79642-50-5 | Disuccinimidyl glutarate

Packsize	Purity	Availability	Price	Discounted Price
100mg	98%	in stock	$12.00	$8.00
250mg	98%	in stock	$18.00	$12.00
1g	98%	in stock	$48.00	$33.00
5g	98%	in stock	$198.00	$138.00
10g	98%	in stock	$341.00	$239.00
25g	98%	in stock	$667.00	$467.00

Description

• Catalog Number: AC34553
• Chemical Name: Disuccinimidyl glutarate
• CAS Number: 79642-50-5
• Molecular Formula: C13H14N2O8
• Molecular Weight: 326.2589
• MDL Number: MFCD00153597
• SMILES: O=C(ON1C(=O)CCC1=O)CCCC(=O)ON1C(=O)CCC1=O

Computed Properties

• Complexity: 503
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 23
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 8
• XLogP3: -1.5

Upstream Synthesis Route

Disuccinimidyl glutarate, also known as DSG, is a versatile chemical reagent commonly used in chemical synthesis processes. It functions as a crosslinking agent that forms stable amide bonds between primary amines, making it a valuable tool in the field of bioconjugation and protein chemistry. In chemical synthesis, DSG plays a crucial role in linking biomolecules such as peptides, proteins, and antibodies to solid surfaces or other molecules. This enables the creation of conjugates that retain the biological activity of the individual components while facilitating their study or manipulation in various research applications. Furthermore, DSG's ability to selectively react with primary amines in physiological conditions makes it a preferred choice for creating stable conjugates in biological systems. Its high water solubility and mild reaction conditions ensure minimal interference with the structure and function of biomolecules, making it a versatile tool in the realms of drug delivery, diagnostics, and biomaterials.

Literature

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  Biochemistry 20070703

• Base sequence- and T m-dependent DNA oligomer separation by open tubular capillary columns carrying complementary DNA oligomers as probes.

  Analytical and bioanalytical chemistry 20070601

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  Bioconjugate chemistry 20050101

• Lysine directed cross-linking of viral DNA-RNA:DNA hybrid substrate to the isolated RNase H domain of HIV-1 reverse transcriptase.

  Biochemistry 20040210

• Synthesis of the Lewis b hexasaccharide and HSA-conjugates thereof.

  Glycoconjugate journal 20040101

• Cross-linked hemoglobin as a potential membrane for an artificial red blood cell.

  Artificial cells, blood substitutes, and immobilization biotechnology 20010701

• Algorithms for identifying protein cross-links via tandem mass spectrometry.

  Journal of computational biology : a journal of computational molecular cell biology 20010101