66-27-3 | Methyl methanesulfonate

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$8.00	$5.00
5g	98%	in stock	$9.00	$6.00
10g	98%	in stock	$10.00	$7.00
25g	98%	in stock	$23.00	$16.00
500g	98%	in stock	$432.00	$303.00

Description

• Catalog Number: AB76090
• Chemical Name: Methyl methanesulfonate
• CAS Number: 66-27-3
• Molecular Formula: C2H6O3S
• Molecular Weight: 110.1322
• MDL Number: MFCD00007557
• SMILES: COS(=O)(=O)C
• NSC Number: 50256

Computed Properties

• Complexity: 105
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 6
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• XLogP3: -0.4

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  Molecular cancer 20110101

• Differences in sensitivity to DNA-damaging Agents between XRCC4- and Artemis-deficient human cells.

  Journal of radiation research 20110101

• Methyl methanesulfonate.

  Report on carcinogens : carcinogen profiles 20110101

• Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding.

  PloS one 20110101

• Functional characterization of the Saccharomyces cerevisiae protein Chl1 reveals the role of sister chromatid cohesion in the maintenance of spindle length during S-phase arrest.

  BMC genetics 20110101

• Schizosaccharomyces pombe Ofd2 is a nuclear 2-oxoglutarate and iron dependent dioxygenase interacting with histones.

  PloS one 20110101

• The role of Candida albicans homologous recombination factors Rad54 and Rdh54 in DNA damage sensitivity.

  BMC microbiology 20110101

• Differential chromatin proteomics of the MMS-induced DNA damage response in yeast.

  Proteome science 20110101

• Genomic phenotyping of the essential and non-essential yeast genome detects novel pathways for alkylation resistance.

  BMC systems biology 20110101

• Liver cancer stem cells.

  International journal of hepatology 20110101

• Differential genetic interactions between Sgs1, DNA-damage checkpoint components and DNA repair factors in the maintenance of chromosome stability.

  Genome integrity 20110101

• Systems analysis of ATF3 in stress response and cancer reveals opposing effects on pro-apoptotic genes in p53 pathway.

  PloS one 20110101

• Translesion DNA synthesis in the context of cancer research.

  Cancer cell international 20110101

• A plant virus movement protein regulates the Gcn2p kinase in budding yeast.

  PloS one 20110101

• The alkylation response protein AidB is localized at the new poles and constriction sites in Brucella abortus.

  BMC microbiology 20110101

• Toxicity ranking and toxic mode of action evaluation of commonly used agricultural adjuvants on the basis of bacterial gene expression profiles.

  PloS one 20110101

• Determination of Alkyl Methanesulfonates in Doxazosin Mesylate by Gas Chromatography-mass Spectrometer.

  Indian journal of pharmaceutical sciences 20110101

• DNA electrophoretic migration patterns change after exposure of Jurkat cells to a single intense nanosecond electric pulse.

  PloS one 20110101

• The effect of royal sun agaricus, Agaricus brasiliensis S. Wasser et al., extract on methyl methanesulfonate caused genotoxicity in Drosophila melanogaster.

  International journal of medicinal mushrooms 20110101

• Preparation, characterization, and biological properties of β-glucans.

  Journal of advanced pharmaceutical technology & research 20110101

• Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil.

  PloS one 20110101

• Estimates of DNA damage by the comet assay in the direct-developing frog Eleutherodactylus johnstonei (Anura, Eleutherodactylidae).

  Genetics and molecular biology 20110101

• Caffeine abolishes the ultraviolet-induced REV3 translesion replication pathway in mouse cells.

  International journal of molecular sciences 20110101

• Homologs of breast cancer genes in plants.

  Frontiers in plant science 20110101

• Transgenerational adaptation to heavy metal salts in Arabidopsis.

  Frontiers in plant science 20110101

• Angiotensin II, a Neuropeptide at the Frontier between Endocrinology and Neuroscience: Is There a Link between the Angiotensin II Type 2 Receptor and Alzheimer's Disease?

  Frontiers in endocrinology 20110101

• Broad spectrum antimutagenic activity of antioxidant active fraction of punica granatum L. peel extracts.

  Mutation research 20101221

• Miniaturized flow cytometric in vitro micronucleus assay represents an efficient tool for comprehensively characterizing genotoxicity dose-response relationships.

  Mutation research 20101221

• Accumulation of true single strand breaks and AP sites in base excision repair deficient cells.

  Mutation research 20101210

• Genetics. The DNA damage road map.

  Science (New York, N.Y.) 20101203

• Rewiring of genetic networks in response to DNA damage.

  Science (New York, N.Y.) 20101203

• Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20101201

• Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis.

  Carcinogenesis 20101201

• Differential sensitivity of Arabidopsis siRNA biogenesis mutants to genotoxic stress.

  Plant cell reports 20101201

• Prediction of the contact sensitizing potential of chemicals using analysis of gene expression changes in human THP-1 monocytes.

  Toxicology letters 20101110

• Characterisation of Muta™Mouse λgt10-lacZ transgene: evidence for in vivo rearrangements.

  Mutagenesis 20101101

• Ovate family protein 1 as a plant Ku70 interacting protein involving in DNA double-strand break repair.

  Plant molecular biology 20101101

• DNA methylation and normal chromosome behavior in Neurospora depend on five components of a histone methyltransferase complex, DCDC.

  PLoS genetics 20101101

• Activation of P53 in HepG2 cells as surrogate to detect mutagens and promutagens in vitro.

  Toxicology letters 20101005

• Regulation of tolerance to DNA alkylating damage by Dot1 and Rad53 in Saccharomyces cerevisiae.

  DNA repair 20101005

• The Werner's Syndrome protein collaborates with REV1 to promote replication fork progression on damaged DNA.

  DNA repair 20101005

• Homologous recombination protects mammalian cells from replication-associated DNA double-strand breaks arising in response to methyl methanesulfonate.

  DNA repair 20101005

• The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages.

  Nucleic acids research 20101001

• Carboxymethyl chitin-glucan (CM-CG) protects human HepG2 and HeLa cells against oxidative DNA lesions and stimulates DNA repair of lesions induced by alkylating agents.

  Toxicology in vitro : an international journal published in association with BIBRA 20101001

• Simultaneous disruption of two DNA polymerases, Polη and Polζ, in Avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions.

  PLoS genetics 20101001

• Subtle alterations in PCNA-partner interactions severely impair DNA replication and repair.

  PLoS biology 20101001

• Linking Klotho, Nrf2, MAP kinases and aging.

  Aging 20101001

• p300-mediated acetylation of histone H3 lysine 56 functions in DNA damage response in mammals.

  The Journal of biological chemistry 20100910

• Methylated DNA causes a physical block to replication forks independently of damage signalling, O(6)-methylguanine or DNA single-strand breaks and results in DNA damage.

  Journal of molecular biology 20100910

• Proficient repair in chromatin remodeling defective ino80 mutants of Saccharomyces cerevisiae highlights replication defects as the main contributor to DNA damage sensitivity.

  DNA repair 20100904

• Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells.

  The Journal of pharmacology and experimental therapeutics 20100901

• Functional characterization of the PP2C phosphatase CaPtc2p in the human fungal pathogen Candida albicans.

  Yeast (Chichester, England) 20100901

• The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging.

  Aging 20100901

• Critical functions of Rpa3/Ssb3 in S-phase DNA damage responses in fission yeast.

  PLoS genetics 20100901

• The ability of the high-throughput comet assay to measure the sensitivity of five cell lines toward methyl methanesulfonate, hydrogen peroxide, and pentachlorophenol.

  Mutation research 20100830

• Nicotine and methyl methane sulfonate in mini organ cultures of human parotid gland tissue.

  Toxicology letters 20100816

• Alkylation DNA damage in combination with PARP inhibition results in formation of S-phase-dependent double-strand breaks.

  DNA repair 20100805

• A single-strand specific lesion drives MMS-induced hyper-mutability at a double-strand break in yeast.

  DNA repair 20100805

• Ferrochelatase is a conserved downstream target of the blue light-sensing White collar complex in fungi.

  Microbiology (Reading, England) 20100801

• Tobacco mosaic virus infection results in an increase in recombination frequency and resistance to viral, bacterial, and fungal pathogens in the progeny of infected tobacco plants.

  Plant physiology 20100801

• Deletion of a novel F-box protein, MUS-10, in Neurospora crassa leads to altered mitochondrial morphology, instability of mtDNA and senescence.

  Genetics 20100801

• Genotoxicity assessment in the amphipod Gammarus fossarum by use of the alkaline Comet assay.

  Mutation research 20100719

• Effect of the dibenzylbutyrolactone lignan (-)-hinokinin on doxorubicin and methyl methanesulfonate clastogenicity in V79 Chinese hamster lung fibroblasts.

  Mutation research 20100719

• Whole cell-ELISA to measure the gammaH2AX response of six aneugens and eight DNA-damaging chemicals.

  Mutation research 20100719

• Delineation of WRN helicase function with EXO1 in the replicational stress response.

  DNA repair 20100701

• In vitro evaluation of baseline and induced DNA damage in human sperm exposed to benzo[a]pyrene or its metabolite benzo[a]pyrene-7,8-diol-9,10-epoxide, using the comet assay.

  Mutagenesis 20100701

• Arabidopsis cockayne syndrome A-like proteins 1A and 1B form a complex with CULLIN4 and damage DNA binding protein 1A and regulate the response to UV irradiation.

  The Plant cell 20100701

• The BRCT domain of PARP-1 is required for immunoglobulin gene conversion.

  PLoS biology 20100701

• Overexpression of POLQ confers a poor prognosis in early breast cancer patients.

  Oncotarget 20100701

• Mutagenicity of N-ethyl-N-nitrosourea, N-methyl-N-nitrosourea, methyl methanesulfonate and ethyl methanesulfonate in the developing Syrian hamster fetus.

  Mutation research 20100617

• Genetic interactions between HNT3/Aprataxin and RAD27/FEN1 suggest parallel pathways for 5' end processing during base excision repair.

  DNA repair 20100604

• Leaving group property of dimethyl sulfide.

  The Journal of organic chemistry 20100604

• Antiproliferative, apoptotic and antimutagenic activity of isolated compounds from Polyalthia cerasoides seeds.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20100601

• Antioxidant and antimutagenic activity of Carum copticum fruit extracts.

  Toxicology in vitro : an international journal published in association with BIBRA 20100601

• Contribution of transcription-coupled DNA repair to MMS-induced mutagenesis in E. coli strains deficient in functional AlkB protein.

  Mutation research 20100601

• Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair.

  Molecular cancer therapeutics 20100601

• Casein kinase 2-dependent phosphorylation of human Rad9 mediates the interaction between human Rad9-Hus1-Rad1 complex and TopBP1.

  Genes to cells : devoted to molecular & cellular mechanisms 20100601

• The Dbf4 motif C zinc finger promotes DNA replication and mediates resistance to genotoxic stress.

  Cell cycle (Georgetown, Tex.) 20100515

• Antigenotoxic potential of Gymnema montanum leaves on DNA damage in human peripheral blood lymphocytes and HL-60 cell line.

  Environmental and molecular mutagenesis 20100501

• The role of reactive oxygen species in the induction of Ty1 retrotransposition in Saccharomyces cerevisiae.

  Yeast (Chichester, England) 20100501

• Fission yeast Hsk1 (Cdc7) kinase is required after replication initiation for induced mutagenesis and proper response to DNA alkylation damage.

  Genetics 20100501

• FACT prevents the accumulation of free histones evicted from transcribed chromatin and a subsequent cell cycle delay in G1.

  PLoS genetics 20100501

• Automated analysis of DNA damage in the high-throughput version of the comet assay.

  Mutation research 20100430

• Comet assay in murine bone-marrow cell line (FDC-P2).

  Toxicology in vitro : an international journal published in association with BIBRA 20100401

• High content flow cytometric micronucleus scoring method is applicable to attachment cell lines.

  Environmental and molecular mutagenesis 20100401

• Validation of an in vitro screening test for predicting the tumor promoting potential of chemicals based on gene expression.

  Toxicology in vitro : an international journal published in association with BIBRA 20100401

• Parp1 activation in mouse embryonic fibroblasts promotes Pol beta-dependent cellular hypersensitivity to alkylation damage.

  Mutation research 20100401

• A molecular beacon approach to detecting RAD52 expression in response to DNA damage in human cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20100301

• Lethal and mutagenic properties of MMS-generated DNA lesions in Escherichia coli cells deficient in BER and AlkB-directed DNA repair.

  Mutagenesis 20100301

• Comparative transcriptome analysis reveals novel roles of the Ras and cyclic AMP signaling pathways in environmental stress response and antifungal drug sensitivity in Cryptococcus neoformans.

  Eukaryotic cell 20100301

• Fumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage response.

  PLoS biology 20100301

• Pharmacological and phytochemical study on a Sisymbrium officinale Scop. extract.

  Journal of ethnopharmacology 20100217

• Abundance of ribosomal RNA gene copies maintains genome integrity.

  Science (New York, N.Y.) 20100205

• Caenorhabditis elegans APN-1 plays a vital role in maintaining genome stability.

  DNA repair 20100204

• Defects in DNA lesion bypass lead to spontaneous chromosomal rearrangements and increased cell death.

  Eukaryotic cell 20100201

• Coupling cytotoxicity biomarkers with DNA damage assessment in TK6 human lymphoblast cells.

  Mutation research 20100201

• Proteasome nuclear activity affects chromosome stability by controlling the turnover of Mms22, a protein important for DNA repair.

  PLoS genetics 20100201

• [The Rdh54 protein role in regulation of DNA repair in yeast Saccharomyces cerevisiae].

  Genetika 20100201

• Effects of Saccharomyces cerevisiae mec1, tel1, and mre11 mutations on spontaneous and methylmethane sulfonate-induced genome instability.

  Genes & genetic systems 20100201

• (4-Benzyl-2-oxo-1,3-oxazolidin-5-yl)methyl methane-sulfonate.

  Acta crystallographica. Section E, Structure reports online 20100201

• Genotoxicity and antigenotoxicity evaluation of non-photoactivated hypericin.

  Phytotherapy research : PTR 20100101

• Differential regulation of Apak by various DNA damage signals.

  Molecular and cellular biochemistry 20100101

• Evaluation of the genotoxic and antigenotoxic potential of Baccharis dracunculifolia extract on V79 cells by the comet assay.

  Journal of applied toxicology : JAT 20100101

• Adsorption behavior of ferritin and buffer components, buffer agents and salts, onto silane-coupled silicon substrate.

  Colloids and surfaces. B, Biointerfaces 20100101

• Genotoxicity studies of organically grown broccoli (Brassica oleracea var. italica) and its interactions with urethane, methyl methanesulfonate and 4-nitroquinoline-1-oxide genotoxicity in the wing spot test of Drosophila melanogaster.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100101

• Cytogenetic insights into DNA damage and repair of lesions induced by a monomethylated trivalent arsenical.

  Mutation research 20100101

• Role of mitogen-activated protein kinase Sty1 in regulation of eukaryotic initiation factor 2alpha kinases in response to environmental stress in Schizosaccharomyces pombe.

  Eukaryotic cell 20100101

• Altered gene expression and DNA damage in peripheral blood cells from Friedreich's ataxia patients: cellular model of pathology.

  PLoS genetics 20100101

• Expression profiling of S. pombe acetyltransferase mutants identifies redundant pathways of gene regulation.

  BMC genomics 20100101

• Collaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repair.

  PLoS genetics 20100101

• 4beta-Hydroxywithanolide E from Physalis peruviana (golden berry) inhibits growth of human lung cancer cells through DNA damage, apoptosis and G2/M arrest.

  BMC cancer 20100101

• Transgenerational adaptation of Arabidopsis to stress requires DNA methylation and the function of Dicer-like proteins.

  PloS one 20100101

• Phenotypic effects of the circadian gene Cryptochrome 2 on cancer-related pathways.

