728865-23-4 | CHIR-090

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$29.00	$20.00
2mg	98%	in stock	$36.00	$25.00
5mg	98%	in stock	$52.00	$36.00
50mg	98%	in stock	$195.00	$136.00

Description

• Catalog Number: AH15180
• Chemical Name: CHIR-090
• CAS Number: 728865-23-4
• Molecular Formula: C24H27N3O5
• Molecular Weight: 437.4883
• MDL Number: MFCD22665727
• SMILES: ONC(=O)[C@H]([C@H](O)C)NC(=O)c1ccc(cc1)C#Cc1ccc(cc1)CN1CCOCC1

Computed Properties

• Complexity: 680
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 2
• Heavy Atom Count: 32
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 8
• XLogP3: 1.3

Literature

• Design and stereoselective synthesis of a C-aryl furanoside as a conformationally constrained CHIR-090 analogue.

  Carbohydrate research 20121001

• Potent inhibitors of LpxC for the treatment of Gram-negative infections.

  Journal of medicinal chemistry 20120126

• Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold.

  Bioorganic & medicinal chemistry 20110115

• Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis.

  Current pharmaceutical biotechnology 20080201

• A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin.

  Biochemistry 20051220