79-43-6 | Dichloroacetic acid

Availability
Typically In Stock

Description

• Catalog Number: AB72648
• Chemical Name: Dichloroacetic acid
• CAS Number: 79-43-6
• Molecular Formula: C2H2Cl2O2
• Molecular Weight: 128.9421
• MDL Number: MFCD00004223
• SMILES: ClC(C(=O)O)Cl
• NSC Number: 2654

Computed Properties

• Complexity: 60.6
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 6
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• XLogP3: 0.9

Literature

• Metabolic Disruption Early in Life is Associated With Latent Carcinogenic Activity of Dichloroacetic Acid in Mice.

  Toxicological sciences : an official journal of the Society of Toxicology 20171001

• Disinfection By-Product Exposures and the Risk of Specific Cardiac Birth Defects.

  Environmental health perspectives 20170201

• Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1.

  Pharmacology & therapeutics 20170201

• Trichloroethylene and Its Oxidative Metabolites Enhance the Activated State and Th1 Cytokine Gene Expression in Jurkat Cells.

  International journal of environmental research and public health 20150901

• Silencing gastrin-releasing peptide receptor suppresses key regulators of aerobic glycolysis in neuroblastoma cells.

  Pediatric blood & cancer 20150401

• Dichloroacetate and cancer: new home for an orphan drug?

  Biochimica et biophysica acta 20141201

• Long-term dietary exposure to low concentration of dichloroacetic acid promoted longevity and attenuated cellular and functional declines in aged Drosophila melanogaster.

  Age (Dordrecht, Netherlands) 20140601

• Chloride and other anions inhibit dichloroacetate-induced inactivation of human liver GSTZ1 in a haplotype-dependent manner.

  Chemico-biological interactions 20140525

• Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum.

  Archives of toxicology 20131101

• Design, synthesis and biological evaluation of N-arylphenyl-2,2-dichloroacetamide analogues as anti-cancer agents.

  Bioorganic & medicinal chemistry letters 20121201

• Influence of bacterial extracellular polymeric substances on the formation of carbonaceous and nitrogenous disinfection byproducts.

  Environmental science & technology 20121016

• Application of hyperpolarized [1-¹³C]lactate for the in vivo investigation of cardiac metabolism.

  NMR in biomedicine 20121001

• Unusual complex formation and chemical reaction of haloacetate anion on the exterior surface of cucurbit[6]uril in the gas phase.

  Journal of the American Society for Mass Spectrometry 20121001

• Inactivation of the HIF-1α/PDK3 signaling axis drives melanoma toward mitochondrial oxidative metabolism and potentiates the therapeutic activity of pro-oxidants.

  Cancer research 20121001

• Tormentic acid derivatives: synthesis and apoptotic activity.

  European journal of medicinal chemistry 20121001

• Comparison of spheroids formed by rat glioma stem cells and neural stem cells reveals differences in glucose metabolism and promising therapeutic applications.

  The Journal of biological chemistry 20120928

• Size-exclusion chromatography of poly(ethylene 2,6-naphthalate).

  Journal of chromatography. A 20120921

• Prediction of death in the SMNΔ7 mouse model of spinal muscular atrophy: insight into disease stage and progression.

  Journal of neuroscience methods 20120815

• Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma: Implication of altered glucose metabolism, pH homeostasis and cell survival regulation.

  Chemico-biological interactions 20120730

• Human polymorphisms in the glutathione transferase zeta 1/maleylacetoacetate isomerase gene influence the toxicokinetics of dichloroacetate.

  Journal of clinical pharmacology 20120601

• Necrosis of cervical carcinoma by dichloroacetate released from electrospun polylactide mats.

  Biomaterials 20120601

• Co-treatment of dichloroacetate, omeprazole and tamoxifen exhibited synergistically antiproliferative effect on malignant tumors: in vivo experiments and a case report.

  Hepato-gastroenterology 20120601

• 2-Amino-4,6-dimeth-oxy-pyrimidin-1-ium 2,2-dichloro-acetate.

  Acta crystallographica. Section E, Structure reports online 20120601

• Unilateral periventricular leukomalacia in association with pyruvate dehydrogenase deficiency.

  Developmental medicine and child neurology 20120501

• Comparison of trihalomethanes in tap water and blood: a case study in the United States.

  Environmental health perspectives 20120501

• The role of FOXO and PPAR transcription factors in diet-mediated inhibition of PDC activation and carbohydrate oxidation during exercise in humans and the role of pharmacological activation of PDC in overriding these changes.

  Diabetes 20120501

• Effects of three modifiers of glycolysis on ATP, lactate, hypoxia, and growth in human tumor cell lines in vivo.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20120501

• Inorganic arsenic and basal cell carcinoma in areas of Hungary, Romania, and Slovakia: a case-control study.

  Environmental health perspectives 20120501

• Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury.

  Cardiovascular research 20120501

• Treatment for mitochondrial disorders.

  The Cochrane database of systematic reviews 20120418

• Photocatalytic production of 1O2 and *OH mediated by silver oxidation during the photoinactivation of Escherichia coli with TiO2.

  Journal of hazardous materials 20120415

• Dichloroacetate inhibits neuroblastoma growth by specifically acting against malignant undifferentiated cells.

  International journal of cancer 20120401

• Toxicological evaluation of paper mill sewage sediment treated by indigenous dibenzofuran-degrading Pseudomonas sp.

  Bioresource technology 20120401

• Mitochondrial genome-knockout cells demonstrate a dual mechanism of action for the electron transport complex I inhibitor mycothiazole.

  Marine drugs 20120401

• Predicting the safety and efficacy of buffer therapy to raise tumour pHe: an integrative modelling study.

  British journal of cancer 20120327

• Lung ¹⁸F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertension.

  American journal of respiratory and critical care medicine 20120315

• Mitaplatin increases sensitivity of tumor cells to cisplatin by inducing mitochondrial dysfunction.

  Molecular pharmaceutics 20120305

• Susceptibility to breast cancer and three polymorphisms of GSTZ1.

  DNA and cell biology 20120301

• Vitamin E restriction in the diet enhances phagocytic activation by dichloroacetate and trichloroacetate in mice.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120301

• The cycling of acetyl-coenzyme A through acetylcarnitine buffers cardiac substrate supply: a hyperpolarized 13C magnetic resonance study.

  Circulation. Cardiovascular imaging 20120301

• One-flask synthesis of cyclic diguanosine monophosphate (c-di-GMP).

  Current protocols in nucleic acid chemistry 20120301

• The effects of a low vitamin E diet on dichloroacetate- and trichloroacetate-induced oxidative stress in the livers of mice.

  Journal of biochemical and molecular toxicology 20120301

• Multi-substituted N-phenyl-2, 2-dichloroacetamide analogues as anti-cancer drugs: design, synthesis and biological evaluation.

  Yao xue xue bao = Acta pharmaceutica Sinica 20120301

• Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH E1α gene.

  Brain & development 20120201

• Prenatal and postnatal expression of glutathione transferase ζ 1 in human liver and the roles of haplotype and subject age in determining activity with dichloroacetate.

  Drug metabolism and disposition: the biological fate of chemicals 20120201

• The role of low-level lactate production in airway inflammation in asthma.

  American journal of physiology. Lung cellular and molecular physiology 20120201

• Dichloroacetic acid up-regulates hepatic glutathione synthesis via the induction of glutamate-cysteine ligase.

  Biochemical pharmacology 20120201

• Formation of halogenated C-, N-DBPs from chlor(am)ination and UV irradiation of tyrosine in drinking water.

  Environmental pollution (Barking, Essex : 1987) 20120201

• Flow cytometric evaluation of the effects of 3-bromopyruvate (3BP) and dichloracetate (DCA) on THP-1 cells: a multiparameter analysis.

  Journal of bioenergetics and biomembranes 20120201

• Clinicopathologic Manifestations of Patients with Fordyce's Spots.

  Annals of dermatology 20120201

• Cancer metabolism: current perspectives and future directions.

  Cell death & disease 20120101

• Risk of stillbirth in the relation to water disinfection by-products: a population-based case-control study in Taiwan.

  PloS one 20120101

• Correlation of diffusion and metabolic alterations in different clinical forms of multiple sclerosis.

  PloS one 20120101

• Dichloroacetate induces different rates of cell death in cancer and noncancer cell lines in vitro.

  Tumori 20120101

• Design and characterization of a silk-fibroin-based drug delivery platform using naproxen as a model drug.

  Journal of drug delivery 20120101

• Synergistic effect of the combination of immobilized TiO2, UVA and ozone on the decomposition of dichloroacetic acid.

  Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering 20120101

• Influence of dichloroacetate (DCA) on lactate production and oxygen consumption in neuroblastoma cells: is DCA a suitable drug for neuroblastoma therapy?

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

• Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis.

  PloS one 20120101

• Protection of rat cardiac myocytes by fructose-1,6-bisphosphate and 2,3-butanedione.

  PloS one 20120101

• Defluorination of sodium fluoroacetate by bacteria from soil and plants in Brazil.

  TheScientificWorldJournal 20120101

• PPARs: Interference with Warburg' Effect and Clinical Anticancer Trials.

  PPAR research 20120101

• EMT and stem cell-like properties associated with HIF-2α are involved in arsenite-induced transformation of human bronchial epithelial cells.

  PloS one 20120101

• Enzymatic synthesis of DNA strands containing α-L-LNA (α-L-configured locked nucleic acid) thymine nucleotides.

  Artificial DNA, PNA & XNA 20120101

• Mitochondrial metabolism - neglected link of cancer transformation and treatment.

  Prague medical report 20120101

• The reproducibility of 31-phosphorus MRS measures of muscle energetics at 3 Tesla in trained men.

  PloS one 20120101

• Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage.

  PloS one 20120101

• Glucose is a pH-dependent motor for sperm beat frequency during early activation.

  PloS one 20120101

• Dichloroacetate induces apoptosis of epithelial ovarian cancer cells through a mechanism involving modulation of oxidative stress.

  Reproductive sciences (Thousand Oaks, Calif.) 20111201

• Exposure to trihalomethanes through different water uses and birth weight, small for gestational age, and preterm delivery in Spain.

  Environmental health perspectives 20111201

• In vitro effects of an in silico-modelled 17β-estradiol derivative in combination with dichloroacetic acid on MCF-7 and MCF-12A cells.

  Cell proliferation 20111201

• The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37.

  Experimental oncology 20111201

• Characteristic transformation of humic acid during photoelectrocatalysis process and its subsequent disinfection byproduct formation potential.

  Water research 20111115

• Electromembrane extraction and HPLC analysis of haloacetic acids and aromatic acetic acids in wastewater.

  Talanta 20111030

• Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling.

  Aging 20111001

• Prospective power calculations for the Four Lab study of a multigenerational reproductive/developmental toxicity rodent bioassay using a complex mixture of disinfection by-products in the low-response region.

  International journal of environmental research and public health 20111001

• Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate.

