67416-61-9 | AKBA

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$13.00	$9.00
5mg	95%	in stock	$34.00	$24.00
10mg	95%	in stock	$50.00	$35.00
25mg	95%	in stock	$122.00	$85.00
100mg	95%	in stock	$292.00	$205.00
250mg	95%	in stock	$395.00	$276.00

Description

• Catalog Number: AC64818
• Chemical Name: AKBA
• CAS Number: 67416-61-9
• Molecular Formula: C32H48O5
• Molecular Weight: 512.7205
• MDL Number: MFCD03788777
• SMILES: CC(=O)OC1CCC2(C(C1(C)C(=O)O)CCC1(C2C(=O)C=C2C1(C)CCC1(C2C(C)C(C)CC1)C)C)C

Computed Properties

• Complexity: 1060
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 11
• Heavy Atom Count: 37
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 3
• XLogP3: 7.2

Literature

• Cellular and molecular mechanisms of anti-inflammatory effect of Aflapin: a novel Boswellia serrata extract.

  Molecular and cellular biochemistry 20110801

• Acetyl-11-keto-β-boswellic acid suppresses invasion of pancreatic cancer cells through the downregulation of CXCR4 chemokine receptor expression.

  International journal of cancer 20110701

• Antistaphylococcal and biofilm inhibitory activities of acetyl-11-keto-β-boswellic acid from Boswellia serrata.

  BMC microbiology 20110101

• Boswellic acid suppresses growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model through modulation of multiple targets.

  PloS one 20110101

• A novel anticancer agent, retigeric acid B, displays proliferation inhibition, S phase arrest and apoptosis activation in human prostate cancer cells.

  Chemico-biological interactions 20101205

• [Acetyl-11-keto-beta-boswellic acid and arsenic trioxide regulate the productions and activities of matrix metalloproteinases in human skin fibroblasts and human leukemia cell line THP-1].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20101101

• 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches.

  Bioorganic & medicinal chemistry 20100215

• 3-Acetyl-11-keto-beta-boswellic acid loaded-polymeric nanomicelles for topical anti-inflammatory and anti-arthritic activity.

  The Journal of pharmacy and pharmacology 20100201

• Permeation of Boswellia extract in the Caco-2 model and possible interactions of its constituents KBA and AKBA with OATP1B3 and MRP2.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090215

• Antiinflammatory and antiatherogenic effects of the NF-kappaB inhibitor acetyl-11-keto-beta-boswellic acid in LPS-challenged ApoE-/- mice.

  Arteriosclerosis, thrombosis, and vascular biology 20080201

• Effect of acetyl 11-keto beta-boswellic acid on metastatic growth factor responsible for angiogenesis.

  Vascular pharmacology 20070501

• Co-administration of acetyl-11-keto-beta-boswellic acid, a specific 5-lipoxygenase inhibitor, potentiates the protective effect of COX-2 inhibitors in kainic acid-induced neurotoxicity in mice.

  Pharmacology 20070101

• Boswellic acids stimulate arachidonic acid release and 12-lipoxygenase activity in human platelets independent of Ca2+ and differentially interact with platelet-type 12-lipoxygenase.

  Molecular pharmacology 20060901

• Separation and quantification of terpenoids of Boswellia serrata Roxb. extract by planar chromatography techniques (TLC and AMD).

  Journal of separation science 20060901

• Acetyl-11-keto-beta-boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-kappa B and NF-kappa B-regulated gene expression.

  Journal of immunology (Baltimore, Md. : 1950) 20060301

• Potentiation of antinociceptive effect of NSAIDs by a specific lipooxygenase inhibitor, acetyl 11-keto-beta boswellic acid.

  Indian journal of experimental biology 20060201

• 3-O-acetyl-11-keto-boswellic acid decreases basal intracellular Ca2+ levels and inhibits agonist-induced Ca2+ mobilization and mitogen-activated protein kinase activation in human monocytic cells.

  The Journal of pharmacology and experimental therapeutics 20060101

• Protective effects of nimesulide (COX Inhibitor), AKBA (5-LOX Inhibitor), and their combination in aging-associated abnormalities in mice.

  Methods and findings in experimental and clinical pharmacology 20050901

• Bioactive constituents from Boswellia papyrifera.

  Journal of natural products 20050201

• Acetyl-11-keto-beta-boswellic acid (AKBA) is cytotoxic for meningioma cells and inhibits phosphorylation of the extracellular-signal regulated kinase 1 and 2.

  Advances in experimental medicine and biology 20020101

• Acetyl-boswellic acids are novel catalytic inhibitors of human topoisomerases I and IIalpha.

  Molecular pharmacology 20000701