74536-44-0 | (2S)-5-oxopyrrolidine-2-carboxylic acid; 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol

Packsize	Purity	Availability	Price	Discounted Price
5g	95%	in stock	$19.00	$13.00
25g	95%	in stock	$42.00	$30.00
100g	95%	in stock	$137.00	$96.00
500g	95%	in stock	$386.00	$270.00

Description

• Catalog Number: AI55851
• Chemical Name: (2S)-5-oxopyrrolidine-2-carboxylic acid; 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
• CAS Number: 74536-44-0
• Molecular Formula: C13H18N2O6
• Molecular Weight: 298.2918
• MDL Number: MFCD08704232
• SMILES: O=C1CC[C@H](N1)C(=O)O.OCc1c(CO)cnc(c1O)C

Computed Properties

• Complexity: 297
• Covalently-Bonded Unit Count: 2
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 21
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 5
• Rotatable Bond Count: 3

Literature

• Preliminary findings on the use of metadoxine for the treatment of alcohol dependence and alcoholic liver disease.

  Human psychopharmacology 20111201

• [Dynamics of antipirin test at patients with alcoholic liver disease on the background of metadoksin drug receiving].

  Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20110101

• Negligible effect of oral garlic oil on the oral absorption of pyridoxine in metadoxine in rats.

  Archives of pharmacal research 20100701

• Metadoxine, an ion-pair of pyridoxine and L-2-pyrrolidone-5-carboxylate, blocks adipocyte differentiation in association with inhibition of the PKA-CREB pathway.

  Archives of biochemistry and biophysics 20090815

• [Capsule metadoxine in the treatment of alcoholic liver disease: a randomized, double-blind, placebo-controlled, multicenter study].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20090301

• [Non-alcoholic fatty liver disease: age peculiarities, breakthrough in pathogenetic therapy].

  Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20090101

• Acute alcohol intoxication.

  European journal of internal medicine 20081201

• Combined metadoxine and garlic oil treatment efficaciously abrogates alcoholic steatosis and CYP2E1 induction in rat liver with restoration of AMPK activity.

  Chemico-biological interactions 20070830

• Pharmacokinetics of metadoxine for injection after repeated doses in healthy volunteers.

  Chinese medical journal 20070120

• A follow up study on the efficacy of metadoxine in the treatment of alcohol dependence.

  Substance abuse treatment, prevention, and policy 20060101

• [The therapeutic effect of metadoxine on alcoholic and non-alcoholic steatohepatitis].

  Orvosi hetilap 20051120

• Application of stability-indicating HPTLC method for quantitative determination of metadoxine in pharmaceutical dosage form.

  Farmaco (Societa chimica italiana : 1989) 20050401

• [Role of metadoxyl in the treatment of the hepatotoxic effects of cytostatics].

  Voprosy onkologii 20050101

• [Antioxidants in liver protection].

  Orvosi hetilap 20040704

• [Study on the mechanism of male reproductive toxicity of metadoxine in mice and rats].

  Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20040701

• Fibrosis and glycogen stores depletion induced by prolonged biliary obstruction in the rat are ameliorated by metadoxine.

  Liver international : official journal of the International Association for the Study of the Liver 20030801

• [Reproductive toxicity of metadoxine in rats].

  Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20030501

• Metadoxine in the treatment of acute and chronic alcoholism: a review.

  International journal of immunopathology and pharmacology 20030101

• A new approach to drug therapy in non-alcoholic steatohepatitis (NASH).

  The Journal of international medical research 20030101

• Metadoxine in acute alcohol intoxication: a double-blind, randomized, placebo-controlled study.

  Alcoholism, clinical and experimental research 20020301

• Efficacy of metadoxine in the management of acute alcohol intoxication.

  The Journal of international medical research 20020101

• Metadoxine prevents damage produced by ethanol and acetaldehyde in hepatocyte and hepatic stellate cells in culture.

  Pharmacological research 20011101

• [Metadoxyl in combined treatment of alcohol damage to the liver].

  Klinicheskaia meditsina 20010101