80-70-6 | 1,1,3,3-Tetramethylguanidine

Packsize	Purity	Availability	Price	Discounted Price
5g	97%	in stock	$12.00	$8.00
25g	97%	in stock	$32.00	$22.00

Description

• Catalog Number: AB56851
• Chemical Name: 1,1,3,3-Tetramethylguanidine
• CAS Number: 80-70-6
• Molecular Formula: C5H13N3
• Molecular Weight: 115.1768
• MDL Number: MFCD00075588
• SMILES: CN(C(=N)N(C)C)C
• NSC Number: 148309

Computed Properties

• Complexity: 75.7
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 8
• Hydrogen Bond Acceptor Count: 1
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 2
• XLogP3: 0.4

Upstream Synthesis Route

1,1,3,3-Tetramethylguanidine, also known as TMG, is a versatile organic compound commonly used in chemical synthesis as a strong, non-nucleophilic base. Its unique structure and properties make it a valuable reagent in various reactions, particularly in organic transformations where high basicity and steric hindrance are required.In organic synthesis, TMG is frequently employed as a base catalyst in reactions such as deprotonation, elimination, and condensation. Due to its strong basicity and lack of nucleophilicity, TMG is an ideal choice for promoting reactions that involve sensitive functional groups or require precise control over selectivity. Its bulky structure helps to prevent unwanted side reactions by hindering unwanted interactions with neighboring functional groups or substrates.Additionally, 1,1,3,3-Tetramethylguanidine is often used in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals where the precise manipulation of reaction conditions is crucial to achieving high yields and selectivity. Its application extends to various organic transformations including the formation of carbon-carbon bonds, the activation of electrophiles, and the deprotection of functional groups.Overall, TMG plays a significant role in modern organic synthesis by providing chemists with a powerful tool to facilitate complex reactions with enhanced control and efficiency.

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