  BMC cancer 20100101

• Building and analyzing protein interactome networks by cross-species comparisons.

  BMC systems biology 20100101

• Histone H3 serine 57 and lysine 56 interplay in transcription elongation and recovery from S-phase stress.

  PloS one 20100101

• Environmental exposure of the mouse germ line: DNA adducts in spermatozoa and formation of de novo mutations during spermatogenesis.

  PloS one 20100101

• The global dynamics of RNA stability orchestrates responses to cellular activation.

  BMC biology 20100101

• The effect of a DNA damaging agent on embryonic cell cycles of the cnidarian Hydractinia echinata.

  PloS one 20100101

• The SWR1 histone replacement complex causes genetic instability and genome-wide transcription misregulation in the absence of H2A.Z.

  PloS one 20100101

• Plant DNA recombinases: a long way to go.

  Journal of nucleic acids 20100101

• DNA polymerases beta and lambda mediate overlapping and independent roles in base excision repair in mouse embryonic fibroblasts.

  PloS one 20100101

• Genetic and biochemical characterization of human AP endonuclease 1 mutants deficient in nucleotide incision repair activity.

  PloS one 20100101

• Identification of response-modulated genetic interactions by sensitivity-based epistatic analysis.

  BMC genomics 20100101

• The unfolded protein response is not necessary for the G1/S transition, but it is required for chromosome maintenance in Saccharomyces cerevisiae.

  PloS one 20100101

• Characterisation of the SUMO-like domains of Schizosaccharomyces pombe Rad60.

  PloS one 20100101

• The Roles of UmuD in Regulating Mutagenesis.

  Journal of nucleic acids 20100101

• Mus308 processes oxygen and nitrogen ethylation DNA damage in germ cells of Drosophila.

  Journal of nucleic acids 20100101

• Effect of n3-methyladenine and an isosteric stable analogue on DNA polymerization.

  Journal of nucleic acids 20100101

• Early Steps in the DNA Base Excision Repair Pathway of a Fission Yeast Schizosaccharomyces pombe.

  Journal of nucleic acids 20100101

• Comparison of mitotic cell death by chromosome fragmentation to premature chromosome condensation.

  Molecular cytogenetics 20100101

• Checkpoint-dependent and -independent roles of Swi3 in replication fork recovery and sister chromatid cohesion in fission yeast.

  PloS one 20100101

• Overview of DNA Repair in Trypanosoma cruzi, Trypanosoma brucei, and Leishmania major.

  Journal of nucleic acids 20100101

• Is the comet assay a sensitive procedure for detecting genotoxicity?

  Journal of nucleic acids 20100101

• The roles of the Saccharomyces cerevisiae RecQ helicase SGS1 in meiotic genome surveillance.

  PloS one 20100101

• PI 3 kinase related kinases-independent proteolysis of BRCA1 regulates Rad51 recruitment during genotoxic stress in human cells.

  PloS one 20100101

• DNA damage induced by alkylating agents and repair pathways.

  Journal of nucleic acids 20100101

• Rrd1 isomerizes RNA polymerase II in response to rapamycin.

  BMC molecular biology 20100101

• Antigenotoxic effect of Chamomilla recutita (L.) Rauschert essential oil in mouse spermatogonial cells, and determination of its antioxidant capacity in vitro.

  International journal of molecular sciences 20100101

• Genetic analysis of DNA repair in the hyperthermophilic archaeon, Thermococcus kodakaraensis.

  Genes & genetic systems 20100101

• Mammalian target of rapamycin: hitting the bull's-eye for neurological disorders.

  Oxidative medicine and cellular longevity 20100101

• Determination of the antimutagenicity of an aqueous extract of Rhizophora mangle L. (Rhizophoraceae), using in vivo and in vitro test systems.

  Genetics and molecular biology 20100101

• Protective effect of Hemidesmus indicus R.Br. root extract against cisplatin-induced cytogenetic damage in mouse bone marrow cells.

  Genetics and molecular biology 20100101

• Effect of annatto on micronuclei induction by direct and indirect mutagens in HepG2 cells.

  Environmental and molecular mutagenesis 20091201

• Mutagenic potency of MMS-induced 1meA/3meC lesions in E. coli.

  Environmental and molecular mutagenesis 20091201

• Cells deficient in PARP-1 show an accelerated accumulation of DNA single strand breaks, but not AP sites, over the PARP-1-proficient cells exposed to MMS.

  Mutation research 20091201

• Replication protein A (RPA1a) is required for meiotic and somatic DNA repair but is dispensable for DNA replication and homologous recombination in rice.

  Plant physiology 20091201

• Distinct mechanisms are utilized to induce stress sensor gadd45b by different stress stimuli.

  Journal of cellular biochemistry 20091201

• A metabolomic and multivariate statistical process to assess the effects of genotoxins in Saccharomyces cerevisiae.

  Molecular bioSystems 20091201

• EMS in Viracept--initial ('traditional') assessment of risk to patients based on linear dose response relations.

  Toxicology letters 20091112

• PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATM.

  DNA repair 20091102

• Micronucleus and chromosome aberrations induced in onion (Allium cepa) by a petroleum refinery effluent and by river water that receives this effluent.

  Ecotoxicology and environmental safety 20091101

• Arabidopsis actin-related protein ARP5 in multicellular development and DNA repair.

  Developmental biology 20091101

• Involvement of a chromatin remodeling complex in damage tolerance during DNA replication.

  Nature structural & molecular biology 20091101

• Global analysis of mutual interaction surfaces of nucleosomes with comprehensive point mutants.

  Genes to cells : devoted to molecular & cellular mechanisms 20091101

• Clock gene mutation modulates the cellular sensitivity to genotoxic stress through altering the expression of N-methylpurine DNA glycosylase gene.

  Biochemical pharmacology 20091015

• Optimization of bacterial whole cell bioreporters for toxicity assay of environmental samples.

  Environmental science & technology 20091015

• Chromatographic method for quick estimation of DNA interaction potency of environmental pollutants.

  Environmental toxicology and chemistry 20091001

• The elongator complex interacts with PCNA and modulates transcriptional silencing and sensitivity to DNA damage agents.

  PLoS genetics 20091001

• Dermal fibroblasts from long-lived Ames dwarf mice maintain their in vivo resistance to mitochondrial generated reactive oxygen species (ROS).

  Aging 20090901

• Linking genotoxic responses with cytotoxic and behavioural or physiological consequences: differential sensitivity of echinoderms (Asterias rubens) and marine molluscs (Mytilus edulis).

  Aquatic toxicology (Amsterdam, Netherlands) 20090813

• SnCl(2)-induced DNA damage and repair inhibition of MMS-caused lesions in V79 Chinese hamster fibroblasts.

  Archives of toxicology 20090801

• Statistical model to estimate a threshold dose and its confidence limits for the analysis of sublinear dose-response relationships, exemplified for mutagenicity data.

  Mutation research 20090801

• Antimutagenic activity of a secoisopimarane diterpenoid from Salvia cinnabarina M. Martens et Galeotti in the bacterial reverse mutation assay.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090801

• Transcriptional gene silencing mediated by a plastid inner envelope phosphoenolpyruvate/phosphate translocator CUE1 in Arabidopsis.

  Plant physiology 20090801

• Biological significance of DNA adducts: comparison of increments over background for various biomarkers of genotoxicity in L5178Y tk(+/-) mouse lymphoma cells treated with hydrogen peroxide and cumene hydroperoxide.

  Mutation research 20090801

• Dose-response and operational thresholds/NOAELs for in vitro mutagenic effects from DNA-reactive mutagens, MMS and MNU.

  Mutation research 20090801

• Conformational and vibrational analysis of methyl methanesulfonate, CH3SO2OCH3.

  The journal of physical chemistry. A 20090723

• Kinetics of an extracellular exo-inulinase production from a 5-flourocytosine resistant mutant of Geotrichum candidum using two-factorial design.

  Bioresource technology 20090701

• Inefficient double-strand DNA break repair is associated with increased fasciation in Arabidopsis BRCA2 mutants.

  Journal of experimental botany 20090701

• Mre11-Rad50 promotes rapid repair of DNA damage in the polyploid archaeon Haloferax volcanii by restraining homologous recombination.

  PLoS genetics 20090701

• FEN1 is overexpressed in testis, lung and brain tumors.

  Anticancer research 20090701

• Predicting functionality of protein-DNA interactions by integrating diverse evidence.

  Bioinformatics (Oxford, England) 20090615

• Accumulation of sumoylated Rad52 in checkpoint mutants perturbed in DNA replication.

  DNA repair 20090604

• Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin.

  DNA repair 20090604

• Metabolic response to MMS-mediated DNA damage in Saccharomyces cerevisiae is dependent on the glucose concentration in the medium.

  FEMS yeast research 20090601

• A phylogenetically conserved DNA damage response resets the circadian clock.

  Journal of biological rhythms 20090601

• A network of conserved damage survival pathways revealed by a genomic RNAi screen.

  PLoS genetics 20090601

• Telomere recombination accelerates cellular aging in Saccharomyces cerevisiae.

  PLoS genetics 20090601

• Analysis of 7,8-dihydro-8-oxo-2'-deoxyguanosine in cellular DNA during oxidative stress.

  Chemical research in toxicology 20090518

• Characterization in vitro and in vivo of the DNA helicase encoded by Deinococcus radiodurans locus DR1572.

  DNA repair 20090501

• The role of novel genes rrp1(+) and rrp2(+) in the repair of DNA damage in Schizosaccharomyces pombe.

  DNA repair 20090501

• Requirement of the Saccharomyces cerevisiae APN1 gene for the repair of mitochondrial DNA alkylation damage.

  Environmental and molecular mutagenesis 20090501

• Determination of genotoxic effects of copper sulphate and cobalt chloride in Allium cepa root cells by chromosome aberration and comet assays.

  Chemosphere 20090501

• Tetrahymena meiotic nuclear reorganization is induced by a checkpoint kinase-dependent response to DNA damage.

  Molecular biology of the cell 20090501

• Performance of the comet assay in a high-throughput version.

  Mutation research 20090430

• Differential regulation of homologous recombination at DNA breaks and replication forks by the Mrc1 branch of the S-phase checkpoint.

  The EMBO journal 20090422

• Maximal extraction of biological information from genetic interaction data.

  PLoS computational biology 20090401

• Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracil.

  PLoS biology 20090401

• Enhancement of methyl methanesulfonate-induced base excision repair in the presence of selenomethionine on p53-dependent pathway.

  Journal of medicinal food 20090401

• DNA damage, signalling and repair after exposure of cells to the sulphur mustard analogue 2-chloroethyl ethyl sulphide.

  Toxicology 20090329

• Hydroxyurea sensitivity reveals a role for ISC1 in the regulation of G2/M.

  The Journal of biological chemistry 20090327

• Chelator-facilitated chemical modification of IMP-1 metallo-beta-lactamase and its consequences on metal binding.

  Biochemical and biophysical research communications 20090327

• Cooperativity of Mus81.Mms4 with Rad54 in the resolution of recombination and replication intermediates.

  The Journal of biological chemistry 20090320

• Intralaboratory and interlaboratory evaluation of the EpiDerm 3D human reconstructed skin micronucleus (RSMN) assay.

  Mutation research 20090317

• Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage.

  The Biochemical journal 20090315

• Differential roles of proteins involved in migration of Holliday junctions on recombination and tolerance to DNA damaging agents in Rhizobium etli.

  Gene 20090301

• The DNA repair protein NBS1 influences the base excision repair pathway.

  Carcinogenesis 20090301

• Ubiquitination and deubiquitination of PCNA in response to stalling of the replication fork.

  Cell cycle (Georgetown, Tex.) 20090301

• A novel protein, MAPO1, that functions in apoptosis triggered by O6-methylguanine mispair in DNA.

  Oncogene 20090226

• Introduction and characterization of a polymerase-dead point mutation into the POLK gene in vertebrates.

  FEBS letters 20090218

• Detection of excision repaired DNA damage in the comet assay by using Ara-C and hydroxyurea in three different cell types.

  Cell biology and toxicology 20090201

• Inhibition of DNA double-strand break repair by the Ku heterodimer in mrx mutants of Saccharomyces cerevisiae.

  DNA repair 20090201

• Functional characterization of the RAD51D E233G genetic variant.

  Pharmacogenetics and genomics 20090201

• Genome-wide analysis of factors affecting transcription elongation and DNA repair: a new role for PAF and Ccr4-not in transcription-coupled repair.

  PLoS genetics 20090201

• Epigenetic regulation, somatic homologous recombination, and abscisic acid signaling are influenced by DNA polymerase epsilon mutation in Arabidopsis.

  The Plant cell 20090201

• Reproductive consequences of paternal genotoxin exposure in marine invertebrates.

  Environmental science & technology 20090201

• Investigation on the protective effect of α-mannan against the DNA damage induced by aflatoxin B₁in mouse hepatocytes.

  International journal of molecular sciences 20090201

• HBx protein modulates PI3K/Akt pathway to overcome genotoxic stress-induced destabilization of cyclin D1 and arrest of cell cycle.

  Indian journal of biochemistry & biophysics 20090201

• Adherens junction-dependent PI3K/Akt activation induces resistance to genotoxin-induced cell death in differentiated intestinal epithelial cells.

  Biochemical and biophysical research communications 20090123

• Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA.

  Molecular cell 20090116

• Gene targeting in a nonhomologous end joining deficient Hypocrea jecorina.

  Journal of biotechnology 20090115

• Systems based mapping demonstrates that recovery from alkylation damage requires DNA repair, RNA processing, and translation associated networks.

  Genomics 20090101

• Automated image analysis of cytokinesis-blocked micronuclei: an adapted protocol and a validated scoring procedure for biomonitoring.

  Mutagenesis 20090101

• Drosophila hold'em is required for a subset of meiotic crossovers and interacts with the dna repair endonuclease complex subunits MEI-9 and ERCC1.

  Genetics 20090101

• Antimutagenic effect of sage tea in the wing spot test of Drosophila melanogaster.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090101

• Evaluation of cytotoxic and cytostatic effects in Saccharomyces cerevisiae by poissoner quantitative drop test.

  Basic & clinical pharmacology & toxicology 20090101

• The Elg1-RFC clamp-loading complex performs a role in sister chromatid cohesion.

  PloS one 20090101

• Three new structures of left-handed RADA helical filaments: structural flexibility of N-terminal domain is critical for recombinase activity.

  PloS one 20090101

• The N-terminal domain of Escherichia coli RecA have multiple functions in promoting homologous recombination.

  Journal of biomedical science 20090101

• Serpin genes AtSRP2 and AtSRP3 are required for normal growth sensitivity to a DNA alkylating agent in Arabidopsis.

  BMC plant biology 20090101

• The ELG1 clamp loader plays a role in sister chromatid cohesion.

  PloS one 20090101

• Attaching and effacing Escherichia coli downregulate DNA mismatch repair protein in vitro and are associated with colorectal adenocarcinomas in humans.

  PloS one 20090101

• Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1.

  PloS one 20090101

• Comparative genome-wide screening identifies a conserved doxorubicin repair network that is diploid specific in Saccharomyces cerevisiae.

  PloS one 20090101

• Genotoxicity evaluation of chlorpyrifos to amphibian Chinese toad (Amphibian: Anura) by Comet assay and Micronucleus test.

  Mutation research 20090101

• Adaptive response to DNA-damaging agents in natural Saccharomyces cerevisiae populations from 'Evolution Canyon', Mt. Carmel, Israel.

  PloS one 20090101

• Screening of antimutagenicity via antioxidant activity in different extracts from the flowers of Phlomis crinita Cav. ssp mauritanica munby from the center of Tunisia.

  Drug and chemical toxicology 20090101

• DNA ligase 1 deficient plants display severe growth defects and delayed repair of both DNA single and double strand breaks.

