759-05-7 | 3-Methyl-2-oxo-butanoic acid

Packsize	Purity	Availability	Price	Discounted Price
250mg	95%	in stock	$26.00	$18.00
1g	95%	in stock	$53.00	$37.00
5g	95%	in stock	$191.00	$134.00
25g	95%	in stock	$882.00	$618.00
100g	95%	in stock	$2,623.00	$1,836.00

Description

• Catalog Number: AB44630
• Chemical Name: 3-Methyl-2-oxo-butanoic acid
• CAS Number: 759-05-7
• Molecular Formula: C5H8O3
• Molecular Weight: 116.1152
• MDL Number: MFCD00040427
• SMILES: CC(C(=O)C(=O)O)C

Computed Properties

• Complexity: 115
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 8
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 2
• XLogP3: 0.7

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  Pharmacology, biochemistry, and behavior 20040101

• Catabolism of leucine to branched-chain fatty acids in Staphylococcus xylosus.

  Journal of applied microbiology 20040101

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  Nutrition (Burbank, Los Angeles County, Calif.) 20040101

• A simple and rapid enzymatic assay for the branched-chain alpha-ketoacid dehydrogenase complex using high-performance liquid chromatography.

  Journal of inherited metabolic disease 20040101

• Branched chain amino acids (BCAAs) in heart diseases (ischaemic heart disease and myocardial infarction).

  Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina 20040101

• Markers of inflammation, proteolysis, and apoptosis in ESRD.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20031201

• Inhibition of brain energy metabolism by the alpha-keto acids accumulating in maple syrup urine disease.

  Biochimica et biophysica acta 20031120

• Ile, Leu, and Val methyl assignments of the 723-residue malate synthase G using a new labeling strategy and novel NMR methods.

  Journal of the American Chemical Society 20031112

• Protein components of mitochondrial DNA nucleoids in higher eukaryotes.

  Molecular & cellular proteomics : MCP 20031101

• Identification of twelve novel mutations in patients with classic and variant forms of maple syrup urine disease.

  Human mutation 20031101

• Roles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase: refined phosphorylation loop structure in the active site.

  The Journal of biological chemistry 20031031

• Premorbid weight, body mass, and varsity athletics in ALS.

  Neurology 20031014

• Substrate specificity and kinetic isotope effect analysis of the Eschericia coli ketopantoate reductase.

  Biochemistry 20030930

• Structure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sites.

  Structure (London, England : 1993) 20030801

• Dietary carbohydrate deprivation increases 24-hour nitrogen excretion without affecting postabsorptive hepatic or whole body protein metabolism in healthy men.

  The Journal of clinical endocrinology and metabolism 20030801

• Reaction mechanism of the heterotetrameric (alpha2beta2) E1 component of 2-oxo acid dehydrogenase multienzyme complexes.

  Biochemistry 20030617

• MR diffusion imaging and MR spectroscopy of maple syrup urine disease during acute metabolic decompensation.

  Neuroradiology 20030601

• Development of a capillary electrophoretic method for the analysis of amino acids containing tablets.

  Journal of chromatography. A 20030418

• Regulatory effects of alanine-group amino acids on serine alkaline protease production by recombinant Bacillus licheniformis.

  Biotechnology and applied biochemistry 20030401

• 2-Oxo acid dehydrogenase complexes of multicellular organisms.

  European journal of biochemistry 20030301

• 2-Oxo acid dehydrogenase complexes in redox regulation.

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• A sensitive and robust method for obtaining intermolecular NOEs between side chains in large protein complexes.

  Journal of biomolecular NMR 20030301

• Reaction of 1-amino-2-methylenecyclopropane-1-carboxylate with 1-aminocyclopropane-1-carboxylate deaminase: analysis and mechanistic implications.

  Biochemistry 20030225

• Encapsulation of an 86-kDa assembly intermediate inside the cavities of GroEL and its single-ring variant SR1 by GroES.

