6600-40-4 | L-Norvaline

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$16.00	$11.00
5g	98%	in stock	$19.00	$13.00
10g	98%	in stock	$28.00	$19.00
25g	98%	in stock	$42.00	$30.00
100g	98%	in stock	$60.00	$42.00
500g	98%	in stock	$73.00	$51.00

Description

• Catalog Number: AB75228
• Chemical Name: L-Norvaline
• CAS Number: 6600-40-4
• Molecular Formula: C5H11NO2
• Molecular Weight: 117.14633999999998
• MDL Number: MFCD00064421
• SMILES: CCC[C@@H](C(=O)O)N

Computed Properties

• Complexity: 82.5
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 8
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 3
• XLogP3: -2.1

Literature

• Kinetic partitioning between synthetic and editing pathways in class I aminoacyl-tRNA synthetases occurs at both pre-transfer and post-transfer hydrolytic steps.

  The Journal of biological chemistry 20120720

• Glutamine and glutathione at ICU admission in relation to outcome.

  Clinical science (London, England : 1979) 20120601

• Metabolome analysis of gram-positive bacteria such as Staphylococcus aureus by GC-MS and LC-MS.

  Methods in molecular biology (Clifton, N.J.) 20120101

• Arginase inhibition alleviates hypertension associated with diabetes: effect on endothelial dependent relaxation and NO production.

  Vascular pharmacology 20120101

• New insight into the transcarbamylase family: the structure of putrescine transcarbamylase, a key catalyst for fermentative utilization of agmatine.

  PloS one 20120101

• Combination of valproate and paroxetine in mice exposed to picrotoxin.

  International journal of nanomedicine 20120101

• Jadomycins derived from the assimilation and incorporation of norvaline and norleucine.

  Journal of natural products 20111128

• An evolutionary strategy for isobutanol production strain development in Escherichia coli.

  Metabolic engineering 20111101

• A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis.

  The FEBS journal 20110901

• Understanding the molecular dynamics associated with polymorphic transitions of DL-norvaline with solid-state NMR methods.

  The journal of physical chemistry. B 20110331

• Solid-state phase transitions in DL-norvaline studied by single-crystal X-ray diffraction.

  The journal of physical chemistry. B 20110317

• A blue native-PAGE analysis of membrane protein complexes in Clostridium thermocellum.

  BMC microbiology 20110101

• Arginase inhibitor in the pharmacological correction of endothelial dysfunction.

  International journal of hypertension 20110101

• Establishment of reference range of plasma amino acids for younger Chinese children by reverse phase HPLC.

  Journal of pediatric endocrinology & metabolism : JPEM 20110101

• Ligand-induced changes in the conformational stability and flexibility of glutamate dehydrogenase and their role in catalysis and regulation.

  Protein science : a publication of the Protein Society 20101001

• RNAi-mediated suppression of isoprene emission in poplar transiently impacts phenolic metabolism under high temperature and high light intensities: a transcriptomic and metabolomic analysis.

  Plant molecular biology 20100901

• Caloric restriction reverses high-fat diet-induced endothelial dysfunction and vascular superoxide production in C57Bl/6 mice.

  Heart and vessels 20100501

• A series of alpha-amino acid ester prodrugs of camptothecin: in vitro hydrolysis and A549 human lung carcinoma cell cytotoxicity.

  Journal of medicinal chemistry 20100211

• Specificities of olfactory receptor neuron responses to amino acids in the black bullhead catfish (Ameiurus melas).

  Pflugers Archiv : European journal of physiology 20100201

• Solid-solid phase transitions in DL-norvaline studied by differential scanning calorimetry and Raman spectroscopy.

  The journal of physical chemistry. B 20100128

• Glutathione-supported arsenate reduction coupled to arsenolysis catalyzed by ornithine carbamoyl transferase.

  Toxicology and applied pharmacology 20090901

• Kinetic and thermodynamic control in the stereoselective formation of trans- and cis-2-ferrocenyl-3-pivaloyl-4-alkyl-1,3-oxazolidin-5-ones.

  Organic & biomolecular chemistry 20090207

• Cyclosporins from Mycelium sterilae MS 2929.

  Journal of natural products 20090101

• Inhibition of S6K1 accounts partially for the anti-inflammatory effects of the arginase inhibitor L-norvaline.