  BMC plant biology 20090101

• dRecQ4 is required for DNA synthesis and essential for cell proliferation in Drosophila.

  PloS one 20090101

• Histological analysis of low dose NMU effects in the rat mammary gland.

  BMC cancer 20090101

• SUMO chain formation is required for response to replication arrest in S. pombe.

  PloS one 20090101

• Transcriptome and proteome analyses of adaptive responses to methyl methanesulfonate in Escherichia coli K-12 and ada mutant strains.

  BMC microbiology 20090101

• The role of specific checkpoint-induced S-phase transcripts in resistance to replicative stress.

  PloS one 20090101

• Graph ranking for exploratory gene data analysis.

  BMC bioinformatics 20090101

• DNA damage induced by cis- and carboplatin as indicator for in vitro sensitivity of ovarian carcinoma cells.

  BMC cancer 20090101

• The pol3-t hyperrecombination phenotype and DNA damage-induced recombination in Saccharomyces cerevisiae is RAD50 dependent.

  Journal of biomedicine & biotechnology 20090101

• Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A.

  Aging 20090101

• [Streptomyces globisporus 1912 mutants highly sensitive to ultraviolet radiation, their antibiotic activity and reparation ability].

  Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993) 20090101

• Recruitment of Rad51 and Rad52 to short telomeres triggers a Mec1-mediated hypersensitivity to double-stranded DNA breaks in senescent budding yeast.

  PloS one 20090101

• Sirtuins at the breaking point: SIRT6 in DNA repair.

  Aging 20090101

• Application of the comet assay in erythrocytes of Oreochromis niloticus (Pisces): A methodological comparison.

  Genetics and molecular biology 20090101

• Cytotoxic and genotoxic effects of Br-containing oxaphosphole on Allium cepa L. root tip cells and mouse bone marrow cells.

  Genetics and molecular biology 20090101

• Saw palmetto extract induces nuclear heterogeneity in mice.

  Environmental toxicology and pharmacology 20090101

• Regulated proteolysis of DNA polymerase eta during the DNA-damage response in C. elegans.

  Molecular cell 20081226

• Micronucleus induction in V79 cells by the anabolic doping steroids desoxymethyltestosterone (madol) and 19-norandrostenedione.

  Toxicology letters 20081215

• No-observed effect levels are associated with up-regulation of MGMT following MMS exposure.

  Mutation research 20081215

• The G1-S checkpoint in fission yeast is not a general DNA damage checkpoint.

  Journal of cell science 20081215

• Tests for genotoxicity and mutagenicity of furan and its metabolite cis-2-butene-1,4-dial in L5178Y tk+/- mouse lymphoma cells.

  Mutation research 20081208

• The expression level of the chromatin-associated HMGB1 protein influences growth, stress tolerance, and transcriptome in Arabidopsis.

  Journal of molecular biology 20081205

• Genotoxicity screening of the river Rasina in Serbia using the Allium anaphase-telophase test.

  Environmental monitoring and assessment 20081201

• Influence of DNA repair gene polymorphisms on the initial repair of MMS-induced DNA damage in human lymphocytes as measured by the alkaline comet assay.

  Environmental and molecular mutagenesis 20081201

• Novel methylotrophic bacteria isolated from the River Thames (London, UK).

  Environmental microbiology 20081201

• Deletion of MAG1 and MRE11 enhances the sensitivity of the Saccharomyces cerevisiae HUG1P-GFP promoter-reporter construct to genotoxicity.

  Biosensors & bioelectronics 20081201

• Protective effect of Crocus sativus stigma extract and crocin (trans-crocin 4) on methyl methanesulfonate-induced DNA damage in mice organs.

  DNA and cell biology 20081201

• Kinetics of gamma-H2AX focus formation upon treatment of cells with UV light and alkylating agents.

  Environmental and molecular mutagenesis 20081201

• An in vivo comet assay of multiple organs (liver, kidney and bone marrow) in mice treated with methyl methanesulfonate and acetaminophen accompanied by hematology and/or blood chemistry.

  The Journal of toxicological sciences 20081201

• Embryonic mortality and intrauterine growth retardation (IUGR) associated with placental alterations in pregnant rats treated with methyl methanesulfonate (MMS) at the peri-implantation stage.

  The Journal of toxicological sciences 20081201

• Spt2p defines a new transcription-dependent gross chromosomal rearrangement pathway.

  PLoS genetics 20081201

• News from Arabidopsis on the meiotic roles of Blap75/Rmi1 and Top3alpha.

  PLoS genetics 20081201

• Localization of Smc5/6 to centromeres and telomeres requires heterochromatin and SUMO, respectively.

  The EMBO journal 20081119

• Expression of death receptor 4 induces caspase-independent cell death in MMS-treated yeast.

  Biochemical and biophysical research communications 20081114

• Human glyceraldehyde-3-phosphate dehydrogenase plays a direct role in reactivating oxidized forms of the DNA repair enzyme APE1.

  The Journal of biological chemistry 20081107

• A molecular bar-coded DNA repair resource for pooled toxicogenomic screens.

  DNA repair 20081101

• Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae.

  PLoS genetics 20081101

• Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells.

  PLoS genetics 20081101

• Interplay between Np95 and Eme1 in the DNA damage response.

  Biochemical and biophysical research communications 20081024

• Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells.

  Proceedings of the National Academy of Sciences of the United States of America 20081021

• Identification and characterization of novel SNPs in CHEK2 in Ashkenazi Jewish men with prostate cancer.

  Cancer letters 20081018

• DNA damage-induced reactive oxygen species (ROS) stress response in Saccharomyces cerevisiae.

  Free radical biology & medicine 20081015

• BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome.

  Genes & development 20081015

• The FANCM ortholog Fml1 promotes recombination at stalled replication forks and limits crossing over during DNA double-strand break repair.

  Molecular cell 20081010

• Multiple pathways cooperate to facilitate DNA replication fork progression through alkylated DNA.

  DNA repair 20081001

• Substrate binding pocket residues of human alkyladenine-DNA glycosylase critical for methylating agent survival.

  DNA repair 20081001

• Analysis of Saccharomyces cerevisiae histone H3 mutants reveals the role of the alphaN helix in nucleosome function.

  Biochemical and biophysical research communications 20080926

• Histone H2AX is a critical factor for cellular protection against DNA alkylating agents.

  Oncogene 20080925

• SUMO modification of PCNA is controlled by DNA.

  The EMBO journal 20080917

• Constitutive SOS expression and damage-inducible AddAB-mediated recombinational repair systems for Coxiella burnetii as potential adaptations for survival within macrophages.

  Molecular microbiology 20080901

• uvsF RFC1, the large subunit of replication factor C in Aspergillus nidulans, is essential for DNA replication, functions in UV repair and is upregulated in response to MMS-induced DNA damage.

  Fungal genetics and biology : FG & B 20080901

• Antimutagenic activity of methanolic extracts of four ayurvedic medicinal plants.

  Indian journal of experimental biology 20080901

• Model of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromes.

  Clinical interventions in aging 20080901

• Transcription increases methylmethane sulfonate-induced mutations in alkB strains of Escherichia coli.

  DNA repair 20080802

• Characterization of the role of a trimeric protein phosphatase complex in recovery from cisplatin-induced versus noncrosslinking DNA damage.

  The FEBS journal 20080801

• Inference of protein complex activities from chemical-genetic profile and its applications: predicting drug-target pathways.

  PLoS computational biology 20080801

• [Role of hREV3 in cell cycle and proliferation].

  Yi chuan = Hereditas 20080801

• Rad53 regulates replication fork restart after DNA damage in Saccharomyces cerevisiae.

  Genes & development 20080715

• Planarian neoblast micronucleus assay for evaluating genotoxicity.

  Chemosphere 20080701

• Role of Dot1 in the response to alkylating DNA damage in Saccharomyces cerevisiae: regulation of DNA damage tolerance by the error-prone polymerases Polzeta/Rev1.

  Genetics 20080701

• A potential link between alternative splicing of the NBS1 gene and DNA damage/environmental stress.

  Radiation research 20080701

• Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks.

  Genes & development 20080701

• Identification and dissection of a complex DNA repair sensitivity phenotype in Baker's yeast.

  PLoS genetics 20080701

• Genotoxic damage in polychaetes: a study of species and cell-type sensitivities.

  Mutation research 20080630

• DNA damage response protein ASCIZ links base excision repair with immunoglobulin gene conversion.

  Biochemical and biophysical research communications 20080627

• Cdc6 determines utilization of p21(WAF1/CIP1)-dependent damage checkpoint in S phase cells.

  The Journal of biological chemistry 20080627

• Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies.

  Drug metabolism and disposition: the biological fate of chemicals 20080601

• The methyl methanesulfonate induced S-phase delay in XRCC1-deficient cells requires ATM and ATR.

  DNA repair 20080601

• Rad52 sumoylation and its involvement in the efficient induction of homologous recombination.

  DNA repair 20080601

• The anaphase-promoting complex/cyclosome controls repair and recombination by ubiquitylating Rhp54 in fission yeast.

  Molecular and cellular biology 20080601

• Trypanosoma brucei BRCA2 acts in antigenic variation and has undergone a recent expansion in BRC repeat number that is important during homologous recombination.

  Molecular microbiology 20080601

• Antimutagenic and mutagenic activities of some terpenes in the bacterial reverse mutation assay.

  Mutation research 20080531

• Budding yeast Mms22 and Mms1 regulate homologous recombination induced by replisome blockage.

  DNA repair 20080503

• A yeast-based genetic screening to identify human proteins that increase homologous recombination.

  FEMS yeast research 20080501

• Evaluation of DNA damage in Chinese toad (Bufo bufo gargarizans) after in vivo exposure to sublethal concentrations of four herbicides using the comet assay.

  Ecotoxicology (London, England) 20080501

• Decreased expression of methyl methansulfonate and ultraviolet-sensitive gene clone 81 (Mus81) is correlated with a poor prognosis in patients with hepatocellular carcinoma.

  Cancer 20080501

• Schizosaccharomyces pombe Hst4 functions in DNA damage response by regulating histone H3 K56 acetylation.

  Eukaryotic cell 20080501

• Angiotensin II type 2 receptor deletion enhances vascular senescence by methyl methanesulfonate sensitive 2 inhibition.

  Hypertension (Dallas, Tex. : 1979) 20080501

• Quantitation of methylated hemoglobin adducts in a signature peptide from rat blood by liquid chromatography/negative electrospray ionization tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20080501

• ATP-dependent chromatin remodeling shapes the DNA replication landscape.

  Nature structural & molecular biology 20080501

• Completely automated short-term genotoxicity testing for the assessment of chemicals and characterisation of contaminated soils and waste waters.

  Environmental science and pollution research international 20080501

• Binding of MutS protein to oligonucleotides containing a methylated or an ethylated guanine residue, and correlation with mutation frequency.

  Mutation research 20080402

• Unique and overlapping functions of the Exo1, Mre11 and Pso2 nucleases in DNA repair.

  DNA repair 20080402

• A homolog of ScRAD5 is involved in DNA repair and homologous recombination in Arabidopsis.

  Plant physiology 20080401

• Location-specific functions of the two forkhead-associated domains in Rad53 checkpoint kinase signaling.

  Biochemistry 20080325

• The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest.

  Cell cycle (Georgetown, Tex.) 20080315

• Activation of ubiquitin-dependent DNA damage bypass is mediated by replication protein a.

  Molecular cell 20080314

• Development and validation of GC-MS method for the determination of methyl methanesulfonate and ethyl methanesulfonate in imatinib mesylate.

  Journal of pharmaceutical and biomedical analysis 20080313

• Inhibition of translation and modification of translation factors during apoptosis induced by the DNA-damaging agent MMS in sea urchin embryos.

  Experimental cell research 20080310

• In vitro antioxidant, antimutagenic and genoprotective activity of Rosa roxburghii fruit extract.

  Phytotherapy research : PTR 20080301

• Role of homologous recombination in trabectedin-induced DNA damage.

  European journal of cancer (Oxford, England : 1990) 20080301

• The Medicinal Mushroom Agaricus blazei Murrill: Review of Literature and Pharmaco-Toxicological Problems.

  Evidence-based complementary and alternative medicine : eCAM 20080301

• Cells from long-lived mutant mice exhibit enhanced repair of ultraviolet lesions.

  The journals of gerontology. Series A, Biological sciences and medical sciences 20080301

• Fibroblasts from naked mole-rats are resistant to multiple forms of cell injury, but sensitive to peroxide, ultraviolet light, and endoplasmic reticulum stress.

  The journals of gerontology. Series A, Biological sciences and medical sciences 20080301

• Using exonuclease III to enhance electrochemical detection of natural DNA damage in layered films.

  Biosensors & bioelectronics 20080227

• The Neurospora crassa UVS-3 epistasis group encodes homologues of the ATR/ATRIP checkpoint control system.

  DNA repair 20080201

• Species-specific inhibition of Giardia lamblia triosephosphate isomerase by localized perturbation of the homodimer.

  Molecular and biochemical parasitology 20080201

• Analyses of functional interaction between RECQL1, RECQL5, and BLM which physically interact with DNA topoisomerase IIIalpha.

  Biochimica et biophysica acta 20080201

• Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex.

  Molecular and cellular biology 20080201

• Functional interactions between Sae2 and the Mre11 complex.

  Genetics 20080201

• Drosophila brca2 is required for mitotic and meiotic DNA repair and efficient activation of the meiotic recombination checkpoint.

  PLoS genetics 20080201

• Increased transmission of mutations by low-condition females: evidence for condition-dependent DNA repair.

  PLoS biology 20080201

• Genetic analysis of the Neurospora crassa RAD14 homolog mus-43 and the RAD10 homolog mus-44 reveals that they belong to the mus-38 pathway of two nucleotide excision repair systems.

  Genes & genetic systems 20080201

• Vertebrate WRNIP1 and BLM are required for efficient maintenance of genome stability.

  Genes & genetic systems 20080201

• DNA damage activates the SAC in an ATM/ATR-dependent manner, independently of the kinetochore.

  PLoS genetics 20080201

• Extremely low frequency (ELF) magnetic fields enhance chemically induced formation of apurinic/apyrimidinic (AP) sites in A172 cells.

  International journal of radiation biology 20080101

• Deletion of the cpku80 gene in the chestnut blight fungus, Cryphonectria parasitica, enhances gene disruption efficiency.

  Current genetics 20080101

• Arabidopsis UEV1D promotes Lysine-63-linked polyubiquitination and is involved in DNA damage response.

  The Plant cell 20080101

• Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction.

  PloS one 20080101

• Essential and distinct roles of the F-box and helicase domains of Fbh1 in DNA damage repair.

  BMC molecular biology 20080101

• Membrane transporters and protein traffic networks differentially affecting metal tolerance: a genomic phenotyping study in yeast.

  Genome biology 20080101

• Acetylation regulates WRN catalytic activities and affects base excision DNA repair.

  PloS one 20080101

• Structural insights on the pamoic acid and the 8 kDa domain of DNA polymerase beta complex: towards the design of higher-affinity inhibitors.

  BMC structural biology 20080101

• Homeostatic imbalance between apoptosis and cell renewal in the liver of premature aging Xpd mice.

  PloS one 20080101

• The effects of protein interactions, gene essentiality and regulatory regions on expression variation.

  BMC systems biology 20080101

• Structure and properties of transcriptional networks driving selenite stress response in yeasts.

  BMC genomics 20080101

• Selective inhibition of yeast regulons by daunorubicin: a transcriptome-wide analysis.

  BMC genomics 20080101

• [Rpn4p is a positive and negative transcriptional regulator of the ubiquitin-proteasome system].

  Molekuliarnaia biologiia 20080101

• Chemogenetic fingerprinting by analysis of cellular growth dynamics.

  BMC chemical biology 20080101

• The essential function of Swc4p - a protein shared by two chromatin-modifying complexes of the yeast Saccharomyces cerevisiae - resides within its N-terminal part.

