77883-43-3 | 2-{4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazin-1-yl}-6,7-dimethoxyquinazolin-4-amine; methanesulfonic acid

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$16.00	$11.00
100mg	98%	in stock	$22.00	$15.00
250mg	98%	in stock	$29.00	$20.00
1g	98%	in stock	$49.00	$34.00
5g	98%	in stock	$153.00	$107.00
25g	98%	in stock	$448.00	$314.00

Description

• Catalog Number: AI56328
• Chemical Name: 2-{4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazin-1-yl}-6,7-dimethoxyquinazolin-4-amine; methanesulfonic acid
• CAS Number: 77883-43-3
• Molecular Formula: C24H29N5O8S
• Molecular Weight: 547.5808
• MDL Number: MFCD00216023
• SMILES: CS(=O)(=O)O.COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2
• NSC Number: 759284

Computed Properties

• Complexity: 770
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 38
• Hydrogen Bond Acceptor Count: 12
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 4
• Undefined Atom Stereocenter Count: 1

Literature

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• Effect of doxazosin on expression of eNOS in rat kidney in the presence of partial bladder outlet obstruction.

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  Life sciences 20090812

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  Acta cardiologica 20090801

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  The Prostate 20090501

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  Hypertension research : official journal of the Japanese Society of Hypertension 20090501

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  The Journal of urology 20080901

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  Eye (London, England) 20080801

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  Hypertension research : official journal of the Japanese Society of Hypertension 20080801

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  Journal of biomedical science 20080701

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  Circulation 20080701

• Intraoperative floppy-iris syndrome associated with systemic alpha blockers.

  Journal of cataract and refractive surgery 20080701

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  International journal of andrology 20080601

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  Cell and tissue research 20080401

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  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20080301

• Add-on therapy with a nighttime dose of doxazosin in patients with uncontrolled hypertension: effects on autonomic modulation of the cardiovascular system.

  Hypertension research : official journal of the Japanese Society of Hypertension 20080301

• alpha(1)-Adrenoceptor antagonists prevent paracetamol-induced hepatotoxicity in mice.

  British journal of pharmacology 20080201

• Doxazosin induces apoptosis of cells expressing hERG K+ channels.

  European journal of pharmacology 20080128

• Clinical outcomes by race in hypertensive patients with and without the metabolic syndrome: Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).

  Archives of internal medicine 20080128

• Pharmacogenetic association of the NPPA T2238C genetic variant with cardiovascular disease outcomes in patients with hypertension.

  JAMA 20080123

• The influence of alpha1-antagonist on the expression pattern of TNF receptor family in primary culture of prostate epithelial cells from BPH patients.

  Prostate cancer and prostatic diseases 20080101

• The alpha1-adrenergic receptor antagonist doxazosin inhibits EGFR and NF-kappaB signalling to induce breast cancer cell apoptosis.

  European journal of cancer (Oxford, England : 1990) 20080101

• Comparison of the effects of doxazosin and atenolol on target organ damage in adults with type 2 diabetes mellitus and hypertension in the CARDHIAC study: a 9-month, prospective, randomized, open-label, blinded-evaluation trial.

  Clinical therapeutics 20080101

• Treatment for chronic prostatitis/chronic pelvic pain syndrome: levofloxacin, doxazosin and their combination.

  Urologia internationalis 20080101

• The effect of various alpha1-adrenergic receptor antagonists on pupillary dilation.

  Annals of ophthalmology (Skokie, Ill.) 20080101

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  Klinicheskaia meditsina 20080101

• Recurrent autonomic dysreflexia due to chronic aortic dissection in an adult male with cervical spinal cord injury.

  TheScientificWorldJournal 20080101

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  Urologiia (Moscow, Russia : 1999) 20080101

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  Advances in gerontology = Uspekhi gerontologii 20080101

• Histologic influence of doxazosin and finasteride in benign prostatic hyperplasia accompanying chronic inflammation.

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  Urologiia (Moscow, Russia : 1999) 20080101

• Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay.

  European journal of pharmacology 20071222

• Add-on therapy with doxazosin in patients with hypertension influences arterial stiffness and albuterol-mediated arterial vasodilation.

  British journal of clinical pharmacology 20071201

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  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20071101

• Blood pressure control in Hispanics in the antihypertensive and lipid-lowering treatment to prevent heart attack trial.

  Hypertension (Dallas, Tex. : 1979) 20071101

• The effect of doxazosin, finasteride and combination therapy on nocturia in men with benign prostatic hyperplasia.

  The Journal of urology 20071101

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• Effects of alpha1-adrenergic receptor blockade by doxazosin on renin-angiotensin system-regulating aminopeptidase and vasopressin-degrading activities in male and female rat thalamus.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20071101

• Doxazosin in metabolically complicated hypertension.

  Expert review of cardiovascular therapy 20071101

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  Journal of the Royal Society of Medicine 20071101

• New insights into the therapeutic management of morning hypertension with alpha1-adrenergic receptor blockers.

  Hypertension research : official journal of the Japanese Society of Hypertension 20071101

• Add-on effect of bedtime dosing of the alpha(1)-adrenergic receptor antagonist doxazosin on morning hypertension and left ventricular hypertrophy in patients undergoing long-term amlodipine monotherapy.

  Hypertension research : official journal of the Japanese Society of Hypertension 20071101

• Doxazosin blockade of alpha 1-adrenergic receptors increases rat serum progesterone levels: a putative role of ovarian angiotensin III in steroidogenesis.

  Fertility and sterility 20071001

• Hemodynamic interaction between a daily dosed phosphodiesterase 5 inhibitor, tadalafil, and the alpha-adrenergic blockers, doxazosin and tamsulosin, in middle-aged healthy male subjects.

  Journal of clinical pharmacology 20071001

• Doxazosin relaxes ureteral smooth muscle and inhibits epinephrine-induced ureteral contractility in vitro.

  Urology 20071001

• [Case of baroreflex failure after bilateral revascularization of the cervical carotid artery].

  Rinsho shinkeigaku = Clinical neurology 20071001

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  Actas dermo-sifiliograficas 20070901

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• Editorial comment on: Immunohistochemical distribution of cyclic GMP-dependent protein kinase-1 in human prostate tissue.

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• Comparative study of modified release alpha-blocker exposure in elderly patients with fractures.

  Pharmacoepidemiology and drug safety 20070801

• Unresponsive asystolic cardiac arrest responding to external cardiac pacing in a patient with phaeochromocytoma.

  Anaesthesia 20070801

• Pharmacokinetics of doxazosin gastrointestinal therapeutic system after multiple administration in Korean healthy volunteers.

  Drug development and industrial pharmacy 20070801

• Management of chronic nonbacterial prostatitis/chronic pelvic pain syndrome.

  Bosnian journal of basic medical sciences 20070801

• ATP-binding cassette transporter A1 gene transcription is downregulated by activator protein 2alpha. Doxazosin inhibits activator protein 2alpha and increases high-density lipoprotein biogenesis independent of alpha1-adrenoceptor blockade.

  Circulation research 20070720

• Old drug, new tricks: the unexpected effect of doxazosin on high-density lipoprotein.

  Circulation research 20070720

• [Comparison of different drugs on the treatment of benign prostate hyperplasia].

  Zhonghua wai ke za zhi [Chinese journal of surgery] 20070715

• [Using of alpha1-adrenoreceptor blockers in urologic practice].

  Voenno-meditsinskii zhurnal 20070701

• [Chiral separation of doxazosin and its intermediate by capillary electrophoresis using tetramethylammonium hydroxide to control electroosmotic flow].

  Se pu = Chinese journal of chromatography 20070701

• Effects of doxazosin on blood flow and mRNA expression of nitric oxide synthase in the spontaneously hypertensive rat genitourinary tract.

  Life sciences 20070627

• Advances in the medical management of benign prostatic hyperplasia.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20070619

• Incidence of intraoperative floppy iris syndrome in patients on either systemic or topical alpha1-adrenoceptor antagonist.

  American journal of ophthalmology 20070601

• Finasteride and doxazosin alone or in combination for the treatment of benign prostatic hyperplasia.

  Expert opinion on pharmacotherapy 20070601

• Intraoperative floppy iris syndrome with doxazosin.

