725247-18-7 | Xct790

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$43.00	$30.00
5mg	98%	in stock	$169.00	$118.00
10mg	98%	in stock	$274.00	$192.00

Description

• Catalog Number: AC86132
• Chemical Name: Xct790
• CAS Number: 725247-18-7
• Molecular Formula: C23H13F9N4O3S
• Molecular Weight: 596.4249
• MDL Number: MFCD08277031
• SMILES: N#CC(=Cc1ccc(c(c1)OC)OCc1ccc(cc1C(F)(F)F)C(F)(F)F)C(=O)Nc1nnc(s1)C(F)(F)F

Computed Properties

• Complexity: 966
• Covalently-Bonded Unit Count: 1
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 40
• Hydrogen Bond Acceptor Count: 16
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 7
• XLogP3: 6.6

Literature

• Development of a stable cell line with an intact PGC-1α/ERRα axis for screening environmental chemicals.

  Biochemical and biophysical research communications 20140207

• The cannabinoid receptor inverse agonist AM251 regulates the expression of the EGF receptor and its ligands via destabilization of oestrogen-related receptor α protein.

  British journal of pharmacology 20111001

• Estrogen-related receptor α regulates skeletal myocyte differentiation via modulation of the ERK MAP kinase pathway.

  American journal of physiology. Cell physiology 20110901

• Protein kinase C epsilon affects mitochondrial function through estrogen-related receptor alpha.

  Cellular signalling 20110901

• Identification of diaryl ether-based ligands for estrogen-related receptor α as potential antidiabetic agents.

  Journal of medicinal chemistry 20110210

• A Role for the orphan nuclear receptor estrogen-related receptor alpha in endometrial stromal cell decidualization and expression of genes implicated in energy metabolism.

  The Journal of clinical endocrinology and metabolism 20101001

• Oestrogen-related receptor alpha inverse agonist XCT-790 arrests A549 lung cancer cell population growth by inducing mitochondrial reactive oxygen species production.

  Cell proliferation 20100401

• Estrogen-related receptor alpha (ERRalpha) inverse agonist XCT-790 induces cell death in chemotherapeutic resistant cancer cells.

  Chemico-biological interactions 20091007

• Peroxisome proliferator-activated receptor gamma coactivator-1alpha enhances antiproliferative activity of 5'-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase.

  Molecular pharmacology 20091001

• Estrogen-related receptor alpha inverse agonist enhances basal glucose uptake in myotubes through reactive oxygen species.

  Biological & pharmaceutical bulletin 20090701

• MCF-7aro/ERE, a novel cell line for rapid screening of aromatase inhibitors, ERalpha ligands and ERRalpha ligands.

  Biochemical pharmacology 20080715

• Potentiation of ICI182,780 (Fulvestrant)-induced estrogen receptor-alpha degradation by the estrogen receptor-related receptor-alpha inverse agonist XCT790.

  The Journal of biological chemistry 20070928

• Estrogen-related receptors as emerging targets in cancer and metabolic disorders.

  Current topics in medicinal chemistry 20060101

• Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma.

  Journal of medicinal chemistry 20050505

• Regulation of PPARgamma coactivator 1alpha (PGC-1alpha) signaling by an estrogen-related receptor alpha (ERRalpha) ligand.

  Proceedings of the National Academy of Sciences of the United States of America 20040615

• Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors.

  Molecular cancer research : MCR 20031101

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419