  The Journal of biological chemistry 20030124

• Mycobacterium tuberculosis ketopantoate hydroxymethyltransferase: tetrahydrofolate-independent hydroxymethyltransferase and enolization reactions with alpha-keto acids.

  Biochemistry 20030114

• The genomics and proteomics of biofilm formation.

  Genome biology 20030101

• Evolution of mosaic operons by horizontal gene transfer and gene displacement in situ.

  Genome biology 20030101

• Clofibric acid stimulates branched-chain amino acid catabolism by three mechanisms.

  Archives of biochemistry and biophysics 20021115

• Folding kinetics of the lipoic acid-bearing domain of human mitochondrial branched chain alpha-ketoacid dehydrogenase complex.

  FEBS letters 20021023

• The C-terminal hinge region of lipoic acid-bearing domain of E2b is essential for domain interaction with branched-chain alpha-keto acid dehydrogenase kinase.

  The Journal of biological chemistry 20021004

• Tissue-specific effects of chronic dietary leucine and norleucine supplementation on protein synthesis in rats.

  American journal of physiology. Endocrinology and metabolism 20021001

• Insulin increases branched-chain alpha-ketoacid dehydrogenase kinase expression in Clone 9 rat cells.

  American journal of physiology. Endocrinology and metabolism 20021001

• Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species.

  European journal of biochemistry 20021001

• Primary biliary cirrhosis: seeking the silent partner of autoimmunity.

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• Diagnosis and treatment of maple syrup disease: a study of 36 patients.

  Pediatrics 20020601

• Effect of the branched-chain alpha-ketoacids accumulating in maple syrup urine disease on the high molecular weight neurofilament subunit (NF-H) in rat cerebral cortex.

  Metabolic brain disease 20020601

• Solution structure and dynamics of the lipoic acid-bearing domain of human mitochondrial branched-chain alpha-keto acid dehydrogenase complex.

  The Journal of biological chemistry 20020503

• Maple syrup urine disease: mutation analysis in Turkish patients.

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• Recurrent intragenomic recombination leading to sequence homogenization during the evolution of the lipoyl-binding domain.

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• Substrate channelling in 2-oxo acid dehydrogenase multienzyme complexes.

  Biochemical Society transactions 20020401

• Activation of the promoters of Arabidopsis genes for the branched-chain alpha-keto acid dehydrogenase complex in transgenic tobacco BY-2 cells under sugar starvation.

  Plant & cell physiology 20020301

• Clinical significance of positive immunoblotting but negative immunofluorescence for antimitochondrial antibodies in patients with liver diseases other than primary biliary cirrhosis.

  Autoimmunity 20020301

• Structural basis of the dysfunctioning of human 2-oxo acid dehydrogenase complexes.

  Current medicinal chemistry 20020201

• Evidence of common ancestry for the maple syrup urine disease (MSUD) Y438N allele in non-Mennonite MSUD patients.

  Molecular genetics and metabolism 20020101

• The complex fate of alpha-ketoacids.

  Annual review of plant biology 20020101

• Dietary L-carnitine suppresses mitochondrial branched-chain keto acid dehydrogenase activity and enhances protein accretion and carcass characteristics of swine.

  Journal of animal science 20011201

• Primary biliary cirrhosis: lessons learned from an organ-specific disease.

  Clinical and experimental medicine 20011201

• Uteroplacental insufficiency alters liver and skeletal muscle branched-chain amino acid metabolism in intrauterine growth-restricted fetal rats.

  Pediatric research 20011101

• A gene controlling variation in Arabidopsis glucosinolate composition is part of the methionine chain elongation pathway.

  Plant physiology 20011101

• Natural osmolyte trimethylamine N-oxide corrects assembly defects of mutant branched-chain alpha-ketoacid decarboxylase in maple syrup urine disease.

  The Journal of biological chemistry 20011026

• A trail of research from lipoic acid to alpha-keto acid dehydrogenase complexes.

