68-95-1 | (2S)-1-acetylpyrrolidine-2-carboxylic acid

Packsize	Purity	Availability	Price	Discounted Price
5g	97%	in stock	$25.00	$17.00
25g	97%	in stock	$41.00	$29.00
100g	97%	in stock	$121.00	$85.00
500g	97%	in stock	$386.00	$270.00

Description

• Catalog Number: AB76959
• Chemical Name: (2S)-1-acetylpyrrolidine-2-carboxylic acid
• CAS Number: 68-95-1
• Molecular Formula: C7H11NO3
• Molecular Weight: 157.16714000000005
• MDL Number: MFCD00020837
• SMILES: CC(=O)N1CCC[C@H]1C(=O)O

Computed Properties

• Complexity: 190
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• XLogP3: -0.7

Literature

• Radicals formed in N-acetylproline by electron attachment: electron spin resonance spectroscopy and computational studies.

  The journal of physical chemistry. B 20111215

• The influence of the peptide bond on the conformation of amino acids: a theoretical and FT-IR matrix-isolation study of N-acetylproline.

  Biophysical chemistry 20111201

• N-acetylated Proline-Glycine-Proline induced G-protein dependent chemotaxis of neutrophils is independent of CXCL8 release.

  European journal of pharmacology 20111015

• CXCR2 antagonists block the N-Ac-PGP-induced neutrophil influx in the airways of mice, but not the production of the chemokine CXCL1.

  European journal of pharmacology 20111015

• A CXCL8 receptor antagonist based on the structure of N-acetyl-proline-glycine-proline.

  European journal of pharmacology 20111015

• Valence anions of N-acetylproline in the gas phase: computational and anion photoelectron spectroscopic studies.

  The Journal of chemical physics 20110921

• A self-propagating matrix metalloprotease-9 (MMP-9) dependent cycle of chronic neutrophilic inflammation.

  PloS one 20110101

• The collagen-breakdown product N-acetyl-Proline-Glycine-Proline (N-alpha-PGP) does not interact directly with human CXCR1 and CXCR2.

  European journal of pharmacology 20100915

• Anti-proline-glycine-proline or antielastin autoantibodies are not evident in chronic inflammatory lung disease.

  American journal of respiratory and critical care medicine 20100101

• Proline-Glycine-Proline (PGP) and High Mobility Group Box Protein-1 (HMGB1): Potential Mediators of Cystic Fibrosis Airway Inflammation.

  The open respiratory medicine journal 20100101

• Quantum mechanical and NMR studies of ring puckering and cis/trans-rotameric interconversion in prolines and hydroxyprolines.

  The journal of physical chemistry. A 20091008

• A proline-based neuraminidase inhibitor: DFT studies on the zwitterion conformation, stability and formation.

  International journal of molecular sciences 20090901

• Identification of N-acetyl Proline-Glycine-Proline (acPGP) in human serum of adults and newborns by liquid chromatography-tandem mass spectrometry.

  Clinica chimica acta; international journal of clinical chemistry 20090401

• Mechanism of action of cyclophilin a explored by metadynamics simulations.

  PLoS computational biology 20090301

• Simultaneous measurement of proline and related compounds in oak leaves by high-performance ligand-exchange chromatography and electrospray ionization mass spectrometry for environmental stress studies.

  Journal of chromatography. A 20090213

• N-alpha-PGP and PGP, potential biomarkers and therapeutic targets for COPD.

  Respiratory research 20090101

• Induction of lung emphysema is prevented by L-arginine-threonine-arginine.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080901

• Interfering with extracellular matrix degradation to blunt inflammation.

  Current opinion in pharmacology 20080601

• Modeling the solvation of peptides. The case of (s)-N-acetylproline amide in liquid water.

  The journal of physical chemistry. B 20080320

• Conformational analysis of L-prolines in water.

  The journal of physical chemistry. B 20071220

• Structure of N-acetylproline amide in liquid water: experimentally measured and numerically simulated infrared and vibrational circular dichroism spectra.

  The journal of physical chemistry. B 20060928

• Theoretical and experimental investigation of the energetics of cis-trans proline isomerization in peptide models.

  The journal of physical chemistry. A 20060525

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation.

  Nature medicine 20060301

• The matrix degrades, neutrophils invade.

  Nature medicine 20060301

• Purification and characterization of a novel aminoacylase from Streptomyces mobaraensis.

  Bioscience, biotechnology, and biochemistry 20051001

• Protein heterodimerization through ligand-bridged multivalent pre-organization: enhancing ligand binding toward both protein targets.

  Journal of the American Chemical Society 20050223

• The effect of penetration enhancers on drug delivery through skin: a QSAR study.

  Journal of controlled release : official journal of the Controlled Release Society 20040914

• Theoretical calculations of infrared absorption, vibrational circular dichroism, and two-dimensional vibrational spectra of acetylproline in liquids water and chloroform.

  The Journal of chemical physics 20040722

• Crystal structure of carbapenem synthase (CarC).

  The Journal of biological chemistry 20030606

• Inhibitory effect of a complementary peptide on ulceration in the alkali-injured rabbit cornea.

  Investigative ophthalmology & visual science 20011101

• NMR conformational analysis of cis and trans proline isomers in the neutrophil chemoattractant, N-acetyl-proline-glycine-proline.

  Biopolymers 20010501