69-44-3 | Amodiaquine dihydrochloride

Packsize	Purity	Availability	Price	Discounted Price
25mg	95%	in stock	$10.00	$7.00
10g	95%	in stock	$13.00	$9.00
25g	95%	in stock	$25.00	$17.00
500g	95%	in stock	$309.00	$216.00

Description

• Catalog Number: AB65598
• Chemical Name: Amodiaquine dihydrochloride
• CAS Number: 69-44-3
• Molecular Formula: C20H24Cl3N3O
• Molecular Weight: 428.7831
• MDL Number: MFCD00078857
• SMILES: CCN(Cc1cc(ccc1O)Nc1ccnc2c1ccc(c2)Cl)CC.Cl.Cl

Computed Properties

• Complexity: 406
• Covalently-Bonded Unit Count: 3
• Heavy Atom Count: 27
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 6

Literature

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  Journal of pharmaceutical sciences 20121201

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  Chemical research in toxicology 20080401

• Studies on antimalarial drug susceptibility in Colombia, in relation to Pfmdr1 and Pfcrt.

  Parasitology 20080401

• High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080401

• Disease and drug interactions: treating malaria with artesunate plus amodiaquine in patients also receiving treatment for concomitant HIV infection.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080401

• [Assessing the application of Rwanda's national protocol for uncomplicated malaria treatment in healthcare institutions in Kigali City, Rwanda].

  Medecine et maladies infectieuses 20080301

• Increased Plasmodium falciparum gametocyte production in mixed infections with P. malariae.

  The American journal of tropical medicine and hygiene 20080301

• Efficacy, safety, and selection of molecular markers of drug resistance by two ACTs in Mali.

  The American journal of tropical medicine and hygiene 20080301

• [Efficacy of the amodiaquine+sulfadoxine-pyrimethamine combination and of chloroquine for the treatment of malaria in Córdoba, Colombia, 2006].

  Biomedica : revista del Instituto Nacional de Salud 20080301

• Determination of N-desethylamodiaquine by hydrophilic interaction liquid chromatography with tandem mass spectrometry: application to in vitro drug metabolism studies.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080215

• Synthesis and antimalarial activity of new analogues of amodiaquine.

  European journal of medicinal chemistry 20080201

• Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20080201

• Antimalarial resistance and DHFR/DHPS genotypes of Plasmodium falciparum three years after introduction of sulfadoxine-pyrimethamine and amodiaquine in rural Tanzania.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20080201

• Chloroquine-resistance molecular markers (Pfcrt T76 and Pfmdr-1 Y86) and amodiaquine resistance in Burkina Faso.

  Tropical medicine & international health : TM & IH 20080201

• Chloroquine resistant Plasmodium falciparum malaria in Osogbo Nigeria: efficacy of amodiaquine + sulfadoxine-pyrimethamine and chloroquine + chlorpheniramine for treatment.

  Memorias do Instituto Oswaldo Cruz 20080201

• Feasibility and acceptability of artemisinin-based combination therapy for the home management of malaria in four African sites.

  Malaria journal 20080101

• Randomized, comparative study of the efficacy and safety of artesunate plus amodiaquine, administered as a single daily intake versus two daily intakes in the treatment of uncomplicated falciparum malaria.

  Malaria journal 20080101

• A trial of the efficacy, safety and impact on drug resistance of four drug regimens for seasonal intermittent preventive treatment for malaria in Senegalese children.

  PloS one 20080101

• Sulphadoxine/pyrimethamine versus amodiaquine for treating uncomplicated childhood malaria in Gabon: a randomized trial to guide national policy.

  Malaria journal 20080101

• Safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso.

  PloS one 20080101

• Enhanced efficacy of amodiaquine and chlorpheniramine combination over amodiaquine alone in the treatment of acute uncomplicated Plasmodium falciparum malaria in children.

  Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20080101

• Efficacy of amodiaquine in the treatment of uncomplicated falciparum malaria in young children of rural north-western Burkina Faso.

  Malaria journal 20080101

• The usefulness of twenty-four molecular markers in predicting treatment outcome with combination therapy of amodiaquine plus sulphadoxine-pyrimethamine against falciparum malaria in Papua New Guinea.

  Malaria journal 20080101

• Safety and tolerability of combination antimalarial therapies for uncomplicated falciparum malaria in Ugandan children.

  Malaria journal 20080101

• Activities of artemether-lumefantrine and amodiaquine-sulfalene-pyrimethamine against sexual-stage parasites in falciparum malaria in children.

  Chemotherapy 20080101

• An open label, randomised trial of artesunate+amodiaquine, artesunate+chlorproguanil-dapsone and artemether-lumefantrine for the treatment of uncomplicated malaria.

