694-59-7 | Pyridine-n-oxide

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$15.00	$10.00
10g	95%	in stock	$18.00	$12.00
25g	95%	in stock	$34.00	$24.00
100g	95%	in stock	$79.00	$55.00
250g	95%	in stock	$193.00	$135.00
500g	95%	in stock	$231.00	$162.00
5kg	95%	in stock	$2,195.00	$1,537.00

Description

• Catalog Number: AB46962
• Chemical Name: Pyridine-n-oxide
• CAS Number: 694-59-7
• Molecular Formula: C5H5NO
• Molecular Weight: 95.0993
• MDL Number: MFCD11113379
• SMILES: [O-][n+]1ccccc1
• NSC Number: 18250

Computed Properties

• Complexity: 50
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 7
• Hydrogen Bond Acceptor Count: 1
• XLogP3: -1.2

Literature

• Substitution of the nitro group with Grignard reagents: facile arylation and alkenylation of pyridine N-oxides.

  Organic letters 20121102

• Production of a new pyridine N-oxide by bioconversion with Cunninghamella echinulata var. elegans.

  Journal of bioscience and bioengineering 20121101

• Enantioselective addition of cyclic enol silyl ethers to 2-alkenoyl-pyridine-N-oxides catalysed by Cu(II)-bis(oxazoline) complexes.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20120910

• Gold-catalysed cycloisomerisation reactions of 2-(2-propynyl)pyridine N-oxides leading to indolizinones.

  Chemical communications (Cambridge, England) 20120807

• Temperature and solvent structure dependence of VO2+ complexes of pyridine-N-oxide derivatives and their interaction with human serum transferrin.

  Dalton transactions (Cambridge, England : 2003) 20120628

• Effects of metal pyrithione antifoulants on freshwater macrophyte Lemna gibba G3 determined by image analysis.

  Ecotoxicology (London, England) 20120501

• Mechanistic studies on direct arylation of pyridine N-oxide: evidence for cooperative catalysis between two distinct palladium centers.

  Journal of the American Chemical Society 20120227

• Cu(I)-catalyzed oxidative cyclization of alkynyl oxiranes and oxetanes.

  Journal of the American Chemical Society 20120118

• Photochemical activation of ruthenium(II)-pyridylamine complexes having a pyridine-N-oxide pendant toward oxygenation of organic substrates.

  Journal of the American Chemical Society 20111109

• Radiolabeling of PAMAM dendrimers conjugated to a pyridine-N-oxide DOTA analog with ¹¹¹In: Optimization of reaction conditions and biodistribution.

  Journal of pharmaceutical and biomedical analysis 20111101

• Synthesis of pyridine-N-oxide-borane intramolecular complexes by palladium-catalyzed reaction of 2-bromopyridine-N-oxides with alkynyltriarylborates.

  Organic letters 20110617

• Highly enantioselective nitrone cycloadditions with 2-alkenoyl pyridine N-oxides catalyzed by Cu(II)-BOX complexes.

  Organic letters 20110204

• Influence of polarity on the scalability and reproducibility of solvent-free microwave-assisted reactions.

  Combinatorial chemistry & high throughput screening 20110201

• General and mild preparation of 2-aminopyridines.

  Organic letters 20101119

• Modulation of the luminescence quantum efficiency for blue luminophor {Al(salophen)}(+) by ester-substituents.

  Dalton transactions (Cambridge, England : 2003) 20100227

• The stability of aryl carbanions derived from pyridine N-oxide: the role of resonance in stabilizing aryl anions.

  Journal of the American Chemical Society 20100113

• Densely packed Gd(III)-chelates with fast water exchange on a calix[4]arene scaffold: a potential MRI contrast agent.

  Dalton transactions (Cambridge, England : 2003) 20100107

• Pyridine N-oxides as ligands in Cu-catalyzed N-arylation of imidazoles in water.

  Organic letters 20090806

• Bioactive pyridine-N-oxide disulfides from Allium stipitatum.

  Journal of natural products 20090327

• Molecular recognition of pyridine N-oxides in water using calix[4]pyrrole receptors.

  Journal of the American Chemical Society 20090311

• Direct dehydrative N-pyridinylation of amides.

  The Journal of organic chemistry 20090206

• Identification of aliphatic and aromatic tertiary N-oxide functionalities in protonated analytes via ion/molecule and dissociation reactions in an FT-ICR mass spectrometer.

  The Journal of organic chemistry 20090206

• Lanthanide(III) complexes of pyridine-N-oxide analogues of DOTA in solution and in the solid state. A new kind of isomerism in complexes of DOTA-like ligands.

  Inorganic chemistry 20090119

• Pyridine-N-oxide analogues of DOTA and their gadolinium(III) complexes endowed with a fast water exchange on the square-antiprismatic isomer.

  Inorganic chemistry 20090119

• Pharmacokinetics of sorafenib in patients with renal impairment undergoing hemodialysis.

