67-73-2 | Fluocinolone acetonide

Packsize	Purity	Availability	Price	Discounted Price
1g	≥97%	in stock	$58.00	$40.00
5g	≥97%	in stock	$143.00	$100.00

Description

• Catalog Number: AB46159
• Chemical Name: Fluocinolone acetonide
• CAS Number: 67-73-2
• Molecular Formula: C24H30F2O6
• Molecular Weight: 452.4882
• MDL Number: MFCD00010525
• SMILES: OCC(=O)[C@@]12OC(O[C@@H]1C[C@@H]1[C@]2(C)C[C@H](O)[C@]2([C@H]1C[C@@H](C1=CC(=O)C=C[C@]21C)F)F)(C)C
• NSC Number: 92339

Computed Properties

• Complexity: 960
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 9
• Heavy Atom Count: 32
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 2
• XLogP3: 2.5

Literature

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  Retina (Philadelphia, Pa.) 20141101

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• Postinflammatory hyperpigmentation: evolving combination treatment strategies.

  Cutis 20060801

• Efficacy of low-release-rate fluocinolone acetonide intravitreal implants to treat experimental uveitis.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20060701

• Fluocinolone acetonide implant (Retisert) for noninfectious posterior uveitis: thirty-four-week results of a multicenter randomized clinical study.

  Ophthalmology 20060601

• Dark brown scaly plaques on face and ears.

  The Journal of family practice 20060601

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Long-term continuous efalizumab therapy in patients with moderate to severe chronic plaque psoriasis: updated results from an ongoing trial.

  Journal of the American Academy of Dermatology 20060401

• Once-daily intranasal corticosteroids for allergic rhinitis. Examining Treatment issues.

  Advance for nurse practitioners 20060401

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  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20060301

• Community-based trial of a triple-combination agent for the treatment of facial melasma.

  Cutis 20060301

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  Respiration; international review of thoracic diseases 20060101

• Inhaled flunisolide suppresses the hypothalamic-pituitary-adrenocortical axis, but has minimal systemic immune effects in healthy cats.

  Journal of veterinary internal medicine 20060101

• A comprehensive review of the long-term and short-term treatment of melasma with a triple combination cream.

  American journal of clinical dermatology 20060101

• Flunisolide decreases exhaled nitric oxide and nitrotyrosine levels in asthmatic children.

  Mediators of inflammation 20060101

• Nebulized drug admixtures: effect on aerosol characteristics and albuterol output.

  Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 20060101

• Evidence of remodeling in peripheral airways of patients with mild to moderate asthma: effect of hydrofluoroalkane-flunisolide.

  The Journal of allergy and clinical immunology 20051101

• Retisert (Bausch & Lomb/Control Delivery Systems).

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• Long-term follow-up results of a pilot trial of a fluocinolone acetonide implant to treat posterior uveitis.

  Ophthalmology 20050701

• The nitrosterols--a step forward from the steroid anti-inflammatory drugs?

  Expert opinion on investigational drugs 20050701

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  American journal of veterinary research 20050701

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20050601

• The safety profile of long-term, high-dose intraocular corticosteroid delivery.

  American journal of ophthalmology 20050301

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  American journal of ophthalmology 20050301

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  Photochemistry and photobiology 20050101

• Comparison of the analysis of corticosteroids using different techniques.

  Analytical and bioanalytical chemistry 20050101

• Hydroquinone 4%, tretinoin 0.05%, fluocinolone acetonide 0.01%: a safe and efficacious 12-month treatment for melasma.

  Cutis 20050101

• Fluocinolone acetonide ophthalmic--Bausch & Lomb: fluocinolone acetonide Envision TD implant.

  Drugs in R&D 20050101

• A large 12-month extension study of an 8-week trial to evaluate the safety and efficacy of triple combination (TC) cream in melasma patients previously treated with TC cream or one of its dyads.

  Journal of drugs in dermatology : JDD 20050101

• Fluocinolone acetonide topical oil for scalp psoriasis.