  PloS one 20080101

• Amodiaquine-artesunate vs artemether-lumefantrine for uncomplicated malaria in Ghanaian children: a randomized efficacy and safety trial with one year follow-up.

  Malaria journal 20080101

• Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children.

  Malaria journal 20080101

• Plasmodium falciparum gametocyte sex ratios in children with acute, symptomatic, uncomplicated infections treated with amodiaquine.

  Malaria journal 20080101

• Effectiveness of artemisinin-based combination therapy used in the context of home management of malaria: a report from three study sites in sub-Saharan Africa.

  Malaria journal 20080101

• Trends in malaria morbidity following the introduction of artesunate plus amodiaquine combination in M'lomp village dispensary, south-western Senegal.

  Malaria journal 20080101

• Malariological baseline survey and in vitro antimalarial drug resistance in Gulu district, Northern Uganda.

  Wiener klinische Wochenschrift 20080101

• Pharmacodynamic interaction between 4-aminoquinolines and retinol in Plasmodium falciparum in vitro.

  Wiener klinische Wochenschrift 20080101

• Seasonal intermittent preventive treatment for the prevention of anaemia and malaria in Ghanaian children: a randomized, placebo controlled trial.

  PloS one 20080101

• A randomized trial on effectiveness of artemether-lumefantrine versus artesunate plus amodiaquine for unsupervised treatment of uncomplicated Plasmodium falciparum malaria in Ghanaian children.

  Malaria journal 20080101

• High risk of severe anaemia after chlorproguanil-dapsone+artesunate antimalarial treatment in patients with G6PD (A-) deficiency.

  PloS one 20080101

• The effect of administration of amodiaquine on some parameters of neurobehaviour of Wistar rats.

  Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria 20080101

• Randomized comparison of amodiaquine plus sulfadoxine-pyrimethamine, artemether-lumefantrine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Burkina Faso.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20071201

• Simultaneous determination of amodiaquine and its active metabolite in human blood by ion-pair liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071201

• Short report: polymorphisms in the pfcrt and pfmdr1 genes of Plasmodium falciparum and in vitro susceptibility to amodiaquine and desethylamodiaquine.

  The American journal of tropical medicine and hygiene 20071201

• Pharmacologic advances in the global control and treatment of malaria: combination therapy and resistance.

  Clinical pharmacology and therapeutics 20071101

• A field-adapted HPLC method for determination of amodiaquine and its metabolite in whole blood dried on filter paper.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071101

• The safety of amodiaquine use in pregnant women.

  Expert opinion on drug safety 20071101

• Low efficacy of amodiaquine or chloroquine plus sulfadoxine-pyrimethamine against Plasmodium falciparum and P. vivax malaria in Papua New Guinea.

  The American journal of tropical medicine and hygiene 20071101

• Clinical symptoms, treatment and outcome of highlands malaria in Eldoret (2420 m a.s.l.) and comparison to malaria in hyper-immune population in endemic region of Southern Sudan.

  Neuro endocrinology letters 20071101

• Population pharmacokinetics of amodiaquine and desethylamodiaquine in pediatric patients with uncomplicated falciparum malaria.

  Journal of pharmacokinetics and pharmacodynamics 20071001

• Selection of pfmdr1 mutations after amodiaquine monotherapy and amodiaquine plus artemisinin combination therapy in East Africa.

  Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20070901

• Efficacy of sulfadoxine-pyrimethamine, amodiaquine, and sulfadoxine-pyrimethamine-amodiaquine combination for the treatment of uncomplicated falciparum malaria in the urban and suburban areas of Brazzaville (Congo).

  Acta tropica 20070901

• Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa.

  Clinical pharmacology and therapeutics 20070801

• Therapeutic efficacy and effects of artemether-lumefantrine and amodiaquine-sulfalene-pyrimethamine on gametocyte carriage in children with uncomplicated Plasmodium falciparum malaria in southwestern Nigeria.

  The American journal of tropical medicine and hygiene 20070801

• A non-radiolabeled heme-GSH interaction test for the screening of antimalarial compounds.

  Experimental parasitology 20070701

• The in-vitro susceptibilities of Ghanaian Plasmodium falciparum to antimalarial drugs.

  Annals of tropical medicine and parasitology 20070701

• Artesunate-amodiaquine for the treatment of uncomplicated malaria.

  Expert opinion on investigational drugs 20070701

• Emergency liver transplantation in amodiaquine-induced fulminant hepatitis.

  The American journal of tropical medicine and hygiene 20070701

• Amodiaquine in future combination treatment of malaria in Ghana.

  Tropical doctor 20070701

• Prevalent pfmdr1 n86y mutant Plasmodium falciparum in Madagascar despite absence of pfcrt mutant strains.