  Oncogene 20110922

• Comparative electrochemical treatments of two chlorinated aliphatic hydrocarbons. Time course of the main reaction by-products.

  Journal of hazardous materials 20110915

• Why are there no proven therapies for genetic mitochondrial diseases?

  Mitochondrion 20110901

• Functionalized polystyrene supports for solid-phase synthesis of glycyl-, alanyl-, and isoleucyl-RNA conjugates as hydrolysis-resistant mimics of peptidyl-tRNAs.

  Bioorganic & medicinal chemistry 20110901

• Structures of a putative ζ-class glutathione S-transferase from the pathogenic fungus Coccidioides immitis.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20110901

• Bis-(chloro-acetato-κO)bis(trimethyl-silylmethyl)tin(IV).

  Acta crystallographica. Section E, Structure reports online 20110901

• Use of oral dichloroacetate for palliation of leg pain arising from metastatic poorly differentiated carcinoma: a case report.

  Journal of palliative medicine 20110801

• Removal of dichloroacetic acid from drinking water by using adsorptive ozonation.

  Ecotoxicology (London, England) 20110701

• Haloacetic acids in swimming pools: swimmer and worker exposure.

  Environmental science & technology 20110701

• [Chlorination byproducts formation potentials of typical nitrogenous organic compounds in water].

  Huan jing ke xue= Huanjing kexue 20110701

• Inhibition of alanine aminotransferase in silico and in vivo promotes mitochondrial metabolism to impair malignant growth.

  The Journal of biological chemistry 20110624

• Development and evaluation of a harmonized physiologically based pharmacokinetic (PBPK) model for perchloroethylene toxicokinetics in mice, rats, and humans.

  Toxicology and applied pharmacology 20110615

• Role of pyruvate dehydrogenase inhibition in the development of hypertrophy in the hyperthyroid rat heart: a combined magnetic resonance imaging and hyperpolarized magnetic resonance spectroscopy study.

  Circulation 20110607

• Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex.

  International journal of cancer 20110601

• The effect of dichloroacetate on health- and lifespan in C. elegans.

  Biogerontology 20110601

• Development of a dichloroacetic acid-hemoglobin conjugate as a potential targeted anti-cancer therapeutic.

  Biotechnology and bioengineering 20110601

• Metabolism and brain cancer.

  Clinics (Sao Paulo, Brazil) 20110601

• Effects of iron and manganese on the formation of HAAs upon chlorinating Chlorella vulgaris.

  Journal of hazardous materials 20110515

• Effects of chlorinated acetates on the glutathione metabolism and on glycolysis of cultured astrocytes.

  Neurotoxicity research 20110501

• Glutathione transferase zeta: discovery, polymorphic variants, catalysis, inactivation, and properties of Gstz1-/- mice.

  Drug metabolism reviews 20110501

• Chronic and acute exposure of mouse hearts to fatty acids increases oxygen cost of excitation-contraction coupling.

  American journal of physiology. Heart and circulatory physiology 20110501

• Formation and modeling of disinfection by-products in drinking water of six cities in China.

  Journal of environmental monitoring : JEM 20110501

• Degradation of dichloroacetic acid in homogeneous aqueous media employing ozone and UVC radiation.

  Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20110302

• Dichloroacetate metabolically targeted therapy defeats cytotoxicity of standard anticancer drugs.

  Cancer chemotherapy and pharmacology 20110301

• Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm?

  International journal of cancer 20110301

• High concentrations of dichloroacetate have minor effects on the vitality of the mammalian nerve fibers: an ex-vivo electrophysiological study.

  Anti-cancer drugs 20110301

• Effects of environmental endocrine disruptors on pubertal development.

  Journal of clinical research in pediatric endocrinology 20110301

• Pros and cons of analytical methods to quantify surrogate contaminants from the challenge test in recycled polyethylene terephthalate.

  Analytica chimica acta 20110214

• Validation of the in vivo assessment of pyruvate dehydrogenase activity using hyperpolarised 13C MRS.

  NMR in biomedicine 20110201

• The dichloroacetate dilemma: environmental hazard versus therapeutic goldmine--both or neither?

  Environmental health perspectives 20110201

• Dichloroacetate shifts the metabolism from glycolysis to glucose oxidation and exhibits synergistic growth inhibition with cisplatin in HeLa cells.

  International journal of oncology 20110201

• Influence of soluble microbial products (SMP) on wastewater disinfection byproducts: trihalomethanes and haloacetic acid species from the chlorination of SMP.

  Environmental science and pollution research international 20110101

• A screening level fate model of organic contaminants from advanced water treatment in a potable water supply reservoir.

  Water research 20110101

• Iron overload and diabetes risk: a shift from glucose to Fatty Acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis.

  Diabetes 20110101

• Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1.

  The Journal of pharmacology and experimental therapeutics 20110101

• Metabolic-targeted therapy with dichloroacetate (DCA): a novel treatment strategy to improve the outcome of photodynamic therapy.

  Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20110101

• Developing new anti-cancer drugs.

  Recent patents on anti-cancer drug discovery 20110101

• In vitro cytotoxicity of novel platinum-based drugs and dichloroacetate against lung carcinoid cell lines.

  Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20110101

• On-target inhibition of tumor fermentative glycolysis as visualized by hyperpolarized pyruvate.

  Neoplasia (New York, N.Y.) 20110101

• Further optimization of detritylation in solid-phase oligodeoxyribonucleotide synthesis.

  Nucleosides, nucleotides & nucleic acids 20110101

• Chronic CSE treatment induces the growth of normal oral keratinocytes via PDK2 upregulation, increased glycolysis and HIF1α stabilization.

  PloS one 20110101

• Efficacy of fumaric acid esters in the R6/2 and YAC128 models of Huntington's disease.

  PloS one 20110101

• Skeletal muscle metabolic gene expression is not affected by dichloroacetate-mediated modulation of substrate utilisation.

  Annals of nutrition & metabolism 20110101

• Synergistic antitumor effect of dichloroacetate in combination with 5-fluorouracil in colorectal cancer.

  Journal of biomedicine & biotechnology 20110101

• Stereocomplexes Formed From Select Oligomers of Polymer d-lactic Acid (PDLA) and l-lactate May Inhibit Growth of Cancer Cells and Help Diagnose Aggressive Cancers-Applications of the Warburg Effect.

  Perspectives in medicinal chemistry 20110101

• Amyloid beta resistance in nerve cell lines is mediated by the Warburg effect.

  PloS one 20110101

• Mitochondrial approaches to protect against cardiac ischemia and reperfusion injury.

  Frontiers in physiology 20110101

• Mitochondrial changes in ageing Caenorhabditis elegans--what do we learn from superoxide dismutase knockouts?

  PloS one 20110101

• The metabolic advantage of tumor cells.

  Molecular cancer 20110101

• Bicarbonate and dichloroacetate: evaluating pH altering therapies in a mouse model for metastatic breast cancer.

  BMC cancer 20110101

• Stage-related alterations in renal cell carcinoma--comprehensive quantitative analysis by 2D-DIGE and protein network analysis.

  PloS one 20110101

• Exploiting mitochondrial dysfunction for effective elimination of imatinib-resistant leukemic cells.

  PloS one 20110101

• Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review.

  Frontiers in pharmacology 20110101

• Probucol attenuates oxidative stress, energy starvation, and nitric acid production following transient forebrain ischemia in the rat hippocampus.

  Oxidative medicine and cellular longevity 20110101

• Hepatocyte Lysosomal Membrane Stabilization by Olive Leaves against Chemically Induced Hepatocellular Neoplasia in Rats.

  International journal of hepatology 20110101

• Bioremediation via Methanotrophy: Overview of Recent Findings and Suggestions for Future Research.

  Frontiers in microbiology 20110101

• Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure.

  PloS one 20110101

• Screening for active small molecules in mitochondrial complex I deficient patient's fibroblasts, reveals AICAR as the most beneficial compound.

  PloS one 20110101

• Formation of disinfection byproducts in typical Chinese drinking water.

  Journal of environmental sciences (China) 20110101

• 8-Modified-2'-deoxyadenosine analogues induce delayed polymerization arrest during HIV-1 reverse transcription.

  PloS one 20110101

• Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells.

  Molecular cancer 20110101

• Ingestion exposure to nitrosamines in chlorinated drinking water.

  Environmental health and toxicology 20110101

• The genetics of pulmonary arterial hypertension in the post-BMPR2 era.

  Pulmonary circulation 20110101

• Arsenic exposure and the induction of human cancers.

  Journal of toxicology 20110101

• Induction of human squamous cell-type carcinomas by arsenic.

  Journal of skin cancer 20110101

• Biological roles and therapeutic potential of hydroxy-carboxylic Acid receptors.

  Frontiers in endocrinology 20110101

• Glutathione s-transferases in pediatric cancer.

  Frontiers in oncology 20110101

• Identification of radiolysis products of solid thiamphenicol.

  Journal of pharmaceutical and biomedical analysis 20101201

• Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC.

  International journal of cancer 20101201

• Severe encephalopathy and polyneuropathy induced by dichloroacetate.

  Journal of neurology 20101201

• Acid-base disorders in ICU patients.

  Electrolyte & blood pressure : E & BP 20101201

• Sodium dichloroacetate (DCA) reduces apoptosis in colorectal tumor hypoxia.

  Cancer letters 20101101

• Polymorphisms in GSTT1, GSTZ1, and CYP2E1, disinfection by-products, and risk of bladder cancer in Spain.

  Environmental health perspectives 20101101

• Differential response to trichloroethylene-induced hepatosteatosis in wild-type and PPARalpha-humanized mice.

  Environmental health perspectives 20101101

• Genotoxic effects in swimmers exposed to disinfection by-products in indoor swimming pools.

  Environmental health perspectives 20101101

• Production of various disinfection byproducts in indoor swimming pool waters treated with different disinfection methods.

  International journal of hygiene and environmental health 20101101

• The serum metabolite response to diet intervention with probiotic acidified milk in irritable bowel syndrome patients is indistinguishable from that of non-probiotic acidified milk by 1H NMR-based metabonomic analysis.

  Nutrients 20101101

• Enhanced production and isotope enrichment of recombinant glycoproteins produced in cultured mammalian cells.

  Journal of biomolecular NMR 20101001

• 5'-Bis-conjugation of oligonucleotides by amidative oxidation and click chemistry.

  The Journal of organic chemistry 20101001

• Mitochondrial metabolic adaptation in right ventricular hypertrophy and failure.

  Journal of molecular medicine (Berlin, Germany) 20101001

• Role of pyruvate dehydrogenase kinase 4 in regulation of blood glucose levels.

  Korean diabetes journal 20101001

• Counteranion-dependent mechanisms of intramolecular proton transfer in aprotic solution.

  Physical chemistry chemical physics : PCCP 20100921

• Potential of the TCE-degrading endophyte Pseudomonas putida W619-TCE to improve plant growth and reduce TCE phytotoxicity and evapotranspiration in poplar cuttings.