  Eye (London, England) 20070501

• Alpha antagonists and intraoperative floppy iris syndrome (IFIS) during trabeculectomy.

  Eye (London, England) 20070501

• Indirect role of alpha2-adrenoreceptors in anti-ulcer effect mechanism of nimesulide in rats.

  Naunyn-Schmiedeberg's archives of pharmacology 20070501

• Doxazosin for the management of distal-ureteral stones.

  Journal of endourology 20070501

• Antihypertensive therapy, the alpha-adducin polymorphism, and cardiovascular disease in high-risk hypertensive persons: the Genetics of Hypertension-Associated Treatment Study.

  The pharmacogenomics journal 20070401

• Assessment of alpha1-adrenoceptor antagonists in benign prostatic hyperplasia based on the receptor occupancy theory.

  British journal of clinical pharmacology 20070401

• A placebo-controlled comparison of the efficiency of triple- and monotherapy in category III B chronic pelvic pain syndrome (CPPS).

  European urology 20070401

• Effect of antihypertensive agents on plasma adiponectin levels in hypertensive patients with metabolic syndrome.

  Nephrology (Carlton, Vic.) 20070401

• Intraoperative floppy-iris syndrome with doxazosin.

  Journal of cataract and refractive surgery 20070401

• [Perioperative treatment of a patient with ectopic ACTH-producing pheochromocytoma].

  Masui. The Japanese journal of anesthesiology 20070401

• Usefulness of the alpha1-blocker doxazosin as a third-line antihypertensive drug.

  Hypertension research : official journal of the Japanese Society of Hypertension 20070401

• Differential effects of urapidil and doxazosin on heart rate.

  European journal of clinical pharmacology 20070301

• The effects of systemic alpha-1 adrenergic antagonists on pupil diameter in rats.

  Current eye research 20070301

• [Recurrent syncopes secondary to pheochromocytoma].

  Medicina clinica 20070224

• LC-MS determination and relative bioavailability of doxazosin mesylate tablets in healthy Chinese male volunteers.

  Journal of pharmaceutical and biomedical analysis 20070219

• Doxazosin gastrointestinal therapeutic system versus tamsulosin for the treatment of benign prostatic hyperplasia: a study in Chinese patients.

  International journal of urology : official journal of the Japanese Urological Association 20070201

• [Anesthetic management for off-pump coronary artery bypass grafting in a patient with a pheochromocytoma and followed by the resection of the pheochromocytoma].

  Masui. The Japanese journal of anesthesiology 20070201

• Separation, characterization, and quantitation of process-related substances of the anti-hypertensive drug doxazosin mesylate by reversed-phase LC with PDA and ESI-MS as detectors.

  Journal of chromatographic science 20070201

• [Effects of doxazosin enantiomers on alpha-adrenoceptors of isolated rabbit blood vessels].

  Yao xue xue bao = Acta pharmaceutica Sinica 20070201

• Contractile responses of rabbit bladder neck to adrenaline, acetylcholine and papaverine after doxazosin treatment.

  International urology and nephrology 20070101

• The Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) Heart Failure Validation Study: diagnosis and prognosis.

  American heart journal 20070101

• Effects of doxazosin and amlodipine on mean platelet volume and serum serotonin level in patients with metabolic syndrome: a randomised, controlled study.

  Clinical drug investigation 20070101

• Doxazosin-induced clusterin expression and apoptosis in prostate cancer cells.

  Urologic oncology 20070101

• Targeting pituitary tumors.

  Hormone research 20070101

• Assessment of cognitive function in patients with essential hypertension treated with lercanidipine.

  Vascular health and risk management 20061201

• Doxazosin in the treatment of benign prostatic hypertrophy: an update.

  Clinical interventions in aging 20061201

• High-performance liquid chromatographic determination of doxazosin in human plasma for bioequivalence study of controlled release doxazosin tablets.

  Biomedical chromatography : BMC 20061101

• Chiral selective effects of doxazosin enantiomers on blood pressure and urinary bladder pressure in anesthetized rats.

  Acta pharmacologica Sinica 20061101

• Efficacy and safety of tamsulosin hydrochloride compared to doxazosin in the treatment of Indonesian patients with lower urinary tract symptoms due to benign prostatic hyperplasia.

  International journal of urology : official journal of the Japanese Urological Association 20061101

• Adrenergic stimulation and blocking of hormonal secretion activity of cultured cow granulosa cells.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20061101

• The influence of alpha-adrenergic receptors stimulator and blockers and beta-blocker on the ovary and endocrinological activity in heifers during superovulation.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20061101

• Evaluation of short term clinical effects and presumptive mechanism of botulinum toxin type A as a treatment modality of benign prostatic hyperplasia.

  Yonsei medical journal 20061031

• On-line simultaneous removal of human serum albumin and enrichment of doxazosin using a weak cation-exchange monolithic column.

  Journal of chromatography. A 20061006

• A randomised, double-blind study comparing the efficacy and tolerability of controlled-release doxazosin and tamsulosin in the treatment of benign prostatic hyperplasia in Brazil.

  International journal of clinical practice 20061001

• Myostatin expression in ventricular myocardium in a rat model of volume-overload heart failure.

  European journal of clinical investigation 20061001

• Intraoperative floppy iris syndrome.

  Ophthalmology 20061001

• [A novel microemulsion electrokinetic chromatography for measuring lipid-water partition coefficients of pharmaceuticals].

  Yao xue xue bao = Acta pharmaceutica Sinica 20061001

• The role of the alpha-1 adrenoceptor in modulating human mesangial cell matrix production.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060901

• Incidence and predictors of angioedema in elderly hypertensive patients at high risk for cardiovascular disease: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).

  Journal of clinical hypertension (Greenwich, Conn.) 20060901

• Validation and pharmacokinetic application of a method for determination of doxazosin in human plasma by high-performance liquid chromatography.

  Biomedical chromatography : BMC 20060801

• alpha-blocker treatment of urolithiasis.

  European urology 20060801

• UPLC-MS/MS determination of doxazosine in human plasma.

  Analytical and bioanalytical chemistry 20060801

• Benign prostatic hyperplasia (BPH).

  Harvard men's health watch 20060801

• Doxazosin induces activation of GADD153 and cleavage of focal adhesion kinase in cardiomyocytes en route to apoptosis.

  Cardiovascular research 20060701

• Survival benefits of different antiadrenergic interventions in pressure overload left ventricular hypertrophy/failure.

  Hypertension (Dallas, Tex. : 1979) 20060701

• Enantiomeric resolution of doxazosin mesylate and its process-related substances on polysaccharide chiral stationary phases.

  Journal of pharmaceutical and biomedical analysis 20060607

• Effect of doxazosin with and without rho-kinase inhibitor on human corpus cavernosum smooth muscle in the presence of bladder outlet obstruction.

  The Journal of urology 20060601

• Anxiety-induced plasma norepinephrine augmentation increases reactive oxygen species formation by monocytes in essential hypertension.

  American journal of hypertension 20060601

• Role of diuretics in the prevention of heart failure: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.

  Circulation 20060509

• Preventing vascular events due to elevated blood pressure.

  Circulation 20060509

• The role of noradrenaline in the generation of the preovulatory LH surge in the ewe.

  Domestic animal endocrinology 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• The effect of carvedilol on metabolic parameters in patients with metabolic syndrome.

  International heart journal 20060501

• [One-year controlled therapy with doxazosin in patients with pulmonary hypertension due to chronic obstructive pulmonary disease].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20060501

• Baseline factors as predictors of clinical progression of benign prostatic hyperplasia in men treated with placebo.

  The Journal of urology 20060401

• Treatment and pharmacologic management of BPH in the context of common comorbidities.

  The American journal of managed care 20060401

• Effect of doxazosin on C-reactive protein plasma levels and on nitric oxide in patients with hypertension.

  Journal of cardiovascular pharmacology 20060401

• Association of IFIS and vasodepressor medication.

  Journal of cataract and refractive surgery 20060401

• Are all alpha-blockers created the same?

  European urology 20060301

• Beneficial effects of extended-release doxazosin and doxazosin standard on sexual health.