  The American journal of tropical medicine and hygiene 20070601

• Efficacy of artesunate plus amodiaquine, artesunate plus sulfadoxine-pyrimethamine, and chloroquine plus sulfadoxine-pyrimethamine in patients with uncomplicated Plasmodium falciparum in the Comoros Union.

  Acta tropica 20070601

• Enhancement of the antimalarial efficacy of amodiaquine by chlorpheniramine in vivo.

  Memorias do Instituto Oswaldo Cruz 20070601

• [Polymorphisms of the pfmdr1 gene in field samples of Plasmodium falciparum and their association with therapeutic response to antimalarial drugs and severe malaria in Colombia].

  Biomedica : revista del Instituto Nacional de Salud 20070601

• [Tolerance of amodiaquine].

  Medecine tropicale : revue du Corps de sante colonial 20070601

• [Open radomized study comparing chloroquine and amodiaquine for treatment of uncomplicated plasmodium falciparum malaria in children in Aboisso, Cote d' Ivoire].

  Medecine tropicale : revue du Corps de sante colonial 20070601

• [A new, cheaper and simpler anti-malaria preparation].

  Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20070531

• Antimalarial drugs--here and on the horizon.

  JAMA 20070523

• Combination therapy for uncomplicated falciparum malaria in Ugandan children: a randomized trial.

  JAMA 20070523

• Plasmodium falciparum genotypes associated with chloroquine and amodiaquine resistance in Guinea-Bissau.

  The American journal of tropical medicine and hygiene 20070501

• Dihydroartemisinin-piperaquine versus artesunate-amodiaquine: superior efficacy and posttreatment prophylaxis against multidrug-resistant Plasmodium falciparum and Plasmodium vivax malaria.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070415

• A randomised trial to assess the safety and efficacy of artemether-lumefantrine (Coartem) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwanda.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20070401

• Effects of prior administration of amodiaquine on the disposition of halofantrine in healthy volunteers.

  Therapeutic drug monitoring 20070401

• [ASAQ, a breakthrough in the fight against malaria].

  Medecine tropicale : revue du Corps de sante colonial 20070401

• Hepatotoxicity due to a drug interaction between amodiaquine plus artesunate and efavirenz.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070315

• [Against malaria: ASAQ, one dollar per box].

  Revue medicale suisse 20070314

• Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice.

  European journal of pharmacology 20070308

• New once a day, fixed dose antimalarial is now available for adults and children.

  BMJ (Clinical research ed.) 20070303

• Correlations between treatment outcome and both anti-MSP119 antibody response and erythrocyte-related genetic factors in Plasmodium falciparum malaria.

  Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20070301

• Different doses of amodiaquine and chloroquine for treatment of uncomplicated malaria in children in Guinea-Bissau: implications for future treatment recommendations.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20070301

• Practical HPLC methods for the quantitative determination of common antimalarials in Africa.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070301

• In vitro assessment of artesunate, artemether and amodiaquine susceptibility and molecular analysis of putative resistance-associated mutations of Plasmodium falciparum from São Tomé and Príncipe.

  Tropical medicine & international health : TM & IH 20070301

• The comparative efficacies of malartin, with and without amodiaquine, in the treatment of Plasmodium falciparum malaria in the Buea district of Cameroon.

  Annals of tropical medicine and parasitology 20070301

• [Assessment of the efficacy of antimalarial drugs in Tarapacá, in the Colombian Amazon basin].

  Biomedica : revista del Instituto Nacional de Salud 20070301

• Chloroquine-resistant malaria in Malawi.

  The New England journal of medicine 20070222

• Antimalarial drug combinations in vastly different settings.

  Lancet (London, England) 20070210

• Artemether-lumefantrine versus amodiaquine plus sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Burkina Faso: a randomised non-inferiority trial.

  Lancet (London, England) 20070210

• Antischistosomal efficacy of artesunate combination therapies administered as curative treatments for malaria attacks.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20070201

• Amodiaquine combined with sulfadoxine/pyrimethamine versus artemisinin-based combinations for the treatment of uncomplicated falciparum malaria in Africa: a meta-analysis.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20070201

• The effects of artemether-lumefantrine vs amodiaquine-sulfalene-pyrimethamine on the hepatomegaly associated with Plasmodium falciparum malaria in children.

  Parasitology research 20070201

• [Benzo[c][2,7]naphthyridine-5-yl-arylamines-phenol Mannich bases of the amodiaquine-, cycloquine- and pyronaridine-type].

  Die Pharmazie 20070201

• In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin.