  Environmental pollution (Barking, Essex : 1987) 20100901

• Novel N-phenyl dichloroacetamide derivatives as anticancer reagents: design, synthesis and biological evaluation.

  European journal of medicinal chemistry 20100901

• Electromigration diffusivity spectrometry: a way for simultaneous determination of diffusion coefficients from mixed samples.

  Electrophoresis 20100901

• Platinized WO3 as an environmental photocatalyst that generates OH radicals under visible light.

  Environmental science & technology 20100901

• Oncology's energetic pipeline.

  Nature biotechnology 20100901

• Lactic acidemia in the pathogenesis of mice carrying mitochondrial DNA with a deletion.

  Human molecular genetics 20100815

• Pyruvate suppresses PGC1alpha expression and substrate utilization despite increased respiratory chain content in C2C12 myotubes.

  American journal of physiology. Cell physiology 20100801

• A simple and effective treatment for ectopic sebaceous glands on the areola.

  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20100801

• Determination of haloacetic acids in water using solid-phase extraction/microchip capillary electrophoresis with capacitively coupled contactless conductivity detection.

  Electrophoresis 20100801

• Dichloroacetate (DCA) enhances tumor cell death in combination with oncolytic adenovirus armed with MDA-7/IL-24.

  Molecular and cellular biochemistry 20100701

• Dichloroacetate- and trichloroacetate-induced oxidative stress in the hepatic tissues of mice after long-term exposure.

  Journal of applied toxicology : JAT 20100701

• Electrochemically assisted photocatalytic degradation of 4-chlorophenol by ZnFe2O4-modified TiO2 nanotube array electrode under visible light irradiation.

  Environmental science & technology 20100701

• Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells.

  British journal of cancer 20100608

• Oxidative stress therapy for solid tumors - a proposal.

  Medical hypotheses 20100601

• Novel strategy for treatment of pulmonary arterial hypertension: enhancement of apoptosis.

  Lung 20100601

• Change of purpose.

  Nature 20100520

• The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts.

  Cell cycle (Georgetown, Tex.) 20100515

• Targeting cell metabolism in cancer patients.

  Science translational medicine 20100512

• Metabolic modulation of glioblastoma with dichloroacetate.

  Science translational medicine 20100512

• Practical strategies for suppressing hypoxia-inducible factor activity in cancer therapy.

  Medical hypotheses 20100501

• Analysis of metabolic remodeling in compensated left ventricular hypertrophy and heart failure.

  Circulation. Heart failure 20100501

• Physiologically based pharmacokinetic modeling of dibromoacetic acid in F344 rats.

  Toxicology and applied pharmacology 20100415

• Selection of cancer cells with repressed mitochondria triggers colon cancer progression.

  Carcinogenesis 20100401

• New therapies for pulmonary arterial hypertension: an update on current bench to bedside translation.

  Expert opinion on investigational drugs 20100401

• Metabolic network topology reveals transcriptional regulatory signatures of type 2 diabetes.

  PLoS computational biology 20100401

• Demand-induced ischemia in volume expanded isolated rat heart; the effect of dichloroacetate and trimetazidine.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20100401

• Three-level topology switching in a molecular Möbius band.

  Journal of the American Chemical Society 20100310

• Generation of disinfection by-products (DBPs) at two advanced water treatment plants.

  Environmental monitoring and assessment 20100301

• Occurrence of haloacetic acids (HAAs) and trihalomethanes (THMs) in drinking water of Taiwan.

  Environmental monitoring and assessment 20100301

• Treatment of mitochondrial electron transport chain disorders: a review of clinical trials over the past decade.

  Molecular genetics and metabolism 20100301

• Emerging therapies for the treatment of pulmonary hypertension.

  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20100301

• Expression and characterization of three new glutathione transferases, an epsilon (AcGSTE2-2), omega (AcGSTO1-1), and theta (AcGSTT1-1) from Anopheles cracens (Diptera: Culicidae), a major Thai malaria vector.

  Journal of medical entomology 20100301

• The induction of tumor necrosis factor-alpha, superoxide anion, myeloperoxidase, and superoxide dismutase in the peritoneal lavage cells of mice after prolonged exposure to dichloroacetate and trichloroacetate.

  Journal of biochemical and molecular toxicology 20100301

• [Determination of trihalomethanes and haloacetic acids in the sample holding time, and their stability in the extract].

  Wei sheng yan jiu = Journal of hygiene research 20100301

• Effect of zinc on the transformation of haloacetic acids (HAAs) in drinking water.

  Journal of hazardous materials 20100215

• Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo.

  Breast cancer research and treatment 20100201

• Bis(2,2'-bipyrid-yl)(dichloro-acetato)copper(II) dichloro-acetate dihydrate.

  Acta crystallographica. Section E, Structure reports online 20100201

• Formation of haloacetamides during chlorination of dissolved organic nitrogen aspartic acid.

  Journal of hazardous materials 20100115

• The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle.

  Journal of molecular medicine (Berlin, Germany) 20100101

• Polymerase-endonuclease amplification reaction (PEAR) for large-scale enzymatic production of antisense oligonucleotides.

  PloS one 20100101

• Gene expression in a Drosophila model of mitochondrial disease.

  PloS one 20100101

• Cancer proliferation and therapy: the Warburg effect and quantum metabolism.

  Theoretical biology & medical modelling 20100101

• Bacteria in cancer therapy: a novel experimental strategy.

  Journal of biomedical science 20100101

• [Cytotoxicity of dichloroacetic acid in lymphocyte and expression of chemokine receptor CXCR2 and chemokine receptor CXCR3 mRNA].

  Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20100101

• Synthesis and photocatalytic activity of boron-doped TiO(2) in aqueous suspensions under UV-A irradiation.

  Water science and technology : a journal of the International Association on Water Pollution Research 20100101

• Degradation of a mixture of pollutants in water using the UV/H2O2 process.

  Water science and technology : a journal of the International Association on Water Pollution Research 20100101

• Mammalian cell cytotoxicity and genotoxicity of the haloacetic acids, a major class of drinking water disinfection by-products.

  Environmental and molecular mutagenesis 20100101

• Non-Hodgkin's Lymphoma Reversal with Dichloroacetate.

  Journal of oncology 20100101

• The assessment of population exposure to chlorination by-products: a study on the influence of the water distribution system.

  Environmental health : a global access science source 20100101

• Glucagon-like peptide-1 and the exenatide analogue AC3174 improve cardiac function, cardiac remodeling, and survival in rats with chronic heart failure.

  Cardiovascular diabetology 20100101

• Enhanced ozonation of dichloroacetic acid in aqueous solution using nanometer ZnO powders.

  Journal of environmental sciences (China) 20100101

• Development of a less toxic dichloroacetate analogue by docking and descriptor analysis.

  Bioinformation 20100101

• Diaqua-hexa-μ(2)-dichloro-acetato-μ(3)-oxido-tetra-hydro-furan-diiron(III)manganese(II).

  Acta crystallographica. Section E, Structure reports online 20100101

• In vitro cytotoxicity of combinations of dichloroacetate with anticancer platinum compounds.

  Clinical pharmacology : advances and applications 20100101

• Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate.

  The Journal of biological chemistry 20091204

• Hypoxia and the metabolic phenotype of prostate cancer cells.

  Biochimica et biophysica acta 20091201

• Dichloroacetate treatment partially regresses established pulmonary hypertension in mice with SM22alpha-targeted overexpression of the serotonin transporter.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20091201

• Both substrate availability and utilisation contribute to the defence of core temperature in response to acute cold.

  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20091201

• Pharmacologically increased tumor hypoxia can be measured by 18F-Fluoroazomycin arabinoside positron emission tomography and enhances tumor response to hypoxic cytotoxin PR-104.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20091201

• Effects of crystalline structures and surface functional groups on the adsorption of haloacetic acids by inorganic materials.

  Journal of hazardous materials 20091115

• In vitro effects of dichloroacetate and CO2 on hypoxic HeLa cells.

  Anticancer research 20091101

• A reexamination of the PPAR-alpha activation mode of action as a basis for assessing human cancer risks of environmental contaminants.

  Environmental health perspectives 20091101

• Depressive episode with catatonic features in a case of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS).

  Journal of child neurology 20091001

• Quantitative mitochondrial phosphoproteomics using iTRAQ on an LTQ-Orbitrap with high energy collision dissociation.

  Journal of proteome research 20091001

• Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses.

  Environmental health perspectives 20091001

• Aqua-tris(1H-benzimidazole-κN)(dichloro-acetato-κO)copper(II) dichloro-acetate dihydrate.

  Acta crystallographica. Section E, Structure reports online 20091001

• Influence of dichloroacetate on pulmonary gas exchange and ventilation during incremental exercise in healthy humans.

  Respiratory physiology & neurobiology 20090930

• Zero-valent aluminum for oxidative degradation of aqueous organic pollutants.

  Environmental science & technology 20090915

• Kinetics and effects of dichloroacetic acid in rainbow trout.

  Aquatic toxicology (Amsterdam, Netherlands) 20090914

• Dichloroacetate modulates the oxidative stress and inflammatory response to exercise in COPD.

  Chest 20090901

• Peripheral neuropathy in rats exposed to dichloroacetate.

  Journal of neuropathology and experimental neurology 20090901

• Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine.

  Toxicology 20090821

• From proton nuclear magnetic resonance spectra to pH. Assessment of 1H NMR pH indicator compound set for deuterium oxide solutions.

  Analytica chimica acta 20090819

• Glycerol-induced folding of unstructured disulfide-deficient lysozyme into a native-like conformation.

  Biopolymers 20090801

• Disinfection byproduct formation and fractionation behavior of natural organic matter surrogates.

  Environmental science & technology 20090801

• Experimental and theoretical investigation of the catalytic ozonation on the surface of NiO-CuO nanoparticles.

  Langmuir : the ACS journal of surfaces and colloids 20090721

• Reduction of protons assisted by a hexanuclear nickel thiolate metallacrown: protonation and electrocatalytic dihydrogen evolution.

  Physical chemistry chemical physics : PCCP 20090721

• High rates of residual fatty acid oxidation during mild ischemia decrease cardiac work and efficiency.

  Journal of molecular and cellular cardiology 20090701

• Pharmacokinetic analysis of trichloroethylene metabolism in male B6C3F1 mice: Formation and disposition of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine.

  Toxicology and applied pharmacology 20090701

• Formation of chlorinated disinfection by-products in viticulture.

  Environmental science and pollution research international 20090701

• Monitoring phosphorylation of the pyruvate dehydrogenase complex.

  Analytical biochemistry 20090615

• Augmented cerebellar lactate in copper deficient rat pups originates from both blood and cerebellum.

  Metabolic brain disease 20090601

• 1,3-Dihydr-oxy-2-(hydroxy-meth-yl)propan-2-aminium 2,2-dichloro-acetate.

