760-78-1 | Dl-norvaline

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$15.00	$10.00
5g	98%	in stock	$16.00	$11.00
25g	98%	in stock	$19.00	$13.00
100g	98%	in stock	$52.00	$36.00
500g	98%	in stock	$249.00	$175.00

Description

• Catalog Number: AB48195
• Chemical Name: Dl-norvaline
• CAS Number: 760-78-1
• Molecular Formula: C5H11NO2
• Molecular Weight: 117.1463
• MDL Number: MFCD00064420
• SMILES: CCCC(C(=O)O)N

Computed Properties

• Complexity: 82.5
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 8
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 3
• Undefined Atom Stereocenter Count: 1
• XLogP3: -2.1

Literature

• Control of leakage activities of alamethicin analogs by metals: side chain-dependent adverse gating response to Zn(2+).

  Bioorganic & medicinal chemistry 20121201

• Solid-state phase transitions of DL-aminobutyric acid.

  The journal of physical chemistry. B 20120906

• Kinetic partitioning between synthetic and editing pathways in class I aminoacyl-tRNA synthetases occurs at both pre-transfer and post-transfer hydrolytic steps.

  The Journal of biological chemistry 20120720

• Salt effects on solvent features of coexisting phases in aqueous polymer/polymer two-phase systems.

  Journal of chromatography. A 20120316

• pH regulation in anoxic rice coleoptiles at pH 3.5: biochemical pHstats and net H+ influx in the absence and presence of NOFormula.

  Journal of experimental botany 20120301

• Metabolome analysis of gram-positive bacteria such as Staphylococcus aureus by GC-MS and LC-MS.

  Methods in molecular biology (Clifton, N.J.) 20120101

• Metabolic fingerprinting using comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry.

  Methods in molecular biology (Clifton, N.J.) 20120101

• Development of Class IIa Bacteriocins as Therapeutic Agents.

  International journal of microbiology 20120101

• Arginase inhibition alleviates hypertension associated with diabetes: effect on endothelial dependent relaxation and NO production.

  Vascular pharmacology 20120101

• Effect of low temperature on growth and ultra-structure of Staphylococcus spp.

  PloS one 20120101

• The ζ toxin induces a set of protective responses and dormancy.

  PloS one 20120101

• Incorporation of noncanonical amino acids into Rosetta and use in computational protein-peptide interface design.

  PloS one 20120101

• Effect of rolipram, a phosphodiesterase enzyme type-4 inhibitor, on γ-amino butyric acid content of the frontal cortex in mice exposed to chronic mild stress.

  Journal of pharmacology & pharmacotherapeutics 20120101

• The Arginine Residue within the C-Terminal Active Core of Bombyx mori Pheromone Biosynthesis-Activating Neuropeptide is Essential for Receptor Binding and Activation.

  Frontiers in endocrinology 20120101

• Combination of valproate and paroxetine in mice exposed to picrotoxin.

  International journal of nanomedicine 20120101

• Jadomycins derived from the assimilation and incorporation of norvaline and norleucine.

  Journal of natural products 20111128

• An evolutionary strategy for isobutanol production strain development in Escherichia coli.

  Metabolic engineering 20111101

• A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis.

  The FEBS journal 20110901

• Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT.

  Bioorganic & medicinal chemistry letters 20110815

• Structure-activity relationships of a series of analogues of the RFamide-related peptide 26RFa.

  Journal of medicinal chemistry 20110714

• ¹³C metabolic flux analysis identifies an unusual route for pyruvate dissimilation in mycobacteria which requires isocitrate lyase and carbon dioxide fixation.

  PLoS pathogens 20110701

• [Classification of anticancer drugs with different mechanisms based on amino-acid consumption profiling in culture media].

  Se pu = Chinese journal of chromatography 20110401

• Understanding the molecular dynamics associated with polymorphic transitions of DL-norvaline with solid-state NMR methods.

  The journal of physical chemistry. B 20110331

• Solid-state phase transitions in DL-norvaline studied by single-crystal X-ray diffraction.

  The journal of physical chemistry. B 20110317

• Serum markers and intestinal mucosal injury in chronic gastrointestinal ischemia.