  The Journal of biological chemistry 20070126

• Efficacies of artesunate plus either sulfadoxine-pyrimethamine or amodiaquine, for the treatment of uncomplicated, Plasmodium falciparum malaria in eastern Sudan.

  Annals of tropical medicine and parasitology 20070101

• Artemisinin-based combination therapy for uncomplicated Plasmodium falciparum malaria in Colombia.

  Malaria journal 20070101

• Artesunate--amodiaquine combination therapy for falciparum malaria in young Gabonese children.

  Malaria journal 20070101

• Exploration of rate-limiting conformational state for 5-[(7-chloro-4-quinolinyl)amino]-3-[(alkylamino)methyl][1,1'-biphenyl]-2-ols and N(omega)-oxides (tebuquine analogues) for antimalarial activity using molecular shape analysis and molecular field analysis studies.

  Journal of chemical information and modeling 20070101

• Amodiaquine failure associated with erythrocytic glutathione in Plasmodium falciparum malaria.

  Malaria journal 20070101

• Efficacy of antimalarial treatment in Guinea: in vivo study of two artemisinin combination therapies in Dabola and molecular markers of resistance to sulphadoxine-pyrimethamine in N'Zérékoré.

  Malaria journal 20070101

• Randomized clinical trial of artemisinin versus non-artemisinin combination therapy for uncomplicated falciparum malaria in Madagascar.

  Malaria journal 20070101

• Efficacy and tolerability of four antimalarial combinations in the treatment of uncomplicated Plasmodium falciparum malaria in Senegal.

  Malaria journal 20070101

• [Place of artemisinin derivatives as anti-malarial drugs in paediatric hospitalization in Abidjan].

  Therapie 20070101

• Community coverage of an antimalarial combination of artesunate and amodiaquine in Makamba Province, Burundi, nine months after its introduction.

  Malaria journal 20070101

• [Therapeutic efficacy of amodiaquine against uncomplicated malaria in Madagascar].

  Sante (Montrouge, France) 20070101

• Efficacy and safety of artemisinin-based antimalarial in the treatment of uncomplicated malaria in children in southern Tanzania.

  Malaria journal 20070101

• Efficacy and safety of artesunate plus amodiaquine in routine use for the treatment of uncomplicated malaria in Casamance, southern Sénégal.

  Malaria journal 20070101

• Potential impact of host immunity on malaria treatment outcome in Tanzanian children infected with Plasmodium falciparum.

  Malaria journal 20070101

• Photophysical properties and photobiological behavior of amodiaquine, primaquine and chloroquine.

  Photochemistry and photobiology 20070101

• Amodiaquine resistance is not related to rare findings of pfmdr1 gene amplifications in Kenya.

  Tropical medicine & international health : TM & IH 20061201

• Use of weight-for-age-data to optimize tablet strength and dosing regimens for a new fixed-dose artesunate-amodiaquine combination for treating falciparum malaria.

  Bulletin of the World Health Organization 20061201

• Effects of pyrimethamine-sulphadoxine, chloroquine plus chlorpheniramine, and amodiaquine plus pyrimethamine-sulphadoxine on gametocytes during and after treatment of acute, uncomplicated malaria in children.

  Memorias do Instituto Oswaldo Cruz 20061201

• Improved efficacy with amodiaquine instead of chloroquine in sulfadoxine/pyrimethamine combination treatment of falciparum malaria in Uganda: experience with fixed-dose formulation.

  Acta tropica 20061101

• Amodiaquine, malaria, pregnancy: the old new drug.

  Lancet (London, England) 20061014

• Efficacy, safety, and tolerability of amodiaquine plus sulphadoxine-pyrimethamine used alone or in combination for malaria treatment in pregnancy: a randomised trial.

  Lancet (London, England) 20061014

• Artesunate + amodiaquine and artesunate + sulphadoxine-pyrimethamine for treatment of uncomplicated malaria in Democratic Republic of Congo: a clinical trial with determination of sulphadoxine and pyrimethamine-resistant haplotypes.

  Tropical medicine & international health : TM & IH 20061001

• Cost-effectiveness study of three antimalarial drug combinations in Tanzania.

  PLoS medicine 20061001

• Molecular epidemiology of malaria in Cameroon. XXI. Baseline therapeutic efficacy of chloroquine, amodiaquine, and sulfadoxine-pyrimethamine monotherapies in children before national drug policy change.

  The American journal of tropical medicine and hygiene 20060901

• A simple technique for the detection of anti-malarial drug formulations and their presence in human urine.

  Tanzania health research bulletin 20060901

• Heterotropic and homotropic cooperativity by a drug-metabolising mutant of cytochrome P450 BM3.

  Biochemical and biophysical research communications 20060804

• Factors contributing to the development of anaemia in Plasmodium falciparum malaria: what about drug-resistant parasites?

