692-04-6 | N-Epsilon-acetyl-l-lysine

Packsize	Purity	Availability	Price	Discounted Price
250mg	97%	in stock	$13.00	$9.00
1g	97%	in stock	$18.00	$12.00
5g	97%	in stock	$40.00	$28.00
10g	97%	in stock	$79.00	$55.00
25g	97%	in stock	$123.00	$86.00
100g	97%	in stock	$463.00	$324.00
500g	97%	in stock	$2,064.00	$1,445.00

Description

• Catalog Number: AB77317
• Chemical Name: N-Epsilon-acetyl-l-lysine
• CAS Number: 692-04-6
• Molecular Formula: C8H16N2O3
• Molecular Weight: 188.2242
• MDL Number: MFCD00002639
• SMILES: CC(=O)NCCCC[C@@H](C(=O)O)N

Computed Properties

• Complexity: 182
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 13
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 6
• XLogP3: -2.8

Literature

• Molecular basis of maillard amide-advanced glycation end product (AGE) formation in vivo.

  The Journal of biological chemistry 20111230

• RF1 knockout allows ribosomal incorporation of unnatural amino acids at multiple sites.

  Nature chemical biology 20111101

• Transition state of ADP-ribosylation of acetyllysine catalyzed by Archaeoglobus fulgidus Sir2 determined by kinetic isotope effects and computational approaches.

  Journal of the American Chemical Society 20100908

• N(epsilon)-Modified lysine containing inhibitors for SIRT1 and SIRT2.

  Bioorganic & medicinal chemistry 20100801

• Synthetic biology approaches in drug discovery and pharmaceutical biotechnology.

  Applied microbiology and biotechnology 20100601

• Degradation of 1-deoxy-D-erythro-hexo-2,3-diulose in the presence of lysine leads to formation of carboxylic acid amides.

  Journal of agricultural and food chemistry 20100526

• Acetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization.

  Nature chemical biology 20100501

• A convenient method for genetic incorporation of multiple noncanonical amino acids into one protein in Escherichia coli.

  Molecular bioSystems 20100401

• Substrate specificity of SIRT1-catalyzed lysine Nepsilon-deacetylation reaction probed with the side chain modified Nepsilon-acetyl-lysine analogs.

  Bioorganic chemistry 20100201

• Nε-lysine acetylation of a bacterial transcription factor inhibits Its DNA-binding activity.

  PloS one 20100101

• A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylation.

  Molecular cell 20091009

• Plasmodium falciparum Sir2 is an NAD+-dependent deacetylase and an acetyllysine-dependent and acetyllysine-independent NAD+ glycohydrolase.

  Biochemistry 20080923

• Adding l-lysine derivatives to the genetic code of mammalian cells with engineered pyrrolysyl-tRNA synthetases.

  Biochemical and biophysical research communications 20080711

• Utility of immonium ions for assignment of epsilon-N-acetyllysine-containing peptides by tandem mass spectrometry.

  Analytical chemistry 20080501

• Genetically encoding N(epsilon)-acetyllysine in recombinant proteins.

  Nature chemical biology 20080401

• A spectrophotometric assay for histone deacetylase 8.

  Analytical biochemistry 20080101

• Substituting N(epsilon)-thioacetyl-lysine for N(epsilon)-acetyl-lysine in peptide substrates as a general approach to inhibiting human NAD(+)-dependent protein deacetylases.

  International journal of molecular sciences 20080101

• Characterization of Nalpha-benzyloxycarbonyl-L-lysine oxidizing enzyme from Rhodococcus sp. AIU Z-35-1.

  Journal of bioscience and bioengineering 20070901

• N(epsilon)-methanesulfonyl-lysine as a non-hydrolyzable functional surrogate for N(epsilon)-acetyl-lysine.

  Organic & biomolecular chemistry 20070321

• Antibacterial lysine analogs that target lysine riboswitches.

  Nature chemical biology 20070101

• Nepsilon-thioacetyl-lysine: a multi-facet functional probe for enzymatic protein lysine Nepsilon-deacetylation.

  Bioorganic & medicinal chemistry letters 20060715

• Proteomic analysis of organ-specific post-translational lysine-acetylation and -methylation in mice by use of anti-acetyllysine and -methyllysine mouse monoclonal antibodies.

  Proteomics 20051201

• Purification and characterization of a novel aminoacylase from Streptomyces mobaraensis.

  Bioscience, biotechnology, and biochemistry 20051001

• Kinetics and comparative reactivity of human class I and class IIb histone deacetylases.

  Biochemistry 20040831

• Four different clones of mouse anti-acetyllysine monoclonal antibodies having different recognition properties share a common immunoglobulin framework structure.

  Journal of immunological methods 20030115

• Switching osmolyte strategies: response of Methanococcus thermolithotrophicus to changes in external NaCl.

  Biochimica et biophysica acta 20011115