7321-93-9 | 5-Amino-2,4-dichloropyridine

Packsize	Purity	Availability	Price	Discounted Price
100mg	97%	in stock	$7.00	$5.00
250mg	97%	in stock	$15.00	$11.00
1g	97%	in stock	$22.00	$16.00
5g	≥98%	in stock	$105.00	$73.00
25g	98%	in stock	$449.00	$315.00
100g	98%	in stock	$1,505.00	$1,054.00

Description

• Catalog Number: AB68750
• Chemical Name: 5-Amino-2,4-dichloropyridine
• CAS Number: 7321-93-9
• Molecular Formula: C5H4Cl2N2
• Molecular Weight: 163.0047
• MDL Number: MFCD00234054
• SMILES: Clc1ncc(c(c1)Cl)N

Computed Properties

• Complexity: 99
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• XLogP3: 1.8

Upstream Synthesis Route

The upstream synthesis of 5-Amino-2,4-dichloropyridine generally involves the following steps:

1. **Synthesis of 2,4-Dichloropyridine**: This can be achieved by chlorination of pyridine, for instance using SOCl2 (thionyl chloride) to obtain 2,4-dichloropyridine.

2. **Amination**: Introduce the amino group at the 5-position of the 2,4-dichloropyridine compound. This can be done through nucleophilic substitution reactions, often using ammonia (NH3) or an ammonium salt under controlled conditions.

Care must be taken to protect other reactive sites, control reaction temperatures, and purify the products at each stage. The specific conditions for each reaction, such as solvent choice, temperature, and reaction time, will vary based on the desired scale, yield, and purity requirements.