  BJU international 20060301

• Clinical efficacy and tolerability of alpha-blocker doxazosin as add-on therapy in patients with hypertension and impaired glucose metabolism.

  Nutrition, metabolism, and cardiovascular diseases : NMCD 20060301

• Controlled-release doxazosin as combination therapy in hypertension: the GATES study.

  Journal of clinical hypertension (Greenwich, Conn.) 20060301

• Doxazosin gastrointestinal therapeutic system: a clinical perspective.

  Journal of clinical hypertension (Greenwich, Conn.) 20060301

• Comparison of doxazosin GITS and standard doxazosin in the treatment of high blood pressure.

  International journal of clinical pharmacology and therapeutics 20060301

• [The objective of medical treatment: relieve the symptoms or stop the course?].

  Annales d'urologie 20060301

• The Japan Morning Surge-1 (JMS-1) study: protocol description.

  Hypertension research : official journal of the Japanese Society of Hypertension 20060301

• Should patients with benign prostatic hypertrophy stop taking doxazosin in the light of the ALLHAT study?

  International journal of cardiology 20060215

• Comparison of the protein profile of established and regressed hypertension-induced left ventricular hypertrophy.

  Journal of proteome research 20060201

• In vivo studies on the effects of alpha1-adrenoceptor antagonists on pupil diameter and urethral tone in rabbits.

  Naunyn-Schmiedeberg's archives of pharmacology 20060201

• Effect of doxazosin gastrointestinal therapeutic system on patients with uncontrolled hypertension: the ASOCIA Study.

  Journal of cardiovascular pharmacology 20060201

• Effect of doxazosin on oxidative stress related proteins in essential hypertensive patients.

  Clinical and experimental hypertension (New York, N.Y. : 1993) 20060201

• Antinociceptive and behavioral effects of ribavirin in mice.

  Pharmacology, biochemistry, and behavior 20060201

• Effect of doxazosin gastrointestinal therapeutic system on platelet degranulation and platelet-leukocyte microaggregate formation induced by physiologic shear stress in hypertension.

  Thrombosis research 20060101

• Long-term follow-up study to evaluate the efficacy and safety of the doxazosin gastrointestinal therapeutic system in patients with benign prostatic hyperplasia with or without concomitant hypertension.

  BJU international 20060101

• Doxazosin induces apoptosis of benign and malignant prostate cells via a death receptor-mediated pathway.

  Cancer research 20060101

• Effect of doxazosin on oxidative stress-related proteins in benign prostatic hyperplasia.

  Urologia internationalis 20060101

• Combination therapy with doxazosin and finasteride for benign prostatic hyperplasia in patients with lower urinary tract symptoms and a baseline total prostate volume of 25 ml or greater.

  The Journal of urology 20060101

• Combination regimen in the treatment of chronic prostatitis.

  Archives of andrology 20060101

• Cytoplasmic free calcium mobilization in platelets, expression of P-selectin, phosphatidylserine, and microparticle formation, measured by whole blood flow cytometry, in hypertensive patients. Effect of doxazosin GITS.

  Thrombosis research 20060101

• Effects of alpha(1)-adrenoceptor antagonists on male sexual function.

  Drugs 20060101

• Doxazosin and serotonin (5-HT) receptor (1A, 2A, and 4) antagonists inhibit 5-HT-mediated human cavernosal contraction.

  Journal of andrology 20060101

• Pharmacologic expulsive treatment of ureteral calculi.

  The Annals of pharmacotherapy 20060101

• [The comparative study on selective alpha1-blocker and behavioural therapy in the treatment of discoordinated voiding in children].

  Przeglad lekarski 20060101

• [The system of management nocturnal enuresis based on functional classification].

  Przeglad lekarski 20060101

• Potentially inappropriate medication prescribing for elderly outpatients in Emilia Romagna, Italy: a population-based cohort study.

  Drugs & aging 20060101

• Treatment of detrusor sphincter dyssynergia with baclofen and doxazosin.

  International urology and nephrology 20060101

• Long-term organ protection by doxazosin and/or quinapril as antihypertensive therapy.

  Journal of nephrology 20060101

• Linguistic adaptation and validation of the Spanish version of the Benign Prostatic Hyperplasia-Patient Impact Measure (BPH-PIM).

  Clinical drug investigation 20060101

• Synergistic effect of doxazosin and acarbose in improving metabolic control in patients with impaired glucose tolerance.

  Clinical drug investigation 20060101

• [Using doxasosine and finasteride combination in the treatment of prostate adenoma].

  Urologiia (Moscow, Russia : 1999) 20060101

• Multiple cutaneous and uterine leiomyomatosis (Reed's syndrome).

  Dermatology online journal 20051230

• Alpha1-adrenergic receptor antagonists: novel therapy for pituitary adenomas.

  Molecular endocrinology (Baltimore, Md.) 20051201

• Doxazosin induces apoptosis in LNCaP prostate cancer cell line through DNA binding and DNA-dependent protein kinase down-regulation.

  International journal of oncology 20051201

• Bioequivalence evaluation of two formulations of doxazosin tablet in healthy thai male volunteers.

  Drug development and industrial pharmacy 20051201

• Alpha1-adrenergic antagonists and floppy iris syndrome: tip of the iceberg?

  Ophthalmology 20051201

• Sympathectomy or doxazosin, but not propranolol, blunt myocardial interstitial fibrosis in pressure-overload hypertrophy.

  Hypertension (Dallas, Tex. : 1979) 20051101

• The effects of alpha-adrenoceptor antagonists on the urethral perfusion pressure of the female rat.

  BJU international 20051101

• Efficacy of the combination of an alpha1-blocker with an anticholinergic agent in the treatment of lower urinary tract symptoms associated with bladder outlet obstruction.

  Expert opinion on pharmacotherapy 20051101

• Combination treatment with propiverine hydrochloride plus doxazosin controlled release gastrointestinal therapeutic system formulation for overactive bladder and coexisting benign prostatic obstruction: a prospective, randomized, controlled multicenter study.

  The Journal of urology 20051001

• Can alpha-blocker therapy be an alternative to biofeedback for dysfunctional voiding and urinary retention? A prospective study.

  The Journal of urology 20051001

• Hemodynamic effects of alpha1-adrenoceptor antagonist, doxazosin, in patients with chronic congestive heart failure.

  Journal of cardiovascular pharmacology 20051001

• Effects of doxazosin on ambulatory blood pressure and sympathetic nervous activity in hypertensive Type 2 diabetic patients with overt nephropathy.

  Diabetic medicine : a journal of the British Diabetic Association 20051001

• [ASCOT-BPLA Study raises new questions regarding: which is the best initial antihypertensive drug?].

  MMW Fortschritte der Medizin 20050929

• Oral treatment of the TRAMP mice with doxazosin suppresses prostate tumor growth and metastasis.

  The Prostate 20050901

• A double-blind placebo-controlled study evaluating the onset of action of doxazosin gastrointestinal therapeutic system in the treatment of benign prostatic hyperplasia.

  European urology 20050901

• One drug fits all.

  BJU international 20050901

• Maspin sensitizes prostate cancer cells to doxazosin-induced apoptosis.

  Oncogene 20050811

• Benign prostatic hyperplasia cell line viability and modulation of jm-27 by doxazosin and Ibuprofen.

  The Journal of urology 20050701

• Pharmacogenetic association of the angiotensin-converting enzyme insertion/deletion polymorphism on blood pressure and cardiovascular risk in relation to antihypertensive treatment: the Genetics of Hypertension-Associated Treatment (GenHAT) study.

  Circulation 20050628

• [Inhibitory effect of doxazosin on the growth of transplanted tumor of prostate cancer cell PC-3 in nude mice].

  Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20050618

• Molecular classification of doxazosin-induced alterations in the rat prostate using gene expression profiling.

  Life sciences 20050610

• The comparison and efficacy of 3 different alpha1-adrenergic blockers for distal ureteral stones.

  The Journal of urology 20050601

• Double-blind placebo controlled study of alpha-adrenergic receptor antagonists (doxazosin) for treatment of voiding dysfunction in the pediatric population.

  The Journal of urology 20050601

• Effects of doxazosin and irbesartan on blood pressure and metabolic control in patients with type 2 diabetes and hypertension.