  The Journal of dermatological treatment 20041201

• Enhanced anti-inflammatory potency of a nitric oxide-releasing derivative of flunisolide: role of nuclear factor-kappaB.

  The Journal of pharmacology and experimental therapeutics 20040901

• In vitro effects of flunisolide on MMP-9, TIMP-1, fibronectin, TGF-beta1 release and apoptosis in sputum cells freshly isolated from mild to moderate asthmatics.

  Allergy 20040901

• Ocular pharmacokinetics of fluocinolone acetonide after Retisert intravitreal implantation in rabbits over a 1-year period.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20040601

• Treatment with inhaled flunisolide.

  Chest 20040501

• Flunisolide HFA for the treatment of asthma: an old friend reformulated.

  Expert opinion on pharmacotherapy 20040501

• A comparative study of punch grafting followed by topical corticosteroid versus punch grafting followed by PUVA therapy in stable vitiligo.

  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20040101

• Rationale for the use of topical corticosteroids in melasma.

  Journal of drugs in dermatology : JDD 20040101

• Improved quality of life with effective treatment of facial melasma: the pigment trial.

  Journal of drugs in dermatology : JDD 20040101

• Utilizing combination therapy to optimize melasma outcomes.

  Journal of drugs in dermatology : JDD 20040101

• Asthma steroid pharmacogenetics: a study strategy to identify replicated treatment responses.

  Proceedings of the American Thoracic Society 20040101

• Common hyperpigmentation disorders in adults: Part II. Melanoma, seborrheic keratoses, acanthosis nigricans, melasma, diabetic dermopathy, tinea versicolor, and postinflammatory hyperpigmentation.

  American family physician 20031115

• A randomized controlled trial of inhaled flunisolide in the management of acute asthma in children.

  Chest 20030901

• Effect of topical nasal corticosteroids on patients with chronic fatigue syndrome and rhinitis.

  The Journal of the American Osteopathic Association 20030901

• Clinical evaluation in treatment of oral lichen planus with topical fluocinolone acetonide: a 2-year follow-up.

  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20030701

• Effect of HFA-flunisolide on peripheral lung inflammation in asthma.

  The Journal of allergy and clinical immunology 20030701

• Efficacy and safety of a new triple-combination agent for the treatment of facial melasma.

  Cutis 20030701

• Triple inhaled drug protocol for the treatment of acute severe asthma.

  Chest 20030601

• Recurrent oral ulceration.

  SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging 20030601

• Fluocinolone acetonide 0.01% in peanut oil: therapy for childhood atopic dermatitis, even in patients who are peanut sensitive.

  Journal of the American Academy of Dermatology 20030401

• Evaluation of efficacy and safety of flunisolide hydrofluoroalkane for the treatment of asthma.

  Clinical therapeutics 20030301

• Small airway asthma therapy, challenges, and the future.

  Postgraduate medicine 20030201

• A curious keloid of the penis.

  Acta dermato-venereologica 20030101

• Nasal cellularity in 183 unselected schoolchildren aged 9 to 11 years.

  Pediatrics 20021201

• Hematologic abnormalities in recurrent oral ulceration.

  The Southeast Asian journal of tropical medicine and public health 20021201

• Intranasal corticosteroids versus topical H1 receptor antagonists for the treatment of allergic rhinitis: a systematic review with meta-analysis.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20021101

• Comparison of high-dose inhaled flunisolide to systemic corticosteroids in severe adult asthma.

  Chest 20021001

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  Pharmaceutical research 20021001

• Deciphering the phosphorylation 'code' of the glucocorticoid receptor in vivo.

  The Journal of biological chemistry 20020719

• One-year trial on safety and normal linear growth with flunisolide HFA in children with asthma.

  Clinical pediatrics 20020601

• Systemic effect comparisons of six inhaled corticosteroid preparations.

  American journal of respiratory and critical care medicine 20020515

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20020501

• The output of flunisolide from different nebulisers.

