6823-69-4 | Gw4869

Packsize	Purity	Availability	Price	Discounted Price
2mg	97%	in stock	$69.00	$49.00
5mg	97%	in stock	$103.00	$72.00
10mg	97%	in stock	$153.00	$107.00
25mg	97%	in stock	$231.00	$162.00
50mg	97%	in stock	$346.00	$242.00

Description

• Catalog Number: AH14573
• Chemical Name: Gw4869
• CAS Number: 6823-69-4
• Molecular Formula: C30H32Cl2N6O3
• Molecular Weight: 595.5195
• MDL Number: MFCD06411564
• SMILES: O=C(Nc1ccc(cc1)C1=NCCN1)/C=C/c1ccc(cc1)/C=C/C(=O)Nc1ccc(cc1)C1=NCCN1.O.Cl.Cl

Computed Properties

• Complexity: 856
• Covalently-Bonded Unit Count: 3
• Defined Bond Stereocenter Count: 2
• Heavy Atom Count: 40
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 6
• Rotatable Bond Count: 8

Literature

• Exosomal miR-940 maintains SRC-mediated oncogenic activity in cancer cells: a possible role for exosomal disposal of tumor suppressor miRNAs.

  Oncotarget 20170321

• Group VIA Phospholipase A2 (iPLA2β) Modulates Bcl-x 5'-Splice Site Selection and Suppresses Anti-apoptotic Bcl-x(L) in β-Cells.

  The Journal of biological chemistry 20150424

• Ceramide/sphingomyelin cycle involvement in gentamicin-induced cochlear hair cell death.

  Archives of toxicology 20150301

• γ-Synuclein: seeding of α-synuclein aggregation and transmission between cells.

  Biochemistry 20120612

• Sphingosine-1-phosphate is a mediator of TNF-α action on the Na+/K+ ATPase in HepG2 cells.

  Journal of cellular biochemistry 20120601

• The critical role of spinal ceramide in the development of partial sciatic nerve ligation-induced neuropathic pain in mice.

  Biochemical and biophysical research communications 20120504

• Endothelin-1 stimulates small artery VCAM-1 expression through p38MAPK-dependent neutral sphingomyelinase.

  Journal of vascular research 20120101

• A key role for matrix metalloproteinases and neutral sphingomyelinase-2 in transplant vasculopathy triggered by anti-HLA antibody.

  Circulation 20111213

• Ceramide inhibits Kv currents and contributes to TP-receptor-induced vasoconstriction in rat and human pulmonary arteries.

  American journal of physiology. Cell physiology 20110701

• An obligate role for membrane-associated neutral sphingomyelinase activity in orienting chemotactic migration of human neutrophils.

  American journal of respiratory cell and molecular biology 20110201

• Identification and evaluation of neutral sphingomyelinase 2 inhibitors.

  Archives of pharmacal research 20110201

• Probiotic sonicates selectively induce mucosal immune cells apoptosis through ceramide generation via neutral sphingomyelinase.

  PloS one 20110101

• Inhibition of neutral sphingomyelinase-2 perturbs brain sphingolipid balance and spatial memory in mice.

  Journal of neuroscience research 20101001

• Secretory mechanisms and intercellular transfer of microRNAs in living cells.

  The Journal of biological chemistry 20100604

• Inhibitory effect of ethanol on AMPK phosphorylation is mediated in part through elevated ceramide levels.

  American journal of physiology. Gastrointestinal and liver physiology 20100601

• Neutral sphingomyelinase 2 induces dopamine uptake through regulation of intracellular calcium.

  Cellular signalling 20100501

• Purification of neutral sphingomyelinase 2 from bovine brain and its calcium-dependent activation.

  Journal of neurochemistry 20100201

• Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase.

  Molecular cancer 20100101

• Tumor necrosis factor-alpha-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors.

  Journal of neurochemistry 20090601

• Caspase-dependent and -independent induction of phosphatidylserine externalization during apoptosis in human renal carcinoma Cak(1)-1 and A-498 cells.

  Toxicology 20070105

• Apolipoprotein C-I induces apoptosis in human aortic smooth muscle cells via recruiting neutral sphingomyelinase.

  Arteriosclerosis, thrombosis, and vascular biology 20040201

• Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism.

  The Journal of biological chemistry 20030418

• Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase.

  The Journal of biological chemistry 20021025