745017-94-1 | Monomethyl Auristatin F

Packsize	Purity	Availability	Price	Discounted Price
5mg	95%	in stock	$58.00	$41.00
10mg	95%	in stock	$88.00	$62.00
25mg	95%	in stock	$188.00	$132.00
50mg	95%	in stock	$345.00	$242.00
100mg	95%	in stock	$460.00	$322.00
250mg	95%	in stock	$692.00	$484.00
1g	95%	in stock	$1,879.00	$1,316.00

Description

• Catalog Number: AB46604
• Chemical Name: Monomethyl Auristatin F
• CAS Number: 745017-94-1
• Molecular Formula: C39H65N5O8
• Molecular Weight: 731.9621
• MDL Number: MFCD25976742
• SMILES: CN[C@H](C(=O)N[C@H](C(=O)N(C([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@H](C(=O)N[C@H](C(=O)O)Cc1ccccc1)C)OC)OC)[C@H](CC)C)C)C(C)C)C(C)C

Computed Properties

• Complexity: 1160
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 9
• Heavy Atom Count: 52
• Hydrogen Bond Acceptor Count: 9
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 21
• XLogP3: 2.1

Literature

• Native intact mass determination of antibodies conjugated with monomethyl Auristatin E and F at interchain cysteine residues.

  Analytical chemistry 20120320

• Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats.

  Bioconjugate chemistry 20111019

• Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection.

  Cancer research 20090315

• A human antibody-drug conjugate targeting EphA2 inhibits tumor growth in vivo.

  Cancer research 20081115

• Anti-CD22-MCC-DM1 and MC-MMAF conjugates: impact of assay format on pharmacokinetic parameters determination.

  Bioconjugate chemistry 20080801