  Acta biochimica Polonica 20080101

• Gadd45 in stress signaling.

  Journal of molecular signaling 20080101

• Inducible SOS response system of DNA repair and mutagenesis in Escherichia coli.

  International journal of biological sciences 20080101

• A genome wide analysis of the response to uncapped telomeres in budding yeast reveals a novel role for the NAD+ biosynthetic gene BNA2 in chromosome end protection.

  Genome biology 20080101

• Transient transcriptional responses to stress are generated by opposing effects of mRNA production and degradation.

  Molecular systems biology 20080101

• Effect of Ku80 deficiency on mutation frequencies and spectra at a LacZ reporter locus in mouse tissues and cells.

  PloS one 20080101

• Anc1, a protein associated with multiple transcription complexes, is involved in postreplication repair pathway in S. cerevisiae.

  PloS one 20080101

• Rapid telomere motions in live human cells analyzed by highly time-resolved microscopy.

  Epigenetics & chromatin 20080101

• Drug design with Cdc7 kinase: a potential novel cancer therapy target.

  Drug design, development and therapy 20080101

• Chemical DNA damage activates p21 WAF1/CIP1-dependent intra-S checkpoint.

  FEBS letters 20071222

• Measurement of the heme affinity for yeast dap1p, and its importance in cellular function.

  Biochemistry 20071218

• Structure/function analysis of the interaction of adenomatous polyposis coli with DNA polymerase beta and its implications for base excision repair.

  Biochemistry 20071211

• Biological significance of DNA adducts investigated by simultaneous analysis of different endpoints of genotoxicity in L5178Y mouse lymphoma cells treated with methyl methanesulfonate.

  Mutation research 20071201

• Genotoxicity and antigenotoxicity of cashew (Anacardium occidentale L.) in V79 cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20071201

• Effect of safranal, a constituent of Crocus sativus (saffron), on methyl methanesulfonate (MMS)-induced DNA damage in mouse organs: an alkaline single-cell gel electrophoresis (comet) assay.

  DNA and cell biology 20071201

• Role of DNA mismatch repair and double-strand break repair in genome stability and antifungal drug resistance in Candida albicans.

  Eukaryotic cell 20071201

• Amelioration of cognitive impairment in the type-2 diabetic mouse by the angiotensin II type-1 receptor blocker candesartan.

  Hypertension (Dallas, Tex. : 1979) 20071201

• The protein degradation response of Saccharomyces cerevisiae to classical DNA-damaging agents.

  Chemical research in toxicology 20071201

• Novel roles for selected genes in meiotic DNA processing.

  PLoS genetics 20071201

• Differential susceptibility of rat embryos to methyl methanesulfonate during the pregastrulation period.

  The Journal of toxicological sciences 20071201

• Involvement of 3-methyladenine DNA glycosylases Mag1p and Mag2p in base excision repair of methyl methanesulfonate-damaged DNA in the fission yeast Schizosaccharomyces pombe.

  Genes & genetic systems 20071201

• Base excision DNA repair defect in Gadd45a-deficient cells.

  Oncogene 20071129

• Crystal structure and DNA repair activities of the AP endonuclease from Leishmania major.

  Journal of molecular biology 20071102

• A mutation in EXO1 defines separable roles in DNA mismatch repair and post-replication repair.

  DNA repair 20071101

• Histone H1 variant, H1R is involved in DNA damage response.

  DNA repair 20071101

• SAD2, an importin -like protein, is required for UV-B response in Arabidopsis by mediating MYB4 nuclear trafficking.

  The Plant cell 20071101

• Gas-phase structure, rotational barrier, and vibrational properties of methyl methanethiosulfonate, CH3SO2SCH3: an experimental and computational study.

  The journal of physical chemistry. A 20071004

• Silencing of endo-exonuclease expression sensitizes mouse B16F10 melanoma cells to DNA damaging agents.

  Investigational new drugs 20071001

• Adenomatous polyposis coli-mediated hypersensitivity of mouse embryonic fibroblast cell lines to methylmethane sulfonate treatment: implication of base excision repair pathways.

  Carcinogenesis 20071001

• ReProComet: a new in vitro method to assess DNA damage in mammalian sperm.

  Toxicological sciences : an official journal of the Society of Toxicology 20071001

• Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival.

  Cell 20070921

• Genome-wide gene expression profiling suggests distinct radiation susceptibilities in sporadic and post-Chernobyl papillary thyroid cancers.

  British journal of cancer 20070911

• Identification of sequences that target BRCA1 to nuclear foci following alkylative DNA damage.

  Cellular signalling 20070901

• Identification of cysteines in rat organic cation transporters rOCT1 (C322, C451) and rOCT2 (C451) critical for transport activity and substrate affinity.

  American journal of physiology. Renal physiology 20070901

• Specific transcriptional responses induced by 8-methoxypsoralen and UVA in yeast.

  FEMS yeast research 20070901

• Phosphorylation of Slx4 by Mec1 and Tel1 regulates the single-strand annealing mode of DNA repair in budding yeast.

  Molecular and cellular biology 20070901

• Neurosprora crassa RAD5 homologue, mus-41, inactivation results in higher sensitivity to mutagens but has little effect on PCNA-ubiquitylation in response to UV-irradiation.

  Current genetics 20070901

• Tissue factor coagulant function is enhanced by protein-disulfide isomerase independent of oxidoreductase activity.

  The Journal of biological chemistry 20070831

• Alkylating agent methyl methanesulfonate (MMS) induces a wave of global protein hyperacetylation: implications in cancer cell death.

  Biochemical and biophysical research communications 20070824

• Lycopene activity against chemically induced DNA damage in Chinese hamster ovary cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20070801

• Nicotinamidase activity is important for germination.

  The Plant journal : for cell and molecular biology 20070801

• Bacillus subtilis RecG branch migration translocase is required for DNA repair and chromosomal segregation.

  Molecular microbiology 20070801

• The role of AtMUS81 in interference-insensitive crossovers in A. thaliana.

  PLoS genetics 20070801

• A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions.

  PLoS genetics 20070801

• DNA damage measured by comet assay and 8-OH-dG formation related to blood chemical analyses in aged rats.

  The Journal of toxicological sciences 20070801

• The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications.

  Current genomics 20070801

• Antioxidant activity of diphenyl diselenide prevents the genotoxicity of several mutagens in Chinese hamster V79 cells.

  Mutation research 20070710

• Sea urchin embryo as a model for analysis of the signaling pathways linking DNA damage checkpoint, DNA repair and apoptosis.

  Cellular and molecular life sciences : CMLS 20070701

• Development of a highly efficient gene targeting system induced by transient repression of YKU80 expression in Candida glabrata.

  Eukaryotic cell 20070701

• Freshwater planarians as novel organisms for genotoxicity testing: Analysis of chromosome aberrations.

  Environmental and molecular mutagenesis 20070701

• Induction of V(D)J-mediated recombination of an extrachromosomal substrate following exposure to DNA-damaging agents.

  Environmental and molecular mutagenesis 20070701

• XRCC1 down-regulation in human cells leads to DNA-damaging agent hypersensitivity, elevated sister chromatid exchange, and reduced survival of BRCA2 mutant cells.

  Environmental and molecular mutagenesis 20070701

• In vitro micronucleus assay scored by flow cytometry provides a comprehensive evaluation of cytogenetic damage and cytotoxicity.

  Mutation research 20070615

• Functional and genetic analysis of the Saccharomyces cerevisiae RNC1/TRM2: evidences for its involvement in DNA double-strand break repair.

  Molecular and cellular biochemistry 20070601

• ATR signaling mediates an S-phase checkpoint after inhibition of poly(ADP-ribose) polymerase activity.

  DNA repair 20070601

• The novel gene mus7(+) is involved in the repair of replication-associated DNA damage in fission yeast.

  DNA repair 20070601

• Analysis of DNA repair and recombination responses in mouse cells depleted for Brca2 by SiRNA.

  DNA repair 20070601

• WRN functions in a RAD18-dependent damage avoidance pathway.

  Biological & pharmaceutical bulletin 20070601

• Evidence that a RecQ helicase slows senescence by resolving recombining telomeres.

  PLoS biology 20070601

• A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta.

  The Journal of biological chemistry 20070525

• Investigation of the mutagenic and antimutagenic effects of Origanum compactum essential oil and some of its constituents.

  Mutation research 20070518

• Nitric oxide donors attenuate clongenic potential in rat C6 glioma cells treated with alkylating chemotherapeutic agents.

  Neuroscience letters 20070511

• Schistosoma mansoni: the IMP4 gene is involved in DNA repair/tolerance after treatment with alkylating agent methyl methane sulfonate.

  Experimental parasitology 20070501

• Dose-response relationships and statistical performance of a battery of bacterial gene profiling assays.

  Applied microbiology and biotechnology 20070501

• Protective effect of DCTN (trans-dehydrocrotonin) against induction of micronuclei and apoptosis by different mutagenic agents in vitro.

  Mutation research 20070420

• Mechanistic influences for mutation induction curves after exposure to DNA-reactive carcinogens.

  Cancer research 20070415

• Hypersensitivity phenotypes associated with genetic and synthetic inhibitor-induced base excision repair deficiency.

  DNA repair 20070401

• Crosstalk between the subunits of the homodimeric enzyme triosephosphate isomerase.

  Proteins 20070401

• Does s-methyl methanethiosulfonate trap the thiol-disulfide state of proteins?

  Antioxidants & redox signaling 20070401

• Cooperative roles of vertebrate Fbh1 and Blm DNA helicases in avoidance of crossovers during recombination initiated by replication fork collapse.

  Molecular and cellular biology 20070401

• Multiple-pathway analysis of double-strand break repair mutations in Drosophila.

  PLoS genetics 20070401

• Rad50 is involved in MMS-induced recombination between homologous chromosomes in mitotic cells.

  Genes & genetic systems 20070401

• The Prp19/Pso4 core complex undergoes ubiquitylation and structural alterations in response to DNA damage.

  Biochemical and biophysical research communications 20070323

• An essential role for Drosophila hus1 in somatic and meiotic DNA damage responses.

  Journal of cell science 20070315

• Modelling the probability distribution of the number of DNA double-strand breaks due to sporadic alkylation of nucleotide bases.

  Journal of theoretical biology 20070307

• Chl1 and Ctf4 are required for damage-induced recombinations.

  Biochemical and biophysical research communications 20070302

• Is the repair of oxidative DNA base modifications inducible by a preceding DNA damage induction?

  DNA repair 20070301

• Global protein expression profiling of budding yeast in response to DNA damage.

  Yeast (Chichester, England) 20070301

• Cyclosporin A potentiates the cytotoxic effects of methyl methanesulphonate in HL-60 and K562 cells.

  Alternatives to laboratory animals : ATLA 20070301

• Anticancer effects of four varieties of muscadine grape.

  Journal of medicinal food 20070301

• The effect of dietary folic acid deficiency on the cytotoxic and mutagenic responses to methyl methanesulfonate in wild-type and in 3-methyladenine DNA glycosylase-deficient Aag null mice.

  Mutation research 20070203

• Rtt109 acetylates histone H3 lysine 56 and functions in DNA replication.

  Science (New York, N.Y.) 20070202

• Regulation of Cdx2 expression by promoter methylation, and effects of Cdx2 transfection on morphology and gene expression of human esophageal epithelial cells.

  Carcinogenesis 20070201

• Lead promotes abasic site accumulation and co-mutagenesis in mammalian cells by inhibiting the major abasic endonuclease Ape1.

  Molecular carcinogenesis 20070201

• A role for the yeast cell cycle/splicing factor Cdc40 in the G1/S transition.

  Current genetics 20070201

• Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions.

  Nature genetics 20070201

• [Cell phenotypes of a mutant in the gene encoding a Rad51 paralog in fission yeast].

  Genetika 20070201

• Involvement of mitochondrial-targeted RecA in the repair of mitochondrial DNA in the moss, Physcomitrella patens.

  Genes & genetic systems 20070201

• Doxorubicin down-regulates Kruppel-associated box domain-associated protein 1 sumoylation that relieves its transcription repression on p21WAF1/CIP1 in breast cancer MCF-7 cells.

  The Journal of biological chemistry 20070119

• Properties of the type B histone acetyltransferase Hat1: H4 tail interaction, site preference, and involvement in DNA repair.

  The Journal of biological chemistry 20070112

• Knockdown of ribosomal protein S3 protects human cells from genotoxic stress.

  DNA repair 20070104

• The protein kinase TOUSLED is required for maintenance of transcriptional gene silencing in Arabidopsis.

  EMBO reports 20070101

• Human monocytes, but not dendritic cells derived from them, are defective in base excision repair and hypersensitive to methylating agents.

  Cancer research 20070101

• Global analysis of functional surfaces of core histones with comprehensive point mutants.

  Genes to cells : devoted to molecular & cellular mechanisms 20070101

• Reduction of gene repair by selenomethionine with the use of single-stranded oligonucleotides.

  BMC molecular biology 20070101

• A dominant-negative form of the major human abasic endonuclease enhances cellular sensitivity to laboratory and clinical DNA-damaging agents.

  Molecular cancer research : MCR 20070101

• Manipulation of cell cycle progression can counteract the apparent loss of correction frequency following oligonucleotide-directed gene repair.

  BMC molecular biology 20070101

• Quantitation of lower levels of the DNA adduct of thymidylyl(3'-5')thymidine methyl phosphotriester by liquid chromatography/negative atmospheric pressure chemical ionization tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20070101

• Genome analysis of DNA repair genes in the alpha proteobacterium Caulobacter crescentus.

  BMC microbiology 20070101

• Stripped-down DNA repair in a highly reduced parasite.

  BMC molecular biology 20070101

• Colony size measurement of the yeast gene deletion strains for functional genomics.

  BMC bioinformatics 20070101

• Lack of effect of prior treatment with fluoride on genotoxicity of two chemical agents in vitro.

  Caries research 20070101

• Global transcriptional responses of fission and budding yeast to changes in copper and iron levels: a comparative study.

  Genome biology 20070101

• ATM-mediated transcriptional and developmental responses to gamma-rays in Arabidopsis.

  PloS one 20070101

• Gene expression profiling of long-lived dwarf mice: longevity-associated genes and relationships with diet, gender and aging.

  BMC genomics 20070101

• DNA damage repair is unaffected by mimicked heterozygous levels of BRCA2 in HT-29 cells.

  International journal of biological sciences 20070101

• Transcriptional networks in S. cerevisiae linked to an accumulation of base excision repair intermediates.

  PloS one 20070101

• Checkpoint independence of most DNA replication origins in fission yeast.

  BMC molecular biology 20070101

• Regulation of heme oxygenase-1 mRNA deadenylation and turnover in NIH3T3 cells by nitrosative or alkylation stress.

  BMC molecular biology 20070101

• Shiitake (Lentinula edodes (Berkeley) Pegler) extracts as a modulator of micronuclei induced in HEp-2 cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20061201

• In vitro genotoxicity and cytotoxicity of benzalkonium chloride.

  Toxicology in vitro : an international journal published in association with BIBRA 20061201

• Four human FANCG polymorphic variants show normal biological function in hamster CHO cells.

  Mutation research 20061201

• DNA damage checkpoints are involved in postreplication repair.

  Genetics 20061201

• Deletion of the chromatin remodeling gene SPT10 sensitizes yeast cells to a subclass of DNA-damaging agents.

  Environmental and molecular mutagenesis 20061201

• DNA damage by ochratoxin A in rat kidney assessed by the alkaline comet assay.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20061201

• Methylating agents and DNA repair responses: Methylated bases and sources of strand breaks.

  Chemical research in toxicology 20061201

• Modulation of chromosome damage localization by DNA replication timing.

  International journal of radiation biology 20061201

• Lung cell fiber evanescent wave spectroscopic biosensing of inhalation health hazards.