  The Journal of pharmacy and pharmacology 20020401

• A comparison of methods for assessing hypothalamic-pituitary-adrenal (HPA) axis activity in asthma patients treated with inhaled corticosteroids.

  Journal of clinical pharmacology 20020301

• Single-dose study to compare the pharmacokinetics of HFA flunisolide and CFC flunisolide.

  Journal of pharmaceutical sciences 20020201

• Therapeutic significance of distal airway inflammation in asthma.

  The Journal of allergy and clinical immunology 20020201

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20020101

• Multiple-dose proportionality study of flunisolide hydrofluoroalkane.

  Allergy and asthma proceedings 20020101

• Flunisolide HFA.

  American journal of respiratory medicine : drugs, devices, and other interventions 20020101

• Poor sleep and daytime somnolence in allergic rhinitis: significance of nasal congestion.

  American journal of respiratory medicine : drugs, devices, and other interventions 20020101

• Evidence of P-glycoprotein mediated apical to basolateral transport of flunisolide in human broncho-tracheal epithelial cells (Calu-3).

  British journal of pharmacology 20011201

• Cost analysis of the use of inhaled corticosteroids in the treatment of asthma: a 1-year follow-up.

  Respiratory medicine 20011201

• Flunisolide HFA vs flunisolide CFC: pharmacokinetic comparison in healthy volunteers.

  Biopharmaceutics & drug disposition 20011201

• Adrenal suppression with inhaled corticosteroids.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20011101

• Suppression of hypothalamic-pituitary-adrenal axis activity with inhaled flunisolide and fluticasone propionate in adult asthma patients.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20011101

• Effective control of asthma with hydrofluoroalkane flunisolide delivered as an extrafine aerosol in asthma patients.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20011101

• Investigation of the allergenicity of a refined peanut oil-containing topical dermatologic agent in persons who are sensitive to peanuts.

  Cutis 20010801

• Pharmacokinetics of intranasal corticosteroids.

  The Journal of allergy and clinical immunology 20010701

• Improved asthma control after changing from low-to-medium doses of other inhaled corticosteroids to low-dose fluticasone propionate.

  MedGenMed : Medscape general medicine 20010608

• Transactivation of RARE and GRE in the cellular response to arsenic.

  Molecular and cellular biochemistry 20010601

• e-NO peak versus e-NO plateau values in evaluating e-NO production in steroid-naive and in steroid-treated asthmatic children and in detecting response to inhaled steroid treatment.

  Pediatric pulmonology 20010101

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  Gaceta medica de Mexico 20010101

• Deposition and pharmacokinetics of flunisolide delivered from pressurized inhalers containing non-CFC and CFC propellants.

  Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 20010101

• Corticosteroids administered by nebulization to children with bronchial asthma.

  Advances in therapy 20010101

• Safety and pharmacokinetics of an intraocular fluocinolone acetonide sustained delivery device.

  Investigative ophthalmology & visual science 20001001

• Modulation of interleukin-1 alpha mRNA expression in mouse epidermis by tumor promoters and antagonists.

  Molecular carcinogenesis 19930101

• Murine epidermal xanthine oxidase activity: correlation with degree of hyperplasia induced by tumor promoters.

  Cancer research 19871201

• Comparison of amcinonide ointment 0.1 percent twice daily and fluocinonide ointment 0.05 percent three times daily in the treatment of psoriasis.

  Cutis 19830501

• Treatment of psoriasis with amcinonide 0.1 percent and fluocinonide 0.05 percent ointments. A comparative double-blind study.

  Cutis 19820601

• Corticosteroid-induced cutaneous atrophy and telangiectasia. Experimental production associated with weight loss in rats.

  Archives of dermatology 19760801

• The treatment of steroid-induced rosacea and perioral dermatitis.

  Dermatologica 19760101

• Steroid rosacea.

  Archives of dermatology 19741001

• Iatrogenic dermatitis.

  British medical journal 19691004

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  British medical journal 19690315