67-16-3 | Thiamine disulfide

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$33.00	$23.00
5g	95%	in stock	$73.00	$51.00
25g	95%	in stock	$157.00	$110.00
100g	95%	in stock	$572.00	$400.00

Description

• Catalog Number: AB79648
• Chemical Name: Thiamine disulfide
• CAS Number: 67-16-3
• Molecular Formula: C23H32N8O4S2
• Molecular Weight: 548.6813800000001
• MDL Number: MFCD00010427
• SMILES: OCCC(=CN(Cc1cnc(nc1N)C)C=O)SSC(=C(N(Cc1cnc(nc1N)C)C=O)C)CCO

Computed Properties

• Complexity: 767
• Covalently-Bonded Unit Count: 1
• Defined Bond Stereocenter Count: 2
• Heavy Atom Count: 38
• Hydrogen Bond Acceptor Count: 12
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 13
• XLogP3: -0.5

Literature

• Oxidation of thiamine on reaction with nitrogen dioxide generated by ferric myoglobin and hemoglobin in the presence of nitrite and hydrogen peroxide.

  Biochemistry. Biokhimiia 20120101

• Thiamine inhibits formation of dityrosine, a specific marker of oxidative injury, in reactions catalyzed by oxoferryl forms of hemoglobin.

  Biochemistry. Biokhimiia 20080901

• Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives.

  BMC pharmacology 20080101

• Thiamine and vasculopathies.

  Prostaglandins, leukotrienes, and essential fatty acids 20050201

• Bioavailability of theophylline and thiamine disulfide incorporated into mucoadhesive microspheres consisting of dextran derivatives and cellulose acetate butyrate.

  Biological & pharmaceutical bulletin 20031201

• Zinc ejection as a new rationale for the use of cystamine and related disulfide-containing antiviral agents in the treatment of AIDS.

  Journal of medicinal chemistry 19970620

• Thiamine disulfide as a potent inhibitor of human immunodeficiency virus (type-1) production.

  Biochemical and biophysical research communications 19941130