  Digestive diseases and sciences 20110201

• Antisense inhibition of the iron-sulphur subunit of succinate dehydrogenase enhances photosynthesis and growth in tomato via an organic acid-mediated effect on stomatal aperture.

  The Plant cell 20110201

• From amino acid to glucosinolate biosynthesis: protein sequence changes in the evolution of methylthioalkylmalate synthase in Arabidopsis.

  The Plant cell 20110101

• Molecular breeding of advanced microorganisms for biofuel production.

  Journal of biomedicine & biotechnology 20110101

• Lack of neuroprotection in the absence of P2X7 receptors in toxin-induced animal models of Parkinson's disease.

  Molecular neurodegeneration 20110101

• Thrombospondin-1: multiple paths to inflammation.

  Mediators of inflammation 20110101

• Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth.

  Molecular systems biology 20110101

• Design and development of a peptide-based adiponectin receptor agonist for cancer treatment.

  BMC biotechnology 20110101

• Investigation of the adaptation of Lactococcus lactis to isoleucine starvation integrating dynamic transcriptome and proteome information.

  Microbial cell factories 20110101

• A new diketopiperazine, cyclo-(4-S-hydroxy-R-proline-R-isoleucine), from an Australian specimen of the sponge Stelletta sp.

  Marine drugs 20110101

• Chiroptical study of α-aliphatic amino acid films in the vacuum ultraviolet region.

  The journal of physical chemistry. A 20101111

• Ligand-induced changes in the conformational stability and flexibility of glutamate dehydrogenase and their role in catalysis and regulation.

  Protein science : a publication of the Protein Society 20101001

• pH-dependent permeation of amino acids through isolated ivy cuticles is affected by cuticular water sorption and hydration shell size of the solute.

  Journal of experimental botany 20100901

• The effect of the P1 side chain on the binding of optimized carboxylate and activated carbonyl inhibitors of the hepatitis C virus NS3 protease.

  Future medicinal chemistry 20100701

• A series of alpha-amino acid ester prodrugs of camptothecin: in vitro hydrolysis and A549 human lung carcinoma cell cytotoxicity.

  Journal of medicinal chemistry 20100211

• Specificities of olfactory receptor neuron responses to amino acids in the black bullhead catfish (Ameiurus melas).

  Pflugers Archiv : European journal of physiology 20100201

• Solid-solid phase transitions in DL-norvaline studied by differential scanning calorimetry and Raman spectroscopy.

  The journal of physical chemistry. B 20100128

• Pulmonary targeting microparticulate camptothecin delivery system: anticancer evaluation in a rat orthotopic lung cancer model.

  Anti-cancer drugs 20100101

• A residue outside the active site CXXC motif regulates the catalytic efficiency of Glutaredoxin 3.

  Molecular bioSystems 20100101

• The path to next generation biofuels: successes and challenges in the era of synthetic biology.

  Microbial cell factories 20100101

• Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes.

  PloS one 20100101

• Specificity of the Acute Tryptophan and Tyrosine Plus Phenylalanine Depletion and Loading Tests Part II: Normalisation of the Tryptophan and the Tyrosine Plus Phenylalanine to Competing Amino Acid Ratios in a New Control Formulation.

  International journal of tryptophan research : IJTR 20100101

• Structure-activity relationships of HCV NS3 protease inhibitors evaluated on the drug-resistant variants A156T and D168V.

  Antiviral therapy 20100101

• Fed-batch process for the psychrotolerant marine bacterium Pseudoalteromonas haloplanktis.

  Microbial cell factories 20100101

• Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain.

  Molecular pain 20100101

• Traditional herbal medicine in far-west Nepal: a pharmacological appraisal.

  Journal of ethnobiology and ethnomedicine 20100101

• Context-independent, temperature-dependent helical propensities for amino acid residues.

  Journal of the American Chemical Society 20090916

• Pharmacokinetics of acute tryptophan depletion using a gelatin-based protein in male and female Wistar rats.

  Amino acids 20090701

• Human neutrophil elastase responsive delivery from poly(ethylene glycol) hydrogels.