  Journal of cardiovascular pharmacology 20050601

• [Therapeutic strategy for morning blood pressure elevation in elderly hypertensives].

  Nihon rinsho. Japanese journal of clinical medicine 20050601

• Doxazosin versus bendrofluazide: a comparison of the metabolic effects in British South Asians with hypertension.

  The British journal of general practice : the journal of the Royal College of General Practitioners 20050601

• Acute intoxication with doxazosin.

  Human & experimental toxicology 20050601

• [Effects of doxazosin mosylate and phenoxybenzamine in preoperative volume expansion of pheochromocytoma: a comparative study in 38 cases].

  Zhonghua yi xue za zhi 20050601

• Polymorphism of doxazosin mesylate.

  Archives of pharmacal research 20050601

• Doxazosin GITS versus standard doxazosin in mild to moderate hypertension.

  International journal of cardiology 20050511

• Comparison of doxazosin with or without tolterodine in men with symptomatic bladder outlet obstruction and an overactive bladder.

  BJU international 20050501

• The bedtime administration of doxazosin controls morning hypertension and albuminuria in patients with type-2 diabetes: evaluation using home-based blood pressure measurements.

  Clinical and experimental hypertension (New York, N.Y. : 1993) 20050501

• [Antihypertensive therapy and congestive heart failure].

  Medicina clinica 20050409

• The perioperative management of a patient with complex single ventricle physiology and pheochromocytoma.

  Anesthesia and analgesia 20050401

• Molecular targets of doxazosin in human prostatic stromal cells.

  The Prostate 20050301

• The clinical efficacy and tolerability of doxazosin standard and gastrointestinal therapeutic system for benign prostatic hyperplasia.

  BJU international 20050301

• Finasteride with doxazosin to reduce BPH progression.

  The Nurse practitioner 20050301

• [Alfa-blockade with doxazosin vs tamsulozin in combination of intermittent androgen blockade in patients with prostate cancer].

  Georgian medical news 20050301

• [Impact of 30 day therapy with doxazosin--alpha1 adrenergic blocker on pulmonary hemodynamics in patients with secondary pulmonary hypertension due to chronic obstructive pulmonary disease].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20050301

• Doxazosin inhibits human vascular endothelial cell adhesion, migration, and invasion.

  Journal of cellular biochemistry 20050201

• The vascular effects of doxazosin in hypertension complicated by metabolic syndrome.

  Coronary artery disease 20050201

• pH-mediated acid stacking with reverse pressure for the analysis of cationic pharmaceuticals in capillary electrophoresis.

  Electrophoresis 20050201

• Doxazosin for benign prostatic hyperplasia: an open-label, baseline-controlled study in Korean general practice.

  International journal of urology : official journal of the Japanese Urological Association 20050201

• Re: an economic evaluation of doxazosin, finasteride and combination therapy in the treatment of benign prostatic hyperplasia.

  The Canadian journal of urology 20050201

• Improvement of doxazosin determination in human plasma using high-performance liquid chromatography with fluorescence detection.

  Journal of chromatographic science 20050201

• Primary bladder neck dysfunction in children and adolescents II: results of treatment with alpha-adrenergic antagonists.

  The Journal of urology 20050101

• alpha1-Adrenergic receptor antagonists induce production of IL-18 and expression of ICAM-1 and CD40 in human monocytes.

  Journal of immunotherapy (Hagerstown, Md. : 1997) 20050101

• Efficacy of extended-release doxazosin and doxazosin standard in patients with concomitant benign prostatic hyperplasia and sexual dysfunction.

  BJU international 20050101

• Clinical ease of using doxazosin in BPH patients with and without hypertension.

  Prostate cancer and prostatic diseases 20050101

• Carvedilol prevents cardiac hypertrophy and overexpression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor in pressure-overloaded rat heart.

  Journal of biomedical science 20050101

• Different effects on inhibition of cardiac hypertrophy in spontaneously hypertensive rats by monotherapy and combination therapy of adrenergic receptor antagonists and/or the angiotensin II type 1 receptor blocker under comparable blood pressure reduction.

  Hypertension research : official journal of the Japanese Society of Hypertension 20050101

• Doxazosin gastrointestinal therapeutic system: a review of its use in benign prostatic hyperplasia.

  Drugs 20050101

• Controlled-release doxazosin in the treatment of benign prostatic hyperplasia.

  Prostate cancer and prostatic diseases 20050101

• Growth inhibitory effect of doxazosin on prostate and bladder cancer cells. Is the serotonin receptor pathway involved?

  Anticancer research 20050101

• [Doxazosine associated to renin-angiotensin blockers and calcioantagonists in chronic renal failure patients].

  Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20050101

• Successful alpha-1 receptor blockade therapy in a toddler with infrequent and difficult voiding.

  Advances in therapy 20050101

• Eliciting preferences for drug treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia.

  The Journal of urology 20041201

• Effects of chronic administration of doxazosin on alpha1-adrenoceptors in the rat prostate.

  The Journal of urology 20041201

• Doxazosin for treating lower urinary tract symptoms compatible with benign prostatic obstruction: a systematic review of efficacy and adverse effects.

  BJU international 20041201

• Blood pressure and urologists: like oil and water?

  BJU international 20041201

• Interaction between the phosphodiesterase 5 inhibitor, tadalafil and 2 alpha-blockers, doxazosin and tamsulosin in healthy normotensive men.

  The Journal of urology 20041101

• MTOPS: conclusions about invasive therapy for BPH should be interpreted with caution.

  BJU international 20041101

• Parameters of cell energy metabolism during stress in laboratory animals and energotropic effect of alpha1-adrenoblocker doxazosin.

  Bulletin of experimental biology and medicine 20041101

• Doxazosin treatment causes differential alterations of alpha 1-adrenoceptor subtypes in the rat kidney, heart and aorta.

  Life sciences 20041008

• Inhibition of mitogenic signaling and induction of apoptosis in human bladder smooth muscle cells treated with doxazosin.

  The Journal of urology 20041001

• Comparison of doxazosin with or without tolterodine in men with symptomatic bladder outlet obstruction and an overactive bladder.

  BJU international 20041001

• Doxazosin-induced up-regulation of alpha 1A-adrenoceptor mRNA in the rat lower urinary tract.

  Canadian journal of physiology and pharmacology 20041001

• [Effect of modified liberation doxazosin on blood pressure, insulin resistance, and catecholamine secretion in patients with true resistant hypertension].

  Medicina clinica 20040911

• Importance of antioxidant and antiapoptotic effects of beta-receptor blockers in heart failure therapy.

  American journal of physiology. Heart and circulatory physiology 20040901

• After ALLHAT: doxazosin for the treatment of benign prostatic hyperplasia.

  Expert opinion on pharmacotherapy 20040901

• [Therapy of benign prostatic hyperplasia with finasteride and doxazosin -- long-term studies support the combination].

  Aktuelle Urologie 20040901

• Doxazosin in the sigmoid.

  Lancet (London, England) 20040901

• Long-term efficacy of doxazosin plus atenolol in the management of severe and sustained arterial hypertension and reversibility of the cardiac damage induced by chronic cathecolamine excess. A case report in a young girl with recurrent, functioning paraganglioma.

  Journal of endocrinological investigation 20040901

• Pharmacological exploitation of the alpha1-adrenoreceptor antagonist doxazosin to develop a novel class of antitumor agents that block intracellular protein kinase B/Akt activation.

  Journal of medicinal chemistry 20040826

• Induction of anoikis by doxazosin in prostate cancer cells is associated with activation of caspase-3 and a reduction of focal adhesion kinase.

  Urological research 20040801

• Morning blood pressure surge and hypertensive cerebrovascular disease: role of the alpha adrenergic sympathetic nervous system.

  American journal of hypertension 20040801

• An economic evaluation of doxazosin, finasteride and combination therapy in the treatment of benign prostatic hyperplasia.

  The Canadian journal of urology 20040801

• Doxazosin effects on cholinergic and adrenergic responses in rat isolated detrusor smooth muscle preparations from obstructed bladder.