  Acta crystallographica. Section E, Structure reports online 20090601

• Evidence of autoimmune-related effects of trichloroethylene exposure from studies in mice and humans.

  Environmental health perspectives 20090501

• Biodegradation of haloacetic acids by bacterial isolates and enrichment cultures from drinking water systems.

  Environmental science & technology 20090501

• Phenylalanine-induced leucopenia in genetic and dichloroacetic acid generated deficiency of glutathione transferase Zeta.

  Biochemical pharmacology 20090415

• Pyruvate dehydrogenase phosphatase 1 (PDP1) null mutation produces a lethal infantile phenotype.

  Human genetics 20090401

• Treatment for Leigh syndrome by monitoring dichloroacetate concentration.

  Pediatrics international : official journal of the Japan Pediatric Society 20090401

• Epigenetics and environmental chemicals.

  Current opinion in pediatrics 20090401

• Substrate-enzyme competition attenuates upregulated anaplerotic flux through malic enzyme in hypertrophied rat heart and restores triacylglyceride content: attenuating upregulated anaplerosis in hypertrophy.

  Circulation research 20090327

• Innate short-circuiting of mitochondrial metabolism in cardiac hypertrophy: identification of novel consequences of enhanced anaplerosis.

  Circulation research 20090327

• Decomposition of two haloacetic acids in water using UV radiation, ozone and advanced oxidation processes.

  Journal of hazardous materials 20090315

• Chloroform- and water-soluble sol-gel derived Eu+++/Y2O3 (red) and Tb+++/Y2O3 (green) nanophosphors: synthesis, characterization, and surface modification.

  IEEE transactions on nanobioscience 20090301

• Central nervous system imaging in mitochondrial disorders.

  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20090301

• Biological Basis of Differential Susceptibility to Hepatocarcinogenesis among Mouse Strains.

  Journal of toxicologic pathology 20090301

• N2'-->p3' phosphoramidate glycerol nucleic acid as a potential alternative genetic system.

  Journal of the American Chemical Society 20090218

• Fate of THMs and HAAs in low TOC surface water.

  Environmental research 20090201

• Mitochondrial mutations contribute to HIF1alpha accumulation via increased reactive oxygen species and up-regulated pyruvate dehydrogenease kinase 2 in head and neck squamous cell carcinoma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090115

• The kinetics and mechanism of the acid-catalysed detritylation of nucleotides in non-aqueous solution.

  Organic & biomolecular chemistry 20090107

• Stimulation-induced increases of astrocytic oxidative metabolism in rats and humans investigated with 1-11C-acetate.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20090101

• Evaluation of dichloroacetic acid for carcinogenicity in genetically modified Tg.AC hemizygous and p53 haploinsufficient mice.

  Toxicological sciences : an official journal of the Society of Toxicology 20090101

• Therapeutic targets in pulmonary arterial hypertension.

  Pharmacology & therapeutics 20090101

• Update on medication-induced peripheral neuropathy.

  Current neurology and neuroscience reports 20090101

• Determination of ten haloacetic acids in drinking water using high-performance and ultra-performance liquid chromatography-tandem mass spectrometry.

  Journal of chromatographic science 20090101

• The metabolic treatment of patients with coronary artery disease: effects on quality of life and effort angina.

  Current pharmaceutical design 20090101

• Acetoacetate reduces growth and ATP concentration in cancer cell lines which over-express uncoupling protein 2.

  Cancer cell international 20090101

• Dichloroacetate alleviates development of collagen II-induced arthritis in female DBA/1 mice.

  Arthritis research & therapy 20090101

• Metabolism as means for hypoxia adaptation: metabolic profiling and flux balance analysis.

  BMC systems biology 20090101

• Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect.

  PloS one 20090101

• Interferon for the treatment of genital warts: a systematic review.

  BMC infectious diseases 20090101

• PathBinder--text empirics and automatic extraction of biomolecular interactions.

  BMC bioinformatics 20090101

• Trichloroethylene risk assessment: a review and commentary.

  Critical reviews in toxicology 20090101

• A systematic review of the reporting of Data Monitoring Committees' roles, interim analysis and early termination in pediatric clinical trials.

  BMC pediatrics 20090101

• Aqua-bis(dichloro-acetato-κO)(1,10-phenanthroline-κN,N')copper(II).

  Acta crystallographica. Section E, Structure reports online 20090101

• Dichloroacetate-induced modulation of cellular antioxidant enzyme activities and glutathione level in the J774A.1 cells.

  Journal of applied toxicology : JAT 20081101

• Visible light photo-oxidations in the presence of alpha-Bi(2)O(3).

  Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20081101

• Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer.

  British journal of cancer 20081007

• Differential effects of in vivo and in vitro lactate treatments on liver carbohydrate metabolism of rainbow trout.

  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20081001

• Theoretical studies of different tautomers of anti cancer drug: dichloroacetate.

  Pakistan journal of pharmaceutical sciences 20081001

• Trichloroethylene transformation by natural mineral pyrite: the deciding role of oxygen.

  Environmental science & technology 20081001

• Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity.

  The Journal of biological chemistry 20080912

• Pyruvate dehydrogenase kinase 4: regulation by thiazolidinediones and implication in glyceroneogenesis in adipose tissue.

  Diabetes 20080901

• The heme precursor delta-aminolevulinate blocks peripheral myelin formation.

  Journal of neurochemistry 20080901

• Comparison of H2O2/UV and heterogeneous photocatalytic processes for the degradation of dichloroacetic acid in water.

  Environmental science & technology 20080815

• Allosteric coupling in pyruvate dehydrogenase kinase 2.

  Biochemistry 20080812

• Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation.

  The Prostate 20080801

• Case: asymptomatic lesions on eyelids.

  Geriatrics 20080801

• Characterization of Ser73 in Arabidopsis thaliana Glutathione S-transferase zeta class.

  Journal of genetics and genomics = Yi chuan xue bao 20080801

• Analysis of in vivo mutation data can inform cancer risk assessment.

  Regulatory toxicology and pharmacology : RTP 20080701

• ECVAM retrospective validation of in vitro micronucleus test (MNT).

  Mutagenesis 20080701

• Domoic acid excretion in dungeness crabs, razor clams and mussels.

  Marine environmental research 20080701

• Human health risk assessment of chlorinated disinfection by-products in drinking water using a probabilistic approach.

  Water research 20080701

• Dichloroacetate stabilizes the intraoperative acid-base balance during liver transplantation.

  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20080701

• A dynamic and chamber-specific mitochondrial remodeling in right ventricular hypertrophy can be therapeutically targeted.

  The Journal of thoracic and cardiovascular surgery 20080701

• Metabolic agents in the management of diabetic coronary patients: a new era.

  International journal of cardiology 20080623

• Metabolic agents in the management of diabetic coronary patients: a new era.

  International journal of cardiology 20080623

• Role of glucose metabolism in the recovery of postischemic LV mechanical function: effects of insulin and other metabolic modulators.

  American journal of physiology. Heart and circulatory physiology 20080601

• Dichloroacetate induces apoptosis in endometrial cancer cells.

  Gynecologic oncology 20080601

• Oxidoreductase regulation of Kv currents in rat ventricle.

  Journal of molecular and cellular cardiology 20080601

• Dichloroacetate enhances performance and reduces blood lactate during maximal cycle exercise in chronic obstructive pulmonary disease.

  American journal of respiratory and critical care medicine 20080515

• Halogenated derivatives QSAR model using spectral moments to predict haloacetic acids (HAA) mutagenicity.

  Bioorganic & medicinal chemistry 20080515

• Evaluation of long-term treatment of children with congenital lactic acidosis with dichloroacetate.

  Pediatrics 20080501

• Haloacetic acid and trihalomethane formation from the chlorination and bromination of aliphatic beta-dicarbonyl acid model compounds.

  Environmental science & technology 20080501

• A combined therapeutic approach for pyruvate dehydrogenase deficiency using self-complementary adeno-associated virus serotype-specific vectors and dichloroacetate.

  Molecular genetics and metabolism 20080401

• Correlations between organic matter properties and DBP formation during chloramination.

  Water research 20080401

• Glucose-insulin therapy, plasma substrate levels and cardiac recovery after cardiac ischemic events.

  Cardiovascular drugs and therapy 20080401

• In situ derivatization/solid-phase microextraction coupled with gas chromatography/negative chemical ionization mass spectrometry for the determination of trichloroethylene metabolites in rat blood.

  Rapid communications in mass spectrometry : RCM 20080401

• Involvement of lactate in glucose metabolism and glucosensing function in selected tissues of rainbow trout.

  The Journal of experimental biology 20080401

• The formation and distribution of haloacetic acids in copper pipe during chlorination.

  Journal of hazardous materials 20080321

• Quantitative evaluation of dichloroacetic acid kinetics in human--a physiologically based pharmacokinetic modeling investigation.

  Toxicology 20080312

• Kinetics of chloral hydrate and its metabolites in male human volunteers.

  Toxicology 20080312

• Difficulty of mode of action determination for trichloroethylene: An example of complex interactions of metabolites and other chemical exposures.

  Environmental and molecular mutagenesis 20080301

• Age-dependent kinetics and metabolism of dichloroacetate: possible relevance to toxicity.

  The Journal of pharmacology and experimental therapeutics 20080301

• Treatment of Fordyce spots with bichloracetic acid.

  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20080301

• RNA interference in mammalia cells by RNA-3'-PNA chimeras.

  International journal of molecular sciences 20080301

• A refined radio-telemetry technique to monitor right ventricle or pulmonary artery pressures in rats: a useful tool in pulmonary hypertension research.

  Pflugers Archiv : European journal of physiology 20080201

• Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer.

  American journal of physiology. Heart and circulatory physiology 20080201

• Dichloroacetate- and trichloroacetate-induced phagocytic activation and production of oxidative stress in the hepatic tissues of mice after acute exposure.

  Journal of biochemical and molecular toxicology 20080201

• [Determination of five halogenated acetic acids in water using ion chromatography].

  Se pu = Chinese journal of chromatography 20080101

• Water disinfection by-products and the risk of specific birth defects: a population-based cross-sectional study in Taiwan.

  Environmental health : a global access science source 20080101

• Role of dichloroacetate in the treatment of genetic mitochondrial diseases.

  Advanced drug delivery reviews 20080101

• Effect of streptozotocin-induced diabetes on myocardial blood flow reserve assessed by myocardial contrast echocardiography in rats.

  Cardiovascular diabetology 20080101

• Evaluation of the role of peroxisome proliferator-activated receptor alpha (PPARalpha) in mouse liver tumor induction by trichloroethylene and metabolites.

  Critical reviews in toxicology 20080101

• Gateways to clinical trials. July-August 2008.

  Methods and findings in experimental and clinical pharmacology 20080101

• Metformin-associated lactic acidosis in an intensive care unit.

  Critical care (London, England) 20080101

• Abstracts of papers presented at the 2008 pittsburgh conference.