  Biomacromolecules 20090608

• Defects in transient tRNA translocation bypass tRNA synthetase quality control mechanisms.

  The Journal of biological chemistry 20090424

• Dual mechanism of brain injury and novel treatment strategy in maple syrup urine disease.

  Brain : a journal of neurology 20090401

• Cyclosporins from Mycelium sterilae MS 2929.

  Journal of natural products 20090101

• Inhibition of S6K1 accounts partially for the anti-inflammatory effects of the arginase inhibitor L-norvaline.

  BMC cardiovascular disorders 20090101

• Increased hepatic oxidative metabolism distinguishes the action of Peroxisome proliferator-activated receptor delta from Peroxisome proliferator-activated receptor gamma in the ob/ob mouse.

  Genome medicine 20090101

• Co-ordinated expression of amino acid metabolism in response to N and S deficiency during wheat grain filling.

  Journal of experimental botany 20081001

• Unique residues crucial for optimal editing in yeast cytoplasmic Leucyl-tRNA synthetase are revealed by using a novel knockout yeast strain.

  The Journal of biological chemistry 20080815

• Mutation in the rel gene of Sorangium cellulosum affects morphological and physiological differentiation.

  Molecular microbiology 20080701

• Application of the Phenomenex EZ:faasttrade mark amino acid analysis kit for rapid gas-chromatographic determination of concentrations of plasma tryptophan and its brain uptake competitors.

  Amino acids 20080501

• The crystal structures of ornithine carbamoyltransferase from Mycobacterium tuberculosis and its ternary complex with carbamoyl phosphate and L-norvaline reveal the enzyme's catalytic mechanism.

  Journal of molecular biology 20080125

• Metabolic control analysis: a tool for designing strategies to manipulate metabolic pathways.

  Journal of biomedicine & biotechnology 20080101

• Growth rate regulated genes and their wide involvement in the Lactococcus lactis stress responses.

  BMC genomics 20080101

• Norvaline is accumulated after a down-shift of oxygen in Escherichia coli W3110.

  Microbial cell factories 20080101

• Detecting coevolution in and among protein domains.

  PLoS computational biology 20071101

• The PDE4 inhibitor rolipram reverses object memory impairment induced by acute tryptophan depletion in the rat.

  Psychopharmacology 20070601

• Genetic evidence for a link between glycolysis and DNA replication.

  PloS one 20070101

• Novel method for measurement of glutathione kinetics in neonates using liquid chromatography coupled to isotope ratio mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20070101

• The global role of ppGpp synthesis in morphological differentiation and antibiotic production in Streptomyces coelicolor A3(2).

  Genome biology 20070101

• An expanded set of amino acid analogs for the ribosomal translation of unnatural peptides.

  PloS one 20070101

• [Overproduction of noncanonical amino acids by Escherichia coli cells].

  Mikrobiologiia 20070101

• Arginase activity in a murine macrophage cell line (RAW264.7) stimulated with lipopolysaccharide from Actinobacillus actinomycetemcomitans.

  Oral microbiology and immunology 20060601

• Determination of intrinsic hydrophilicity/hydrophobicity of amino acid side chains in peptides in the absence of nearest-neighbor or conformational effects.

  Biopolymers 20060101

• Global gene expression during stringent response in Corynebacterium glutamicum in presence and absence of the rel gene encoding (p)ppGpp synthase.

  BMC genomics 20060101

• Glutamine analogues containing a keto function--novel inhibitors of fungal glucosamine-6-phosphate synthase.

  Journal of enzyme inhibition and medicinal chemistry 20051001

• Main chain hydrogen bond interactions in the binding of proline-rich gluten peptides to the celiac disease-associated HLA-DQ2 molecule.

  The Journal of biological chemistry 20050610

• Synthesis of the beta-hydroxydopa-gamma-hydroxy-delta-sulfinylnorvaline component of ustiloxins A and B.

  Organic & biomolecular chemistry 20050307

• Correlations between olfactory discrimination, olfactory receptor neuron responses and chemotopy of amino acids in fishes.