  The Journal of biological chemistry 20011019

• Maple syrup urine disease: identification and carrier-frequency determination of a novel founder mutation in the Ashkenazi Jewish population.

  American journal of human genetics 20011001

• Modification by exercise training of activity and enzyme expression of hepatic branched-chain alpha-ketoacid dehydrogenase complex in streptozotocin-induced diabetic rats.

  Journal of nutritional science and vitaminology 20011001

• Biochemical basis of type IB (E1beta ) mutations in maple syrup urine disease. A prevalent allele in patients from the Druze kindred in Israel.

  The Journal of biological chemistry 20010928

• Nitrogen source governs the patterns of growth and pristinamycin production in 'Streptomyces pristinaespiralis'.

  Microbiology (Reading, England) 20010901

• Regulation of branched-chain amino acid catabolism: nutritional and hormonal regulation of activity and expression of the branched-chain alpha-keto acid dehydrogenase kinase.

  Current opinion in clinical nutrition and metabolic care 20010901

• Psychrophilic valine dehydrogenase of the antarctic psychrophile, Cytophaga sp. KUC-1: purification, molecular characterization and expression.

  European journal of biochemistry 20010801

• Leucine and its keto acid enhance the coordinated expression of genes for branched-chain amino acid catabolism in Arabidopsis under sugar starvation.

  FEBS letters 20010615

• Autoantibodies of sera from patients with primary biliary cirrhosis recognize the alpha subunit of the decarboxylase component of human branched-chain 2-oxo acid dehydrogenase complex.

  Journal of hepatology 20010601

• Carrier detection and rapid newborn diagnostic test for the common Y393N maple syrup urine disease allele by PCR-RFLP: culturally permissible testing in the Mennonite community.

  Journal of inherited metabolic disease 20010601

• Alteration of the co-substrate selectivity of deacetoxycephalosporin C synthase. The role of arginine 258.

  The Journal of biological chemistry 20010525

• Acidification and glucocorticoids independently regulate branched-chain alpha-ketoacid dehydrogenase subunit genes.

  American journal of physiology. Cell physiology 20010501

• Protection by thiols of the mitochondrial complexes from 4-hydroxy-2-nonenal.

  Free radical biology & medicine 20010501

• Pharmacological evidence that alpha-ketoisovaleric acid induces convulsions through GABAergic and glutamatergic mechanisms in rats.

  Brain research 20010309

• Regulation of the activity of branched-chain 2-oxo acid dehydrogenase (BCODH) complex by binding BCODH kinase.

  FEBS letters 20010223

• Roles of active site and novel K+ ion-binding site residues in human mitochondrial branched-chain alpha-ketoacid decarboxylase/dehydrogenase.

  The Journal of biological chemistry 20010209

• cDNA cloning of the chicken branched-chain alpha-keto acid dehydrogenase complex. Chicken-specific residues of the acyltransferase affect the overall activity and the interaction with the dehydrogenase.

  European journal of biochemistry 20010201

• Multiple display of peptides and proteins on a macromolecular scaffold derived from a multienzyme complex.

  Journal of molecular biology 20010112

• Gene preference in maple syrup urine disease.

  American journal of human genetics 20010101

• The biosynthesis of coenzyme A in bacteria.

  Vitamins and hormones 20010101

• 2-keto acid oxidoreductases from Pyrococcus furiosus and Thermococcus litoralis.

  Methods in enzymology 20010101

• Effect of starvation on branched-chain alpha-keto acid dehydrogenase activity in rat heart and skeletal muscle.

  Physiological research 20010101

• Channeling of substrates and intermediates in enzyme-catalyzed reactions.

  Annual review of biochemistry 20010101

• Induction of expression of branched-chain aminotransferase and alpha-keto acid dehydrogenase in rat tissues during lactation.

  Advances in experimental medicine and biology 20010101