  Journal of pharmacological sciences 20040701

• Renoprotective effect of angiotensin-converting enzyme inhibitor combined with alpha1-adrenergic antagonist in spontaneously hypertensive rats with renal ablation.

  Hypertension research : official journal of the Japanese Society of Hypertension 20040701

• The role of alpha-blockers in the management of prostate cancer.

  Expert opinion on pharmacotherapy 20040601

• Inhibition of human ether-a-go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin, doxazosin, and terazosin.

  Naunyn-Schmiedeberg's archives of pharmacology 20040501

• Two-drug therapy is best for symptomatic prostate enlargement: could a combination of doxazosin and finasteride change clinical practice?

  BJU international 20040501

• Combination of finasteride and doxazosin for the treatment of benign prostatic hyperplasia.

  Expert opinion on pharmacotherapy 20040501

• Apoptotic impact of alpha1-blockers on prostate cancer growth: a myth or an inviting reality?

  The Prostate 20040401

• Comparative efficacy of two alpha-adrenoreceptor antagonists, doxazosin and alfuzosin, in patients with lower urinary tract symptoms from benign prostatic enlargement.

  BJU international 20040401

• Successful treatment of pain in two patients with cutaneous leiomyomata with the oral alpha-1 adrenoceptor antagonist, doxazosin.

  The British journal of dermatology 20040401

• [Treatment with Doxazosin in 3347 patients with lower urinary tract symptoms. Impact on sexual function. The impros study].

  Actas urologicas espanolas 20040401

• Finasteride in benign prostatic hyperplasia.

  The New England journal of medicine 20040325

• Cardiovascular outcomes using doxazosin vs. chlorthalidone for the treatment of hypertension in older adults with and without glucose disorders: a report from the ALLHAT study.

  Journal of clinical hypertension (Greenwich, Conn.) 20040301

• [Alpha blocker for protection against hypertensive target-organ damage].

  Nihon rinsho. Japanese journal of clinical medicine 20040301

• [ALLHAT trial--antithesis to the overuse of vasodilating antihypertensive drugs].

  Nihon rinsho. Japanese journal of clinical medicine 20040301

• Administration-time-dependent effects of doxazosin GITS on ambulatory blood pressure of hypertensive subjects.

  Chronobiology international 20040301

• Male breast cancer during finasteride therapy.

  Journal of the National Cancer Institute 20040218

• Prostate apoptosis after doxazosin treatment in the spontaneous hypertensive rat model.

  BJU international 20040201

• Herbal and vitamin supplement use in a prostate cancer screening population.

  Urology 20040201

• Patients with uncontrolled hypertension or concomitant hypertension and benign prostatic hyperplasia.

  Clinical cardiology 20040201

• Drug combo stalls BPH progression.

  Health news (Waltham, Mass.) 20040201

• A current review of medical therapy for benign prostatic hyperplasia.

  The Journal of the American Osteopathic Association 20040201

• Validated specific HPLC methods for determination of prazosin, terazosin and doxazosin in the presence of degradation products formed under ICH-recommended stress conditions.

  Journal of pharmaceutical and biomedical analysis 20040127

• [ALLHAT--remaining questions await answers].

  Lakartidningen 20040115

• [Choice of antihypertensive agent--insignificant role of doxazosin (Alfadil). How are evidence-based recommendations implemented?].

  Lakartidningen 20040115

• Impact of clinical trial results on national trends in alpha-blocker prescribing, 1996-2002.

  JAMA 20040107

• Clinical application of wave intensity for the treatment of essential hypertension.

  Heart and vessels 20040101

• Doxazosin controlled release vs tamsulosin in the management of benign prostatic hyperplasia: an efficacy analysis.

  International journal of clinical practice 20040101

• [Doxazosin in the gastrointestinal therapeutic system (GITS) formulation and trial without catheter after acute urinary retention due to BPH. Dose increase action on recovery effect].

  Actas urologicas espanolas 20040101

• Relationship between body mass index and anti-hypertensive efficacy of doxazosin according to a survey of Japanese patients.

  The Journal of international medical research 20040101

• Clinical usefulness of doxazosin in patients with type 2 diabetes complicated by hypertension: effects on glucose and lipid metabolism.

  The Journal of international medical research 20040101

• [Interstitial pneumonitis associated with sirolimus administration in a renal transplantation patient: a clinical case].

  Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20040101

• [Epidemiology of lower urinary tract symptoms and use of doxazosin in the treatment of early stages of benign prostate hyperplasia].

  Likars'ka sprava 20040101

• Terazosin and doxazosin in the treatment of BPH: results of a randomized study with crossover in non-responders.

  Urologia internationalis 20040101

• Long-term treatment with doxazosin in men with benign prostatic hyperplasia: 10-year follow-up.

  International urology and nephrology 20040101

• Cost-effectiveness of tamsulosin, doxazosin, and terazosin in the treatment of benign prostatic hyperplasia.

  Journal of managed care pharmacy : JMCP 20040101

• [Viagra effects on polysystemic energy metabolism in stress (an experimental study)].

  Urologiia (Moscow, Russia : 1999) 20040101

• [Analysis of doxazosin efficacy in the treatment of the benign prostatic enlargement].

  Medicinski arhiv 20040101

• [Use of alpha-adrenoblockers in therapy of benign prostatic hyperplasia in patients with arterial hypertension].

  Terapevticheskii arkhiv 20040101

• Pheochromocytoma.

  Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society 20040101

• A comparison of four different alpha1-blockers in benign prostatic hyperplasia patients with and without diabetes.

  Scandinavian journal of urology and nephrology 20040101

• [LUTS in women and possible therapeutic effects of alfa1-adrenoblockers].

  Khirurgiia 20040101

• The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia.

  The New England journal of medicine 20031218

• [Doxazosin and heart failure: a clinical conclusion is wanted].

  Lakartidningen 20031218

• [Alfadil--positive documentation when it comes to safety is missing].

  Lakartidningen 20031218

• [Alfadil and heart failure--clinical conclusions do exist!].

  Lakartidningen 20031204

• Protonation site and hydrogen bonding in anhydrous and hydrated crystalline forms of doxazosin mesylate from powder data.

  Acta crystallographica. Section B, Structural science 20031201

• Relapse of Graves' disease in a patient with pheochromocytoma.

  Endocrine journal 20031201

• Doxazosin GITS versus hydrochlorothiazide as add-on therapy in patients with uncontrolled hypertension.

  Blood pressure. Supplement 20031201

• [Doxazosin and heart failure: truthful information--for the sake of patients].

  Lakartidningen 20031127

• [Treatment of hypertension in a clinical trial. Depot alpha 1 blocker simplifies dosing].

  MMW Fortschritte der Medizin 20031120

• [Two drugs have a better outcome. Finasteride plus alpha blocker improves urine flow].

  MMW Fortschritte der Medizin 20031120

• Short-term subjective efficacy of doxazosin in predicting probability of prostatectomy in the management of benign prostatic hyperplasia in patients with severe symptoms.

  International journal of urology : official journal of the Japanese Urological Association 20031101

• The effects of alpha and beta blockade on ventilatory responses to exercise in chronic heart failure.

  Heart (British Cardiac Society) 20031001

• Alpha blocker therapy for children with dysfunctional voiding and urinary retention.

  The Journal of urology 20031001

• Doxazosin, an alpha-1 antagonist, prevents further progression of the advanced atherosclerotic lesion in hypercholesterolemic hamsters.

  Metabolism: clinical and experimental 20031001

• [Benign prostatic syndrome. 3-step plan for the treatment].

  MMW Fortschritte der Medizin 20030925

• [Pharmacologic treatment of benign prostatic hyperplasia].

  Orvosi hetilap 20030914

• Diuretic versus alpha-blocker as first-step antihypertensive therapy: final results from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).

  Hypertension (Dallas, Tex. : 1979) 20030901

• Effect of the alpha-adrenergic blocker, doxazosin, on endothelial function and insulin action.

  Metabolism: clinical and experimental 20030901

• Effect of doxazosin on insulin resistance in hypertensive patients with obesity.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20030901

• Chronic ischemia increases prostatic smooth muscle contraction in the rabbit.

  The Journal of urology 20030801

• The role of combination therapy for lower urinary tract symptoms secondary to benign prostatic hyperplasia.