  Journal of automated methods & management in chemistry 20080101

• Total excision and V-Y plasty technique in the anal area condyloma acuminatum.

  Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India 20080101

• Don't take vitals, take a lactate.

  Intensive care medicine 20071101

• Cytometric assessment of DNA damage by exogenous and endogenous oxidants reports aging-related processes.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20071101

• MALDI-linear ion trap microprobe MS/MS studies of the effects of dichloroacetate on lipid content of nerve tissue.

  Analytical chemistry 20071101

• Wolff-Parkinson-White syndrome in Patients With MELAS.

  Archives of neurology 20071101

• Formation and fate of haloacetic acids (HAAs) within the water treatment plant.

  Water research 20071001

• A general, positive ion mode ESI-MS approach for the analysis of singly charged inorganic and organic anions using a dicationic reagent.

  Analytical chemistry 20071001

• The ultrafast dynamics of hydrogen-bonded liquids: molecular structure-dependent occurrence of normal arrhenius or fractional Stokes-Einstein-Debye rotational diffusive relaxation.

  The journal of physical chemistry. B 20070816

• Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol.

  Structure (London, England : 1993) 20070801

• The healthy men study: an evaluation of exposure to disinfection by-products in tap water and sperm quality.

  Environmental health perspectives 20070801

• Amino acid residues responsible for the recognition of dichloroacetate by pyruvate dehydrogenase kinase 2.

  FEBS letters 20070626

• Lactate interferes with ATP release from red blood cells.

  American journal of physiology. Heart and circulatory physiology 20070601

• Functional diagnostics in mitochondrial diseases.

  Bioscience reports 20070601

• The beneficial effects of dichloroacetate in acute limb ischemia.

  Military medicine 20070601

• Trials and tribulations.

  Nature reviews. Drug discovery 20070501

• Examination of NOM chlorination reactions by conventional and stop-flow differential absorbance spectroscopy.

  Environmental science & technology 20070415

• Metabolic targeting as an anticancer strategy: dawn of a new era?

  Science's STKE : signal transduction knowledge environment 20070410

• Toxicology and carcinogenesis studies of dibromoacetic acid (Cas No. 631-64-1) in F344/N rats and B6C3F1 mice (drinking water studies).

  National Toxicology Program technical report series 20070401

• NTP report on the toxicology studies of dichloroacetic acid (CAS No. 79-43-6) in genetically modified (FVB Tg.AC hemizygous) mice (dermal and drinking water studies) and carcinogenicity studies of dichloroacetic acid in genetically modified [B6.129-Trp53(tm1Brd) (N5) haploinsufficient] mice (drinking water studies).

  National Toxicology Program genetically modified model report 20070401

• Immuno- and hepato-toxicity of dichloroacetic acid in MRL(+/+) and B(6)C(3)F(1) mice.

  Journal of immunotoxicology 20070401

• Cancer patients opt for unapproved drug.

  Nature 20070329

• Insulin regulation of glutathione and contractile phenotype in diabetic rat ventricular myocytes.

  American journal of physiology. Heart and circulatory physiology 20070301

• Modulation of the expression of peroxisome proliferators-activated receptors in human fibroblasts.

  Fertility and sterility 20070301

• Myocardial lactate deprivation is associated with decreased cardiovascular performance, decreased myocardial energetics, and early death in endotoxic shock.

  Intensive care medicine 20070301

• The use of Markov chain Monte Carlo uncertainty analysis to support a Public Health Goal for perchloroethylene.

  Regulatory toxicology and pharmacology : RTP 20070201

• Malonyl coenzyme A affects insulin-stimulated glucose transport in myotubes.

  Archives of physiology and biochemistry 20070201

• Dichloroacetic acid degradation employing hydrogen peroxide and UV radiation.

  Chemosphere 20070101

• Reductive dehalogenation of haloacetic acids by hemoglobin-loaded carbon nanotube electrode.

  Water research 20070101

• A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth.

  Cancer cell 20070101

• Dichloroacetate causes reversible demyelination in vitro: potential mechanism for its neuropathic effect.

  Journal of neurochemistry 20070101

• Modelling the kinetics of UV/H2O2 oxidation of dichloroacetic acid.

  Water science and technology : a journal of the International Association on Water Pollution Research 20070101

• Effect of streptozotocin-induced diabetes on left ventricular function in adult rats: an in vivo Pinhole Gated SPECT study.

  Cardiovascular diabetology 20070101

• Determination of haloacetic acids in hospital effluent after chlorination by ion chromatography.

  Journal of environmental sciences (China) 20070101

• Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for research.

  Mutation research 20070101

• Abstracts of papers presented at the 2007 pittsburgh conference.

  Journal of automated methods & management in chemistry 20070101

• The role of glucose metabolism and glucose-associated signalling in cancer.

  Perspectives in medicinal chemistry 20070101

• The role of k+ channels in determining pulmonary vascular tone, oxygen sensing, cell proliferation, and apoptosis: implications in hypoxic pulmonary vasoconstriction and pulmonary arterial hypertension.

  Microcirculation (New York, N.Y. : 1994) 20061201

• Human kinetics of orally and intravenously administered low-dose 1,2-(13)C-dichloroacetate.

  Journal of clinical pharmacology 20061201

• [Study on rat's DNA damage of p53 induced by chlorinated acetic acids of drinking water disinfection by-products].

  Wei sheng yan jiu = Journal of hygiene research 20061101

• Autoimmune response in MRL+/+ mice following treatment with dichloroacetyl chloride or dichloroacetic anhydride.

  Toxicology and applied pharmacology 20061015

• Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial.

  Neurology 20061010

• Short-term exposures to dihaloacetic acids produce dysmorphogenesis in mouse conceptuses in vitro.

  Reproductive toxicology (Elmsford, N.Y.) 20061001

• Bayesian population analysis of a harmonized physiologically based pharmacokinetic model of trichloroethylene and its metabolites.

  Regulatory toxicology and pharmacology : RTP 20061001

• Severe malaria: lessons learned from the management of critical illness in children.

  Trends in parasitology 20061001

• New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 2): Identification of nephrotoxic metabolites.

  Anesthesiology 20061001

• A Korean female patient with thiamine-responsive pyruvate dehydrogenase complex deficiency due to a novel point mutation (Y161C)in the PDHA1 gene.

  Journal of Korean medical science 20061001

• Tricarboxylic acid cycle intermediates accumulate at the onset of intense exercise in man but are not essential for the increase in muscle oxygen uptake.

  Pflugers Archiv : European journal of physiology 20060901

• The key role of apoptosis in the pathogenesis and treatment of pulmonary hypertension.

  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20060901

• Optimizing cardiac fatty acid and glucose metabolism as an approach to treating heart failure.

  Seminars in cardiothoracic and vascular anesthesia 20060901

• Key scientific issues in the health risk assessment of trichloroethylene.

  Environmental health perspectives 20060901

• Issues in the pharmacokinetics of trichloroethylene and its metabolites.

  Environmental health perspectives 20060901

• Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesis.

  Environmental health perspectives 20060901

• Key issues in the role of peroxisome proliferator-activated receptor agonism and cell signaling in trichloroethylene toxicity.

  Environmental health perspectives 20060901

• Volume expansion with albumin compared to gelofusine in children with severe malaria: results of a controlled trial.

  PLoS clinical trials 20060901

• Modeling dichloroacetic acid formation from the reaction of monochloramine with natural organic matter.

  Water research 20060801

• Application of cryopreserved human hepatocytes in trichloroethylene risk assessment: relative disposition of chloral hydrate to trichloroacetate and trichloroethanol.

  Environmental health perspectives 20060801

• Effects of indoor drinking water handling on trihalomethanes and haloacetic acids.

  Water research 20060801

• Trichloroethylene uptake by apple and peach trees and transfer to fruit.

  Environmental science & technology 20060801

• [Impact of catalytic ozonation with ferric hydroxide on HAAs formation potential of a filtered surface water].

  Huan jing ke xue= Huanjing kexue 20060801

• Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial.

  Neurology 20060711

• Effect of short-term drinking water exposure to dichloroacetate on its pharmacokinetics and oral bioavailability in human volunteers: a stable isotope study.

  Toxicological sciences : an official journal of the Society of Toxicology 20060701

• An evidence-based approach to the management of pulmonary arterial hypertension.

  Current opinion in cardiology 20060701

• A GC-MS/MS method for the quantitative analysis of low levels of the tyrosine metabolites maleylacetone, succinylacetone, and the tyrosine metabolism inhibitor dichloroacetate in biological fluids and tissues.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060606

• An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension.

  Circulation 20060606

• THM, HAA and CNCl formation from UV irradiation and chlor(am)ination of selected organic waters.

  Water research 20060601

• Therapeutic potential of dichloroacetate for pyruvate dehydrogenase complex deficiency.

  Mitochondrion 20060601

• Trichloroethylene exposure during cardiac valvuloseptal morphogenesis alters cushion formation and cardiac hemodynamics in the avian embryo.

  Environmental health perspectives 20060601

• [Effect of preozonation on disinfection by-products formation potential of algae cells and extracellular organic matter].

  Huan jing ke xue= Huanjing kexue 20060601

• Evaluation of dichloroacetate treatment in a murine model of hereditary tyrosinemia type 1.

  Biochemical pharmacology 20060528

• Photocatalytic hydrogen generation in the presence of chloroacetic acids over Pt/TiO2.

  Chemosphere 20060501

• Polymorphisms in the human glutathione transferase zeta promoter.

  Pharmacogenetics and genomics 20060501

• Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children.

  Pediatrics 20060501

• [Expression of glutathione S-transferase zeta class genes in Saccharomyces cerevisiae].

  Yi chuan = Hereditas 20060501

• [Determination of trace haloacetic acids in drinking water using ion chromatography coupled with solid phase extraction].

  Se pu = Chinese journal of chromatography 20060501

• Dichloroacetate reduces tissue necrosis in a rat transverse rectus abdominis musculocutaneous flap model.

  Annals of plastic surgery 20060301

• Severe malaria: metabolic complications.

  Current molecular medicine 20060301

• Determination of mono- and dichloroacetic acids in betaine media by liquid chromatography.

  Talanta 20060215

• Trial of dichloroacetate in MELAS: toxicity overshadows the assessment of potential benefit.

  Neurology 20060214

• Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial.

  Neurology 20060214

• Pulmonary bronchiolar cytotoxicity and formation of dichloroacetyl lysine protein adducts in mice treated with trichloroethylene.

  The Journal of pharmacology and experimental therapeutics 20060201

• Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways.

  Molecular pharmacology 20060201

• Optical density and photonic efficiency of silica-supported TiO2 photocatalysts.

  Water research 20060201

• Peripheral neuropathy in genetic mitochondrial diseases.

  Pediatric neurology 20060201

• Treatment for mitochondrial disorders.

  The Cochrane database of systematic reviews 20060125

• 9-(4-Bromophenyl)-9-fluorenyl as a safety-catch nitrogen protecting group.

