7341-96-0 | Propiolamide

Packsize	Purity	Availability	Price	Discounted Price
250mg	95%	in stock	$12.00	$8.00
1g	95%	in stock	$13.00	$9.00
5g	95%	in stock	$42.00	$30.00
10g	95%	in stock	$80.00	$56.00
25g	95%	in stock	$199.00	$139.00

Description

• Catalog Number: AB46931
• Chemical Name: Propiolamide
• CAS Number: 7341-96-0
• Molecular Formula: C3H3NO
• Molecular Weight: 69.062
• MDL Number: MFCD04035573
• SMILES: NC(=O)C#C
• NSC Number: 520954

Computed Properties

• Complexity: 86.3
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 5
• Hydrogen Bond Acceptor Count: 1
• Hydrogen Bond Donor Count: 1
• XLogP3: -0.4

Upstream Synthesis Route

Propiolamide, also known as 2-Propynamide or Prop-2-ynamide, plays a crucial role in chemical synthesis as a versatile building block with diverse applications. In the realm of organic chemistry, propiolamide is commonly employed as a key intermediate in the synthesis of various compounds due to its unique reactivity and structural features.One of the significant applications of propiolamide lies in its ability to participate in Sonogashira coupling reactions, where it serves as a valuable component for the formation of carbon-carbon bonds. By reacting with terminal alkynes in the presence of a palladium catalyst, propiolamide facilitates the synthesis of conjugated enynes, which are essential structural motifs present in many biologically active molecules and natural products. This reaction pathway enables chemists to access complex molecular frameworks efficiently.Moreover, propiolamide can undergo transformation into different functional groups such as carboxylic acids, esters, and heterocycles, making it a versatile substrate for the construction of various organic molecules. Its reactivity towards nucleophiles and electrophiles allows for the rapid generation of molecular diversity, making it a valuable tool in the hands of synthetic chemists.Additionally, propiolamide derivatives have shown promise in medicinal chemistry as potential candidates for drug discovery and development. Their unique structural features and reactivity profiles make them attractive targets for the design of novel pharmaceutical agents with enhanced biological activities.Overall, propiolamide's versatility and significance in chemical synthesis make it a valuable building block with wide-ranging applications in organic chemistry, drug discovery, and materials science. By harnessing its reactivity and structural properties, researchers can explore new avenues for the synthesis of complex molecules and the development of innovative materials with tailored functionalities.

Literature

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