  Current urology reports 20030801

• Pharmaceutical review.

  BJU international 20030801

• Effects of preweaning doxazosin treatment on adult pressure in the spontaneously hypertensive rat.

  Clinical and experimental pharmacology & physiology 20030801

• Efficacy and safety of doxazosin GITS in hypertensive renal transplant patients: comparison of 8 and 4 mg.

  Transplantation proceedings 20030801

• Doxazosin GITS trough to peak ratio and 24-hour blood pressure monitoring in the management of hypertension in renal transplant patients.

  Transplantation proceedings 20030801

• Effectiveness of alpha1-adrenergic blockers in boys with low urinary flow rate and urinary incontinence.

  Journal of the Formosan Medical Association = Taiwan yi zhi 20030801

• [5-alpha reductase inhibitors plus alpha blockers. A combination therapy keeps a common disease checked].

  MMW Fortschritte der Medizin 20030710

• Doxazosin as combination therapy for patients with stage 1 and stage 2 hypertension.

  Journal of cardiovascular pharmacology 20030601

• Effect of doxazosin GITS on 24-hour blood pressure profile in patients with stage 1 to stage 2 primary hypertension.

  Blood pressure monitoring 20030601

• Flow cytometric analysis of platelet activation in hypertensive patients. Effect of doxazosin.

  Thrombosis research 20030601

• Quinazoline-based alpha 1-adrenoceptor antagonists induce prostate cancer cell apoptosis via TGF-beta signalling and I kappa B alpha induction.

  British journal of cancer 20030519

• Safety and effectiveness of replacing standard doxazosin with doxazosin in the gastrointestinal therapeutic system (GITS) formulation in elderly hypertensive patients.

  International journal of clinical practice 20030501

• Effect of doxazosin GITS on blood pressure in hypertensive and normotensive patients: a review of hypertension and BPH studies.

  Blood pressure. Supplement 20030501

• Doxazosin and terazosin suppress prostate growth by inducing apoptosis: clinical significance.

  The Journal of urology 20030401

• Diuretics: older, cheaper, better.

  The Johns Hopkins medical letter health after 50 20030401

• By the way, doctor. I'm 77 and have an enlarged prostate. I take Proscar once a day and saw palmetto three times a day. Yet I still have to get up two to seven times a night to urinate. What can I do to reduce the frequency of urination?

  Harvard health letter 20030401

• [ALLHAT: Old Hat Hits All? On selection of the optimal antihypertensive drug].

  Wiener klinische Wochenschrift 20030331

• Anoikis induction by quinazoline based alpha 1-adrenoceptor antagonists in prostate cancer cells: antagonistic effect of bcl-2.

  The Journal of urology 20030301

• The ALLHAT Trial. Diuretics are still the preferred initial drugs for high blood pressure.

  Cleveland Clinic journal of medicine 20030301

• Benign prostatic hyperplasia.

  Hospital medicine (London, England : 1998) 20030201

• Medical treatment for urinary retention in rehabilitating elderly women: is it necessary?

  Aging clinical and experimental research 20030201

• [Old or new antihypertensive drugs? Consequences from ALLHAT. Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial].

  Deutsche medizinische Wochenschrift (1946) 20030131

• [Misleading advertising claims about the indication of doxazosin (Cardura) for type 2 diabetes mellitus and hypertension].

  Nederlands tijdschrift voor geneeskunde 20030118

• [Established blood pressure drug wins out in a comparative study. In hypertension, a diuretic first!].

  MMW Fortschritte der Medizin 20030116

• Doxazosin induces apoptosis in cardiomyocytes cultured in vitro by a mechanism that is independent of alpha1-adrenergic blockade.

  Circulation 20030107

• Stromal/epithelial interactions of murine prostatic cell lines in vivo: a model for benign prostatic hyperplasia and the effect of doxazosin on tissue size.

  The Prostate 20030101

• Efficacy and tolerability of doxazosin and finasteride, alone or in combination, in treatment of symptomatic benign prostatic hyperplasia: the Prospective European Doxazosin and Combination Therapy (PREDICT) trial.

  Urology 20030101

• A randomized, double-blind crossover study of tamsulosin and controlled-release doxazosin in patients with benign prostatic hyperplasia.

  BJU international 20030101

• [The incidence, features of the course, and treatment of arterial hypertension in patients with prostate hyperplasia].

  Likars'ka sprava 20030101

• ALLHAT. Is it all hat?

  The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society 20030101

• [Tonocardin (doxazosin) in treating lower urinary tract symptoms].

  Urologiia (Moscow, Russia : 1999) 20030101

• [The new (old) knowledge in primary prevention of stroke. It depends on lowering of blood pressure].

  MMW Fortschritte der Medizin 20030101

• [Primary prevention of stroke. What helps--what does not help? The guidelines of the German Society of Neurology briefly summarized].

  MMW Fortschritte der Medizin 20030101

• [Dynamics of immunologic indices in patients with ischemic heart disease on a course of doxazosin therapy].

  Likars'ka sprava 20030101

• [Efficacy and safety in the use of doxazosin (cardura) in the treatment of patients with benign prostatic hypertrophy (bph)].

  Urologiia (Moscow, Russia : 1999) 20030101

• [Possibility of predicting the use of doxazosin in the treatment of arterial hypertension].

  Klinicheskaia meditsina 20030101

• Characteristics and lipid distribution of a large, high-risk, hypertensive population: the lipid-lowering component of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).

  Journal of clinical hypertension (Greenwich, Conn.) 20030101

• [Effects of monotherapy with an alpha1-adrenoblocker doxazosin and its combination with beta1-adrenoblocker atenolol on hemodynamics, reversible myocardial ischemia in postmyocardial infarction patients with arterial hypertension].

  Klinicheskaia meditsina 20030101

• Drug effects on aldosterone/plasma renin activity ratio in primary aldosteronism.

  Hypertension (Dallas, Tex. : 1979) 20021201

• Effects of doxazosin and propranolol on A2A adenosine receptors in essential hypertension.

  Hypertension (Dallas, Tex. : 1979) 20021201

• Doxazosin, but not amlodipine decreases insulin resistance in patients with chronic renal failure: a prospective, randomized-controlled study.

  Clinical nephrology 20021201

• Second opinion. I have benign prostatic hyperplasia. The drug my doctor prescribed has helped somewhat, but I'm still making a lot of trips to the bathroom at night. Short of surgery, are there any new approaches to managing this condition that might be more helpful?

  Mayo Clinic health letter (English ed.) 20021201

• [Misleading advertising claims about the indication of doxazosin (Cardura) for type 2 diabetes mellitus and hypertension].

  Nederlands tijdschrift voor geneeskunde 20021102

• [5-alpha reductase inhibitors or alpha blockers? The combination brakes best prostatic hyperplasia].

  MMW Fortschritte der Medizin 20021031

• [Management of hypertensive patients with left ventricular hypertrophy].

  Presse medicale (Paris, France : 1983) 20021001

• Effect of doxazosin on arterial elasticity: functional versus structural changes.

  Journal of clinical pharmacology 20021001

• Prophylactic versus therapeutic alpha-blockers after permanent prostate brachytherapy.

  Urology 20021001

• [Doxazosin and urinary incontinence].

  Anales de medicina interna (Madrid, Spain : 1984) 20021001

• Doxazosin and hydrochlorothiazide equally affect arterial wall thickness in hypertensive males with hypercholesterolaemia (the DAPHNE study). Doxazosin Atherosclerosis Progression Study in Hypertensives in the Netherlands.

  The Netherlands journal of medicine 20021001

• Relationship of antihypertensive treatment regimens and change in blood pressure to risk for heart failure in hypertensive patients randomly assigned to doxazosin or chlorthalidone: further analyses from the Antihypertensive and Lipid-Lowering treatment to prevent Heart Attack Trial.

  Annals of internal medicine 20020903

• Summaries for patients. Blood pressure drugs and heart failure.

  Annals of internal medicine 20020903

• Doxazosin and ALLHAT trial: a response.

  American journal of hypertension 20020901

• The effect of doxazosin on sexual function in patients with benign prostatic hyperplasia, hypertension, or both.

