on apoptosis induction of malignant human B cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 20010801
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Effects of dietary N-(4-hydroxyphenyl)retinamide on N-nitrosomethylbenzylamine metabolism and esophageal tumorigenesis in the Fischer 344 rat.
Journal of the National Cancer Institute 20010704
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N-(4-hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase.
Cancer research 20010701
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An unhydrolyzable analogue of N-(4-hydroxyphenyl)retinamide. synthesis and preliminary biological studies.
Bioorganic & medicinal chemistry letters 20010618
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Decrease in drug accumulation and in tumour aggressiveness marker expression in a fenretinide-induced resistant ovarian tumour cell line.
British journal of cancer 20010601
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Up-regulation of prosaposin by the retinoid HPR and its effect on ceramide production and integrin receptors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010601
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Identification of retinamides that are more potent than N-(4-hydroxyphenyl)retinamide in inhibiting growth and inducing apoptosis of human head and neck and lung cancer cells.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20010601
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Retinoids for ovarian cancer prevention: laboratory data set the stage for thoughtful clinical trials.
Journal of the National Cancer Institute 20010404
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Effects of retinoids on cancerous phenotype and apoptosis in organotypic cultures of ovarian carcinoma.
Journal of the National Cancer Institute 20010404
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Bayesian monitoring of a phase 2 chemoprevention trial in high-risk cohorts for prostate cancer.
Urology 20010401
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Effects of novel phenylretinamides on cell growth and apoptosis in bladder cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20010401
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Safety of the synthetic retinoid fenretinide: long-term results from a controlled clinical trial for the prevention of contralateral breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010315
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The retinoid fenretinide inhibits proliferation and downregulates cyclooxygenase-2 gene expression in human colon adenocarcinoma cell lines.
Cancer letters 20010310
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Suppression of pRB expression in normal human mammary epithelial cells is associated with resistance to all-trans-retinoic acid but not N-(4-hydroxylphenyl)-retinamide.
Breast cancer research and treatment 20010301
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Re: Randomized trial of fenretinide to prevent second breast malignancy in women with early breast cancer.
Journal of the National Cancer Institute 20010207
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4-(N-hydroxyphenyl)retinamide can selectively induce apoptosis in human epidermoid carcinoma cells but not in normal dermal fibroblasts.
Cancer investigation 20010101
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Chemoprevention of breast cancer with fenretinide.
Drugs 20010101
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Effect of high retinoid doses on RAR-beta mRNA expression in female B6D2F1 mice.
Anticancer research 20010101
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Chemotherapeutic evaluation of 4-hydroxybenzylretinone (4-HBR), a nonhydrolyzable C-linked analog of N-(4-hydroxyphenyl) retinamide (4-HPR) against mammary carcinogenesis.
Anticancer research 20010101
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Comparative ability of ibuprofen and N-(4-hydroxyphenyl)retinamide to inhibit development of rat mammary adenocarcinomas associated with differential inhibition of gene expression of cyclooxygenase isoforms.
Anticancer research 19990101
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Retinoid-induced apoptosis and Sp1 cleavage occur independently of transcription and require caspase activation.
Molecular and cellular biology 19971101
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Regulation of apoptosis induced by the retinoid N-(4-hydroxyphenyl) retinamide and effect of deregulated bcl-2.
Blood 19950115
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Phase II trial of fenretinide [N-(4-hydroxyphenyl) retinamide] in myelodysplasia: possible retinoid-induced disease acceleration.
Leukemia research 19890101
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Abnormal retinal function associated with fenretinide, a synthetic retinoid.
Archives of ophthalmology (Chicago, Ill. : 1960) 19860101
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Subacute toxicity of all-trans- and 13-cis-isomers of N-ethyl retinamide, N-2-hydroxyethyl retinamide, and N-4-hydroxyphenyl retinamide.
Toxicology and applied pharmacology 19830915