81-23-2 | Dehydrocholic acid

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$26.00	$18.00
5g	95%	in stock	$42.00	$30.00
25g	95%	in stock	$86.00	$60.00
100g	95%	in stock	$291.00	$204.00

Description

• Catalog Number: AB48169
• Chemical Name: Dehydrocholic acid
• CAS Number: 81-23-2
• Molecular Formula: C24H34O5
• Molecular Weight: 402.5238
• MDL Number: MFCD00066410
• SMILES: OC(=O)CC[C@H]([C@H]1CC[C@@H]2[C@]1(C)C(=O)C[C@H]1[C@H]2C(=O)C[C@H]2[C@]1(C)CCC(=O)C2)C
• NSC Number: 8796

Computed Properties

• Complexity: 756
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 8
• Heavy Atom Count: 29
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 4
• XLogP3: 2.6

Literature

• Novel whole-cell biocatalysts with recombinant hydroxysteroid dehydrogenases for the asymmetric reduction of dehydrocholic acid.

  Applied microbiology and biotechnology 20120901

• Biophysical investigations into the interactions of endotoxins with bile acids.

  Innate immunity 20120401

• Discovery of an entropically-driven small molecule streptavidin binder from nucleic acid-encoded libraries.

  Organic & biomolecular chemistry 20120227

• Preparation and characterization of uniform drug particles: dehydrocholic acid.

  Journal of colloid and interface science 20120215

• Using functional signatures to identify repositioned drugs for breast, myelogenous leukemia and prostate cancer.

  PLoS computational biology 20120201

• The role of the acquisition methods in the analysis of natural and synthetic steroids and cholic acids by gas chromatography-mass spectrometry.

  Journal of chromatography. A 20111111

• Improvement of oxaprozin solubility and permeability by the combined use of cyclodextrin, chitosan, and bile components.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20110801

• Identification, cloning, heterologous expression, and characterization of a NADPH-dependent 7β-hydroxysteroid dehydrogenase from Collinsella aerofaciens.

  Applied microbiology and biotechnology 20110401

• Differentiation of various traditional Chinese medicines derived from animal bile and gallstone: simultaneous determination of bile acids by liquid chromatography coupled with triple quadrupole mass spectrometry.

  Journal of chromatography. A 20110107

• Ursodeoxycholic acid is conjugated with taurine to promote secretin-stimulated biliary hydrocholeresis in the normal rat.

  PloS one 20110101

• Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes.

  Aging 20100701

• Thermodynamic and elastic fluctuation analysis of Langmuir mixed monolayers composed by dehydrocholic acid (HDHC) and didodecyldimethylammonium bromide (DDAB).

  Colloids and surfaces. B, Biointerfaces 20100101

• Surgical outcome in relation to duct size at the porta hepatis and the use of cholagogues in patients with biliary atresia.

  Tropical gastroenterology : official journal of the Digestive Diseases Foundation 20100101

• Study on bioactive compounds of in vitro cultured Calculus Suis and natural Calculus Bovis.

  Animal science journal = Nihon chikusan Gakkaiho 20091201

• Protective effect of bile acid derivatives in phalloidin-induced rat liver toxicity.

  Toxicology and applied pharmacology 20090815

• Acidic and basic solutions dissolve protein plugs made of lithostathine complicating choledochal cyst/pancreaticobiliary maljunction.

  Digestive diseases and sciences 20090701

• Spread mixed monolayers of deoxycholic and dehydrocholic acids at the air-water interface, effect of subphase pH. Characterization by axisymmetric drop shape analysis.

  Biophysical chemistry 20080101

• Magnetic resonance cholangiopancreatography: potential usefulness of dehydrocholic acid (DHCA) administration in the evaluation of anastomotic site.

  Hepato-gastroenterology 20080101

• Magnetic resonance cholangiopancreatography: potential usefulness of dehydrocholic acid (DHCA) administration in the evaluation of biliary disease.

  Hepato-gastroenterology 20080101

• A new approach for diagnosis of hepatolithiasis: magnetic resonance cholangiopancreatography: potential usefulness of dehydrocholic acid (DHCA) administration in the evaluation of hepatolithiasis.

  Hepato-gastroenterology 20080101

• Aqueous sodium dehydrocholate-sodium deoxycholate mixtures at low concentration.

  Journal of colloid and interface science 20071015

• Determination of critical micellar concentrations of cholic acid and its keto derivatives.

  Colloids and surfaces. B, Biointerfaces 20071001

• Regio- and stereoselective reductions of dehydrocholic acid.

  Steroids 20060601

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Bile acids directly augment caudal related homeobox gene Cdx2 expression in oesophageal keratinocytes in Barrett's epithelium.

  Gut 20060101

• A novel insulin derivative chemically modified with dehydrocholic acid: synthesis, characterization and biological activity.

  Biotechnology and applied biochemistry 20050801

• Sterol-derived hormone(s) controls entry into diapause in Caenorhabditis elegans by consecutive activation of DAF-12 and DAF-16.

  PLoS biology 20041001

• Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040908

• Choleretic activity and biliary elimination of lipids and bile acids induced by an artichoke leaf extract in rats.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20021201

• Spasmocanulase in irritable bowel syndrome.

  Saudi medical journal 20020901

• Carbonic anhydrase inhibitors. Preparation of potent sulfonamides inhibitors incorporating bile acid tails.

  Bioorganic & medicinal chemistry letters 20020617

• Choledocholithiasis in an infant of extremely low birthweight.

  Journal of paediatrics and child health 20020401

• Anodic electrochemical oxidation of cholic acid.

  Steroids 20010201

• Estradiol-17 beta-D-glucuronide (E-17G) cholestasis in perfused rat liver: fate of E-17G and choleretic responses to bile salts.

  Hepatology (Baltimore, Md.) 19900501

• 3 beta-Hydroxysteroid dehydrogenase of Ruminococcus sp. from human intestinal bacteria.

  Journal of biochemistry 19860501

• Cholestasis induced by estradiol-17 beta-D-glucuronide: mechanisms and prevention by sodium taurocholate.

  Hepatology (Baltimore, Md.) 19840101