722456-31-7 | 1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$42.00	$29.00
5mg	98%	in stock	$52.00	$36.00
10mg	98%	in stock	$73.00	$51.00
25mg	98%	in stock	$122.00	$85.00

Description

• Catalog Number: AH22914
• Chemical Name: 1,3-benzoxazol-2-yl 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide
• CAS Number: 722456-31-7
• Molecular Formula: C18H12N6OS
• Molecular Weight: 360.3924800000001
• MDL Number: MFCD03407188
• SMILES: c1ccc(cc1)Cn1nnc2c1ncnc2Sc1nc2c(o1)cccc2

Computed Properties

• Complexity: 479
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 26
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 4
• XLogP3: 3.9

Literature

• Aldosterone activates transcription factor Nrf2 in kidney cells both in vitro and in vivo.

  Antioxidants & redox signaling 20141120

• Glutathione peroxidase-1 deficiency potentiates dysregulatory modifications of endothelial nitric oxide synthase and vascular dysfunction in aging.

  Hypertension (Dallas, Tex. : 1979) 20140201

• Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein.

  Cardiovascular research 20121201

• Off-target thiol alkylation by the NADPH oxidase inhibitor 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine (VAS2870).

  Free radical biology & medicine 20120501

• Rapamycin sensitive ROS formation and Na(+)/H(+) exchanger activity in dendritic cells.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

• H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling.

  PloS one 20120101

• The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells.

  Biochemical pharmacology 20110401

• Reactive oxygen species are involved in regulating alpha1-adrenoceptor-activated vascular smooth muscle contraction.

  Journal of biomedical science 20100101

• Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation.

  Cardiovascular research 20060715

• Novel Nox inhibitor of oxLDL-induced reactive oxygen species formation in human endothelial cells.

  Biochemical and biophysical research communications 20060526