83881-52-1 | 2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid dihydrochloride

Packsize	Purity	Availability	Price	Discounted Price
100mg	98%	in stock	$15.00	$10.00
250mg	98%	in stock	$16.00	$11.00
1g	98%	in stock	$22.00	$15.00
5g	98%	in stock	$40.00	$28.00
25g	98%	in stock	$48.00	$33.00

Description

• Catalog Number: AC22505
• Chemical Name: 2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid dihydrochloride
• CAS Number: 83881-52-1
• Molecular Formula: C21H27Cl3N2O3
• Molecular Weight: 461.8096800000001
• MDL Number: MFCD00941428
• SMILES: OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1.Cl.Cl

Computed Properties

• Complexity: 443
• Covalently-Bonded Unit Count: 3
• Heavy Atom Count: 29
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 8
• Undefined Atom Stereocenter Count: 1

Literature

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• Treatment of chronic idiopathic urticaria with levamisole: a multicentre, randomized, double-blind, controlled trial.

  The Journal of international medical research 20090101

• Is silent sinusitis a cause of chronic urticaria in children?

  Asian Pacific journal of allergy and immunology 20090101

• Pharmacokinetics and bioequivalence study of two cetirizine hydrochloride formulations in healthy Chinese male volunteers.

  Arzneimittel-Forschung 20090101

• Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast.

  Drugs 20090101

• A new variant of the basophil activation test for allergen-induced basophil CD63 upregulation. The effect of cetirizine.

  Journal of investigational allergology & clinical immunology 20090101

• Formulation and evaluation of taste-masked levocetirizine dihydrochloride orally disintegrating tablets.

  PDA journal of pharmaceutical science and technology 20090101

• Comparison of hydrophilic interaction and reversed-phase liquid chromatography coupled with tandem mass spectrometric detection for the determination of three pharmaceuticals in human plasma.

  Biomedical chromatography : BMC 20081201

• Hydroxyzine and cetirizine pharmacokinetics and pharmacodynamics after oral and intravenous administration of hydroxyzine to healthy dogs.

  Veterinary dermatology 20081201

• Tinea capitis due to Trichophyton soudanense with a papular IDE reaction in Northern Italy.

  Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 20081201

• Clinical and immunologic effects of H1 antihistamine preventive medication during honeybee venom immunotherapy.

  The Journal of allergy and clinical immunology 20081101

• Levocetirizine in persistent allergic rhinitis: continuous or on-demand use? A pilot study.

  Current medical research and opinion 20081001

• Participation of histamine H3 receptors in experimental allergic rhinitis of mice.

  Journal of pharmacological sciences 20081001

• Levocetirizine modulates lymphocyte activation in patients with allergic rhinitis.

  Journal of pharmacological sciences 20081001

• The safety of cetirizine during pregnancy. A prospective observational cohort study.

  Reproductive toxicology (Elmsford, N.Y.) 20080901

• Cetirizine-induced dystonic reaction in a 6-year-old boy.

  Pediatric emergency care 20080901

• Efficacy comparison of levocetirizine vs montelukast in ragweed sensitized patients.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20080901

• Cetirizine in horses: pharmacokinetics and pharmacodynamics following repeated oral administration.

  Veterinary journal (London, England : 1997) 20080801

• Antihistamine effects on experimental middle ear inflammatory model.

  European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20080801

• Substance P is involved in the effect of histamine H3 receptor agonist, Sch 50971 on nasal allergic symptoms in mice.

  International immunopharmacology 20080801

• Fexofenadine effects on cognitive performance in aviators at ground level and simulated altitude.

  Aviation, space, and environmental medicine 20080801

• Evaluation of cetirizine hydrochloride-based therapeutic strategy for chronic urticaria.

  Nagoya journal of medical science 20080801

• Evaluation of the antihistamine effects of olopatadine, cetirizine and fexofenadine during a 24 h period: a double-blind, randomized, crossover, placebo-controlled comparison in skin responses induced by histamine iontophoresis.

  Archives of dermatological research 20080701

• A 12-week placebo-controlled study of rupatadine 10 mg once daily compared with cetirizine 10 mg once daily, in the treatment of persistent allergic rhinitis.

  Allergy 20080701

• [Dishen Qufeng Decoction for treating allergic rhinitis: a randomized controlled trial].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20080701

• Allergic rhinitis in family practice: the role of levocetirizine in clinical care.

  Postgraduate medicine 20080701

• Reversible parkinsonism and ataxia associated with high-dose octreotide.

  Neurology 20080610

• Quality of life in patients with facial steroid dermatitis before and after treatment.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20080601

• Pharmacokinetics of cetirizine in healthy cats.

  American journal of veterinary research 20080501

• Comparative bioavailability of two cetirizine tablet formulations in Indonesian healthy volunteers.

  International journal of clinical pharmacology and therapeutics 20080501

• A review of the role of levocetirizine as an effective therapy for allergic disease.

  Expert opinion on pharmacotherapy 20080401

• [Effect of integrative Chinese and Western medicine in treating chronic urticaria and its impact on interleukin-10 and interleukin-8 in peripheral blood].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20080401

• Analysis of disease-dependent sedative profiles of H(1)-antihistamines by large-scale surveillance using the visual analog scale.