  Biotechnology and bioengineering 20061105

• Drosophila mus301/spindle-C encodes a helicase with an essential role in double-strand DNA break repair and meiotic progression.

  Genetics 20061101

• Correlated resistance to glucose deprivation and cytotoxic agents in fibroblast cell lines from long-lived pituitary dwarf mice.

  Mechanisms of ageing and development 20061101

• Employing libraries of zinc finger artificial transcription factors to screen for homologous recombination mutants in Arabidopsis.

  The Plant journal : for cell and molecular biology 20061101

• Functional relationships between Rad18 and WRNIP1 in vertebrate cells.

  Biological & pharmaceutical bulletin 20061101

• Characterization of a second proliferating cell nuclear antigen (PCNA2) from Drosophila melanogaster.

  The FEBS journal 20061101

• A role for PCNA ubiquitination in immunoglobulin hypermutation.

  PLoS biology 20061101

• Genotoxicants target distinct molecular networks in neonatal neurons.

  Environmental health perspectives 20061101

• TATA-binding protein-related factor 2 is localized in the cytoplasm of mammalian cells and much of it migrates to the nucleus in response to genotoxic agents.

  Molecules and cells 20061031

• Cellular characterization of cells from the Fanconi anemia complementation group, FA-D1/BRCA2.

  Mutation research 20061010

• Evaluation of antimutagenic activity and mechanisms of action of beta-glucan from barley, in CHO-k1 and HTC cell lines using the micronucleus test.

  Toxicology in vitro : an international journal published in association with BIBRA 20061001

• Arabidopsis SPO11-2 functions with SPO11-1 in meiotic recombination.

  The Plant journal : for cell and molecular biology 20061001

• Cell size checkpoint control by the retinoblastoma tumor suppressor pathway.

  PLoS genetics 20061001

• Both the basal transcriptional activity of the GADD45A gene and its enhancement after ionizing irradiation are mediated by AP-1 element.

  Biochimica et biophysica acta 20061001

• Identification of a stable flavin-thiolate adduct in heterotetrameric sarcosine oxidase.

  Journal of molecular biology 20060929

• Yeast recombination factor Rdh54 functionally interacts with the Rad51 recombinase and catalyzes Rad51 removal from DNA.

  The Journal of biological chemistry 20060908

• The role of Schizosaccharomyces pombe DNA repair enzymes Apn1p and Uve1p in the base excision repair of apurinic/apyrimidinic sites.

  Biochemical and biophysical research communications 20060908

• Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation.

  Nature chemical biology 20060901

• Meiotic chromosome synapsis-promoting proteins antagonize the anti-crossover activity of sgs1.

  PLoS genetics 20060901

• [The tk gene mutation analysis in WTK1 cell line by multiplex PCR].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20060901

• Heritability of DNA-damage-induced apoptosis and its relationship with age in lymphocytes from female twins.

  British journal of cancer 20060821

• Cross-talk between nucleotide excision and homologous recombination DNA repair pathways in the mechanism of action of antitumor trabectedin.

  Cancer research 20060815

• The Neurospora checkpoint kinase 2: a regulatory link between the circadian and cell cycles.

  Science (New York, N.Y.) 20060804

• Evaluation of the alkaline Comet assay conducted with the wetlands plant Bacopa monnieri L. as a model for ecogenotoxicity assessment.

  Environmental and molecular mutagenesis 20060801

• Antimicrobial endodontic compounds do not modulate alkylation-induced genotoxicity and oxidative stress in vitro.

  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20060801

• Arsenic exposure is associated with decreased DNA repair in vitro and in individuals exposed to drinking water arsenic.

  Environmental health perspectives 20060801

• Antigenotoxic effects of three essential oils in diploid yeast (Saccharomyces cerevisiae) after treatments with UVC radiation, 8-MOP plus UVA and MMS.

  Mutation research 20060714

• A high-throughput method to measure the sensitivity of yeast cells to genotoxic agents in liquid cultures.

  Mutation research 20060714

• Characterization of four RecQ homologues from rice (Oryza sativa L. cv. Nipponbare).

  Biochemical and biophysical research communications 20060714

• Histone acetyltransferase 1 is dispensable for replication-coupled chromatin assembly but contributes to recover DNA damages created following replication blockage in vertebrate cells.

  Biochemical and biophysical research communications 20060714

• Development of the in vivo chromosome aberration assay in oyster (Crassostrea gigas) embryo-larvae for genotoxicity assessment.

  Marine environmental research 20060701

• Angiotensin II type-2 receptor stimulation prevents neural damage by transcriptional activation of methyl methanesulfonate sensitive 2.

  Hypertension (Dallas, Tex. : 1979) 20060701

• Kre29p is a novel nuclear protein involved in DNA repair and mitotic fidelity in Candida glabrata.

  Current genetics 20060701

• Lysine 63-polyubiquitination guards against translesion synthesis-induced mutations.

  PLoS genetics 20060701

• The Saccharomyces cerevisiae orthologue of the human protein phosphatase 4 core regulatory subunit R2 confers resistance to the anticancer drug cisplatin.

  The FEBS journal 20060701

• Genotoxic effects of chromium(VI) and cadmium(II) in human blood lymphocytes using the electron microscopy in situ end-labeling (EM-ISEL) assay.

  Toxicology in vitro : an international journal published in association with BIBRA 20060601

• Protective effects of garlic sulfur compounds against DNA damage induced by direct- and indirect-acting genotoxic agents in HepG2 cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060601

• Anti-clastogenic effect of beta-glucan extracted from barley towards chemically induced DNA damage in rodent cells.

  Human & experimental toxicology 20060601

• Longevity in mice: is stress resistance a common factor?

  Age (Dordrecht, Netherlands) 20060601

• A systems approach to mapping DNA damage response pathways.

  Science (New York, N.Y.) 20060519

• P21Cip1/WAF1 downregulation is required for efficient PCNA ubiquitination after UV irradiation.

  Oncogene 20060511

• Esc4/Rtt107 and the control of recombination during replication.

  DNA repair 20060510

• hOGG1 recognizes oxidative damage using the comet assay with greater specificity than FPG or ENDOIII.

  Mutagenesis 20060501

• Characterization of T-DNA insertion mutants and RNAi silenced plants of Arabidopsis thaliana UV-damaged DNA binding protein 2 (AtUV-DDB2).

  Plant molecular biology 20060501

• Ecological-genetic feedback in DNA repair in wild barley, Hordeum spontaneum.

  Genetica 20060501

• DNA damage evaluated by gammaH2AX foci formation by a selective group of chemical/physical stressors.

  Mutation research 20060430

• Drosophila DNA polymerase zeta interacts with recombination repair protein 1, the Drosophila homologue of human abasic endonuclease 1.

  The Journal of biological chemistry 20060428

• The cullin Rtt101p promotes replication fork progression through damaged DNA and natural pause sites.

  Current biology : CB 20060418

• Posttranscriptional derepression of GADD45alpha by genotoxic stress.

  Molecular cell 20060407

• Simultaneous quantitation of 7-methyl- and O6-methylguanine adducts in DNA by liquid chromatography-positive electrospray tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060403

• A stress regulatory network for co-ordinated activation of proteasome expression mediated by yeast heat shock transcription factor.

  Molecular microbiology 20060401

• Disulfiram irreversibly aggregates betaine aldehyde dehydrogenase--a potential target for antimicrobial agents against Pseudomonas aeruginosa.

  Biochemical and biophysical research communications 20060310

• Genotoxicity evaluation of kaurenoic acid, a bioactive diterpenoid present in Copaiba oil.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060301

• A new protein superfamily includes two novel 3-methyladenine DNA glycosylases from Bacillus cereus, AlkC and AlkD.

  Molecular microbiology 20060301

• XRCC1 genotype and breast cancer: functional studies and epidemiologic data show interactions between XRCC1 codon 280 His and smoking.

  Cancer research 20060301

• DSS1 is required for the stability of BRCA2.

  Oncogene 20060223

• Fructose-1,6-bisphosphatase mediates cellular responses to DNA damage and aging in Saccharomyces cerevisiae.

  Mutation research 20060222

• Mutator phenotypes caused by substitution at a conserved motif A residue in eukaryotic DNA polymerase delta.

  The Journal of biological chemistry 20060217

• AlkB dioxygenase in preventing MMS-induced mutagenesis in Escherichia coli: effect of Pol V and AlkA proteins.

  DNA repair 20060203

• Role of DNA polymerase theta in tolerance of endogenous and exogenous DNA damage in mouse B cells.

  Genes to cells : devoted to molecular & cellular mechanisms 20060201

• Fibroblasts from long-lived Snell dwarf mice are resistant to oxygen-induced in vitro growth arrest.

  Aging cell 20060201

• [Effects of overexpression of human pol-beta on cellular response to DNA damage].

  Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20060201

• Involvement of vertebrate Polkappa in translesion DNA synthesis across DNA monoalkylation damage.

  The Journal of biological chemistry 20060127

• In vitro micronucleus scoring by flow cytometry: differential staining of micronuclei versus apoptotic and necrotic chromatin enhances assay reliability.

  Environmental and molecular mutagenesis 20060101

• DNA polymerase 4 of Saccharomyces cerevisiae is important for accurate repair of methyl-methanesulfonate-induced DNA damage.

  Genetics 20060101

• DNA strand breaks are not induced in human cells exposed to 2.1425 GHz band CW and W-CDMA modulated radiofrequency fields allocated to mobile radio base stations.

  Bioelectromagnetics 20060101

• Loss of DNA polymerase zeta causes chromosomal instability in mammalian cells.

  Cancer research 20060101

• The akuB(KU80) mutant deficient for nonhomologous end joining is a powerful tool for analyzing pathogenicity in Aspergillus fumigatus.

  Eukaryotic cell 20060101

• Drosophila damaged DNA binding protein 1 contributes to genome stability in somatic cells.

  Journal of biochemistry 20060101

• Lack of in vitro genotoxicity of povidone-iodine in solution, in ointment or in a liposomal formulation (Repithel).

  Dermatology (Basel, Switzerland) 20060101

• Common features and interesting differences in transcriptional responses to secretion stress in the fungi Trichoderma reesei and Saccharomyces cerevisiae.

  BMC genomics 20060101

• Mutator specificity of Escherichia coli alkB117 allele.

  Acta biochimica Polonica 20060101

• Non-random clustering of stress-related genes during evolution of the S. cerevisiae genome.

  BMC evolutionary biology 20060101

• MicroArray Facility: a laboratory information management system with extended support for Nylon based technologies.

  BMC genomics 20060101

• Colostrinin decreases spontaneous and induced mutation frequencies at the hprt locus in Chinese hamster V79 cells.

  Journal of experimental therapeutics & oncology 20060101

• Microarray expression analysis of meiosis and microsporogenesis in hexaploid bread wheat.

  BMC genomics 20060101

• Analyzing the dose-dependence of the Saccharomyces cerevisiae global transcriptional response to methyl methanesulfonate and ionizing radiation.

  BMC genomics 20060101

• The DNA-damage signature in Saccharomyces cerevisiae is associated with single-strand breaks in DNA.

  BMC genomics 20060101

• Natural microbial polysaccharide sulphoethyl glucan as antigenotoxic and cancer preventing agent.

  Neoplasma 20060101

• Maf1, a new player in the regulation of human RNA polymerase III transcription.

  PloS one 20060101

• Hsk1-Dfp1/Him1, the Cdc7-Dbf4 kinase in Schizosaccharomyces pombe, associates with Swi1, a component of the replication fork protection complex.

  The Journal of biological chemistry 20051230

• Conformation-dependent inactivation of human betaine-homocysteine S-methyltransferase by hydrogen peroxide in vitro.

  The Biochemical journal 20051215

• Mutations in Mre11 phosphoesterase motif I that impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex stability in addition to nuclease activity.

  Genetics 20051201

• The yeast histone chaperone chromatin assembly factor 1 protects against double-strand DNA-damaging agents.

  Genetics 20051201

• Involvement of polyubiquitin chains via specific chain linkages in stress response in mammalian cells.

  Biological & pharmaceutical bulletin 20051201

• A network of multi-tasking proteins at the DNA replication fork preserves genome stability.

  PLoS genetics 20051201

• The role of natural biopolymers in genotoxicity of mutagens/carcinogens elimination.

  Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20051201

• Saccharomyces cerevisiae RAD53 (CHK2) but not CHK1 is required for double-strand break-initiated SCE and DNA damage-associated SCE after exposure to X rays and chemical agents.

  DNA repair 20051121

• Roles of base excision repair enzymes Nth1p and Apn2p from Schizosaccharomyces pombe in processing alkylation and oxidative DNA damage.

  DNA repair 20051121

• Sensitization of human carcinoma cells to alkylating agents by small interfering RNA suppression of 3-alkyladenine-DNA glycosylase.

  Cancer research 20051115

• Mutations in a conserved replication protein suppress transcriptional gene silencing in a DNA-methylation-independent manner in Arabidopsis.

  Current biology : CB 20051108

• The csnD/csnE signalosome genes are involved in the Aspergillus nidulans DNA damage response.

  Genetics 20051101

• Cellular dynamics and modulation of WRN protein is DNA damage specific.

  Mechanisms of ageing and development 20051101

• A mutation in yeast Tel1p that causes differential effects on the DNA damage checkpoint and telomere maintenance.

  Current genetics 20051101

• Ion/molecule reactions in a miniature RIT mass spectrometer.

  Journal of mass spectrometry : JMS 20051101

• HIM1, a new yeast Saccharomyces cerevisiae gene playing a role in control of spontaneous and induced mutagenesis.

  Mutation research 20051015

• Studying the synergistic damage effects induced by 1.8 GHz radiofrequency field radiation (RFR) with four chemical mutagens on human lymphocyte DNA using comet assay in vitro.

  Mutation research 20051015

• Enhanced stimulation of chromosomal translocations and sister chromatid exchanges by either HO-induced double-strand breaks or ionizing radiation in Saccharomyces cerevisiae yku70 mutants.

  Mutation research 20051015

• Relationships between genomic, cell cycle, and mutagenic responses of TK6 cells exposed to DNA damaging chemicals.

  Mutation research 20051015

• Induced mutation spectra at the upp locus in Salmonella typhimurium: response of the target gene in the FU assay to mechanistically different mutagens.

  Mutation research 20051015

• Evaluation of testicular toxicity and sperm morphology in rats treated with methyl methanesulphonate (MMS).

  The Journal of reproduction and development 20051001

• The C. elegans ortholog of mammalian Ku70, interacts with insulin-like signaling to modulate stress resistance and life span.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20051001

• REV1 mediated mutagenesis in base excision repair deficient mouse fibroblast.

  DNA repair 20050928

• Involvement of poly(ADP-ribose) polymerase activity in regulating Chk1-dependent apoptotic cell death.

  DNA repair 20050928

• Mrc1 and Tof1 promote replication fork progression and recovery independently of Rad53.

  Molecular cell 20050902

• Dynamic changes in protein-protein interaction and protein phosphorylation probed with amine-reactive isotope tag.

  Molecular & cellular proteomics : MCP 20050901

• Apaf-1 deficient mouse fibroblasts are resistant to MNNG and MMS-induced apoptotic death without attenuation of Bcl-2 decline.

  Toxicology and applied pharmacology 20050901

• Role of the Schizosaccharomyces pombe F-Box DNA helicase in processing recombination intermediates.

  Molecular and cellular biology 20050901

• Arabidopsis RecQI4A suppresses homologous recombination and modulates DNA damage responses.

  The Plant journal : for cell and molecular biology 20050901

• REC, Drosophila MCM8, drives formation of meiotic crossovers.

  PLoS genetics 20050901

• Genotoxicity sensor response correlated with DNA nucleobase damage rates measured by LC-MS.

  Molecular bioSystems 20050901

• Differentiating mechanisms of toxicity using global gene expression analysis in Saccharomyces cerevisiae.

