72702-95-5 | Statil

Packsize	Purity	Availability	Price	Discounted Price
1mg	97%	in stock	$19.00	$13.00
5mg	97%	in stock	$42.00	$29.00
10mg	97%	in stock	$63.00	$44.00
25mg	97%	in stock	$150.00	$105.00
100mg	97%	in stock	$163.00	$114.00
250mg	97%	in stock	$299.00	$209.00
1g	97%	in stock	$713.00	$499.00
5g	97%	in stock	$2,112.00	$1,479.00

Description

• Catalog Number: AC66545
• Chemical Name: Statil
• CAS Number: 72702-95-5
• Molecular Formula: C17H12BrFN2O3
• Molecular Weight: 391.1912
• MDL Number: MFCD00204117
• SMILES: OC(=O)Cc1nn(Cc2ccc(cc2F)Br)c(=O)c2c1cccc2

Computed Properties

• Complexity: 542
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 24
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 4
• XLogP3: 3.2

Literature

• Aldo-keto reductases protect lung adenocarcinoma cells from the acute toxicity of B[a]P-7,8-trans-dihydrodiol.

  Chemical research in toxicology 20120113

• Synthesis and antimycobacterial evaluation of novel Phthalazin-4-ylacetamides against log- and starved phase cultures.

  Chemical biology & drug design 20100401

• Structure of human aldose reductase holoenzyme in complex with statil: an approach to structure-based inhibitor design of the enzyme.

  Proteins 20030201

• A comparison of quantitative NMR and radiolabelling studies of the metabolism and excretion of Statil (3-(4-bromo-2-fluorobenzyl)-4-oxo-3H-phthalazin-1-ylacetic acid) in the rat.

  Journal of pharmaceutical and biomedical analysis 20020401

• Molecular modeling of the aldose reductase-inhibitor complex based on the X-ray crystal structure and studies with single-site-directed mutants.

  Journal of medicinal chemistry 20000323

• Effect of lipoprotein lipase activators bezafibrate and NO-1886, on B16 melanoma-induced cachexia in mice.

  Anticancer research 19990101

• Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.

  Journal of medicinal chemistry 19850701