  Journal of tropical pediatrics 20060801

• High reinfection rate and treatment failures in children treated with amodiaquine for falciparum malaria in Muheza villages, Northeastern Tanzania.

  The American journal of tropical medicine and hygiene 20060801

• Amodiaquine resistant Plasmodium falciparum malaria in vivo is associated with selection of pfcrt 76T and pfmdr1 86Y.

  Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20060701

• Amodiaquine, its desethylated metabolite, or both, inhibit the metabolism of debrisoquine (CYP2D6) and losartan (CYP2C9) in vivo.

  European journal of clinical pharmacology 20060701

• Low efficacy of the combination artesunate plus amodiaquine for uncomplicated falciparum malaria among children under 5 years in Kailahun, Sierra Leone.

  Tropical medicine & international health : TM & IH 20060701

• High efficacy of two artemisinin-based combinations (artesunate + amodiaquine and artemether + lumefantrine) in Caala, Central Angola.

  The American journal of tropical medicine and hygiene 20060701

• Association between mutations in Plasmodium falciparum chloroquine resistance transporter and P. falciparum multidrug resistance 1 genes and in vivo amodiaquine resistance in P. falciparum malaria-infected children in Nigeria.

  The American journal of tropical medicine and hygiene 20060701

• Roles of specific Plasmodium falciparum mutations in resistance to amodiaquine and sulfadoxine-pyrimethamine in Burkina Faso.

  The American journal of tropical medicine and hygiene 20060701

• Occurrence of the Southeast Asian/South American SVMNT haplotype of the chloroquine-resistance transporter gene in Plasmodium falciparum in Tanzania.

  The Journal of infectious diseases 20060615

• In-vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, dihydroartemisinin and quinine in an area of high chloroquine resistance in Rwanda.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20060601

• Resisting resistance: dealing with the irrepressible problem of malaria.

  British journal of clinical pharmacology 20060601

• Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for uncomplicated malaria: a systematic review.

  Tropical medicine & international health : TM & IH 20060601

• [Knowledge and practice among health workers from the Thiès region with regard to new malaria treatment policies].

  Sante publique (Vandoeuvre-les-Nancy, France) 20060601

• Efficacy of chloroquine, sulfadoxine-pyrimethamine and amodiaquine for treatment of uncomplicated Plasmodium falciparum malaria among children under five in Bongor and Koumra, Chad.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20060501

• Tolerability of amodiaquine and sulphadoxine-pyrimethamine, alone or in combination for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan adults.

  Tropical medicine & international health : TM & IH 20060501

• Susceptibility of Colombian Plasmodium falciparum isolates to 4-aminoquinolines and the definition of amodiaquine resistance in vitro.

  Memorias do Instituto Oswaldo Cruz 20060501

• Amodiaquine polymeric membrane electrode.

  Journal of pharmaceutical and biomedical analysis 20060411

• A new approach to evaluate stability of amodiaquine and its metabolite in blood and plasma.

  Journal of pharmaceutical and biomedical analysis 20060411

• Geographic differences in antimalarial drug efficacy in Uganda are explained by differences in endemicity and not by known molecular markers of drug resistance.

  The Journal of infectious diseases 20060401

• Operational response to malaria epidemics: are rapid diagnostic tests cost-effective?

  Tropical medicine & international health : TM & IH 20060401

• Microscopy and outpatient malaria case management among older children and adults in Kenya.

  Tropical medicine & international health : TM & IH 20060401

• Prevalence of malaria parasitemia among clients seeking treatment for fever or malaria at drug stores in rural Tanzania 2004.

  Tropical medicine & international health : TM & IH 20060401

• The costs of changing national policy: lessons from malaria treatment policy guidelines in Tanzania.

  Tropical medicine & international health : TM & IH 20060401

• Sulfadoxine-pyrimethamine plus artesunate versus sulfadoxine-pyrimethamine plus amodiaquine for treating uncomplicated malaria.

  The Cochrane database of systematic reviews 20060125

• [Cytochrome P-450 and the response to antimalarial drugs].

  Revista panamericana de salud publica = Pan American journal of public health 20060101

• Artemether-lumefantrine versus artesunate plus amodiaquine for treating uncomplicated childhood malaria in Nigeria: randomized controlled trial.

  Malaria journal 20060101

• A medicinal chemistry perspective on 4-aminoquinoline antimalarial drugs.

  Current topics in medicinal chemistry 20060101

• Efficacy of three artemisinin combination therapies for the treatment of uncomplicated Plasmodium falciparum malaria in the Republic of Congo.

  Malaria journal 20060101

• The quality of sulphadoxine-pyrimethamine and amodiaquine products in the Kenyan retail sector.