  BMC cardiovascular disorders 20090101

• A 3(10)-helical pentapeptide in water: interplay of alpha,alpha-disubstituted amino acids and the central residue on structure formation.

  Biopolymers 20090101

• The crystal structures of ornithine carbamoyltransferase from Mycobacterium tuberculosis and its ternary complex with carbamoyl phosphate and L-norvaline reveal the enzyme's catalytic mechanism.

  Journal of molecular biology 20080125

• Molecular evolution of B6 enzymes: binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B6 protoenzyme.

  BMC biochemistry 20080101

• Enzymatic evidence for the key role of arginine in nitrogen translocation by arbuscular mycorrhizal fungi.

  Plant physiology 20070601

• Structural and evolutionary bioinformatics of the SPOUT superfamily of methyltransferases.

  BMC bioinformatics 20070101

• [Overproduction of noncanonical amino acids by Escherichia coli cells].

  Mikrobiologiia 20070101

• Intricate knots in proteins: Function and evolution.

  PLoS computational biology 20060901

• Arginase activity in a murine macrophage cell line (RAW264.7) stimulated with lipopolysaccharide from Actinobacillus actinomycetemcomitans.

  Oral microbiology and immunology 20060601

• Main chain hydrogen bond interactions in the binding of proline-rich gluten peptides to the celiac disease-associated HLA-DQ2 molecule.

  The Journal of biological chemistry 20050610

• Synthesis of the beta-hydroxydopa-gamma-hydroxy-delta-sulfinylnorvaline component of ustiloxins A and B.

  Organic & biomolecular chemistry 20050307

• Correlations between olfactory discrimination, olfactory receptor neuron responses and chemotopy of amino acids in fishes.

  Chemical senses 20050101

• Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: implications for atherosclerotic endothelial dysfunction.

  Circulation 20041214

• Meteoritic C alpha-methylated alpha-amino acids and the homochirality of life: searching for a link.

  Angewandte Chemie (International ed. in English) 20041210

• Presentation and detection of azide functionality in bacterial cell surface proteins.

  Journal of the American Chemical Society 20040901

• The stereospecificity and catalytic efficiency of the tryptophan synthase-catalysed exchange of the alpha-protons of amino acids.

  The Biochemical journal 20040801

• Arginase pathway in human endothelial cells in pathophysiological conditions.

  Journal of molecular and cellular cardiology 20040801

• High glucose augments arginase activity and nitric oxide production in the renal cortex.

  Metabolism: clinical and experimental 20040701

• Kinetic analysis of phenylalanine dehydrogenase mutants designed for aliphatic amino acid dehydrogenase activity with guidance from homology-based modelling.

  European journal of biochemistry 20031201

• Two new cyclosporin folds observed in the structures of the immunosuppressant cyclosporin G and the formyl peptide receptor antagonist cyclosporin H at ultra-high resolution.

  Organic & biomolecular chemistry 20030507

• Changes in the ornithine cycle following ionising radiation cause a cytotoxic conditioning of the culture medium of H35 hepatoma cells.

  British journal of cancer 20030210

• Arginine deprivation and tumour cell death: arginase and its inhibition.

  Molecular and cellular biochemistry 20030201

• Consumption of L-arginine mediated by Entamoeba histolytica L-arginase (EhArg) inhibits amoebicidal activity and nitric oxide production by activated macrophages.

  Parasite immunology 20030101

• Synthesis and biological evaluations of brain-targeted chemical delivery systems of [Nva2]-TRH.

  The Journal of pharmacy and pharmacology 20020701

• Resistance and susceptibility to Marek's disease: nitric oxide synthase/arginase activity balance.

  Veterinary microbiology 20020501

• Sulfamide antifolates inhibiting thymidylate synthase: synthesis, enzyme inhibition and cytotoxicity.

  Acta biochimica Polonica 20020101

• Conversion of a glutamate dehydrogenase into methionine/norleucine dehydrogenase by site-directed mutagenesis.

  European journal of biochemistry 20011101

• Selective functionalization of amino acids in water: a synthetic method via catalytic C-H bond activation.

  Journal of the American Chemical Society 20010822

• Human ornithine transcarbamylase: crystallographic insights into substrate recognition and conformational changes.

  The Biochemical journal 20010315

• Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity.

  Cancer research 20010201