  Mutation research 20050804

• Different types of combination effects for the induction of micronuclei in mouse lymphoma cells by binary mixtures of the genotoxic agents MMS, MNU, and genistein.

  Toxicological sciences : an official journal of the Society of Toxicology 20050801

• Cytotoxicity and gene induction by some essential oils in the yeast Saccharomyces cerevisiae.

  Mutation research 20050801

• Inhibition of c-Jun-N-terminal-kinase sensitizes tumor cells to CD95-induced apoptosis and induces G2/M cell cycle arrest.

  Cancer research 20050801

• Genome-wide requirements for resistance to functionally distinct DNA-damaging agents.

  PLoS genetics 20050801

• Thiol-disulphide interchange in tubulin: kinetics and the effect on polymerization.

  The Biochemical journal 20050715

• Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress.

  American journal of physiology. Endocrinology and metabolism 20050701

• XRCC1 and DNA polymerase beta interaction contributes to cellular alkylating-agent resistance and single-strand break repair.

  Journal of cellular biochemistry 20050701

• Validation of Drosophila melanogaster as an in vivo model for genotoxicity assessment using modified alkaline Comet assay.

  Mutagenesis 20050701

• Genetic and physical interactions between Schizosaccharomyces pombe Mcl1 and Rad2, Dna2 and DNA polymerase alpha: evidence for a multifunctional role of Mcl1 in DNA replication and repair.

  Current genetics 20050701

• Influence of orange juice over the genotoxicity induced by alkylating agents: an in vivo analysis.

  Mutagenesis 20050701

• Two types of replication protein A in seed plants.

  The FEBS journal 20050701

• Antioxidative and antigenotoxic effects of Japanese horse chestnut (Aesculus turbinata) seeds.

  The Journal of veterinary medical science 20050701

• Antigenotoxic effect of allicin against methyl methanesulphonate induced genotoxic damage.

  Journal of environmental biology 20050701

• Stress-specific signatures: expression profiling of p53 wild-type and -null human cells.

  Oncogene 20050630

• Overexpression of Rad51 inhibits double-strand break-induced homologous recombination but does not affect gene conversion tract lengths.

  DNA repair 20050608

• Evaluation of liver and peripheral blood micronucleus assays with 9 chemicals using young rats. A study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Japanese Environmental Mutagen Society (JEMS)-Mammalian Mutagenicity Study Group (MMS).

  Mutation research 20050606

• Characterization of chemically induced hepatotoxicity in collagen sandwiches of rat hepatocytes.

  Toxicological sciences : an official journal of the Society of Toxicology 20050601

• [Influence of 1.8 GHz microwave on DNA damage induced by 4 chemical mutagens].

  Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20050601

• Possible repair action of Vitamin C on DNA damage induced by methyl methanesulfonate, cyclophosphamide, FeSO4 and CuSO4 in mouse blood cells in vivo.

  Mutation research 20050502

• Influence of caspase activity on micronuclei detection: a possible role for caspase-3 in micronucleation.

  Mutagenesis 20050501

• Evaluation of genotoxic effects in human peripheral blood leukocytes following an acute in vitro exposure to 900 MHz radiofrequency fields.

  Bioelectromagnetics 20050501

• A time-course characterization of male reproductive toxicity in rats treated with methyl methanesulphonate (MMS).

  The Journal of toxicological sciences 20050501

• Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after DNA methylating agent exposure.

  The Journal of biological chemistry 20050422

• Mitochondrial targeting of human O6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents.

  Cancer research 20050415

• Ubiquitin ligase activity of TFIIH and the transcriptional response to DNA damage.

  Molecular cell 20050415

• Genetic network interactions among replication, repair and nuclear pore deficiencies in yeast.

  DNA repair 20050404

• The Arg280His polymorphism in X-ray repair cross-complementing gene 1 impairs DNA repair ability.

  Mutation research 20050404

• Activation of budding yeast replication origins and suppression of lethal DNA damage effects on origin function by ectopic expression of the co-chaperone protein Mge1.

  The Journal of biological chemistry 20050401

• The Rad1-Rad10 complex promotes the production of gross chromosomal rearrangements from spontaneous DNA damage in Saccharomyces cerevisiae.

  Genetics 20050401

• Quantitative measurement of DNA adducts using neutral hydrolysis and LC-MS. Validation of genotoxicity sensors.

  Analytical chemistry 20050401

• MIT toxicogenomics research program.

  Environmental health perspectives 20050401

• Characterisation of two novel fork-head gene homologues of Schizosaccharomyces pombe: their involvement in cell cycle and sexual differentiation.

  Gene 20050328

• Induction of a cell stress response gene RTP801 by DNA damaging agent methyl methanesulfonate through CCAAT/enhancer binding protein.

  Biochemistry 20050315

• Extensive chromosomal instability in Rad51d-deficient mouse cells.

  Cancer research 20050315

• Genetic control of temperature preference in the nematode Caenorhabditis elegans.

  Genetics 20050301

• Systematic, RNA-interference-mediated identification of mus-101 modifier genes in Caenorhabditis elegans.

  Genetics 20050301

• The N-terminal region of the Schizosaccharomyces pombe RecQ helicase, Rqh1p, physically interacts with Topoisomerase III and is required for Rqh1p function.

  Molecular genetics and genomics : MGG 20050301

• Expression of insulin-like growth factor-1 and insulin-like growth factor-1 receptors in EL4 lymphoma cells overexpressing growth hormone.

  Cellular immunology 20050301

• Tumor suppressor APC blocks DNA polymerase beta-dependent strand displacement synthesis during long patch but not short patch base excision repair and increases sensitivity to methylmethane sulfonate.

  The Journal of biological chemistry 20050225

• The ability of Sgs1 to interact with DNA topoisomerase III is essential for damage-induced recombination.

  DNA repair 20050203

• Comet assay with nuclear extract incubation.

  Analytical biochemistry 20050201

• Functional specialization of Chlamydomonas reinhardtii cytosolic thioredoxin h1 in the response to alkylation-induced DNA damage.

  Eukaryotic cell 20050201

• Comparative study of the comet assay and the micronucleus test in amphibian larvae (Xenopus laevis) using benzo(a)pyrene, ethyl methanesulfonate, and methyl methanesulfonate: establishment of a positive control in the amphibian comet assay.

  Environmental toxicology 20050201

• The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors.

  Bioorganic & medicinal chemistry letters 20050117

• Role of Escherichia coli DnaK and DnaJ chaperones in spontaneous and induced mutagenesis and their effect on UmuC stability.

  FEMS microbiology letters 20050115

• New insights into the Fanconi anemia pathway from an isogenic FancG hamster CHO mutant.

  DNA repair 20050102

• The Saccharomyces cerevisiae PDS1 and RAD9 checkpoint genes control different DNA double-strand break repair pathways.

  DNA repair 20050102

• Ccr4-not complex mRNA deadenylase activity contributes to DNA damage responses in Saccharomyces cerevisiae.

  Genetics 20050101

• Effects of substrate specificity on initiating the base excision repair of N-methylpurines by variant human 3-methyladenine DNA glycosylases.

  Chemical research in toxicology 20050101

• Differential adduction of proteins vs. deoxynucleosides by methyl methanesulfonate and 1-methyl-1-nitrosourea in vitro.

  Rapid communications in mass spectrometry : RCM 20050101

• Correlation and prediction of gene expression level from amino acid and dipeptide composition of its protein.

  BMC bioinformatics 20050101

• Genome-wide screening for genes whose deletions confer sensitivity to mutagenic purine base analogs in yeast.

  BMC genetics 20050101

• A microarray study of MPP+-treated PC12 Cells: Mechanisms of toxicity (MOT) analysis using bioinformatics tools.

  BMC bioinformatics 20050101

• The potential roles of p53 tumor suppressor in nucleotide excision repair (NER) and base excision repair (BER).

  Experimental & molecular medicine 20041231

• Differential regulation of gene expression by RNA polymerase II in response to DNA damage.

  Biochemical and biophysical research communications 20041217

• Increased genome instability and telomere length in the elg1-deficient Saccharomyces cerevisiae mutant are regulated by S-phase checkpoints.

  Eukaryotic cell 20041201

• Enhancement of genotoxic effects in the comet assay with human blood samples by aphidicolin.

  Toxicology letters 20041128

• DNA replication checkpoint control mediated by the spindle checkpoint protein Mad2p in fission yeast.

  The Journal of biological chemistry 20041105

• 'Knock down' of DNA polymerase beta by RNA interference: recapitulation of null phenotype.

  DNA repair 20041102

• The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4.

  DNA repair 20041102

• Rad62 protein functionally and physically associates with the smc5/smc6 protein complex and is required for chromosome integrity and recombination repair in fission yeast.

  Molecular and cellular biology 20041101

• Brca1-deficient murine mammary epithelial cells have increased sensitivity to CDDP and MMS.

  Cell cycle (Georgetown, Tex.) 20041101

• Antigenotoxic potential of glucomannan on four model test systems.

  Cell biology and toxicology 20041101

• DNA damage-induced accumulation of Rad18 protein at stalled replication forks in mammalian cells involves upstream protein phosphorylation.

  Biochemical and biophysical research communications 20041022

• Genetic variation in XRCC1, sun exposure, and risk of skin cancer.

  British journal of cancer 20041018

• Hot spots for modulating toxicity identified by genomic phenotyping and localization mapping.

  Molecular cell 20041008

• The hyper unequal sister chromatid recombination in an sgs1 mutant of budding yeast requires MSH2.

  DNA repair 20041005

• Identification and characterization of the rlp1+, the novel Rad51 paralog in the fission yeast Schizosaccharomyces pombe.

  DNA repair 20041005

• DNA polymerase beta lyase inhibitors from Maytenus putterlickoides.

  Journal of natural products 20041001

• Identification of small molecule synthetic inhibitors of DNA polymerase beta by NMR chemical shift mapping.

  The Journal of biological chemistry 20040917

• Effects of gemcitabine on APE/ref-1 endonuclease activity in pancreatic cancer cells, and the therapeutic potential of antisense oligonucleotides.

  British journal of cancer 20040913

• Involvement of human p53 in induced intrachromosomal recombination in Saccharomyces cerevisiae.

  Mutagenesis 20040901

• A novel yeast mutation, rad52-L89F, causes a specific defect in Rad51-independent recombination that correlates with a reduced ability of Rad52-L89F to interact with Rad59.

  Genetics 20040901

• [TK locus mutation assay: comparison of L5178Y and TK6 cell lines].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20040901

• Trace analysis of residual methyl methanesulfonate, ethyl methanesulfonate and isopropyl methanesulfonate in pharmaceuticals by capillary gas chromatography with flame ionization detection.

  Journal of chromatography. A 20040813

• Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells.

  Molecular cancer therapeutics 20040801

• CDC7/DBF4 functions in the translesion synthesis branch of the RAD6 epistasis group in Saccharomyces cerevisiae.

  Genetics 20040801

• Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function.

  The Journal of biological chemistry 20040723

• Construction of a recA mutant of Azospirillum lipoferum and involvement of recA in phase variation.

  FEMS microbiology letters 20040715

• Relative cytotoxicity values at the lowest effective concentration for 12 positive chemicals in the in vitro micronucleus test utilizing Chinese hamster ovary cells.

  Mutation research 20040711

• Regulation of mouse GADD34 gene transcription after DNA damaging agent methylmethane sulfonate.

  Gene 20040707

• Preliminary evaluation of DNA damage related with the smoking habit measured by the comet assay in whole blood cells.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20040701

• Protein phosphatase 1, but not protein phosphatase 2A, dephosphorylates DNA-damaging stress-induced phospho-serine 15 of p53.

  FEBS letters 20040604

• Regulatory mechanisms controlling biogenesis of ubiquitin and the proteasome.

  FEBS letters 20040604

• Variation of the antimutagenicity effects of water extracts of Agaricus blazei Murrill in vitro.

  Toxicology in vitro : an international journal published in association with BIBRA 20040601

• Evaluation of the genotoxic potential of the Casearia sylvestris extract on HTC and V79 cells by the comet assay.

  Toxicology in vitro : an international journal published in association with BIBRA 20040601

• Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition.

  Molecular cancer therapeutics 20040601

• Saccharomyces cerevisiae RAD27 complements its Escherichia coli homolog in damage repair but not mutation avoidance.

  Genes & genetic systems 20040601

• Identification of a gene expression profile that discriminates indirect-acting genotoxins from direct-acting genotoxins.

  Mutation research 20040518

• Comet assay using mullet (Mugil sp.) and sea catfish (Netuma sp.) erythrocytes for the detection of genotoxic pollutants in aquatic environment.

  Mutation research 20040509

• Visualization of altered replication dynamics after DNA damage in human cells.

  The Journal of biological chemistry 20040507

• Profiles of gene expression changes in L5178Y mouse lymphoma cells treated with methyl methanesulfonate and sodium chloride.

  Mutagenesis 20040501

• Characterization of the hamster FancG/Xrcc9 gene and mutations in CHO UV40 and NM3.

  Mutagenesis 20040501

• Molecular aspects of plant adaptation to life in the Chernobyl zone.

  Plant physiology 20040501

• Low concentrations of formaldehyde induce DNA damage and delay DNA repair after UV irradiation in human skin cells.

  Experimental dermatology 20040501

• A large-scale screen for mutagen-sensitive loci in Drosophila.

  Genetics 20040501

• Nitric oxide inhibits DNA-adduct excision in nucleotide excision repair.

  Free radical biology & medicine 20040415

• The autoradiographic test for unscheduled DNA synthesis: a sensitive assay for the detection of DNA repair in the HepG2 cell line.

  Mutation research 20040411

• The possible roles of the DNA helicase and C-terminal domains in RECQ5/QE: complementation study in yeast.

  DNA repair 20040401

• SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae.

  DNA repair 20040401

• Antigenotoxic effect of allicin against SCEs induced by methyl methanesulphonate in cultured mammalian cells.

  Indian journal of experimental biology 20040401

• Yeast MPH1 gene functions in an error-free DNA damage bypass pathway that requires genes from Homologous recombination, but not from postreplicative repair.

  Genetics 20040401

• Role of the nuclease activity of Saccharomyces cerevisiae Mre11 in repair of DNA double-strand breaks in mitotic cells.

  Genetics 20040401

• Transcription factors NF-YA regulate the induction of human OGG1 following DNA-alkylating agent methylmethane sulfonate (MMS) treatment.

  The Journal of biological chemistry 20040312

• Ubc9 is required for damage-tolerance and damage-induced interchromosomal homologous recombination in S. cerevisiae.

  DNA repair 20040304

• The absence of a functional relationship between ATM and BLM, the components of BASC, in DT40 cells.

  Biochimica et biophysica acta 20040302

• Coffee-mediated protective effects against directly acting genotoxins and gamma-radiation in mouse lymphoma cells.

  Cell biology and toxicology 20040301

• The Neurospora crassa mus-19 gene is identical to the qde-3 gene, which encodes a RecQ homologue and is involved in recombination repair and postreplication repair.

  Current genetics 20040201

• A domain of Rad9 specifically required for activation of Chk1 in budding yeast.

  Journal of cell science 20040201

• Interchromatid and interhomolog recombination in Arabidopsis thaliana.

  The Plant cell 20040201

• The biological effects of N3-methyladenine.

  Journal of cellular biochemistry 20040201

• Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint.

  The EMBO journal 20040128

• Saccharomyces cerevisiae ubiquitin-like protein Rub1 conjugates to cullin proteins Rtt101 and Cul3 in vivo.

  The Biochemical journal 20040115

• Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes.

  Cell 20040109

• Involvement of two endonuclease III homologs in the base excision repair pathway for the processing of DNA alkylation damage in Saccharomyces cerevisiae.

  DNA repair 20040105

• A comprehensive evolutionary classification of proteins encoded in complete eukaryotic genomes.