  Chemical senses 20050101

• Meteoritic C alpha-methylated alpha-amino acids and the homochirality of life: searching for a link.

  Angewandte Chemie (International ed. in English) 20041210

• Simultaneous high-performance liquid chromatographic analysis of pregabalin, gabapentin and vigabatrin in human serum by precolumn derivatization with o-phtaldialdehyde and fluorescence detection.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041025

• Presentation and detection of azide functionality in bacterial cell surface proteins.

  Journal of the American Chemical Society 20040901

• Rapid and sensitive method for determining free amino acids in honey by gas chromatography with flame ionization or mass spectrometric detection.

  Journal of chromatography. A 20040820

• The stereospecificity and catalytic efficiency of the tryptophan synthase-catalysed exchange of the alpha-protons of amino acids.

  The Biochemical journal 20040801

• Arginase pathway in human endothelial cells in pathophysiological conditions.

  Journal of molecular and cellular cardiology 20040801

• Induction of hyperammonia in irradiated hepatoma cells: a recapitulation and possible explanation of the phenomenon.

  British journal of cancer 20040705

• High glucose augments arginase activity and nitric oxide production in the renal cortex.

  Metabolism: clinical and experimental 20040701

• Peptide-based inhibitors of the hepatitis C virus NS3 protease: structure-activity relationship at the C-terminal position.

  Journal of medicinal chemistry 20040506

• Engineered biosynthesis of regioselectively modified aromatic polyketides using bimodular polyketide synthases.

  PLoS biology 20040201

• Asymmetric synthesis of N-protected amino acids by the addition of organolithium carboxyl synthons to ROPHy/SOPHy-derived aldoximes and ketoximes.

  Organic & biomolecular chemistry 20040121

• Plasma concentrations of 5-fluorouracil and F-beta-alanine following oral administration of S-1, a dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine, as compared with protracted venous infusion of 5-fluorouracil.

  British journal of cancer 20030901

• Changes in the ornithine cycle following ionising radiation cause a cytotoxic conditioning of the culture medium of H35 hepatoma cells.

  British journal of cancer 20030210

• Arginine deprivation and tumour cell death: arginase and its inhibition.

  Molecular and cellular biochemistry 20030201

• Role of salicylic acid in systemic resistance induced by Pseudomonas fluorescens against Fusarium oxysporum f. sp. ciceri in chickpea.

  Microbiological research 20030101

• Evolution of phage with chemically ambiguous proteomes.

  BMC evolutionary biology 20030101

• Consumption of L-arginine mediated by Entamoeba histolytica L-arginase (EhArg) inhibits amoebicidal activity and nitric oxide production by activated macrophages.

  Parasite immunology 20030101

• Attenuation of the editing activity of the Escherichia coli leucyl-tRNA synthetase allows incorporation of novel amino acids into proteins in vivo.

  Biochemistry 20020827

• Synthesis and biological evaluations of brain-targeted chemical delivery systems of [Nva2]-TRH.

  The Journal of pharmacy and pharmacology 20020701

• Resistance and susceptibility to Marek's disease: nitric oxide synthase/arginase activity balance.

  Veterinary microbiology 20020501

• Reactivity of amino acids in nitrosation reactions and its relation to the alkylating potential of their products.

  Journal of the American Chemical Society 20020313

• Antiapoptotic and proapoptotic action of various amino acids and analogs in starving MOLT-4 cells.

  Archives of biochemistry and biophysics 20020201

• Carbon and nitrogen substrate utilization by archival Salmonella typhimurium LT2 cells.

  BMC evolutionary biology 20020101

• Mechanisms of ammonia and amino acid photoproduction from aquatic humic and colloidal matter.

  Water research 20011001

• Selective functionalization of amino acids in water: a synthetic method via catalytic C-H bond activation.

  Journal of the American Chemical Society 20010822

• Identification of an expanded set of translationally active methionine analogues in Escherichia coli.

  FEBS letters 20010727

• Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity.

  Cancer research 20010201

• Experimental shock chemistry of aqueous amino acid solutions and the cometary delivery of prebiotic compounds.

  Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life 20010101