75507-68-5 | Flupirtine maleate

Packsize	Purity	Availability	Price	Discounted Price
25mg	95%	in stock	$48.00	$34.00
250mg	95%	in stock	$58.00	$40.00
1g	95%	in stock	$106.00	$74.00

Description

• Catalog Number: AB46162
• Chemical Name: Flupirtine maleate
• CAS Number: 75507-68-5
• Molecular Formula: C19H21FN4O6
• Molecular Weight: 420.3916
• MDL Number: MFCD00941415
• SMILES: OC(=O)C=CC(=O)O.CCOC(=O)Nc1ccc(nc1N)NCc1ccc(cc1)F

Computed Properties

• Complexity: 469
• Covalently-Bonded Unit Count: 2
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 30
• Hydrogen Bond Acceptor Count: 10
• Hydrogen Bond Donor Count: 5
• Rotatable Bond Count: 8

Literature

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  The Journal of physiology 20120815

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  British journal of pharmacology 20120701

• Unexpected frequent hepatotoxicity of a prescription drug, flupirtine, marketed for about 30 years.

  British journal of clinical pharmacology 20120501

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• Retigabine, a K(V)7 (KCNQ) potassium channel opener, attenuates L-DOPA-induced dyskinesias in 6-OHDA-lesioned rats.

  Neuropharmacology 20120201

• Flupirtine inhibits calcitonin-gene related peptide release from rat brainstem in vitro.

  Neuroscience letters 20120111

• Kv7 potassium channels in airway smooth muscle cells: signal transduction intermediates and pharmacological targets for bronchodilator therapy.

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• Protective effect of the KCNQ activator flupirtine on a model of repetitive febrile seizures.

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  International journal of clinical pharmacology and therapeutics 20111101

• Parent-reported benefits of flupirtine in juvenile neuronal ceroid lipofuscinosis (Batten disease; CLN3) are not supported by quantitative data.

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• Flupirtine is a safe alternative drug in patients with hypersensitivity to NSAIDs.

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• Transcriptional repression of the M channel subunit Kv7.2 in chronic nerve injury.

  Pain 20110401

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• Flupirtine antinociception in the rat orofacial formalin test: an analysis of combination therapies with morphine and tramadol.

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• Flupirtine may stop the progressive course of subacute sclerosing panencephalitis.

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• Green urine following exposure to flupirtine.

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• Flupirtine in pain management: pharmacological properties and clinical use.

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• M-type potassium channels modulate the intrinsic excitability of infralimbic neurons and regulate fear expression and extinction.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20100915

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  MMW Fortschritte der Medizin 20100812

• The Kv7 potassium channel activator flupirtine affects clinical excitability parameters of myelinated axons in isolated rat sural nerve.

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• Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

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  British journal of pharmacology 20090801

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  Brain and nerve = Shinkei kenkyu no shinpo 20090801

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  Annals of neurology 20090301

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  Current medical research and opinion 20081201

• Flupirtine as neuroprotective add-on therapy in autoimmune optic neuritis.

  The American journal of pathology 20081101

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  Pain medicine (Malden, Mass.) 20081001

• Combination therapy with flupirtine and opioid: open-label case series in the treatment of neuropathic pain associated with cancer.

  Pain medicine (Malden, Mass.) 20081001

• Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents.

  British journal of pharmacology 20080901

• Vascular KCNQ potassium channels as novel targets for the control of mesenteric artery constriction by vasopressin, based on studies in single cells, pressurized arteries, and in vivo measurements of mesenteric vascular resistance.

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• KCNQ/M-currents contribute to the resting membrane potential in rat visceral sensory neurons.

  The Journal of physiology 20060815

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  Neuropharmacology 20060801

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• Tumor-necrosis-factor-related apoptosis-inducing-ligand (TRAIL)-mediated death of neurons in living human brain tissue is inhibited by flupirtine-maleate.

  Journal of neuroimmunology 20051001

• Recent developments on KCNQ potassium channel openers.

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  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040121

• Paradoxical cerebral cortical hyperexcitability following flupirtine overdose.

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  Spinal cord 20020601

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  MMW Fortschritte der Medizin 20020506

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  Annals of neurology 20020401

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  Drugs of today (Barcelona, Spain : 1998) 20020101

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