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Epalrestat Stimulated Oxidative Stress, Inflammation, and Fibrogenesis in Mouse Liver.
Toxicological sciences : an official journal of the Society of Toxicology 20180601
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[Protective effect of epalrestat against high glucose-induced endothelial cell injuries].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20120601
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Progresses in the pursuit of aldose reductase inhibitors: the structure-based lead optimization step.
European journal of medicinal chemistry 20120501
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Antidiabetogenic oligostilbenoids and 3-ethyl-4-phenyl-3,4-dihydroisocoumarins from the bark of Shorea roxburghii.
Bioorganic & medicinal chemistry 20120115
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Design, synthesis, and biological evaluation of novel (1-thioxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acids as selective inhibitors for AKR1B1.
Bioorganic & medicinal chemistry 20120101
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1,2-Benzothiazine 1,1-dioxide carboxylate derivatives as novel potent inhibitors of aldose reductase.
Bioorganic & medicinal chemistry 20111201
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AKR1B10 induces cell resistance to daunorubicin and idarubicin by reducing C13 ketonic group.
Toxicology and applied pharmacology 20110815
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Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry 20110714
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Effects of lignans extracted from Eucommia ulmoides and aldose reductase inhibitor epalrestat on hypertensive vascular remodeling.
Journal of ethnopharmacology 20110107
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In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors.
Bioorganic & medicinal chemistry letters 20110101
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6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2.
Bioorganic & medicinal chemistry letters 20101001
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Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10.
Bioorganic & medicinal chemistry 20100401
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[Research progress in aldose reductase].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20100401
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Effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy in patients with type 2 diabetes, in relation to suppression of N(ɛ)-carboxymethyl lysine.
Journal of diabetes and its complications 20100101
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Aldose reductase inhibitors in the treatment of diabetic peripheral neuropathy: a review.
Journal of diabetes and its complications 20100101
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Tau protein and tau aggregation inhibitors.
Neuropharmacology 20100101
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Anti-ischaemic activity of an antioxidant aldose reductase inhibitor on diabetic and non-diabetic rat hearts.
The Journal of pharmacy and pharmacology 20100101
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Rhodanineacetic acid derivatives as potential drugs: preparation, hydrophobic properties and antifungal activity of (5-arylalkylidene-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)acetic acids.
Molecules (Basel, Switzerland) 20091020
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[Examination of questionnaires regarding diabetic peripheral neuropathy in epalrestat-treated patients and their usefulness in the treatment of the patients during the treatment course].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20091001
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[Inhibition effect of epalrestat on rat lens osmotic expansion].
Yao xue xue bao = Acta pharmaceutica Sinica 20091001
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Aldo-keto reductase family 1 member B10 promotes cell survival by regulating lipid synthesis and eliminating carbonyls.
The Journal of biological chemistry 20090925
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Docking and molecular dynamics studies toward the binding of new natural phenolic marine inhibitors and aldose reductase.
Journal of molecular graphics & modelling 20090901
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[Progress in therapy for and diagnosis of diabetic neuropathies].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20090410
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[Pathophysiology and treatment for diabetic neuropathy].
Rinsho shinkeigaku = Clinical neurology 20090401
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Aldose reductase inhibitor, epalrestat, reduces lipid hydroperoxides in type 2 diabetes.
Endocrine journal 20090101
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Inhibitory activities of prenylated flavonoids from Sophora flavescens against aldose reductase and generation of advanced glycation endproducts.
The Journal of pharmacy and pharmacology 20080901
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Stratified analyses for selecting appropriate target patients with diabetic peripheral neuropathy for long-term treatment with an aldose reductase inhibitor, epalrestat.
Diabetic medicine : a journal of the British Diabetic Association 20080701
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Upregulation of aldose reductase during foam cell formation as possible link among diabetes, hyperlipidemia, and atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 20080601
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Epalrestat: an aldose reductase inhibitor for the treatment of diabetic neuropathy.
Pharmacotherapy 20080501
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Design and synthesis of N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamides as aldose reductase inhibitors.
Bioorganic & medicinal chemistry 20080401
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Erigeroflavanone, a flavanone derivative from the flowers of Erigeron annuus with protein glycation and aldose reductase inhibitory activity.
Journal of natural products 20080401
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Aldose reductase inhibitor ONO-2235 restores the alterations of bladder nerve growth factor and neurotrophin receptor p75 genetic expression in streptozotocin induced diabetic rats.
The Journal of urology 20071101
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A long-term effect of epalrestat on motor conduction velocity of diabetic patients: ARI-Diabetes Complications Trial (ADCT).
Diabetes research and clinical practice 20070901
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Phenolic marine natural products as aldose reductase inhibitors.
Journal of natural products 20061001
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Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy: the 3-year, multicenter, comparative Aldose Reductase Inhibitor-Diabetes Complications Trial.
Diabetes care 20060701
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Three-year inhibition of aldose reductase on development of symptomatic neuropathy in diabetic patients.
Journal of the peripheral nervous system : JPNS 20060601
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Aldose reductase inhibition alters nodal Na+ currents and nerve conduction in human diabetics.
Neurology 20060523
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Permeability characteristics of novel aldose reductase inhibitors using rat jejunum in vitro.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060501
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Erythrocyte sorbitol level as a predictor of the efficacy of epalrestat treatment for diabetic peripheral polyneuropathy.