  Genome biology 20040101

• The inhibition of apoptosis in EL4 lymphoma cells overexpressing growth hormone.

  Neuroimmunomodulation 20040101

• [Dynamics of some postreplication DNA repair proteins in carcinogen-damaged mammalian cells].

  Tsitologiia 20040101

• Investigations into the biological relevance of in vitro clastogenic and aneugenic activity.

  Cytogenetic and genome research 20040101

• Systematic quantification of gene interactions by phenotypic array analysis.

  Genome biology 20040101

• Network responses to DNA damaging agents.

  DNA repair 20040101

• Inhibition of the human apurinic/apyrimidinic endonuclease (APE1) repair activity and sensitization of breast cancer cells to DNA alkylating agents with lucanthone.

  Anticancer research 20040101

• Comparison of gene expression changes induced in mouse and human cells treated with direct-acting mutagens.

  Environmental and molecular mutagenesis 20040101

• [Some properties of a mutant of Streptomyces globisporus 1912 supersensitive to ultraviolet radiation].

  Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993) 20040101

• Fish as bioindicators to assess the effects of pollution in two southern Brazilian rivers using the Comet assay and micronucleus test.

  Environmental and molecular mutagenesis 20040101

• Antimutagenic activity of berry extracts.

  Journal of medicinal food 20040101

• The protective effect of mild hyperthermia against UV-mimetic agent 4-nitroquinoline-1-oxide (4NQO) in human colon cells.

  Research communications in molecular pathology and pharmacology 20040101

• Elimination of methyl methanesulfonate (MMS)-induced micronuclei (MNS) under mild hyperthermia via p53-dependent pathway in human lymphoid cells.

  Research communications in molecular pathology and pharmacology 20040101

• Methyl methanesulfonate.

  Report on carcinogens : carcinogen profiles 20040101

• The Drosophila melanogaster DNA Ligase IV gene plays a crucial role in the repair of radiation-induced DNA double-strand breaks and acts synergistically with Rad54.

  Genetics 20031201

• Modification of 1-substituents in the 2-azabicyclo[2.1.1]hexane ring system; approaches to potential nicotinic acetylcholine receptor ligands from 2,4-methanoproline derivatives.

  The Journal of organic chemistry 20031128

• Comparison of checkpoint responses triggered by DNA polymerase inhibition versus DNA damaging agents.

  Mutation research 20031127

• Mechanism-based inactivation of thioredoxin reductase from Plasmodium falciparum by Mannich bases. Implication for cytotoxicity.

  Biochemistry 20031118

• Evidence in Escherichia coli that N3-methyladenine lesions and cytotoxicity induced by a minor groove binding methyl sulfonate ester can be modulated in vivo by netropsin.

  Biochemistry 20031104

• Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses.

  The Journal of biological chemistry 20031010

• Identification and molecular characterisation of DNA damaging agent induced expression of Plasmodium falciparum recombination protein PfRad51.

  International journal for parasitology 20031001

• Recombinogenic effects of DNA-damaging agents are synergistically increased by transcription in Saccharomyces cerevisiae. New insights into transcription-associated recombination.

  Genetics 20031001

• REC, a new member of the MCM-related protein family, is required for meiotic recombination in Drosophila.

  Genes & genetic systems 20031001

• Lyn regulates the cell death response to ultraviolet radiation through c-Jun N terminal kinase-dependent Fas ligand activation.

  Experimental cell research 20030910

• Dephosphorylation of histone gamma-H2AX during repair of DNA double-strand breaks in mammalian cells and its inhibition by calyculin A.

  Radiation research 20030901

• Ku80 plays a role in non-homologous recombination but is not required for T-DNA integration in Arabidopsis.

  The Plant journal : for cell and molecular biology 20030901

• Cadmium inhibits repair of UV-, methyl methanesulfonate- and N-methyl-N-nitrosourea-induced DNA damage in Chinese hamster ovary cells.

  Mutation research 20030828

• The role of yeast DNA 3'-phosphatase Tpp1 and rad1/Rad10 endonuclease in processing spontaneous and induced base lesions.

  The Journal of biological chemistry 20030815

• Nat3p and Mdm20p are required for function of yeast NatB Nalpha-terminal acetyltransferase and of actin and tropomyosin.

  The Journal of biological chemistry 20030815

• Comparative scoring of micronucleated reticulocytes in rat peripheral blood by flow cytometry and microscopy.

  Toxicological sciences : an official journal of the Society of Toxicology 20030801

• Anticlastogenic effect of aqueous extracts of Agaricus blazei on CHO-k1 cells, studying different developmental phases of the mushroom.

  Toxicology in vitro : an international journal published in association with BIBRA 20030801

• Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand breaks but not telomeres.

  Molecular and cellular biology 20030801

• Human-yeast chimeric repair protein protects mammalian cells against alkylating agents: enhancement of MGMT protection.

  Cancer gene therapy 20030801

• DNA ligase IV from a basidiomycete, Coprinus cinereus, and its expression during meiosis.

  Microbiology (Reading, England) 20030801

• Tissue-dependent induction of heme oxygenase-1 and metallothionein-1/2 by methyl methanesulfonate.

  The Journal of toxicological sciences 20030801

• [Effects of 2,450 MHz microwave on DNA damage induced by three chemical mutagens in vitro].

  Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20030801

• High dosage Rhp51 suppression of the MMS sensitivity of DNA structure checkpoint mutants reveals a relationship between Crb2 and Rhp51.

  Genes to cells : devoted to molecular & cellular mechanisms 20030701

• The recombination-deficient mutant RPA (rfa1-t11) is displaced slowly from single-stranded DNA by Rad51 protein.

  The Journal of biological chemistry 20030627

• REX1, a novel gene required for DNA repair.

  The Journal of biological chemistry 20030620

• Multiple roles of Rev3, the catalytic subunit of polzeta in maintaining genome stability in vertebrates.

  The EMBO journal 20030616

• Extrachromosomal circular DNA of tandemly repeated genomic sequences in Drosophila.

  Genome research 20030601

• Phenotypic analysis of separation-of-function alleles of MEI-41, Drosophila ATM/ATR.

  Genetics 20030601

• Suppression of homologous recombination by the Saccharomyces cerevisiae linker histone.

  Molecular cell 20030601

• Osmotic water permeability and regulatory volume decrease of rat thymocytes.

  General physiology and biophysics 20030601

• Mutant casein kinase I (Hrr25p/Kti14p) abrogates the G1 cell cycle arrest induced by Kluyveromyces lactiszymocin in budding yeast.

  Molecular genetics and genomics : MGG 20030501

• Arabidopsis RecQsim, a plant-specific member of the RecQ helicase family, can suppress the MMS hypersensitivity of the yeast sgs1 mutant.

  Plant molecular biology 20030501

• Use of HepG2 cell line for direct or indirect mutagens screening: comparative investigation between comet and micronucleus assays.

  Mutation research 20030420

• The Escherichia coli RecA protein complements recombination defective phenotype of the Saccharomyces cerevisiae rad52 mutant cells.

  Yeast (Chichester, England) 20030415

• Independent roles of XRCC1's two BRCT motifs in recovery from methylation damage.

  DNA repair 20030402

• Enhanced radiation and chemotherapy-mediated cell killing of human cancer cells by small inhibitory RNA silencing of DNA repair factors.

  Cancer research 20030401

• A new Schizosaccharomyces pombe base excision repair mutant, nth1, reveals overlapping pathways for repair of DNA base damage.

  Molecular microbiology 20030401

• Saccharomyces cerevisiae Dap1p, a novel DNA damage response protein related to the mammalian membrane-associated progesterone receptor.

  Eukaryotic cell 20030401

• C/EBP family transcription factors are degraded by the proteasome but stabilized by forming dimer.

  Oncogene 20030306

• Induction of genome instability by DNA damage in Saccharomyces cerevisiae.

  DNA repair 20030301

• Budding yeast mms4 is epistatic with rad52 and the function of Mms4 can be replaced by a bacterial Holliday junction resolvase.

  DNA repair 20030301

• Ionizing irradiation effects on S-phase in checkpoint mutants of the yeast Saccharomyces cerevisiae.

  Current genetics 20030301

• Comet assay on gill cells and hemocytes from the blue mussel Mytilus edulis.

  Ecotoxicology and environmental safety 20030301

• The Drosophila chk2 gene loki is essential for embryonic DNA double-strand-break checkpoints induced in S phase or G2.

  Genetics 20030301

• The possible mechanism of action of ciclopirox olamine in the yeast Saccharomyces cerevisiae.

  Molecules and cells 20030227

• Apoptosis, ageing and cancer susceptibility.

  British journal of cancer 20030224

• Imbalancing the DNA base excision repair pathway in the mitochondria; targeting and overexpressing N-methylpurine DNA glycosylase in mitochondria leads to enhanced cell killing.

  Cancer research 20030201

• The recX gene product is involved in the SOS response in Herbaspirillum seropedicae.

  Canadian journal of microbiology 20030201

• A mechanism of resistance to TRAIL/Apo2L-induced apoptosis of newly established glioma cell line and sensitisation to TRAIL by genotoxic agents.

  British journal of cancer 20030127

• Telomeric DNA ends are essential for the localization of Ku at telomeres in fission yeast.

  The Journal of biological chemistry 20030117

• Anesthesia of fish with benzocaine does not interfere with comet assay results.

  Mutation research 20030110

• Hypersensitivity of DNA polymerase beta null mouse fibroblasts reflects accumulation of cytotoxic repair intermediates from site-specific alkyl DNA lesions.

  DNA repair 20030102

• Antimutagenic properties of bell and black peppers.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20030101

• Repairability during G1 of lesions eliciting sister chromatid exchanges induced by methylmethanesulfonate or ethylmethanesulfonate in bromodeoxyuridine-substituted and unsubstituted DNA strands.

  Mutagenesis 20030101

• The production of nitric oxide in EL4 lymphoma cells overexpressing growth hormone.

  Journal of neuroimmunology 20030101

• AtATM is essential for meiosis and the somatic response to DNA damage in plants.

  The Plant cell 20030101

• The QDE-3 homologue RecQ-2 co-operates with QDE-3 in DNA repair in Neurospora crassa.

  Current genetics 20030101

• Antimutagenicity of sodium selenite in Chinese hamster V79 cells exposed to azoxymethane, methylmethansulphonate and hydrogen peroxide.

  Mutation research 20030101

• The yeast ISN1 (YOR155c) gene encodes a new type of IMP-specific 5'-nucleotidase.

  BMC biochemistry 20030101

• [Biological effect of low doses of alkylating agents in drosophila studies].

  TSitologiia i genetika 20030101

• In silico and in vivo analysis reveal a novel gene in Saccharomyces cerevisiae trehalose metabolism.

  BMC genomics 20030101

• UV- and MMS-induced mutagenesis of lambdaO(am)8 phage under nonpermissive conditions for phage DNA replication.

  Acta biochimica Polonica 20030101

• ORC and the intra-S-phase checkpoint: a threshold regulates Rad53p activation in S phase.

  Genes & development 20021215

• ROS1, a repressor of transcriptional gene silencing in Arabidopsis, encodes a DNA glycosylase/lyase.

  Cell 20021213

• A myogenic differentiation checkpoint activated by genotoxic stress.

  Nature genetics 20021201

• The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair.

  The EMBO journal 20021101

• Monomeric yeast PCNA mutants are defective in interacting with and stimulating the ATPase activity of RFC.

  Biochemistry 20021029

• Characterization of a Schizosaccharomyces pombe strain deleted for a sequence homologue of the human damaged DNA binding 1 (DDB1) gene.

  The Journal of biological chemistry 20021025

• ATF3 induction following DNA damage is regulated by distinct signaling pathways and over-expression of ATF3 protein suppresses cells growth.

  Oncogene 20021024

• COP9 signalosome subunits 4 and 5 regulate multiple pleiotropic pathways in Drosophila melanogaster.

  Development (Cambridge, England) 20021001

• The HMG-CoA reductase inhibitor lovastatin protects cells from the antineoplastic drugs doxorubicin and etoposide.

  International journal of molecular medicine 20021001

• On the cytotoxicity of some microbial volatile organic compounds as studied in the human lung cell line A549.

  Chemosphere 20021001

• Severe developmental defects, hypersensitivity to DNA-damaging agents, and lengthened telomeres in Arabidopsis MRE11 mutants.

  The Plant cell 20021001

• A method for assaying the sensitivity of Drosophila replication checkpoint mutants to anti-cancer and DNA-damaging drugs.

  Genome 20021001

• A requirement for replication in activation of the ATR-dependent DNA damage checkpoint.

  Genes & development 20020915

• Inhibitory effect of chamomile essential oil on the sister chromatid exchanges induced by daunorubicin and methyl methanesulfonate in mouse bone marrow.

  Toxicology letters 20020905

• Interference of papillomavirus E6 protein with single-strand break repair by interaction with XRCC1.

  The EMBO journal 20020902

• GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress.

  Journal of cellular physiology 20020901

• Suppression of Saccharomyces cerevisiae rad27 null mutant phenotypes by the 5' nuclease domain of Escherichia coli DNA polymerase I.

  Current genetics 20020901

• The apurinic/apyrimidinic endonuclease activity of Ape1/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stress.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20020901

• Antifertility effects of methylmethane sulphonate on male reproductive organs of wild Indian house rat: histological and histochemical characteristics.

  Endocrine regulations 20020901

• Radiation- and chemical-induced structural chromosome aberrations in human spermatozoa.

  Mutation research 20020725

• Inactivation of Mre11 does not affect VSG gene duplication mediated by homologous recombination in Trypanosoma brucei.

  The Journal of biological chemistry 20020719

• DNA-damage induction of RAD54 can be regulated independently of the RAD9- and DDC1-dependent checkpoints that regulate RNR2.

  Current genetics 20020701

• Detection of mutation in transgenic CHO cells using green fluorescent protein as a reporter.

  Mutation research 20020627

• Posttranscriptional regulation of the RAD5 DNA repair gene by the Dun1 kinase and the Pan2-Pan3 poly(A)-nuclease complex contributes to survival of replication blocks.

  The Journal of biological chemistry 20020621

• Inactivation of homologous recombination suppresses defects in topoisomerase III-deficient mutants.

  DNA repair 20020621

• Influence of mus201 and mus308 mutations of Drosophila melanogaster on the genotoxicity of model chemicals in somatic cells in vivo measured with the comet assay.

  Mutation research 20020619

• Diol- and triol-type ginseng saponins potentiate the apoptosis of NIH3T3 cells exposed to methyl methanesulfonate.

  Toxicology and applied pharmacology 20020615

• Ku is important for telomere maintenance, but not for differential expression of telomeric VSG genes, in African trypanosomes.

  The Journal of biological chemistry 20020614

• Telomere length deregulation and enhanced sensitivity to genotoxic stress in Arabidopsis mutants deficient in Ku70.

  The EMBO journal 20020603

• Endogenous DNA abasic sites cause cell death in the absence of Apn1, Apn2 and Rad1/Rad10 in Saccharomyces cerevisiae.

  The EMBO journal 20020603

• Chemoprotection profiles of sodium thiosulfate on methyl methanesulfonate-induced mutagenesis of bacteriophage T4.

  Medical science monitor : international medical journal of experimental and clinical research 20020601

• Overlapping roles of the spindle assembly and DNA damage checkpoints in the cell-cycle response to altered chromosomes in Saccharomyces cerevisiae.

  Genetics 20020601

• Cell signaling in aging and apoptosis.

  Mechanisms of ageing and development 20020430

• Suppression of a DNA double-strand break repair gene, Ku70, increases radio- and chemosensitivity in a human lung carcinoma cell line.

  DNA repair 20020429

• Epistatic analysis of the roles of the RAD27 and POL4 gene products in DNA base excision repair in S. cerevisiae.