  Journal of clinical pharmacy and therapeutics 20051201

• Short communication: high prevalence of the cytochrome P450 2C8*2 mutation in Northern Ghana.

  Tropical medicine & international health : TM & IH 20051201

• Open randomized study of artesunate-amodiaquine vs. chloroquine-pyrimethamine-sulfadoxine for the treatment of uncomplicated Plasmodium falciparum malaria in Nigerian children.

  Tropical medicine & international health : TM & IH 20051101

• Amodiaquine and combination chemotherapy for malaria.

  The American journal of tropical medicine and hygiene 20051101

• Amodiaquine, sulfadoxine-pyrimethamine, and combination therapy for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso.

  The American journal of tropical medicine and hygiene 20051101

• Structural basis for inhibition of histamine N-methyltransferase by diverse drugs.

  Journal of molecular biology 20051021

• Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for treating uncomplicated malaria.

  The Cochrane database of systematic reviews 20051019

• Efficacy of artesunate plus amodiaquine versus that of artemether-lumefantrine for the treatment of uncomplicated childhood Plasmodium falciparum malaria in Zanzibar, Tanzania.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20051015

• Therapeutic efficacy of sulfadoxine-pyrimethamine and amodiaquine among children with uncomplicated Plasmodium falciparum malaria in Zanzibar, Tanzania.

  The American journal of tropical medicine and hygiene 20051001

• Rapid increase in resistance of Plasmodium falciparum to chloroquine-Fansidar in Uganda and the potential of amodiaquine-Fansidar as a better alternative.

  Acta tropica 20050901

• Comparative efficacy of antimalarial drugs including ACTs in the treatment of uncomplicated malaria among children under 5 years in Ghana.

  Acta tropica 20050901

• Economic evaluation of a policy change from single-agent treatment for suspected malaria to artesunate-amodiaquine for microscopically confirmed uncomplicated falciparum malaria in the Oussouye District of south-western Senegal.

  Tropical medicine & international health : TM & IH 20050901

• [Evaluation of the therapeutic efficacy of amodiaquine versus chloroquine in the treatment of uncomplicated malaria in Abie, Côte-d'Ivoire].

  Bulletin de la Societe de pathologie exotique (1990) 20050901

• Malaria in the Nuba Mountains of Sudan: baseline genotypic resistance and efficacy of the artesunate plus sulfadoxine-pyrimethamine and artesunate plus amodiaquine combinations.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20050701

• Antimalarial efficacy of chloroquine, amodiaquine, sulfadoxine-pyrimethamine, and the combinations of amodiaquine + artesunate and sulfadoxine-pyrimethamine + artesunate in Huambo and Bie provinces, central Angola.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20050701

• Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda.

  PLoS medicine 20050701

• New malaria combination cheaper and easier to take.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20050607

• Efficacy of amodiaquine in uncomplicated falciparum malaria in Nigeria in an area with high-level resistance to chloroquine and sulphadoxine/pyrimethamine.

  Parasitology research 20050601

• A randomized, placebo-controlled, double-blind trial on sulfadoxine-pyrimethamine alone or combined with artesunate or amodiaquine in uncomplicated malaria.

  Tropical medicine & international health : TM & IH 20050601

• Efficacy of combination therapy with artesunate plus amodiaquine compared to monotherapy with chloroquine, amodiaquine or sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum in Afghanistan.

  Tropical medicine & international health : TM & IH 20050601

• Malaria: uncomplicated, caused by Plasmodium falciparum.

  Clinical evidence 20050601

• New combination drug to treat malaria.

  The Lancet. Infectious diseases 20050501

• Sulfadoxine-pyrimethamine plus chloroquine or amodiaquine for uncomplicated falciparum malaria: a randomized, multisite trial to guide national policy in Uganda.

  The American journal of tropical medicine and hygiene 20050501

• Antimalarial drugs: QT prolongation and cardiac arrhythmias.

  Expert opinion on drug safety 20050501

• Efficacy of chloroquine, amodiaquine, sulfadoxine-pyrimethamine, chloroquine-sulfadoxine-pyrimethamine combination, and amodiaquine-sulfadoxine-pyrimethamine combination in Central African children with noncomplicated malaria.

  The American journal of tropical medicine and hygiene 20050501

• Effectiveness trials in African children with malaria?

  Lancet (London, England) 20050401

• Amodiaquine alone, amodiaquine+sulfadoxine-pyrimethamine, amodiaquine+artesunate, and artemether-lumefantrine for outpatient treatment of malaria in Tanzanian children: a four-arm randomised effectiveness trial.

  Lancet (London, England) 20050401

• Selective inhibition of human cytochrome P4502C8 by montelukast.