Journal of diabetes and its complications 20060101
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The role of sorbitol pathway and treatment effect of aldose reductase inhibitor ONO2235 in the up-regulation of cardiac M2-muscarinic receptors in streptozotocin-induced diabetic rats.
Neuroscience letters 20050701
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[Progress on the drug therapy for diabetic microangiopathies: aldose reductase inhibitor].
Nihon rinsho. Japanese journal of clinical medicine 20050601
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[Nerve flow dynamics in the pathogenesis of diabetic neuropathy].
Nihon rinsho. Japanese journal of clinical medicine 20050601
-
[Development of therapeutic agents for diabetic neuropathies].
Nihon rinsho. Japanese journal of clinical medicine 20050601
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Influence of the polyol pathway on norepinephrine transporter reduction in diabetic cardiac sympathetic nerves: implications for heterogeneous accumulation of MIBG.
European journal of nuclear medicine and molecular imaging 20050401
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Structures and aldose reductase inhibitory effects of bromophenols from the red alga Symphyocladia latiuscula.
Journal of natural products 20050401
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Effect of an aldose reductase inhibitor on esophageal dysfunction in diabetic patients.
Hepato-gastroenterology 20050101
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Anti-diabetic activities of fucosterol from Pelvetia siliquosa.
Archives of pharmacal research 20041101
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Alteration of urinary sorbitol excretion in WBN-kob diabetic rats - treatment with an aldose reductase inhibitor.
The Journal of endocrinology 20040601
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Aldose reductase structures: implications for mechanism and inhibition.
Cellular and molecular life sciences : CMLS 20040401
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[Effects of angiotensin II receptor blockers, angiotensin converting enzyme inhibitors, 3-hydroxy-3-methyl glutaryl (HMG) CoA reductase inhibitors, amlodipine and epalrestat on cultured basilar artery smooth muscle cell proliferation].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040301
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Effects of an aldose reductase inhibitor on gastroenteropathy in streptozotocin-diabetic rats.
Diabetes research and clinical practice 20031101
-
Effects of epalrestat, an aldose reductase inhibitor, on diabetic neuropathy and gastroparesis.
Internal medicine (Tokyo, Japan) 20030801
-
[Improved method of epalrestat synthesis].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20030801
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Substituted pyrrol-1-ylacetic acids that combine aldose reductase enzyme inhibitory activity and ability to prevent the nonenzymatic irreversible modification of proteins from monosaccharides.
Journal of medicinal chemistry 20030130
-
Polyol pathway and protein kinase C activity of rat Schwannoma cells.
Diabetes/metabolism research and reviews 20030101
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Effects of eparlestat on plasma levels of advanced glycation end products in patients with type 2 diabetes.
In vivo (Athens, Greece) 20030101
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Urinary sorbitol measurement and the effect of an aldose reductase inhibitor on its concentration in the diabetic state.
Journal of diabetes and its complications 20030101
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[Prevention and treatment of diabetic neuropathy].
Nihon rinsho. Japanese journal of clinical medicine 20021001
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Improvement of corneal fluorescein staining in post cataract surgery of diabetic patients by an oral aldose reductase inhibitor, ONO-2235.
The British journal of ophthalmology 20020801
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New flavonol oligoglycosides and polyacylated sucroses with inhibitory effects on aldose reductase and platelet aggregation from the flowers of Prunus mume.
Journal of natural products 20020801
-
Role of sorbitol in the up-regulation of urinary bladder M(2) muscarinic receptors in streptozotocin-induced diabetic rats.
Neurourology and urodynamics 20020101
-
Fidarestat (SNK-860), a potent aldose reductase inhibitor, normalizes the elevated sorbitol accumulation in erythrocytes of diabetic patients.
Journal of diabetes and its complications 20020101
-
Mechanisms of inhibitory activity of the aldose reductase inhibitor, epalrestat, on high glucose-mediated endothelial injury: neutrophil-endothelial cell adhesion and surface expression of endothelial adhesion molecules.
Journal of diabetes and its complications 20020101
-
Effects of renal sorbitol accumulation on urinary excretion of enzymes in hyperglycaemic rats.
Annals of clinical biochemistry 20010701
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Abnormal axonal inward rectifier in streptozocin-induced experimental diabetic neuropathy.
Brain : a journal of neurology 20010601
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Aldose reductase inhibition ameliorates pupillary light reflex and F-wave latency in patients with mild diabetic neuropathy.
Diabetes care 20010601
-
Pharmacological properties of fidarestat, a potent aldose reductase inhibitor, clarified by using sorbitol in human and rat erythrocytes.
Pharmacology 20010501
-
Glucose-induced hyperproliferation of cultured rat aortic smooth muscle cells through polyol pathway hyperactivity.
Diabetologia 20010401
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Expression of intercellular adhesion molecule-1 induced by high glucose concentrations in human aortic endothelial cells.
Life sciences 20010105
-
Long-term effect of epalrestat, an aldose reductase inhibitor, on the development of incipient diabetic nephropathy in Type 2 diabetic patients.
Journal of diabetes and its complications 20010101
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Therapeutic effects of aldose reductase inhibitor on experimental diabetic neuropathy through synthesis/secretion of nerve growth factor.
Experimental neurology 19980601
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Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.
Journal of medicinal chemistry 19850701