  International journal of clinical practice 20020901

• Effects of acute administration of doxazosin on fasting and postprandial haemodynamics and lipid metabolism in healthy subjects.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20020901

• alpha1-Adrenergic blockers in young men with primary bladder neck obstruction.

  The Journal of urology 20020801

• Effect of doxazosin on stretch-activated adenosine triphosphate release in bladder urothelial cells from patients with benign prostatic hyperplasia.

  Urology 20020801

• Two-drug therapy is best for symptomatic prostate enlargement: combination should change clinical practice.

  Journal of the American College of Surgeons 20020801

• Efficacy and safety of doxazosin for perioperative management of patients with pheochromocytoma.

  World journal of surgery 20020801

• Managing benign prostatic hyperplasia.

  American family physician 20020701

• [Hypertension and metabolic syndrome in population of one company. Monotherapy with amlodipine and doxazosin].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20020701

• Doxazosin, an inferior antihypertensive agent?

  Journal of human hypertension 20020601

• [Chiral separation and preparation of three new antagonists of alpha 1-adrenoceptors by chiral mobile phase HPLC].

  Yao xue xue bao = Acta pharmaceutica Sinica 20020601

• Reversible ageusia induced by losartan: a case report.

  European journal of neurology 20020501

• A postmarketing, open-label study to evaluate the tolerability and effectiveness of replacing standard-formulation doxazosin with doxazosin in the gastrointestinal therapeutic system formulation in adult patients with hypertension.

  Clinical therapeutics 20020501

• Double-blind, placebo-controlled crossover comparison of five classes of antihypertensive drugs.

  Journal of hypertension 20020401

• [Doxazosin, of modified liberation, in hemodialyzed patients].

  Anales de medicina interna (Madrid, Spain : 1984) 20020401

• Reduction of the soluble cyclic GMP vasorelaxing system in the vascular wall of stroke-prone spontaneously hypertensive rats: effect of the alpha1 -receptor blocker doxazosin.

  Journal of hypertension 20020301

• Interaction of digoxin with antihypertensive drugs via MDR1.

  Life sciences 20020215

• Stability-indicating methods for the determination of doxazosin mezylate and celecoxib.

  Journal of pharmaceutical and biomedical analysis 20020201

• Flow injection analysis of doxazosin mesylate using UV-detection.

  Journal of pharmaceutical and biomedical analysis 20020201

• Combined oral therapy with sildenafil and doxazosin for the treatment of non-organic erectile dysfunction refractory to sildenafil monotherapy.

  International journal of impotence research 20020201

• Double-blind, crossover, comparative study of doxazosin and enalapril in the treatment of hypertension in renal transplant patients under cyclosporine immunosuppression.

  Transplantation proceedings 20020201

• Quinazoline-derived alpha1-adrenoceptor antagonists induce prostate cancer cell apoptosis via an alpha1-adrenoceptor-independent action.

  Cancer research 20020115

• Relationship between arterial distensibility and low-frequency power spectrum of blood pressure in spontaneously hypertensive rats.

  Journal of cardiovascular pharmacology 20020101

• Influence of the alpha-1-adrenergic receptor blocker doxazosin on exercise-induced hyperkalemia in hemodialysis patients.

  Kidney & blood pressure research 20020101

• Observational multicentric trial performed with doxazosin: evaluation of sexual effects on patients with diagnosed benign prostatic hyperplasia.

  Urologia internationalis 20020101

• Stroke associated with alpha blocker therapy for benign prostatic hypertrophy.

  Journal of the National Medical Association 20020101

• Effect of doxazosin on rat urinary bladder function after partial outlet obstruction.

  Neurourology and urodynamics 20020101

• Low-dose doxazosin improved aortic stiffness and endothelial dysfunction as measured by noninvasive evaluation.

  Hypertension research : official journal of the Japanese Society of Hypertension 20020101

• The choice of antihypertensive drugs in patients with erectile dysfunction.

  Current medical research and opinion 20020101

• Doxazosin and congestive heart failure.

  Congestive heart failure (Greenwich, Conn.) 20020101

• Alpha1-adrenoceptor antagonists radiosensitize prostate cancer cells via apoptosis induction.

  Anticancer research 20020101

• Differential actions of naftopidil, doxazosin and nifedipine on platelet thromboxane generation and platelet-derived growth factor efflux in vitro.

  Platelets 20020101

• Alpha blockade in preoperative preparation of patients with pheochromocytomas.

  International surgery 20020101

• [Policy of antihypertensive therapy in arterial hypertension in the elderly. II].

  Klinicheskaia meditsina 20020101

• Apoptotic and proliferative index after Alpha-1-adrenoceptor antagonist and/or finasteride treatment in benign prostatic hyperplasia.

  Urologia internationalis 20020101

• Success and predictors of blood pressure control in diverse North American settings: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT).

  Journal of clinical hypertension (Greenwich, Conn.) 20020101

• [Tonocardin in complex treatment of diabetes mellitus concurrent with hypertension].

  Terapevticheskii arkhiv 20020101

• [Drug therapy of spastic disorder of urine outflow in patients with spinal injury and spinal cord injury].

  Likars'ka sprava 20020101

• Lower urinary tract symptoms, pain and quality of life assessment in chronic non-bacterial prostatitis patients treated with alpha-blocking agent doxazosin; versus placebo.

  International urology and nephrology 20020101

• Terazosin, doxazosin, and prazosin: current clinical experience.

  Urology 20011201

• Doxazosin and congestive heart failure.

  Journal of the American College of Cardiology 20011101

• Doxazosin for the management of hypertension: implications of the findings of the ALLHAT trial.

  American journal of hypertension 20011101

• Warning for antihypertensive drug?

  Lancet (London, England) 20011006

• [Effect of doxazosin on postural changes in blood pressure using a multibiomedical recorder].

  Nihon Jinzo Gakkai shi 20011001

• Heart lines. Cardura update.

  Harvard heart letter : from Harvard Medical School 20010901

• Doxazosin reduces prevalence of small dense low density lipoprotein and remnant-like particle cholesterol levels in nondiabetic and diabetic hypertensive patients.

  American journal of hypertension 20010901

• Discontinuation of alpha-blockade after initial treatment with finasteride and doxazosin in men with lower urinary tract symptoms and clinical evidence of benign prostatic hyperplasia.

  Urology 20010801

• Apoptotic activity of doxazosin on prostate stroma in vitro is mediated through an autocrine expression of TGF-beta1.

  The Prostate 20010801

• Role of alpha1-blockade in congenital long QT syndrome: investigation by exercise stress test.

  Japanese circulation journal 20010701

• [Doxazosin and soluble guanylate cyclase in a rat model of hypertension].

  Revista espanola de cardiologia 20010701

• Antihypertensive effect of alpha- and beta-adrenergic blockade in obese and lean hypertensive subjects.

  American journal of hypertension 20010701

• Safety and availability of doxazosin in treating hypertensive patients with chronic renal failure.

  Hypertension research : official journal of the Japanese Society of Hypertension 20010701

• On call. I'm a 76-year-old man with an enlarged prostate. I've been taking Cardura and it's helped a lot, but my doctor stopped it because he said a study found the drug could cause heart failure. Now I'm getting up three or four times a night again. Is Cadura safe?

  Harvard men's health watch 20010701

• Structure-activity studies for a novel series of bicyclic substituted hexahydrobenz[e]isoindole alpha1A adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia.

  Journal of medicinal chemistry 20010607

• US FDA weighs options for warning on antihypertensive drug.

  Lancet (London, England) 20010602

• Voltammetric determination of doxazosin in tablets using rotating platinum electrode.

  Journal of pharmaceutical and biomedical analysis 20010601

• Low-dose alpha/beta blockade in the treatment of essential hypertension.

  American journal of hypertension 20010601

• [Alpha-blockers in therapy of arterial hypertension. No longer the drug of first choice].

  MMW Fortschritte der Medizin 20010531

• Doxazosin inhibits monocyte chemotactic protein 1-directed migration of human monocytes.

  Journal of cardiovascular pharmacology 20010501

• Effect of antihypertensive therapy on renal artery structure in type 2 diabetic rats with hypertension.

