78967-07-4 | Mofezolac

Packsize	Purity	Availability	Price	Discounted Price
5mg	98%	in stock	$57.00	$40.00
10mg	98%	in stock	$102.00	$72.00
25mg	98%	in stock	$227.00	$159.00
50mg	98%	in stock	$396.00	$278.00

Description

• Catalog Number: AC64444
• Chemical Name: Mofezolac
• CAS Number: 78967-07-4
• Molecular Formula: C19H17NO5
• Molecular Weight: 339.342
• MDL Number: MFCD00712149
• SMILES: COc1ccc(cc1)c1c(onc1c1ccc(cc1)OC)CC(=O)O

Computed Properties

• Complexity: 430
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 25
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 6
• XLogP3: 3.1

Literature

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  PloS one 20160101

• Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold.

  Journal of medicinal chemistry 20120308

• Chemopreventive effect of mofezolac on beef tallow diet/azoxymethane-induced colon carcinogenesis in rats.

  Hepato-gastroenterology 20110101

• Drug-target interaction prediction from chemical, genomic and pharmacological data in an integrated framework.

  Bioinformatics (Oxford, England) 20100615

• The effect of selective cyclooxygenase-2 inhibitor on human osteoclast precursors to influence osteoclastogenesis in vitro.

  Modern rheumatology 20090101

• Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor.

  Journal of medicinal chemistry 20080424

• Role of interleukin-1beta and tumor necrosis factor-alpha-dependent expression of cyclooxygenase-2 mRNA in thermal hyperalgesia induced by chronic inflammation in mice.

  Neuroscience 20080318

• Suppression of azoxymethane-induced colon cancer development in rats by a cyclooxygenase-1 selective inhibitor, mofezolac.

  Cancer science 20061001

• Zaltoprofen, a non-steroidal anti-inflammatory drug, inhibits bradykinin-induced pain responses without blocking bradykinin receptors.

  Neuroscience research 20060401

• Significance of cyclooxygenase-2 induced via p38 mitogen-activated protein kinase in mechanical stimulus-induced peritoneal adhesion in mice.

  The Journal of pharmacology and experimental therapeutics 20050401

• Induction of cyclooxygenase-1 in cultured synovial cells isolated from rheumatoid arthritis patients.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20040601

• Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice.

  International journal of cancer 20040420

• Constitutive expression and involvement of cyclooxygenase-2 in human megakaryocytopoiesis.

  Arteriosclerosis, thrombosis, and vascular biology 20040301

• COX-2/VEGF-dependent facilitation of tumor-associated angiogenesis and tumor growth in vivo.

  Laboratory investigation; a journal of technical methods and pathology 20031001

• Role of kinin and prostaglandin in cutaneous thermal nociception.

  International immunopharmacology 20021201

• Cyclooxygenase-2 inhibitors attenuate increased blood pressure in renovascular hypertensive models, but not in deoxycorticosterone-salt hypertension.

  Hypertension research : official journal of the Japanese Society of Hypertension 20021101

• Inhibitory effects of mofezolac, a cyclooxygenase-1 selective inhibitor, on intestinal carcinogenesis.

  Carcinogenesis 20020901

• Participation of cyclooxygenases in cutaneous thermal nociception under non-inflamed and inflamed conditions.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20010501

• Analgesic effect of mofezolac, a non-steroidal anti-inflammatory drug, against phenylquinone-induced acute pain in mice.

  Prostaglandins & other lipid mediators 19980701

• Involvement of prostaglandins produced by cyclooxygenase-1 in murine visceronociception induced by phenylquinone.

  Prostaglandins & other lipid mediators 19980101

• Principal involvement of cyclooxygenase-1-derived prostaglandins in the c-fos expression of the rat hind brain following visceral stimulation with acetic acid.

  Brain research. Molecular brain research 19971201

• Effects of nonsteroidal anti-inflammatory drugs on interleukin-1 receptor antagonist production in cultured human peripheral blood mononuclear cells.

  Prostaglandins 19971101

• [Pharmacological profile of mofezolac, a new non-steroidal analgesic anti-inflammatory drug].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 19900201