  The Journal of organic chemistry 20060120

• Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands.

  Biochemistry 20060117

• Inhibition and recovery of rat hepatic glutathione S-transferase zeta and alteration of tyrosine metabolism following dichloroacetate exposure and withdrawal.

  Drug metabolism and disposition: the biological fate of chemicals 20060101

• The effects of cyanobacterial exudates on bacterial growth and biodegradation of organic contaminants.

  Microbial ecology 20060101

• Pulmonary arterial hypertension: new insights and new hope.

  Respirology (Carlton, Vic.) 20060101

• A case of Melas (A3243G) on chronic dichloroacetate treatment.

  European neurology 20060101

• Different net effect of TiO2 sintering temperature on the photocatalytic removal rates of 4-chlorophenol, 4-chlorobenzoic acid and dichloroacetic acid in water.

  Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering 20060101

• Interaction between organic species in the formation of haloacetic acids following disinfection.

  Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering 20060101

• Magnetic resonance spectroscopic investigation of mitochondrial fuel metabolism and energetics in cultured human fibroblasts: effects of pyruvate dehydrogenase complex deficiency and dichloroacetate.

  Molecular genetics and metabolism 20060101

• Trichloroethylene, trichloroacetic acid, and dichloroacetic acid: do they affect eye development in the Sprague-Dawley rat?

  International journal of toxicology 20060101

• [Analysis of haloacetic acids in drinking water by gas chromatography-mass spectrometry].

  Se pu = Chinese journal of chromatography 20060101

• Modulation by ellagic acid of DCA-induced developmental toxicity in the zebrafish (Danio rerio).

  Journal of biochemical and molecular toxicology 20060101

• Human malarial disease: a consequence of inflammatory cytokine release.

  Malaria journal 20060101

• Visible light active platinum-ion-doped TiO2 photocatalyst.

  The journal of physical chemistry. B 20051229

• Malaria and fluids--balancing acts.

  Trends in parasitology 20051201

• Platelet mitochondrial evaluation during cytochrome c and dichloroacetate treatments of MELAS.

  Mitochondrion 20051201

• Late pregnancy exposures to disinfection by-products and growth-related birth outcomes.

  Environmental health perspectives 20051201

• Mitochondrial myopathies: diagnosis, exercise intolerance, and treatment options.

  Medicine and science in sports and exercise 20051201

• Metabolic modulators for chronic cardiac ischemia.

  Journal of cardiovascular pharmacology and therapeutics 20051201

• Comparison of haloacetic acids in the environment of the Northern and Southern Hemispheres.

  Environmental science & technology 20051115

• Lung preservation solution substrate composition affects rat lung oxidative metabolism during hypothermic storage.

  Respiratory physiology & neurobiology 20051012

• A review of analytical methods for the determination of trichloroethylene and its major metabolites chloral hydrate, trichloroacetic acid and dichloroacetic acid.

  Biomedical chromatography : BMC 20051001

• DNA hypomethylation induced by drinking water disinfection by-products in mouse and rat kidney.

  Toxicological sciences : an official journal of the Society of Toxicology 20051001

• The relevance of malaria pathophysiology to strategies of clinical management.

  Current opinion in infectious diseases 20051001

• Trichloroacetaldehyde modified oligonucleotides.

  Bioorganic & medicinal chemistry letters 20050915

• Fructose-1,6-bisphosphate enhances hypothermic preservation of cardiac myocytes.

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20050901

• Lack of direct mitogenic activity of dichloroacetate and trichloroacetate in cultured rat hepatocytes.

  Toxicology 20050801

• Pyruvate dehydrogenase phosphatase deficiency: identification of the first mutation in two brothers and restoration of activity by protein complementation.

  The Journal of clinical endocrinology and metabolism 20050701

• The impacts of cyanobacteria on pulp-and-paper wastewater toxicity and biodegradation of wastewater contaminants.

  Canadian journal of microbiology 20050701

• Photocatalytic reactivities of Nafion-coated TiO2 for the degradation of charged organic compounds under UV or visible light.

  The journal of physical chemistry. B 20050616

• Myocardial metabolism and improved outcomes after high risk heart surgery.

  Seminars in cardiothoracic and vascular anesthesia 20050601

• Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).

  Journal of medicinal chemistry 20050505

• Determination of dichloroacetic acid and trichloroacetic acid in drinking water by acidic methanol esterification and headspace gas chromatography.

  Water research 20050501

• [Adsorption performance of haloacetic acids onto 5 GACs from water].

  Huan jing ke xue= Huanjing kexue 20050501

• Impact of high glucose/high insulin and dichloroacetate treatment on carbohydrate oxidation and functional recovery after low-flow ischemia and reperfusion in the isolated perfused rat heart.

  Circulation 20050426

• Photocatalytic reactivity of surface platinized TiO2: substrate specificity and the effect of Pt oxidation state.

  The journal of physical chemistry. B 20050421

• Toxicokinetics and oral bioavailability of halogenated acetic acids mixtures in naïve and GSTzeta-depleted rats.

  Toxicological sciences : an official journal of the Society of Toxicology 20050401

• Visible-light-induced photocatalytic degradation of 4-chlorophenol and phenolic compounds in aqueous suspension of pure titania: demonstrating the existence of a surface-complex-mediated path.

  The journal of physical chemistry. B 20050324

• Hydrogen-deuterium (H/D) exchange mapping of Abeta 1-40 amyloid fibril secondary structure using nuclear magnetic resonance spectroscopy.

  Biochemistry 20050322

• Redox regulation of Ito remodeling in diabetic rat heart.

  American journal of physiology. Heart and circulatory physiology 20050301

• Characterization of the metabolic interaction between trihalomethanes and chloroacetic acids using rat liver microsomes.

  Journal of toxicology and environmental health. Part A 20050227

• Haloacetic acids in drinking water and risk for stillbirth.

  Occupational and environmental medicine 20050201

• Fatty acid oxidation inhibitors in the management of chronic complications of atherosclerosis.

  Current atherosclerosis reports 20050201

• Modulation of the expression of vascular endothelial growth factor in human fibroblasts.

  Fertility and sterility 20050201

• [Diisopropylamine dichloroacetate in the treatment of nonalcoholic fatty liver disease: a multicenter random double-blind controlled trial].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20050201

• Chasing the 'ghost' of the acetyl group deficit.

  Medicine and science in sports and exercise 20050101

• Severe falciparum malaria in Gabonese children: clinical and laboratory features.

  Malaria journal 20050101

• Dichloroacetate-induced developmental toxicity and production of reactive oxygen species in zebrafish embryos.

  Journal of biochemical and molecular toxicology 20050101

• Analysis of dichloroacetic acid in rat blood and tissues by hydrophilic interaction liquid chromatography with tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20050101

• Characterization of the fluoroacetate detoxication enzymes of rat liver cytosol.

  Xenobiotica; the fate of foreign compounds in biological systems 20050101

• Human glutathione transferase zeta.

  Methods in enzymology 20050101

• Acetyl group availability influences phosphocreatine degradation even during intense muscle contraction.

  The Journal of physiology 20041215

• Kinetics of haloacetic acid reactions with Fe(0).

  Environmental science & technology 20041215

• A quantitative description of suicide inhibition of dichloroacetic acid in rats and mice.

  Toxicological sciences : an official journal of the Society of Toxicology 20041201

• Behavior of trihalomethanes and haloacetic acids in a drinking water distribution system.

  Water research 20041201

• Developmental toxicity of mixtures: the water disinfection by-products dichloro-, dibromo- and bromochloro acetic acid in rat embryo culture.

  Reproductive toxicology (Elmsford, N.Y.) 20041101

• Effect of dibromoacetic acid on DNA methylation, glycogen accumulation, and peroxisome proliferation in mouse and rat liver.

  Toxicological sciences : an official journal of the Society of Toxicology 20041101

• Muscle mechanoreceptor sensitivity in heart failure.

  American journal of physiology. Heart and circulatory physiology 20041101

• Pyruvate dehydrogenase kinase isoform 2 activity limited and further inhibited by slowing down the rate of dissociation of ADP.

  Biochemistry 20041026

• Role of the peroxisome proliferator-activated receptor alpha (PPARalpha) in responses to trichloroethylene and metabolites, trichloroacetate and dichloroacetate in mouse liver.

  Toxicology 20041015

• Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis.

  Circulation research 20041015

• Dichloroacetate treatment for mitochondrial cytopathy: long-term effects in MELAS.

  Brain & development 20041001

• Batch-test study on the dechlorination of 1,1,1-trichloroethane in contaminated aquifer material by zero-valent iron.

  Journal of contaminant hydrology 20041001

• Assessment of volume depletion in children with malaria.

  PLoS medicine 20041001

• Direct detection of trace haloacetates in drinking water using microbore ion chromatography. Improved detector sensitivity using a hydroxide gradient and a monolithic ion-exchange type suppressor.

  Journal of chromatography. A 20040827

• Binding and kinetic mechanisms of the Zeta class glutathione transferase.

  The Journal of biological chemistry 20040806

• Haloacetic acids in the aquatic environment. Part I: macrophyte toxicity.

  Environmental pollution (Barking, Essex : 1987) 20040801

• Haloacetic acids in the aquatic environment. Part II: ecological risk assessment.

  Environmental pollution (Barking, Essex : 1987) 20040801

• Mice deficient in glutathione transferase zeta/maleylacetoacetate isomerase exhibit a range of pathological changes and elevated expression of alpha, mu, and pi class glutathione transferases.

  The American journal of pathology 20040801

• Mechanism of dichloroacetate-induced hypolactatemia in humans with or without cirrhosis.

  Metabolism: clinical and experimental 20040801

• Ischemic heart disease: metabolic approaches to management.

  Clinical cardiology 20040801

• Interactions in the tumor-promoting activity of carbon tetrachloride, trichloroacetate, and dichloroacetate in the liver of male B6C3F1 mice.

  Toxicology 20040701

• Influence of DCA on pulmonary (.-)V(O2) kinetics during moderate-intensity cycle exercise.

  Medicine and science in sports and exercise 20040701

• Determination of bromate and chlorinated haloacetic acids in bottled drinking water with chromatographic methods.

  Chemosphere 20040601

• The effect of disinfection by-products and mutagenic activity on birth weight and gestational duration.

  Environmental health perspectives 20040601

• Effects of dichloroacetate and ubiquinone infusions on glycolysis activity and thermal sensitivity during sepsis.

  The Journal of laboratory and clinical medicine 20040601

• Effects of superoxide dismutase and polyclonal tumor necrosis factor-alpha antibodies on chloroacetate-induced cellular death and superoxide anion production by J774.A1 macrophages.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20040601

• Experimental cancer studies of chlorinated by-products.

  Toxicology 20040520

• Induction of peroxisome proliferation in cultured hepatocytes by a series of halogenated acetates.

  Toxicology 20040503

• Formation of haloacetic acids during monochloramination.