  International journal of clinical pharmacology and therapeutics 20090101

• An EXAFS spectroscopic, large-angle X-ray scattering, and crystallographic study of hexahydrated, dimethyl sulfoxide and pyridine 1-oxide hexasolvated mercury(II) ions.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20080101

• A general and efficient 2-amination of pyridines and quinolines.

  The Journal of organic chemistry 20070608

• 2-alkenoyl pyridine N-oxides, highly efficient dienophiles for the enantioselective Cu(II)-bis(oxazoline) catalyzed Diels-Alder reaction.

  Organic letters 20070510

• Synthesis of 2-substituted pyridines via a regiospecific alkylation, alkynylation, and arylation of pyridine N-oxides.

  Organic letters 20070329

• Amide-N-oxide heterosynthon and amide dimer homosynthon in cocrystals of carboxamide drugs and pyridine N-oxides.

  Molecular pharmaceutics 20070101

• Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction.

  Journal of medicinal chemistry 20061214

• Synthesis development of a naphthyridinone p38 kinase inhibitor.

  Current opinion in drug discovery & development 20061101

• Detection of hydrogen bonding in solution: a 2H nuclear magnetic resonance method based on rotational motion of a donor/acceptor complex.

  Physical chemistry chemical physics : PCCP 20060914

• Regioselective synthesis of 3-(2-hydroxyaryl)pyridines via arynes and pyridine N-oxides.

  The Journal of organic chemistry 20060609

• Pyridine N-oxide derivatives inhibit viral transactivation by interfering with NF-kappaB binding.

  Biochemical pharmacology 20060414

• Carboxamide-pyridine N-oxide heterosynthon for crystal engineering and pharmaceutical cocrystals.

  Chemical communications (Cambridge, England) 20060407

• Pyridine N-oxide derivatives are inhibitory to the human SARS and feline infectious peritonitis coronavirus in cell culture.

  The Journal of antimicrobial chemotherapy 20060301

• Calculations on the group 15 intraring substituted benzenes (pyridine to bismin series) and their datively bonded oxides and sulfides.

  The journal of physical chemistry. A 20051013

• In vitro microsomal metabolic studies on a selective mGluR5 antagonist MTEP: characterization of in vitro metabolites and identification of a novel thiazole ring opening aldehyde metabolite.

  Xenobiotica; the fate of foreign compounds in biological systems 20050801

• Enantioselective approach to the hetisine alkaloids. Synthesis of the 3-methyl-1-aza-tricyclo[5.2.1.0(3,8)]decane core via intramolecular dipolar cycloaddition.

  Organic letters 20050721

• Thermally induced N-to-O rearrangement of tert-N-oxides in atmospheric pressure chemical ionization and atmospheric pressure photoionization mass spectrometry: differentiation of N-oxidation from hydroxylation and potential determination of N-oxidation site.

  Analytical chemistry 20050601

• Evidence of the electronic factor for the highly enantioselective catalytic efficiency of Cinchona-derived phase-transfer catalysts.

  Organic letters 20050317

• 1H NMR and DFT study of proton exchange in heterogeneous structures of pyridine-N-oxide/HCl/DCl/H2O.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20050301

• Pyridine N-oxide derivatives: unusual anti-HIV compounds with multiple mechanisms of antiviral action.

  The Journal of antimicrobial chemotherapy 20050201

• Metal-organic rotaxane frameworks: three-dimensional polyrotaxanes from lanthanide-ion nodes, pyridinium N-oxide axles, and crown-ether wheels.

  Angewandte Chemie (International ed. in English) 20050128

• Unique oxidation reaction of amides with pyridine-N-oxide catalyzed by ruthenium porphyrin: direct oxidative conversion of N-acyl-L-proline to N-acyl-L-glutamate.

  Journal of the American Chemical Society 20050126

• Pyridine N-oxide and pyridine-d5 N-oxide: an electrospray/tandem mass spectrometric study carried out at high mass resolution.

  Rapid communications in mass spectrometry : RCM 20050101

• HIV-chemotherapy and -prophylaxis: new drugs, leads and approaches.

  The international journal of biochemistry & cell biology 20040901

• Orally active CCR5 antagonists as anti-HIV-1 agents 2: synthesis and biological activities of anilide derivatives containing a pyridine N-oxide moiety.

  Chemical & pharmaceutical bulletin 20040701

• Inhibition of human immunodeficiency virus by a new class of pyridine oxide derivatives.

  Antimicrobial agents and chemotherapy 20030901

• Chemical speciation of insulinomimetic VO(IV) complexes of pyridine-N-oxide derivatives: binary and ternary systems.

  Journal of inorganic biochemistry 20030601

• CYP1A1 induction by pyridine and its metabolites in HepG2 cells.

  Archives of biochemistry and biophysics 20020815

• Evidence for elevation of cytochrome P4502E1 (alcohol-inducible form) mRNA levels in rat kidney following pyridine administration.

  Biochemical and biophysical research communications 19920731