  Methods and findings in experimental and clinical pharmacology 20080401

• [Effect of cetirizine hydrochloride on the expression of substance P receptor and cytokines production in human epidermal keratinocytes and dermal fibroblasts].

  Yao xue xue bao = Acta pharmaceutica Sinica 20080401

• Enantioseparation of cetirizine by sulfated-beta-cyclodextrin-mediated capillary electrophoresis.

  Journal of separation science 20080301

• Inhibition of allergen-induced wheal and flare reactions by levocetirizine and desloratadine.

  British journal of clinical pharmacology 20080201

• Stereoselective renal tubular secretion of levocetirizine and dextrocetirizine, the two enantiomers of the H1-antihistamine cetirizine.

  Fundamental & clinical pharmacology 20080201

• Determination of levocetirizine in human plasma by liquid chromatography-electrospray tandem mass spectrometry: application to a bioequivalence study.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080201

• Development and validation of a rapid RP-HPLC method for the determination of cetirizine or fexofenadine with pseudoephedrine in binary pharmaceutical dosage forms.

  Journal of pharmaceutical and biomedical analysis 20080122

• Differential responses to various classes of drugs in a model of allergic rhinitis in guinea pigs.

  Pulmonary pharmacology & therapeutics 20080101

• Anaphylaxis induced by Anisakis.

  Allergologia et immunopathologia 20080101

• My bills are headed lower.

  U.S. news & world report 20080101

• Xyzal (levocetirizine dihydrochloride).

  Skinmed 20080101

• Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine : a comparative review.

  Clinical pharmacokinetics 20080101

• Cetirizine, a histamine H1 receptor antagonist, decreases the first stage of orthodontic tooth movement in rats.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20080101

• Non-interventional study comparing treatment satisfaction in patients treated with antihistamines.

  Clinical drug investigation 20080101

• OTC product: Zyrtec and Zyrtec-D 12 hour.

  Journal of the American Pharmacists Association : JAPhA 20080101

• Efficacy of levocetirizine compared with montelukast in subjects with ragweed-induced seasonal allergic rhinitis in the Environmental Exposure Unit.

  Allergy and asthma proceedings 20080101

• Treatment of chronic urticaria with narrowband ultraviolet B phototherapy: a randomized controlled trial.

  Acta dermato-venereologica 20080101

• Oral montelukast and cetirizine for thyroid eye disease.

  Ophthalmic plastic and reconstructive surgery 20080101

• Physicochemical, pharmacological and pharmacokinetic properties of the zwitterionic antihistamines cetirizine and levocetirizine.

  Current medicinal chemistry 20080101

• [Hypocalcaemia in a patient presenting severe solar urticaria].

  Annales de dermatologie et de venereologie 20080101

• Comparative efficacy of levocetirizine, desloratidine and fexofenadine by histamine wheal suppression test.

  Indian journal of dermatology, venereology and leprology 20080101

• Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells.

  Allergy and asthma proceedings 20080101

• Quality of life in patients with persistent allergic rhinitis treated with montelukast alone or in combination with levocetirizine or desloratadine.

  Journal of investigational allergology & clinical immunology 20080101

• Histamine 2 blocker potentiates the effects of histamine 1 blocker in suppressing histamine-induced wheal.

  Indian journal of dermatology, venereology and leprology 20080101

• Levocetirizine (Xyzal) for allergic rhinitis and urticaria.

  The Medical letter on drugs and therapeutics 20071203

• Hybrid approach for the design of highly affine and selective dopamine D(3) receptor ligands using privileged scaffolds of biogenic amine GPCR ligands.

  Bioorganic & medicinal chemistry 20071201

• Early detection of adverse drug events within population-based health networks: application of sequential testing methods.

  Pharmacoepidemiology and drug safety 20071201

• Levocetirizine does not prolong the QT/QTc interval in healthy subjects: results from a thorough QT study.

  European journal of clinical pharmacology 20071101

• Effects of cyproheptadine and cetirizine on eosinophilic airway inflammation in cats with experimentally induced asthma.

  American journal of veterinary research 20071101

• Precolumn fluorescence labeling method for simultaneous determination of hydroxyzine and cetirizine in human serum.

  Biomedical chromatography : BMC 20071001

• Increasing the dose of cetirizine may lead to better control of chronic idiopathic urticaria: an open study of 21 patients.

  The British journal of dermatology 20071001

• Comparison of HPLC and CE methods for the determination of cetirizine dihydrochloride in human plasma samples.

  Biomedical chromatography : BMC 20070901

• Safety of levocetirizine treatment in young atopic children: An 18-month study.

  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20070901

• H1-antihistamine treatment in young atopic children: effect on urticaria.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20070901

• Peripheral and central H1 histamine receptor occupancy by levocetirizine, a non-sedating antihistamine; a time course study in the guinea pig.

  British journal of pharmacology 20070801

• Ionizing radiation induces degranulation of human mast cells and release of tryptase.