  Hypertension (Dallas, Tex. : 1979) 20010501

• Initiation of nonselective alpha1-antagonist therapy and occurrence of hypotension-related adverse events among men with benign prostatic hyperplasia: a retrospective cohort study.

  Clinical therapeutics 20010501

• Baseline characteristics of the diabetic participants in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).

  Diabetes care 20010401

• Reduced heat shock proteins: a mechanism to explain higher cardiovascular events associated with doxazosin.

  Journal of human hypertension 20010401

• Doxazosin, an alpha1-adrenergic antihypertensive agent, decreases serum oxidized LDL.

  American journal of hypertension 20010301

• Doxazosin, an alpha1-adrenoceptor antagonist, inhibits serotonin-induced shape change in human platelets.

  Journal of human hypertension 20010301

• Reduced heat shock proteins--a mechanism to explain higher cardiovascular events associated with doxazosin.

  Journal of human hypertension 20010301

• The cost-effectiveness of doxazosin for the treatment of hypertension in type II diabetic patients in the UK and Italy.

  International journal of clinical practice 20010301

• Apoptotic regression of prostatic tissue induced by short-term doxazosin treatment in benign prostatic hyperplasia.

  Archivos espanoles de urologia 20010301

• [Long-term therapy of benign prostatic hyperplasia. Our experience].

  Minerva urologica e nefrologica = The Italian journal of urology and nephrology 20010301

• Operational aspects of terminating the doxazosin arm of The Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).

  Controlled clinical trials 20010201

• A combined analysis of double-blind trials of the efficacy and tolerability of doxazosin-gastrointestinal therapeutic system, doxazosin standard and placebo in patients with benign prostatic hyperplasia.

  BJU international 20010201

• Renal hemodynamic effects of captopril and doxazosin during slight physical activity in hypertensive patients with type-1 diabetes mellitus.

  Kidney & blood pressure research 20010101

• A quantitative analysis of antagonism and inverse agonism at wild-type and constitutively active hamster alpha1B-adrenoceptors.

  Naunyn-Schmiedeberg's archives of pharmacology 20010101

• pH-mediated field-amplified sample stacking of pharmaceutical cations in high-ionic strength samples.

  Electrophoresis 20010101

• Discontinuation of alpha-blockade after initial treatment with finasteride and doxazosin for bladder outlet obstruction.

  Urologia internationalis 20010101

• Low-dose ACE with alpha- or beta-adrenergic receptor inhibitors have beneficial SHR cardiovascular effects.

  Journal of cardiovascular pharmacology and therapeutics 20010101

• Doxazosin added to single-drug therapy in hypertensive patients with benign prostatic hypertrophy.

  Journal of clinical hypertension (Greenwich, Conn.) 20010101

• [Doksazozin 'Cardura' in acute urinary retention caused by benign prostatic hyperplasia].

  Urologiia (Moscow, Russia : 1999) 20010101

• A comparison of selected antihypertensives and the use of conventional vs ambulatory blood pressure in the detection and treatment of hypertension.

  Cardiology 20010101

• Efficacy and tolerability of drugs for treatment of benign prostatic hyperplasia.

  International urology and nephrology 20010101

• Quality-of-life assessment in patients with benign prostatic hyperplasia: effects of various interventions.

  PharmacoEconomics 20010101

• Clinical significance of alpha1-adrenoceptor selectivity in the management of benign prostatic hyperplasia.

  International urology and nephrology 20010101

• Suppression of human prostate cancer cell growth by alpha1-adrenoceptor antagonists doxazosin and terazosin via induction of apoptosis.

  Cancer research 20000815

• Alpha-blockers and congestive heart failure: early termination of an arm of the ALLHAT trial.

  Cleveland Clinic journal of medicine 20000601

• Characterization of human recombinant alpha(2A)-adrenoceptors expressed in Chinese hamster lung cells using intracellular Ca(2+) changes: evidence for cross-talk between recombinant alpha(2A)- and native alpha(1)-adrenoceptors.

  British journal of pharmacology 20000401

• Platelet alpha2-adrenoceptor alterations in patients with essential hypertension are normalized after treatment with doxazosin but not propranolol.

  Journal of hypertension 20000201

• Effect of alpha1-adrenoceptor blockade on coronary vasodilator reserve in cardiac syndrome X.

  Journal of cardiovascular pharmacology 19991001

• Alpha 1-adrenoceptor antagonists terazosin and doxazosin induce prostate apoptosis without affecting cell proliferation in patients with benign prostatic hyperplasia.

  The Journal of urology 19990601

• A meta-analysis on the efficacy and tolerability of alpha1-adrenoceptor antagonists in patients with lower urinary tract symptoms suggestive of benign prostatic obstruction.

  European urology 19990101

• Doxazosin GITS compared with doxazosin standard and placebo in patients with mild hypertension.

  Blood pressure 19990101

• Stress urinary incontinence due to prescription medications: alpha-blockers and angiotensin converting enzyme inhibitors.

  Obstetrics and gynecology 19980501

• Pharmacology of tamsulosin: saturation-binding isotherms and competition analysis using cloned alpha 1-adrenergic receptor subtypes.

  The Prostate 19970915

• Prostatic alpha 1-adrenoceptors and uroselectivity.

  The Prostate 19970215

• Long-term effects on sexual function of five antihypertensive drugs and nutritional hygienic treatment in hypertensive men and women. Treatment of Mild Hypertension Study (TOMHS).

  Hypertension (Dallas, Tex. : 1979) 19970101

• Micturition in conscious rats with and without bladder outlet obstruction: role of spinal alpha 1-adrenoceptors.

  British journal of pharmacology 19960301

• Blood pressure and blood glucose levels during a cross-over treatment of doxazosin, moduretic and amlodipine in hypertensive patients.

  The Kobe journal of medical sciences 19960201

• Role of the vagus nerve in the antidysrhythmic effect of dexmedetomidine on halothane/epinephrine dysrhythmias in dogs.

  Anesthesiology 19951101

• Verapamil-induced parkinsonism.

  The American journal of medicine 19951001

• Doxazosin in the treatment of benign prostatic hyperplasia in normotensive patients: a multicenter study.

  The Journal of urology 19950701

• Doxazosin for the treatment of benign prostatic hyperplasia in patients with mild to moderate essential hypertension: a double-blind, placebo-controlled, dose-response multicenter study.

  The Journal of urology 19950701

• Use of recombinant alpha 1-adrenoceptors to characterize subtype selectivity of drugs for the treatment of prostatic hypertrophy.

  European journal of pharmacology 19950116

• [Doxazosin in the treatment of light-to-moderate arterial hypertension in a non-comparative multicenter study].

  La Clinica terapeutica 19950101

• Effect of administration and withdrawal of doxazosin on ambulatory blood pressure in patients with essential hypertension.

  Angiology 19950101

• Effect of alpha 1 adrenoceptor antagonists on prostatic pressure and blood pressure in the anesthetized dog.

  Urology 19940701

• Doxazosin versus nitrendipine: a double-blind comparative study in patients adhering to a sodium-restricted diet.

  Cardiovascular drugs and therapy 19940601

• The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype.

  Molecular pharmacology 19940401

• Long-term effects of doxazosin and atenolol on serum lipids and blood pressure in hypertensive smokers.

  Journal of hypertension. Supplement : official journal of the International Society of Hypertension 19900901

• The initial hemodynamic response to newer antihypertensive agents at rest and during exercise: review of visacor, doxazosin, nisoldipine, tiapamil, perindoprilat, pinacidil, dilevalol, and carvedilol.

  Cardiovascular drugs and therapy 19900801

• Doxazosin versus atenolol: a randomized comparison of calculated coronary heart disease risk reduction.

  American heart journal 19881201

• A comparison of the effects of doxazosin and alfuzosin with those of urapidil on preganglionic sympathetic nerve activity in anaesthetised cats.

  European journal of pharmacology 19861007

• Clinical pharmacology and therapeutic role of prazosin and related alpha-adrenoceptor antagonists.

  Cardiology 19860101

• Alpha 1-adrenergic blockade raises epinephrine-arrhythmia threshold in halothane-anesthetized dogs in a dose-dependent fashion.

  Anesthesiology 19851201