817194-38-0 | GSK180736A

Packsize	Purity	Availability	Price	Discounted Price
1mg	99%	in stock	$23.00	$16.00
2mg	99%	in stock	$29.00	$20.00
5mg	99%	in stock	$36.00	$25.00
10mg	99%	in stock	$43.00	$30.00
50mg	99%	in stock	$110.00	$77.00
100mg	99%	in stock	$186.00	$130.00

Description

• Catalog Number: AX63947
• Chemical Name: GSK180736A
• CAS Number: 817194-38-0
• Molecular Formula: C19H16FN5O2
• Molecular Weight: 365.361
• MDL Number: MFCD30533616
• SMILES: O=C1NC(=C(C(N1)c1ccc(cc1)F)C(=O)Nc1ccc2c(c1)cn[nH]2)C

Computed Properties

• Complexity: 632
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 27
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 3
• Undefined Atom Stereocenter Count: 1
• XLogP3: 1.7

Literature

• Identification of potent Yes1 kinase inhibitors using a library screening approach.

  Bioorganic & medicinal chemistry letters 20130801

• Potent, selective and orally bioavailable dihydropyrimidine inhibitors of Rho kinase (ROCK1) as potential therapeutic agents for cardiovascular diseases.

  Journal of medicinal chemistry 20081113

• Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors.

  Journal of medicinal chemistry 20070111