  Water research 20040501

• Glutathione transferase zeta-catalyzed bioactivation of dichloroacetic acid: reaction of glyoxylate with amino acid nucleophiles.

  Chemical research in toxicology 20040501

• Dichloroacetate therapy attenuates the blood lactate response to submaximal exercise in patients with defects in mitochondrial energy metabolism.

  The Journal of clinical endocrinology and metabolism 20040401

• Regulation of expression of tissue plasminogen activator and plasminogen activator inhibitor-1 by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions.

  American journal of obstetrics and gynecology 20040401

• Accurate determination of low pK values by (1)H NMR titration.

  Talanta 20040310

• Dichloroacetate does not speed phase-II pulmonary VO2 kinetics following the onset of heavy intensity cycle exercise.

  Pflugers Archiv : European journal of physiology 20040301

• [Treatment for mitochondrial diseases].

  No to hattatsu = Brain and development 20040301

• Hypomethylation of DNA and the insulin-like growth factor-II gene in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors.

  Toxicology 20040301

• [Heart disease and diabetes: from pathophysiology to therapeutic options].

  Italian heart journal : official journal of the Italian Federation of Cardiology 20040301

• [Investigation of bromate, haloacetic acids and perchlorate in Beijing's drinking water].

  Huan jing ke xue= Huanjing kexue 20040301

• Prevention by methionine of dichloroacetic acid-induced liver cancer and DNA hypomethylation in mice.

  Toxicological sciences : an official journal of the Society of Toxicology 20040201

• Mitochondrial complex I mutations in Caenorhabditis elegans produce cytochrome c oxidase deficiency, oxidative stress and vitamin-responsive lactic acidosis.

  Human molecular genetics 20040201

• Therapeutic effect and [123I]IMP SPECT findings of sodium dichloroacetate in a patient with MELAS.

  Neurology 20040127

• Regulation of matrix metalloproteinase-1 and tissue inhibitor of matrix metalloproteinase-1 by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions.

  Fertility and sterility 20040101

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20040101

• DBP levels in chlorinated drinking water: effect of humic substances.

  Environmental monitoring and assessment 20040101

• Mechanistic implications of the effect of TiO2 accessibility in TiO2-SiO2 coatings upon chlorinated organics photocatalytic removal in water.

  Water science and technology : a journal of the International Association on Water Pollution Research 20040101

• Evaluation of the combined solar TiO2/photo-Fenton process using multivariate analysis.

  Water science and technology : a journal of the International Association on Water Pollution Research 20040101

• Textile wastewater treatment and reuse by solar catalysis: results from a pilot plant in Tunisia.

  Water science and technology : a journal of the International Association on Water Pollution Research 20040101

• Elevated blood lactate is not a primary cause of anorexia in tumor-bearing rats.

  Nutrition and cancer 20040101

• POSaM: a fast, flexible, open-source, inkjet oligonucleotide synthesizer and microarrayer.

  Genome biology 20040101

• Bench-to-bedside review: treating acid-base abnormalities in the intensive care unit - the role of buffers.

  Critical care (London, England) 20040101

• Chronic treatment of mitochondrial disease patients with dichloroacetate.

  Molecular genetics and metabolism 20040101

• Therapy of cutaneous human Papillomavirus infections.

  Dermatologic therapy 20040101

• Some drinking-water disinfectants and contaminants, including arsenic.

  IARC monographs on the evaluation of carcinogenic risks to humans 20040101

• Some drinking-water disinfectants and contaminants, including arsenic. Monographs on chloramine, chloral and chloral hydrate, dichloroacetic acid, trichloroacetic acid and 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone.

  IARC monographs on the evaluation of carcinogenic risks to humans 20040101

• Evaluation of the influence of chloroacetic acids on the pharmacokinetics of trihalomethanes in the rat.

  Journal of toxicology and environmental health. Part A 20031212

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20031201

• Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents.

  Biochemical pharmacology 20031115

• Lactate as a modulator of hypoxia-induced hyperventilation.

  Respiratory physiology & neurobiology 20031016

• Improvement of thermal hydrolysis rate of dichloroacetic acid using alcohol.

  Chemosphere 20031001

• Pyruvate and acetate metabolism in termite mitochondria.

  Journal of insect physiology 20031001

• The effects of dichloroacetate in a rabbit model of acute hind-limb ischemia and reperfusion.

  Journal of the American College of Surgeons 20031001

• Effects of dichloroacetate on VO2 and intramuscular 31P metabolite kinetics during high-intensity exercise in humans.

  Journal of applied physiology (Bethesda, Md. : 1985) 20030901

• Low-frequency modes of peptides and globular proteins in solution observed by ultrafast OHD-RIKES spectroscopy.

  Biophysical journal 20030901

• Evidence for rapid 'metabolic switching' through lipoprotein lipase occupation of endothelial-binding sites.

  Journal of molecular and cellular cardiology 20030901

• Multinuclear NMR investigations on the metabolic recovery of the isolated perfused mouse liver after cold preservation.

  Biochimie 20030901

• Design and synthesis of novel pyridoxine 5'-phosphonates as potential antiischemic agents.

  Journal of medicinal chemistry 20030814

• Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase.

  Circulation research 20030808

• Perturbation of maleylacetoacetic acid metabolism in rats with dichloroacetic Acid-induced glutathione transferase zeta deficiency.

  Toxicological sciences : an official journal of the Society of Toxicology 20030701

• Formation of chloroacetic acids from soil, humic acid and phenolic moieties.

  Chemosphere 20030701

• Differential modulation of glucose, lactate, and pyruvate oxidation by insulin and dichloroacetate in the rat heart.

  American journal of physiology. Heart and circulatory physiology 20030701

• Efficacy of dichloroacetate as a lactate-lowering drug.

  Journal of clinical pharmacology 20030701

• Airborne haloacetic acids.

  Environmental science & technology 20030701

• Impairment of glucose metabolism and energy transfer in the rat heart.

  Molecular and cellular biochemistry 20030701

• Determination of chloroacetates in atmospheric particulate matter.

  Environmental science & technology 20030601

• The induction of oxidative stress and cellular death by the drinking water disinfection by-products, dichloroacetate and trichloroacetate in J774.A1 cells.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20030601

• Vacancy ion-exclusion chromatography of haloacetic acids on a weakly acidic cation-exchange resin.

  Journal of chromatography. A 20030516

• Differential effect of DCA treatment on the pyruvate dehydrogenase complex in patients with severe PDHC deficiency.

  Pediatric research 20030501

• Field level evaluation and risk assessment of the toxicity of dichloroacetic acid to the aquatic macrophytes Lemna gibba, Myriophyllum spicatum, and Myriophyllum sibiricum.

  Ecotoxicology and environmental safety 20030501

• Regulation of transforming growth factor-beta, type III collagen, and fibronectin by dichloroacetic acid in human fibroblasts from normal peritoneum and adhesions.

  Fertility and sterility 20030501

• Population kinetics, efficacy, and safety of dichloroacetate for lactic acidosis due to severe malaria in children.

  Journal of clinical pharmacology 20030401

• Chloroacetic acids in European soils and vegetation.

  Journal of environmental monitoring : JEM 20030401

• [Dichloroacetate treatment for adult patients with mitochondrial disease].

  Rinsho shinkeigaku = Clinical neurology 20030401

• Identification of trichloroethylene and its metabolites in human seminal fluid of workers exposed to trichloroethylene.

  Drug metabolism and disposition: the biological fate of chemicals 20030301

• Pyruvate-dependent preconditioning and cardioprotection in murine myocardium.

  Clinical and experimental pharmacology & physiology 20030301

• Physicochemical characterization of phosphinic pseudopeptides by capillary zone electrophoresis in highly acidic background electrolytes.

  Electrophoresis 20030301

• Altered gene expression in mouse livers after dichloroacetic acid exposure.

  Mutation research 20030301

• Dichloroacetate accelerates the fall in intracellular PO2 at onset of contractions in Xenopus single muscle fibers.

  American journal of physiology. Regulatory, integrative and comparative physiology 20030201

• Measurement of 13C/12C of chloroacetic acids by gas chromatography/combustion/isotope ratio mass spectrometry.

  Chemosphere 20030201

• Synthesis and immunogenic properties of phosphopeptides related to the human insulin receptor.

  The journal of peptide research : official journal of the American Peptide Society 20030101

• A 2-year dose-response study of lesion sequences during hepatocellular carcinogenesis in the male B6C3F(1) mouse given the drinking water chemical dichloroacetic acid.

  Environmental health perspectives 20030101

• [Adverse effects of dichloroacetate in a girl with mitochondrial disorder].

  No to hattatsu = Brain and development 20030101

• Dichloroacetate increases skeletal muscle pyruvate dehydrogenase activity during acute limb ischemia.

  Vascular and endovascular surgery 20030101

• The NO - K+ channel axis in pulmonary arterial hypertension. Activation by experimental oral therapies.

  Advances in experimental medicine and biology 20030101

• Cloning and in vitro and in vivo expression of plant glutathione S-transferase zeta class genes.

  Journal of bioscience and bioengineering 20030101

• Nephrotoxicity of chlorofluoroacetic acid in rats.

  Toxicological sciences : an official journal of the Society of Toxicology 20021201

• Metabolic regulation of collagen I in fibroblasts isolated from normal peritoneum and adhesions by dichloroacetic acid.

  American journal of obstetrics and gynecology 20021201

• Brief increase in carbohydrate oxidation after reperfusion reverses myocardial stunning in conscious pigs.

  Circulation 20021126

• Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats.

  Carcinogenesis 20021101

• Mass spectral characterization of dichloroacetic acid-modified human glutathione transferase zeta.

  Chemical research in toxicology 20021101

• The use of partial fatty acid oxidation inhibitors for metabolic therapy of angina pectoris and heart failure.

  Herz 20021101

• Time-resolved optical Kerr-effect spectroscopy of low-frequency dynamics in Di-L-alanine, poly-L-alanine, and lysozyme in solution.

  Journal of the American Chemical Society 20021016

• The acetyl group deficit at the onset of contraction in ischaemic canine skeletal muscle.

  The Journal of physiology 20021015

• [Acute complications due to diabetes mellitus: Lactic acidosis].

  Nihon rinsho. Japanese journal of clinical medicine 20021001

• Is lactate a mediator of hypoxia-induced anapyrexia?

  Pflugers Archiv : European journal of physiology 20020901

• Dichloroacetate stimulates glycogen accumulation in primary hepatocytes through an insulin-independent mechanism.

  Toxicological sciences : an official journal of the Society of Toxicology 20020801

• Low-dose pharmacokinetics and oral bioavailability of dichloroacetate in naive and GST-zeta-depleted rats.

  Environmental health perspectives 20020801

• Synthesis of optically active homocysteine from methionine and its use in preparing four stereoisomers of cystathionine.

  Chemical & pharmaceutical bulletin 20020801

• Skeletal muscle metabolism is unaffected by DCA infusion and hyperoxia after onset of intense aerobic exercise.

