711085-63-1 | (R)-4-Chloro-N-(quinuclidin-3-yl)benzamide

Packsize	Purity	Availability	Price	Discounted Price
5mg	98%	in stock	$58.00	$40.00
10mg	98%	in stock	$109.00	$76.00
25mg	98%	in stock	$213.00	$149.00
50mg	98%	in stock	$396.00	$277.00
100mg	98%	in stock	$630.00	$441.00

Description

• Catalog Number: AB48343
• Chemical Name: (R)-4-Chloro-N-(quinuclidin-3-yl)benzamide
• CAS Number: 711085-63-1
• Molecular Formula: C14H17ClN2O
• Molecular Weight: 264.75058000000007
• MDL Number: MFCD08703110
• SMILES: O=C(c1ccc(cc1)Cl)N[C@H]1CN2CCC1CC2

Computed Properties

• Complexity: 307
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 18
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 2
• XLogP3: 2.4

Literature

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  Journal of pharmacological sciences 20150301

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• Stroke-induced activation of the α7 nicotinic receptor increases Pseudomonas aeruginosa lung injury.

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• Synthesis and nicotinic receptor activity of chemical space analogues of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide (PNU-282,987) and 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester (SSR180711).

  Journal of medicinal chemistry 20120524

• α7 nicotinic acetylcholine receptor agonism confers neuroprotection through GSK-3β inhibition in a mouse model of intracerebral hemorrhage.

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• α7 nicotinic acetylcholine receptor agonist PNU-282987 attenuates early brain injury in a perforation model of subarachnoid hemorrhage in rats.

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• Characterization of 2-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-4-(4-pyridinyl)-5-thiazolemethanol (JNJ-1930942), a novel positive allosteric modulator of the {alpha}7 nicotinic acetylcholine receptor.

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• Dysfunction of the cholinergic anti-inflammatory pathway mediates organ damage in hypertension.

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• Activation of α7 nicotinic acetylcholine receptors ameliorates indomethacin-induced small intestinal ulceration in mice.

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• Behavioral effects of PNU-282987, an alpha7 nicotinic receptor agonist, in mice.

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• Calcium signalling mediated through α7 and non-α7 nAChR stimulation is differentially regulated in bovine chromaffin cells to induce catecholamine release.

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• Poststress treatment with PNU282987 can rescue SH-SY5Y cells undergoing apoptosis via α7 nicotinic receptors linked to a Jak2/Akt/HO-1 signaling pathway.

  Free radical biology & medicine 20101201

• Surface plasmon resonance biosensor based fragment screening using acetylcholine binding protein identifies ligand efficiency hot spots (LE hot spots) by deconstruction of nicotinic acetylcholine receptor α7 ligands.

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• Alpha3* and alpha 7 nAChR-mediated Ca2+ transient generation in IMR-32 neuroblastoma cells.

  Neurochemistry international 20101001

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• Overexpressed alpha7 nicotinic acetylcholine receptor inhibited proinflammatory cytokine release in NIH3T3 cells.

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• Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor.

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• Alpha7 nicotinic acetylcholine receptor activation ameliorates scopolamine-induced behavioural changes in a modified continuous Y-maze task in mice.

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  Molecular pharmacology 20070901

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• Activation of alpha7 acetylcholine receptors augments stimulation-induced hippocampal theta oscillation.

  The European journal of neuroscience 20060101

• The selective alpha7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats.

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