  Drug metabolism and disposition: the biological fate of chemicals 20050301

• Pharmacodynamic interactions of amodiaquine and its major metabolite desethylamodiaquine with artemisinin, quinine and atovaquone in Plasmodium falciparum in vitro.

  Acta tropica 20050301

• A randomized comparative study of chloroquine, amodiaquine and sulphadoxine-pyrimethamine for the treatment of uncomplicated malaria in Ghana.

  Tropical medicine & international health : TM & IH 20050301

• The disposition of oral amodiaquine in Papua New Guinean children with falciparum malaria.

  British journal of clinical pharmacology 20050301

• CYP2C8 polymorphism frequencies among malaria patients in Zanzibar.

  European journal of clinical pharmacology 20050301

• Evidence basis for antimalarial policy change in Sierra Leone: five in vivo efficacy studies of chloroquine, sulphadoxine-pyrimethamine and amodiaquine.

  Tropical medicine & international health : TM & IH 20050201

• Efficacy of two artemisinin combination therapies for uncomplicated falciparum malaria in children under 5 years, Malakal, Upper Nile, Sudan.

  Malaria journal 20050101

• Antimalarial prescribing practices: a challenge to malaria control in Ghana.

  Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20050101

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  Malaria journal 20050101

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  Papua and New Guinea medical journal 20050101

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  Inorganic chemistry 20041213

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  The Lancet. Infectious diseases 20041201

• Principal role of dihydropteroate synthase mutations in mediating resistance to sulfadoxine-pyrimethamine in single-drug and combination therapy of uncomplicated malaria in Uganda.

  The American journal of tropical medicine and hygiene 20041201

• Combination treatments for uncomplicated falciparum malaria in Kampala, Uganda: randomised clinical trial.

  Lancet (London, England) 20041101

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  The American journal of tropical medicine and hygiene 20041101

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  Tropical medicine & international health : TM & IH 20041001

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  Tropical medicine & international health : TM & IH 20040901

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  Tropical medicine & international health : TM & IH 20040601

• [[1]Benzofuro[3,2-b]pyridin-4-yl-amines - synthesis and investigation of activity against malaria].

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  Parassitologia 20040601

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  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040425

• Malaria intermittent preventive treatment in infants, chemoprophylaxis, and childhood vaccinations.

  Lancet (London, England) 20040424

• Can amodiaquine be used safely during pregnancy?

  The Lancet. Infectious diseases 20040401

• A randomized trial of amodiaquine and artesunate alone and in combination for the treatment of uncomplicated falciparum malaria in children from Burkina Faso.

  Tropical medicine & international health : TM & IH 20040401

• Antimalarial efficacy of sulfadoxine-pyrimethamine, amodiaquine and a combination of chloroquine plus sulfadoxine-pyrimethamine in Bundi Bugyo, western Uganda.

  Tropical medicine & international health : TM & IH 20040401

• Molecular analysis of Plasmodium falciparum from drug treatment failure patients in Papua New Guinea.

  The American journal of tropical medicine and hygiene 20040301

• Efficacy of chloroquine, amodiaquine, sulphadoxine-pyrimethamine and combination therapy with artesunate in Mozambican children with non-complicated malaria.

  Tropical medicine & international health : TM & IH 20040201

• Efficacy of sulphadoxine-pyrimethamine alone or combined with amodiaquine or chloroquine for the treatment of uncomplicated falciparum malaria in Ugandan children.

  Tropical medicine & international health : TM & IH 20040201

• Selective and sensitive liquid chromatographic assay of amodiaquine and desethylamodiaquine in whole blood spotted on filter paper.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040105

• Oro-facial dyskinesias and amodiaquine.

  Therapie 20040101

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  Sante (Montrouge, France) 20040101

• Atovaquone and proguanil versus amodiaquine for the treatment of Plasmodium falciparum malaria in African infants and young children.

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• Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials.

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• Prevention of increasing rates of treatment failure by combining sulfadoxine-pyrimethamine with artesunate or amodiaquine for the sequential treatment of malaria.

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  Tropical medicine & international health : TM & IH 20031001

• Amodiaquine treatment of uncomplicated malaria in children, in an area of chloroquine-resistant Plasmodium falciparum in north-central Nigeria.

  Annals of tropical medicine and parasitology 20031001

• Rapid clearance of Plasmodium falciparum hyperparasitaemia after oral amodiaquine treatment in patients with uncomplicated malaria.

  Acta tropica 20030901

• Plasmodium falciparum gametocytaemia in Nigerian children: before, during and after treatment with antimalarial drugs.

