819058-34-9 | 4-Amino-3-fluorophenylboronic acid pinacol ester

Packsize	Purity	Availability	Price	Discounted Price
100mg	95%	in stock	$6.00	$4.00
250mg	95%	in stock	$8.00	$5.00
1g	95%	in stock	$17.00	$12.00
5g	95%	in stock	$58.00	$40.00
10g	95%	in stock	$109.00	$76.00
25g	95%	in stock	$229.00	$160.00

Description

• Catalog Number: AB44819
• Chemical Name: 4-Amino-3-fluorophenylboronic acid pinacol ester
• CAS Number: 819058-34-9
• Molecular Formula: C12H17BFNO2
• Molecular Weight: 237.0783
• MDL Number: MFCD09033884
• SMILES: Nc1ccc(cc1F)B1OC(C(O1)(C)C)(C)C

Computed Properties

• Complexity: 282
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 17
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1

Upstream Synthesis Route

4-Amino-3-fluorophenylboronic acid, pinacol ester is a key reagent commonly employed in chemical synthesis for various applications. This compound serves as a valuable building block in advanced organic chemistry, particularly in the field of medicinal chemistry and drug development. Its unique structure and reactivity make it a versatile tool for the synthesis of complex molecules with high precision and efficiency.One of the main applications of 4-Amino-3-fluorophenylboronic acid, pinacol ester is in Suzuki-Miyaura cross-coupling reactions. This reaction is widely used in the formation of carbon-carbon bonds, allowing for the rapid and efficient construction of biaryl compounds. By utilizing this boronic acid derivative as a coupling partner, chemists can access a diverse range of functionalized biaryl motifs, which are prevalent in many pharmaceuticals and agrochemicals.Furthermore, 4-Amino-3-fluorophenylboronic acid, pinacol ester can also be used in transition metal-catalyzed C-H activation reactions. In this context, the boronic acid moiety acts as a directing group, enabling the selective functionalization of specific C-H bonds within a molecule. This strategy facilitates the late-stage modification of complex molecules and streamlines the synthesis of valuable intermediates for further elaboration.Overall, the strategic incorporation of 4-Amino-3-fluorophenylboronic acid, pinacol ester in chemical synthesis enables chemists to access diverse structural motifs and accelerate the development of novel compounds with potential biological activity.