79286-79-6 | pyrrolidin-3-amine

Packsize	Purity	Availability	Price	Discounted Price
250mg	95%	in stock	$76.00	$53.00
1g	97%	in stock	$106.00	$75.00
5g	>99.0%(GC)(T)	in stock	$129.00	$90.00
25g	>99.0%(GC)(T)	in stock	$385.00	$270.00

Description

• Catalog Number: AB64324
• Chemical Name: pyrrolidin-3-amine
• CAS Number: 79286-79-6
• Molecular Formula: C4H10N2
• Molecular Weight: 86.1356
• MDL Number: MFCD00059018
• SMILES: NC1CNCC1

Computed Properties

• Complexity: 44.8
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 6
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 2
• Undefined Atom Stereocenter Count: 1
• XLogP3: -0.9

Literature

• Structural insights from binding poses of CCR2 and CCR5 with clinically important antagonists: a combined in silico study.

  PloS one 20120101

• 3D-QSAR studies on CCR2B receptor antagonists: Insight into the structural requirements of (R)-3-aminopyrrolidine series of molecules based on CoMFA/CoMSIA models.

  Journal of pharmacy & bioallied sciences 20120101

• Metabolic profiling of the protozoan parasite Entamoeba invadens revealed activation of unpredicted pathway during encystation.

  PloS one 20120101

• Semi-quantitative analyses of metabolic systems of human colon cancer metastatic xenografts in livers of superimmunodeficient NOG mice.

  Analytical and bioanalytical chemistry 20110601

• Exploration of (S)-3-aminopyrrolidine as a potentially interesting scaffold for discovery of novel Abl and PI3K dual inhibitors.

  European journal of medicinal chemistry 20110401

• Design of selective, ATP-competitive inhibitors of Akt.

  Journal of medicinal chemistry 20100624

• Synthesis and biological evaluation of 3-aminopyrrolidine derivatives as CC chemokine receptor 2 antagonists.

  Bioorganic & medicinal chemistry letters 20100401

• Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit.

  European journal of medicinal chemistry 20090701

• Elucidation of binding sites of dual antagonists in the human chemokine receptors CCR2 and CCR5.

  Molecular pharmacology 20090601

• Synthesis and antimalarial activity of new amino analogues of amodiaquine.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20080901

• Dual-targeting properties of the 3-aminopyrrolidyl quinolones, DC-159a and sitafloxacin, against DNA gyrase and topoisomerase IV: contribution to reducing in vitro emergence of quinolone-resistant Streptococcus pneumoniae.

  The Journal of antimicrobial chemotherapy 20080701

• Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series.

  Bioorganic & medicinal chemistry letters 20080315

• New insight for fluoroquinophenoxazine derivatives as possibly new potent topoisomerase I inhibitor.

  Bioorganic & medicinal chemistry letters 20080215

• 3-Aminopyrrolidines from alpha-aminoacids: total synthesis of (+)-nemonapride from D-alanine.

  The Journal of organic chemistry 20080201

• Palladium-mediated N-arylation of heterocyclic diamines: insights into the origin of an unusual chemoselectivity.

  The Journal of organic chemistry 20070316

• Enantioselective conjugate addition of a lithium ester enolate catalyzed by chiral lithium amides.

  Organic letters 20061207

• Identification of substituted 4-aminopiperidines and 3-aminopyrrolidines as potent MCH-R1 antagonists for the treatment of obesity.

  Bioorganic & medicinal chemistry letters 20061015

• Bis(aminopyrrolidine)-derived ureas (APUs) as potent MCH1 receptor antagonists.

  Bioorganic & medicinal chemistry letters 20050215

• Palladium-mediated arylation of 3-aminopiperidines and 3-aminopyrrolidines.

  The Journal of organic chemistry 20041210

• Design and synthesis of novel biologically active thrombin receptor non-peptide mimetics based on the pharmacophoric cluster Phe/Arg/NH2 of the Ser42-Phe-Leu-Leu-Arg46 motif sequence: platelet aggregation and relaxant activities.

  Journal of medicinal chemistry 20040617

• A NMR and theoretical study of the aggregates between alkyllithium and chiral lithium amides: control of the topology through a single asymmetric center.

  Journal of the American Chemical Society 20021225

• Synthesis and structure-activity relationships of novel 7-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids as antitumor agents. Part 1.

  Journal of medicinal chemistry 20021205