  Tropical medicine & international health : TM & IH 20030901

• Short report: association between chloroquine and amodiaquine resistance and allelic variation in the Plasmodium falciparum multiple drug resistance 1 gene and the chloroquine resistance transporter gene in isolates from the upper Nile in southern Sudan.

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• Molecular epidemiology of malaria in Cameroon. XV. Experimental studies on serum substitutes and supplements and alternative culture media for in vitro drug sensitivity assays using fresh isolates of Plasmodium falciparum.

  The American journal of tropical medicine and hygiene 20030801

• Efficacy of amodiaquine alone and combined with sulfadoxine-pyrimethamine and of sulfadoxine pyrimethamine combined with artesunate.

  The American journal of tropical medicine and hygiene 20030601

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• Questions about the antimalarial amodiaquine.

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• Antibody responses to Plasmodium falciparum merozoite surface protein-1 and efficacy of amodiaquine in Gabonese children with P. falciparum malaria.

  The Journal of infectious diseases 20030401

• Evaluation of the quality of amodiaquine and sulphadoxine/pyrimethamine tablets sold by private wholesale pharmacies in Dar Es Salaam Tanzania.

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  Biomedica : revista del Instituto Nacional de Salud 20030301

• A randomized comparison of chloroquine and chloroquine plus ketotifen in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children.

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  The American journal of tropical medicine and hygiene 20030201

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  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030115

• Amodiaquine for treating malaria.

  The Cochrane database of systematic reviews 20030101

• Vendor-to-vendor education to improve malaria treatment by private drug outlets in Bungoma District, Kenya.

  Malaria journal 20030101

• Chloroquine, sulfadoxine-pyrimethamine and amodiaquine efficacy for the treatment of uncomplicated Plasmodium falciparum malaria in Upper Nile, south Sudan.

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  Malaria journal 20030101

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• Comparison of the in-vitro activity of amodiaquine and its main metabolite, monodesethyl-amodiaquine, in Plasmodium falciparum.

  Wiener klinische Wochenschrift 20030101

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  Papua and New Guinea medical journal 20030101

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• Paracellular tightness and catabolism restrict histamine permeation in the proximal colon of pigs.

  Pflugers Archiv : European journal of physiology 20021001

• The effects of chloroquine, amodiaquine and chloroquine plus chlorpheniramine on the disposition kinetics of the hepatomegaly associated with acute, uncomplicated, Plasmodium falciparum malaria in children.

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• Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum must be delayed in Africa.

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  Pathologie-biologie 20020401

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  Memorias do Instituto Oswaldo Cruz 20020401

• A randomized comparison of chloroquine, amodiaquine and their combination with pyrimethamine-sulfadoxine in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children.

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  Experimental parasitology 20020101

• Therapeutic efficacy of sulfadoxine-pyrimethamine, amodiaquine and the sulfadoxine-pyrimethamine-amodiaquine combination against uncomplicated Plasmodium falciparum malaria in young children in Cameroon.

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  The American journal of tropical medicine and hygiene 20011201

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  Parasite (Paris, France) 20010901

• Randomized comparison of chloroquine and amodiaquine in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children.

  Annals of tropical medicine and parasitology 20010901

• Amodiaquine, sulfadoxine/pyrimethamine, and combination therapy for treatment of uncomplicated falciparum malaria in Kampala, Uganda: a randomised trial.

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• 'One-pot' synthesis and antimalarial activity of formamidine derivatives of 4-anilinoquinoline.

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  Revista panamericana de salud publica = Pan American journal of public health 20010101

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  The Cochrane database of systematic reviews 20010101

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  Transactions of the Royal Society of Tropical Medicine and Hygiene 20010101

• K-channel blockers attenuate the presynaptic effects of the D2/D3 agonist quinpirole in monkeys.

  Pharmacology, biochemistry, and behavior 19950801

• Role of hepatic metabolism in the bioactivation and detoxication of amodiaquine.

  Xenobiotica; the fate of foreign compounds in biological systems 19950201

• The mechanism of bioactivation and antigen formation of amodiaquine in the rat.

  Biochemical pharmacology 19920401

• Detection of antidrug IgG antibodies in patients with adverse drug reactions to amodiaquine.

  International archives of allergy and applied immunology 19910101

• Immunogenicity of amodiaquine in the rat.

  International archives of allergy and applied immunology 19900101

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  Bulletin de la Societe de pathologie exotique et de ses filiales 19890101

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  Journal of hepatology 19880201

• Neuromyopathy associated with amodiaquine hydrochloride.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 19871001

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  Biochemical pharmacology 19870701

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  Schweizerische medizinische Wochenschrift 19860719

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  Annals of internal medicine 19860601

• Amodiaquine-induced involuntary movements.

  British medical journal 19760724