  DNA repair 20020429

• Central role for the XRCC1 BRCT I domain in mammalian DNA single-strand break repair.

  Molecular and cellular biology 20020401

• SN2 DNA-alkylating agent-induced phosphorylation of p53 and activation of p21 gene expression.

  Mutation research 20020320

• Selective depletion of human DNA-methyltransferase DNMT1 proteins by sulfonate-derived methylating agents.

  Cancer research 20020315

• In vivo reconstitution of Saccharomyces cerevisiae DNA polymerase epsilon in insect cells. Purification and characterization.

  The Journal of biological chemistry 20020308

• A comparison of the in vitro Comet assay with the in vitro chromosome aberration assay using whole human blood or Chinese hamster lung cells: validation study using a range of novel pharmaceuticals.

  Mutagenesis 20020301

• Deficiency in DNA polymerase beta provokes replication-dependent apoptosis via DNA breakage, Bcl-2 decline and caspase-3/9 activation.

  Cancer research 20020301

• Identification of Ku70 and Ku80 homologues in Arabidopsis thaliana: evidence for a role in the repair of DNA double-strand breaks.

  The Plant journal : for cell and molecular biology 20020301

• Pnk1, a DNA kinase/phosphatase required for normal response to DNA damage by gamma-radiation or camptothecin in Schizosaccharomyces pombe.

  The Journal of biological chemistry 20020208

• Reduced fertility and hypersensitivity to mitomycin C characterize Fancg/Xrcc9 null mice.

  Human molecular genetics 20020201

• Leucine aminopeptidase during meiotic development.

  European journal of biochemistry 20020201

• Werner and Bloom helicases are involved in DNA repair in a complementary fashion.

  Oncogene 20020131

• A role for Rad23 proteins in 26S proteasome-dependent protein degradation?

  Mutation research 20020129

• Implication of p53 in base excision DNA repair: in vivo evidence.

  Oncogene 20020124

• Structure of spin-labeled methylmethanethiolsulfonate in solution and bound to TEM-1 beta-lactamase determined by electron nuclear double resonance spectroscopy.

  Biochemistry 20020122

• Complementation between N-terminal Saccharomyces cerevisiae mre11 alleles in DNA repair and telomere length maintenance.

  DNA repair 20020122

• Application of the single cell gel electrophoresis on yeast cells.

  Mutation research 20020115

• Evaluation of the genotoxic potential of some microbial volatile organic compounds (MVOC) with the comet assay, the micronucleus assay and the HPRT gene mutation assay.

  Mutation research 20020115

• Defective flap endonuclease 1 activity in mammalian cells is associated with impaired DNA repair and prolonged S phase delay.

  The Journal of biological chemistry 20020104

• Inducible protective processes in animal systems. X. Influence of nicotinamide in methyl methanesulfonate-adapted mouse bone marrow cells.

  Mutagenesis 20020101

• An antisense construct of full-length human RAD50 cDNA confers sensitivity to ionizing radiation and alkylating agents on human cell lines.

  Radiation research 20020101

• Aging alters the apoptotic response to genotoxic stress.

  Nature medicine 20020101

• MMS1 protects against replication-dependent DNA damage in Saccharomyces cerevisiae.

  Molecular genetics and genomics : MGG 20020101

• Distinct functions of BRCA1 and BRCA2 in double-strand break repair.

  Breast cancer research : BCR 20020101

• Synthesis and activities of bactobolin derivatives having new functionality at C-3.

  The Journal of antibiotics 20020101

• Genotoxicity of maleic hydrazide, acridine and DEHP in Allium cepa root cells performed by two different laboratories.

  Hereditas 20020101

• MAP kinase phosphatases.

  Genome biology 20020101

• Trypanosoma brucei MRE11 is non-essential but influences growth, homologous recombination and DNA double-strand break repair.

  Molecular and biochemical parasitology 20020101

• Induction of epithelial tumors in Drosophila melanogaster heterozygous for the tumor suppressor gene wts.

  Environmental and molecular mutagenesis 20020101

• [Functional analysis of yeast homologue gene associated with human DNA helicase causative syndromes].

  Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences 20020101

• Methyl methanesulfonate.

  Report on carcinogens : carcinogen profiles 20020101

• Relationship between base excision repair capacity and DNA alkylating agent sensitivity in mouse monocytes.

  Mutation research 20011219

• Deletion of the MAG1 DNA glycosylase gene suppresses alkylation-induced killing and mutagenesis in yeast cells lacking AP endonucleases.

  Mutation research 20011219

• Detection of DNA adducts using a quantitative long PCR technique and the fluorogenic 5' nuclease assay (TaqMan).

  Mutation research 20011212

• Fission yeast Rad50 stimulates sister chromatid recombination and links cohesion with repair.

  The EMBO journal 20011203

• The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change.

  Oncogene 20011122

• On the nature of conformational openings: native and unfolded-state hydrogen and thiol-disulfide exchange studies of ferric aquomyoglobin.

  Journal of molecular biology 20011116

• Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression.

  The EMBO journal 20011115

• The structure-specific endonuclease Ercc1-Xpf is required for targeted gene replacement in embryonic stem cells.

  The EMBO journal 20011115

• The participation of AtXPB1, the XPB/RAD25 homologue gene from Arabidopsis thaliana, in DNA repair and plant development.

  The Plant journal : for cell and molecular biology 20011101

• Role of the DNA repair nucleases Rad13, Rad2 and Uve1 of Schizosaccharomyces pombe in mismatch correction.

  Journal of molecular biology 20011019

• Differential activation of mitogen-activated protein kinases by methyl methanesulfonate in the kidney of young and old rats.

  Mutation research 20011018

• Genotoxic effects of copper sulphate in freshwater planarian in vivo, studied with the single-cell gel test (comet assay).

  Mutation research 20011018

• Investigation of genotoxic and antigenotoxic activities of chlorophylls and chlorophyllin in cultured V79 cells.

  Mutation research 20011018

• Age-specific changes in expression, activity, and activation of the c-Jun NH(2)-terminal kinase and p38 mitogen-activated protein kinases by methyl methanesulfonate in rats.

  Mechanisms of ageing and development 20011001

• Antimutagenic effects of the mushroom Agaricus blazei Murrill extracts on V79 cells.

  Mutation research 20010920

• TATA binding protein-associated CK2 transduces DNA damage signals to the RNA polymerase III transcriptional machinery.

  Cell 20010907

• DNA alkylation-induced phosphorylation of p53 and activation of kinases in colon cancer cells.

  International journal of oncology 20010901

• Contribution of E. coli AlkA, TagA glycosylases and UvrABC-excinuclease in MMS mutagenesis.

  Mutation research 20010901

• In vivo consequences of putative active site mutations in yeast DNA polymerases alpha, epsilon, delta, and zeta.

  Genetics 20010901

• Multiple interactions among the components of the recombinational DNA repair system in Schizosaccharomyces pombe.

  Genetics 20010901

• Bipartite binding of a kinase activator activates Cdc7-related kinase essential for S phase.

  The Journal of biological chemistry 20010817

• Transcriptional regulation of the human DNA polymerase delta catalytic subunit gene POLD1 by p53 tumor suppressor and Sp1.

  The Journal of biological chemistry 20010810

• Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint.

  Nature 20010802

• The DNA helicase activity of yeast Sgs1p is essential for normal lifespan but not for resistance to topoisomerase inhibitors.

  Mechanisms of ageing and development 20010801

• Synergism between base excision repair, mediated by the DNA glycosylases Ntg1 and Ntg2, and nucleotide excision repair in the removal of oxidatively damaged DNA bases in Saccharomyces cerevisiae.

  Molecular genetics and genomics : MGG 20010801

• On the role of alkylating mechanisms, O-alkylation and DNA-repair in genotoxicity and mutagenicity of alkylating methanesulfonates of widely varying structures in bacterial systems.

  Chemico-biological interactions 20010731

• Identification of genotoxic stress in human cells by fluorescent monitoring of p53 expression.

  Mutation research 20010725

• Overexpression of type I topoisomerases sensitizes yeast cells to DNA damage.

  The Journal of biological chemistry 20010713

• Photoaffinity labeling of mouse fibroblast enzymes by a base excision repair intermediate. Evidence for the role of poly(ADP-ribose) polymerase-1 in DNA repair.

  The Journal of biological chemistry 20010706

• Genetic damage by bifunctional agents in repair-active pre-meiotic stages of Drosophila males.

  Mutation research 20010701

• Micronuclei and other nuclear lesions as genotoxicity indicators in rainbow trout Oncorhynchus mykiss.

  Ecotoxicology and environmental safety 20010701

• The effect of methyl methanesulfonate (MMS)-induced excision repair on p53-dependent apoptosis in human lymphoid cells.

  Research communications in molecular pathology and pharmacology 20010701

• The N-terminal region of Sgs1, which interacts with Top3, is required for complementation of MMS sensitivity and suppression of hyper-recombination in sgs1 disruptants.

  Molecular genetics and genomics : MGG 20010701

• A comparison of intraperitoneal and oral gavage administration in comet assay in mouse eight organs.

  Mutation research 20010627

• DNA damage and repair in Arabidopsis thaliana as measured by the comet assay after treatment with different classes of genotoxins.

  Mutation research 20010627

• A novel protein interacts with the Werner's syndrome gene product physically and functionally.

  The Journal of biological chemistry 20010608

• The death substrate Gas2 binds m-calpain and increases susceptibility to p53-dependent apoptosis.

  The EMBO journal 20010601

• Induction of the SAPK activator MIG-6 by the alkylating agent methyl methanesulfonate.

  Molecular carcinogenesis 20010601

• Disruptions of the Ustilago maydis REC2 gene identify a protein domain important in directing recombinational repair of DNA.

  Molecular microbiology 20010601

• Structural and functional characterization of the recR gene of Streptomyces.

  Molecular genetics and genomics : MGG 20010601

• The essential HupB and HupN proteins of Pseudomonas putida provide redundant and nonspecific DNA-bending functions.

  The Journal of biological chemistry 20010518

• RasG regulates discoidin gene expression during Dictyostelium growth.

  Experimental cell research 20010515

• Transcription factors Oct-1 and NF-YA regulate the p53-independent induction of the GADD45 following DNA damage.

  Oncogene 20010510

• Increased DNA double strand breakage is responsible for sensitivity of the pso3-1 mutant of Saccharomyces cerevisiae to hydrogen peroxide.

  Mutation research 20010510

• Phenotypes of Drosophila homologs of human XPF and XPG to chemically-induced DNA modifications.

  Mutation research 20010509

• DNA damaging agents increase gadd153 (CHOP-10) messenger RNA levels in bovine preimplantation embryos cultured in vitro.

  Biology of reproduction 20010501

• Effect of ultraviolet light, methyl methanesulfonate and ionizing radiation on the genotoxic response and apoptosis of mouse fibroblasts lacking c-Fos, p53 or both.

  Mutagenesis 20010501

• Repression of GADD153/CHOP by NF-kappaB: a possible cellular defense against endoplasmic reticulum stress-induced cell death.

  Oncogene 20010419

• Roles of yeast DNA polymerases delta and zeta and of Rev1 in the bypass of abasic sites.

  Genes & development 20010415

• Rad54 protein stimulates heteroduplex DNA formation in the synaptic phase of DNA strand exchange via specific interactions with the presynaptic Rad51 nucleoprotein filament.

  Journal of molecular biology 20010413

• Isolation and genetic characterisation of the Drosophila homologue of (SCE)REV3, encoding the catalytic subunit of DNA polymerase zeta.

  Mutation research 20010404

• Mitogen-activated protein kinase phosphatase is required for genotoxic stress relief in Arabidopsis.

  Genes & development 20010315

• Factors that control the reactivity of the interface cysteine of triosephosphate isomerase from Trypanosoma brucei and Trypanosoma cruzi.

  Biochemistry 20010313

• Detection of DNA primary damage by premature chromosome condensation in human peripheral blood lymphocytes treated with methyl methanesulfonate.

  Mutagenesis 20010301

• Activation of Ty transposition by mutagens.

  Mutation research 20010301

• Overexpression of endonuclease III protects Escherichia coli mutants defective in alkylation repair against lethal effects of methylmethanesulphonate.

  FEBS letters 20010223

• Cell cycle-dependent and DNA damage-inducible nuclear localization of FEN-1 nuclease is consistent with its dual functions in DNA replication and repair.

  The Journal of biological chemistry 20010216

• Downregulation of MDM2 stabilizes p53 by inhibiting p53 ubiquitination in response to specific alkylating agents.

  FEBS letters 20010216

• Alkylating agent and chromatin structure determine sequence context-dependent formation of alkylpurines.

  Journal of molecular biology 20010216

• Evidence in Escherichia coli that N3-methyladenine lesions induced by a minor groove binding methyl sulfonate ester can be processed by both base and nucleotide excision repair.

  Biochemistry 20010213

• Tof1p regulates DNA damage responses during S phase in Saccharomyces cerevisiae.

  Genetics 20010201

• Novel quantitative assays for estimating the antimicrobial activity of fresh garlic juice.

  Journal of food protection 20010201

• DNA damage leads to a Cyclin A-dependent delay in metaphase-anaphase transition in the Drosophila gastrula.

  Current biology : CB 20010109

• Transcriptional regulation and function during the human cell cycle.

  Nature genetics 20010101

• Antimutagenic activity of fluphenazine in short-term tests.

  Mutagenesis 20010101

• Disruption of the Arabidopsis RAD50 gene leads to plant sterility and MMS sensitivity.

  The Plant journal : for cell and molecular biology 20010101

• Involvement of SGS1 in DNA damage-induced heteroallelic recombination that requires RAD52 in Saccharomyces cerevisiae.

  Molecular & general genetics : MGG 20010101

• An Aspergillus nidulans uvsC null mutant is deficient in homologous DNA integration.

  Molecular & general genetics : MGG 20010101

• BRCA1 and BRCA2 protein expressions in an ovotestis of a 46, XX true hermaphrodite.

  Breast cancer research : BCR 20010101

• Feeding thiol-containing compounds, derived from vegetables, fails to inhibit N-methylnitrosourea-induced mammary tumorigenesis.

  Cancer detection and prevention 20010101

• Mammalian DNA beta-polymerase in base excision repair of alkylation damage.

  Progress in nucleic acid research and molecular biology 20010101

• BRCA2 and homologous recombination.

  Breast cancer research : BCR 20010101

• Detection of alkylation damage in human lymphocyte DNA with the comet assay.

  Acta biochimica Polonica 20010101

• A role for Saccharomyces cerevisiae histone H2A in DNA repair.

  Nature 20001201

• Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin.

  Diabetologia 20001201

• LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae.

  The EMBO journal 20001101

• Upregulation of CHOP-10 (gadd153) expression in the mouse blastocyst as a response to stress.

  Molecular reproduction and development 19991201

• Cadmium induces conformational modifications of wild-type p53 and suppresses p53 response to DNA damage in cultured cells.

  The Journal of biological chemistry 19991029

• Different populations of progesterone receptor-steroid complexes in binding to specific DNA sequences: effects of salts on kinetics and specificity.

  The Journal of steroid biochemistry and molecular biology 19981101

• Conformational change in human DNA repair enzyme O6-methylguanine-DNA methyltransferase upon alkylation of its active site by SN1 (indirect-acting) and SN2 (direct-acting) alkylating agents: breaking a 'salt-link'.

  Biochemistry 19960924

• Role of cysteines 640, 656, and 661 in steroid binding to rat glucocorticoid receptors.

  The Journal of biological chemistry 19920605

• Localization of the vicinal dithiols involved in steroid binding to the rat glucocorticoid receptor.

  Endocrinology 19901101

• Differential mutant quantitation at the mouse lymphoma tk and CHO hgprt loci.

  Mutagenesis 19890901

• Dominant lethal assay in female mice after oral dosing with dichlorvos or exposure to atmospheres containing dichlorovos.

  Mutation research 19760101