  American journal of physiology. Endocrinology and metabolism 20020701

• Bromochloroacetic acid exerts qualitative effects on rat sperm: implications for a novel biomarker.

  Toxicological sciences : an official journal of the Society of Toxicology 20020701

• Manipulations in glycogen metabolism and the failure to influence infarct size in the ischaemic rabbit heart.

  European journal of anaesthesiology 20020701

• Kinetics of the biotransformation of maleylacetone and chlorofluoroacetic acid by polymorphic variants of human glutathione transferase zeta (hGSTZ1-1).

  Chemical research in toxicology 20020701

• Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene.

  Toxicology and applied pharmacology 20020701

• Solar photodegradation of dichloroacetic acid and 2,4-dichlorophenol using an enhanced photo-Fenton process.

  Chemosphere 20020701

• Dichloroacetate therapy in Leigh syndrome with a mitochondrial T8993C mutation.

  Pediatric neurology 20020701

• Glutathione and K(+) channel remodeling in postinfarction rat heart.

  American journal of physiology. Heart and circulatory physiology 20020601

• Immunohistochemical localization and activity of glutathione transferase zeta (GSTZ1-1) in rat tissues.

  Drug metabolism and disposition: the biological fate of chemicals 20020601

• Dichloroacetate toxicokinetics and disruption of tyrosine catabolism in B6C3F1 mice: dose-response relationships and age as a modifying factor.

  Toxicology 20020501

• Alkylation and inactivation of human glutathione transferase zeta (hGSTZ1-1) by maleylacetone and fumarylacetone.

  Chemical research in toxicology 20020501

• Distribution of haloacetic acids in the water columns of the Laurentian Great Lakes and Lake Malawi.

  Environmental science & technology 20020501

• New large solar photocatalytic plant: set-up and preliminary results.

  Chemosphere 20020401

• [Drug therapy for mitochondrial diseases].

  Nihon rinsho. Japanese journal of clinical medicine 20020401

• An acetyl group deficit limits mitochondrial ATP production at the onset of exercise.

  Biochemical Society transactions 20020401

• Genetic polymorphisms in assessing interindividual variability in delivered dose.

  Regulatory toxicology and pharmacology : RTP 20020401

• Glucose-stimulated insulin secretion does not require activation of pyruvate dehydrogenase: impact of adenovirus-mediated overexpression of PDH kinase and PDH phosphate phosphatase in pancreatic islets.

  Biochemical and biophysical research communications 20020308

• Pyruvate dehydrogenase and the regulation of glucose oxidation in hypertrophied rat hearts.

  Cardiovascular research 20020301

• High levels of fatty acids delay the recovery of intracellular pH and cardiac efficiency in post-ischemic hearts by inhibiting glucose oxidation.

  Journal of the American College of Cardiology 20020220

• Measurement of interstitial lactate during hypoxia-induced dilatation in isolated pressurised porcine coronary arteries.

  The Journal of physiology 20020215

• Monochloramine loss in the presence of humic acid.

  Journal of environmental monitoring : JEM 20020201

• Degradation pathways of trichloroethylene and 1,1,1-trichloroethane by Mycobacterium sp. TA27.

  Bioscience, biotechnology, and biochemistry 20020201

• Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels.

  Circulation 20020115

• Enhanced pyruvate dehydrogenase activity does not affect muscle O2 uptake at onset of intense exercise in humans.

  American journal of physiology. Regulatory, integrative and comparative physiology 20020101

• Oxygen uptake on-kinetics in dog gastrocnemius in situ following activation of pyruvate dehydrogenase by dichloroacetate.

  The Journal of physiology 20020101

• Renal manifestations of congenital lactic acidosis.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20020101

• Mouse models of Huntington's disease.

  Trends in pharmacological sciences 20020101

• Analysis of the cytotoxicity and mutagenicity of drinking water disinfection by-products in Salmonella typhimurium.

  Teratogenesis, carcinogenesis, and mutagenesis 20020101

• Mammalian cell cytotoxicity and genotoxicity analysis of drinking water disinfection by-products.

  Environmental and molecular mutagenesis 20020101

• Trichloroethylene oxidative metabolism in plants: the trichloroethanol pathway.

  Phytochemistry 20011201

• GSTZ1d: a new allele of glutathione transferase zeta and maleylacetoacetate isomerase.

  Pharmacogenetics 20011101

• Dichloroacetate reduces diaphragmatic lactate formation but impairs respiratory performance.

  American journal of respiratory and critical care medicine 20011101

• Effect of chloroform on dichloroacetic acid and trichloroacetic acid-induced hypomethylation and expression of the c-myc gene and on their promotion of liver and kidney tumors in mice.

  Carcinogenesis 20010901

• Stereospecific toxicokinetics of bromochloro- and chlorofluoroacetate: effect of GST-zeta depletion.

  Toxicology and applied pharmacology 20010901

• Changes of activity inducing chromosomal aberrations and transformations of chlorinated humic acid.

  Water research 20010801

• Detection of early gene expression changes by differential display in the livers of mice exposed to dichloroacetic acid.

  Carcinogenesis 20010801

• Nerve conduction changes in patients with mitochondrial diseases treated with dichloroacetate.

  Muscle & nerve 20010701

• Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease.

  Annals of neurology 20010701

• Hepatic and renal toxicities associated with perchloroethylene.

  Pharmacological reviews 20010601

• Pyruvate/dichloroacetate supply during reperfusion accelerates recovery of cardiac energetics and improves mechanical function following cardioplegic arrest.

  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20010601

• Oxygen supply and oxidative phosphorylation limitation in rat myocardium in situ.

  American journal of physiology. Heart and circulatory physiology 20010501

• Postischemic Na(+)-K(+)-ATPase reactivation is delayed in the absence of glycolytic ATP in isolated rat hearts.

  American journal of physiology. Heart and circulatory physiology 20010501

• Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders.

  Annals of neurology 20010501

• Exercise intolerance in mitochondrial myopathy is not related to lactic acidosis.

  Annals of neurology 20010501

• Dichloroacetate improves cardiac efficiency after ischemia independent of changes in mitochondrial proton leak.

  American journal of physiology. Heart and circulatory physiology 20010401

• Direct imaging of dehydrogenase activity within living cells using enzyme-dependent fluorescence recovery after photobleaching (ED-FRAP).

  Biophysical journal 20010401

• Identification of novel glutathione transferases and polymorphic variants by expressed sequence tag database analysis.

  Drug metabolism and disposition: the biological fate of chemicals 20010401

• Haloacetates in fog and rain.

  Environmental science & technology 20010401

• Dichloroacetate: population pharmacokinetics with a pharmacodynamic sequential link model.

  Journal of clinical pharmacology 20010301

• Study on the cytochrome P-450- and glutathione-dependent biotransformation of trichloroethylene in humans.

  International archives of occupational and environmental health 20010301

• Photocatalytic degradation of gaseous perchloroethylene: products and pathway.

  Chemosphere 20010201

• Dichloroacetate treatment for severe refractory metabolic acidosis during neonatal sepsis.

  The Pediatric infectious disease journal 20010201

• Lactic acidosis update for critical care clinicians.

  Journal of the American Society of Nephrology : JASN 20010201

• Diffusion-weighted image and MR spectroscopic analysis of a case of MELAS with repeated attacks.

  Yonsei medical journal 20010201

• The fate and persistence of trifluoroacetic and chloroacetic acids in pond waters.

  Chemosphere 20010101

• Effects of dichloroacetate (DCA) on serum insulin levels and insulin-controlled signaling proteins in livers of male B6C3F1 mice.

  Toxicological sciences : an official journal of the Society of Toxicology 20010101

• The effect of dichloroacetic acid and trichloroacetic acid on DNA methylation and cell proliferation in B6C3F1 mice.

  Journal of biochemical and molecular toxicology 20010101

• Differential effects of dihalogenated and trihalogenated acetates in the liver of B6C3F1 mice.

  Journal of applied toxicology : JAT 20010101

• Lack of IL-6 production during exercise in patients with mitochondrial myopathy.

  European journal of applied physiology 20010101

• [Benign infantile mitochondrial myopathy].

  Ryoikibetsu shokogun shirizu 20010101

• Novel mutations in a boy with dihydrolipoamide dehydrogenase deficiency.

  Medical science monitor : international medical journal of experimental and clinical research 20010101

• Solar detoxification of wastewater in a novel aerated cascade photoreactor (ACP).

  Water science and technology : a journal of the International Association on Water Pollution Research 20010101

• Use of structure-activity relationships for probing biochemical mechanisms: glutathione transferase zeta conjugation of haloacids.

  Advances in experimental medicine and biology 20010101

• Trichloroethylene, trichloroacetic acid, and dichloroacetic acid: do they affect fetal rat heart development?

  International journal of toxicology 20010101

• Gene transfer and metabolic modulators as new therapies for pulmonary hypertension. Increasing expression and activity of potassium channels in rat and human models.

  Advances in experimental medicine and biology 20010101

• Role of metabolically active drugs in the management of ischemic heart disease.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20010101

• Effect of trichloroethylene and its metabolites, dichloroacetic acid and trichloroacetic acid, on the methylation and expression of c-Jun and c-Myc protooncogenes in mouse liver: prevention by methionine.

  Toxicological sciences : an official journal of the Society of Toxicology 20000401

• Discovery of a functional polymorphism in human glutathione transferase zeta by expressed sequence tag database analysis.

  Pharmacogenetics 20000201

• The effect of the trichloroethylene metabolites trichloroacetate and dichloroacetate on peroxisome proliferation and DNA synthesis in cultured human hepatocytes.

  Cell biology and toxicology 20000101

• Expression of PPAR(alpha) in human hepatocytes and activation by trichloroacetate and dichloroacetate.

  Research communications in molecular pathology and pharmacology 20000101

• trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals.

  Toxicology and applied pharmacology 19991201

• Inhibition of glutathione S-transferase zeta and tyrosine metabolism by dichloroacetate: a potential unifying mechanism for its altered biotransformation and toxicity.

  Biochemical and biophysical research communications 19990907

• Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids.

  Environmental health perspectives 19980801

• Loss of heterozygosity on chromosome 6 in dichloroacetic acid and trichloroacetic acid-induced liver tumors in female B6C3F1 mice.

  Cancer letters 19961129

• Effects of chemical pretreatment on posttraumatic cortical edema in the rat.

  The American journal of emergency medicine 19960101

• ras proto-oncogene activation in dichloroacetic acid-, trichloroethylene- and tetrachloroethylene-induced liver tumors in B6C3F1 mice.

  Carcinogenesis 19941001

• The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver.

  Toxicology and applied pharmacology 19870915

• Toxic effects of chlorinated and brominated alkanoic acids on Pseudomonas putida PP3: selection at high frequencies of mutations in genes encoding dehalogenases.

  Applied and environmental microbiology 19850601