66-76-2 | Dicumarol

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$26.00	$18.00
5g	98%	in stock	$49.00	$35.00
10g	98%	in stock	$85.00	$60.00
25g	98%	in stock	$106.00	$75.00
100g	98%	in stock	$299.00	$209.00

Description

• Catalog Number: AB72673
• Chemical Name: Dicumarol
• CAS Number: 66-76-2
• Molecular Formula: C19H12O6
• Molecular Weight: 336.295
• MDL Number: MFCD00006857
• SMILES: O=c1oc2ccccc2c(c1Cc1c(=O)oc2c(c1O)cccc2)O

Computed Properties

• Complexity: 605
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 25
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 2
• XLogP3: 2.6

Literature

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  Neurotoxicity research 20030101

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  Biochemical pharmacology 20021201

• Insulin-like growth factor-1 activates Akt and Jun N-terminal kinases (JNKs) in promoting the survival of T lymphocytes.

  Immunology 20021201

• CNS neurons express two distinct plasma membrane electron transport systems implicated in neuronal viability.

  Journal of neurochemistry 20021101

• A novel plasma membrane quinone reductase and NAD(P)H:quinone oxidoreductase 1 are upregulated by serum withdrawal in human promyelocytic HL-60 cells.

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• NAD(P)H: quinone oxidoreductase enhances proliferation inhibition by 4-hydroxytamoxifen.

  Anticancer research 20020101

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  Protoplasma 20010101

• Interaction between electron transport at the plasma membrane and nitrate uptake by maize (Zea mays L.) roots.

  Protoplasma 20010101

• NAD(P)H:quinone oxidoreductase (NQO1) protects astroglial cells against L-dopa toxicity.

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  European urology 19980101

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• Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease.

  Journal of medicinal chemistry 19960621

• Discovery of novel, non-peptide HIV-1 protease inhibitors by pharmacophore searching.

  Journal of medicinal chemistry 19960510

• Molecular mechanisms of tirapazamine (SR 4233, Win 59075)-induced hepatocyte toxicity under low oxygen concentrations.

  British journal of cancer 19950401

• Aspirin-like drugs can protect human T lymphocytes against benzoquinone cytotoxicity: evidence for a NAD(P)H:quinone reductase-dependent mechanism.

  Archives of toxicology 19950101

• Reduction of chromium(VI) to chromium(V) by rat liver cytosolic and microsomal fractions: is DT-diaphorase involved?

  Carcinogenesis 19920701

• [Fatal cerebral hemorrhage caused by overdose of dicumarol, report of a case].

  Anales de medicina interna (Madrid, Spain : 1984) 19920201

• Identification and characterization of the enzymatic activity of zeta-crystallin from guinea pig lens. A novel NADPH:quinone oxidoreductase.

  The Journal of biological chemistry 19920105

• Dicoumarol and warfarin.

  British heart journal 19910801

• Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells.

  Cancer research 19901201

• Activation and deactivation of quinones catalyzed by DT-diaphorase. Evidence for bioreductive activation of diaziquone (AZQ) in human tumor cells and detoxification of benzene metabolites in bone marrow stroma.

  Free radical research communications 19900101

• In-vivo effects of itraconazole on hepatic mixed-function oxidase.

  The Journal of antimicrobial chemotherapy 19880201

• Spontaneous anticoagulant-induced hemopericardium with tamponade.

  Acta haematologica 19820101

• Disseminated intravascular coagulation induced by progesterone in the pregnant rat. Prevention by estogens.

  The American journal of pathology 19770301

• Pineal apoplexy associated with anticoagulant therapy. Case report.

  Journal of neurosurgery 19760801

• Comparison of graphical and computerized methods for calculating binding parameters for two strongly bound drugs to human serum albumin.

  Journal of pharmaceutical sciences 19760801

• Impotence in patients treated with clofibrate.

  Atherosclerosis 19750101

• Management of thrombo-embolism after aortic valve replacement with the Björk-Shiley tilting disc valve. Medicamental prevention with dicumarol in comparison with dipyridamole - acetylsalicylic acid. Surgical treatment of prosthetic thrombosis.

  Scandinavian journal of thoracic and cardiovascular surgery 19750101

• Intraocular hemorrhage and blindness associated with systemic anticoagulation.

  JAMA 19720605

• Unusual gastrointestinal reaction to bishydroxycoumarin(Dicumarol).

  American heart journal 19680701

• Urinary tract complications of anticoagulation therapy; 'pseudotumour' of the kidney.

  The British journal of radiology 19680301

• Antagonism of anticoagulants dicoumarol, tromexan, and phenylindandione by vitamin K.

  British medical journal 19520927