7737-17-9 | 1-Aminopropan-2-one, HCl

Packsize	Purity	Availability	Price	Discounted Price
100mg	95%	in stock	$10.00	$7.00
250mg	95%	in stock	$13.00	$9.00
1g	95%	in stock	$15.00	$10.00
5g	95%	in stock	$26.00	$18.00
10g	95%	in stock	$43.00	$30.00
25g	95%	in stock	$66.00	$46.00

Description

• Catalog Number: AB45545
• Chemical Name: 1-Aminopropan-2-one, HCl
• CAS Number: 7737-17-9
• Molecular Formula: C3H8ClNO
• Molecular Weight: 109.5547
• MDL Number: MFCD00056125
• SMILES: CC(=O)CN.Cl
• NSC Number: 159195

Computed Properties

• Complexity: 42.2
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 6
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 1

Upstream Synthesis Route

The upstream synthesis of 1-Aminopropan-2-one hydrochloride (HCl) can be described as follows:

1. Starting with propiophenone, perform an α-bromination using bromine in the presence of an acid catalyst to create α-bromo-propiophenone.

2. Perform a substitution reaction of the α-bromo-propiophenone with ammonia (NH3) or an ammonium salt to yield 1-aminopropan-2-one. This step requires the displacement of the bromine atom by the amine group.

3. Finally, react the 1-aminopropan-2-one with hydrochloric acid to form the hydrochloride salt, 1-Aminopropan-2-one, HCl. This reaction involves the protonation of the amine group by HCl.

The reagents and conditions must be carefully controlled at each step to ensure the desired product purity and yield.

Literature

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  PloS one 20120101

• Aminoacetone as the penultimate precursor to the antitumor agent azinomycin A.

  Organic letters 20090903

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  Analytical biochemistry 20090101

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  Metabolism: clinical and experimental 20080901

• Aminoacetone, a putative endogenous source of methylglyoxal, causes oxidative stress and death to insulin-producing RINm5f cells.

  Chemical research in toxicology 20080901

• First aminoacetone chelate: [Co(tren){NH2CH2C(O)CH3}]3+-a substrate binding and activation model for zinc(II)-dependent 5-aminolaevulinic acid dehydratase.

  Dalton transactions (Cambridge, England : 2003) 20070814

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  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20070101

• Trace determination of 1-aminopropanone, a potential marker for wastewater contamination by liquid chromatography and atmospheric pressure chemical ionization-mass spectrometry.

  Water research 20060201

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  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050925

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  Chemical research in toxicology 20050401

• Developmental profiles of 5-aminolevulinate, porphobilinogen and porphobilinogen synthase activity in Pieris brassicae related to the synthesis of the bilin-binding protein.

  Insect biochemistry and molecular biology 20050201

• Aminoacetone induces iron-mediated oxidative damage to isolated rat liver mitochondria.

  Archives of biochemistry and biophysics 20041015

• Aminoacetone induces loss of ferritin ferroxidase and iron uptake activities.

  Free radical research 20031001

• Physiological and pathological implications of semicarbazide-sensitive amine oxidase.

  Biochimica et biophysica acta 20030411

• Aerobic oxidation of aminoacetone, a threonine catabolite: iron catalysis and coupled iron release from ferritin.

  Chemical research in toxicology 20010901

• Oxidative DNA damage induced by aminoacetone, an amino acid metabolite.

  Archives of biochemistry and biophysics 19990501

• Interaction between L-threonine dehydrogenase and aminoacetone synthetase and mechanism of aminoacetone production.

  The Journal of biological chemistry 19861215