  International journal of radiation biology 20070801

• Depressive symptoms in urticaria patients treated with first- or second-generation histamine 1 receptor antagonists.

  Journal of clinical psychopharmacology 20070801

• A case of urticaria induced by both hydroxyzine and cetirizine but not by levocetirizine.

  Allergy 20070701

• The effect of antihistamine cetirizine on ventricular repolarization in congenital long QT syndrome.

  Journal of cardiovascular electrophysiology 20070701

• Spectrophotometric estimation of ambroxol and cetirizine hydrochloride from tablet dosage form.

  Pakistan journal of pharmaceutical sciences 20070701

• New hay fever, hives treatment approved.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070701

• Fixed drug eruption to cetirizine with positive lesional patch tests to the three piperazine derivatives.

  International journal of dermatology 20070701

• Stereoselective regulation of MDR1 expression in Caco-2 cells by cetirizine enantiomers.

  Chirality 20070601

• Cetirizine in horses: pharmacokinetics and effect of ivermectin pretreatment.

  Journal of veterinary pharmacology and therapeutics 20070601

• Relevance of H1-receptor occupancy to H1-antihistamine dosing in children.

  The Journal of allergy and clinical immunology 20070601

• Recurrent, pruritic dermal plaques and bullae. Diagnosis: eosinophilic cellulitis (Wells syndrome).

  Archives of dermatology 20070601

• [Efficacy and safety of Mizolastine in the treatment of perennial allergic rhinitis].

  Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery 20070601

• A new class of nitric oxide-releasing derivatives of cetirizine; pharmacological profile in vascular and airway smooth muscle preparations.

  British journal of pharmacology 20070501

• Anti-inflammatory pharmacotherapy for wheezing in preschool children.

  Pediatric pulmonology 20070501

• Transport characteristics of zolmitriptan in a human intestinal epithelial cell line Caco-2.

  The Journal of pharmacy and pharmacology 20070501

• Clinical efficacy and pharmacokinetic profiles of intranasal and oral cetirizine in a repeated allergen challenge model of allergic rhinitis.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20070401

• Acute episode or chronic problem?

  JAAPA : official journal of the American Academy of Physician Assistants 20070401

• Method development and validation for the simultaneous determination of cetirizine dihydrochloride, paracetamol, and phenylpropanolamine hydrochloride in tablets by capillary zone electrophoresis.

  Journal of pharmaceutical and biomedical analysis 20070219

• Development and evaluation of an efficient HPLC/MS/MS method for the simultaneous determination of pseudoephedrine and cetirizine in human plasma: application to phase-I pharmacokinetic study.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070201

• Evaluation of the effect of levocetirizine on nasal mucociliary clearance in allergic rhinitis patients by rhinoscintigraphy.

  Nuclear medicine communications 20070201

• False-positive serum tricyclic antidepressant concentrations using fluorescence polarization immunoassay due to the presence of hydroxyzine and cetirizine.

  Therapeutic drug monitoring 20070201

• Chronic unremitting urticaria: is the use of antihistamines above the licensed dose effective? A preliminary study of cetirizine at licensed and above-licensed doses.

  Clinical and experimental dermatology 20070101

• Combined mediator blockade or topical steroid for treating the unified allergic airway.

  Allergy 20070101

• Contractile properties of various histaprodifen derivatives in guinea pig isolated ileum and trachea.

  Pharmacology 20070101

• Histamine, but not leukotriene C4, is an essential mediator in cold urticaria wheals.

  Acta dermato-venereologica 20070101

• Inhibition of cytokine-induced expression of T-cell cytokines by antihistamines.

  Journal of investigational allergology & clinical immunology 20070101

• Comparative efficacy of cetirizine and levocetirizine in chronic idiopathic urticaria.

  The Journal of dermatological treatment 20070101

• A case of breastfeeding anaphylaxis.

  European annals of allergy and clinical immunology 20070101

• Ciprofloxacin-induced cholestatic jaundice.

  Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology 20070101

• Detection of serum histamine-releasing factors in a patient with idiopathic anaphylaxis and multiple drug allergy syndrome.

  Journal of investigational allergology & clinical immunology 20070101

• Turbidimetric carbamazepine immunoassay on the ADVIA 1650 and 2400 analyzers is free from interference of antihistamine drugs hydroxyzine and cetirizine.

  Journal of clinical laboratory analysis 20070101

• Construction of an environmental exposure unit and investigation of the effects of cetirizine hydrochloride on symptoms of cedar pollinosis in Japan.

  Journal of investigational allergology & clinical immunology 20070101

• Efficacy of montelukast for treating perennial allergic rhinitis.

  Allergy and asthma proceedings 20070101

• Cetirizine, doxepine, and hydroxyzine in the treatment of pruritus due to sulfur mustard: a randomized clinical trial.

  Cutaneous and ocular toxicology 20070101

• Comparison of antileukotrienes and antihistamines in the treatment of allergic rhinitis.

  American journal of rhinology 20070101

• Study of the EEG changes during the combined ingestion of alcohol and H1-antihistamines by using the wavelet transform.

  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 20070101

• Levocetirizine and cytokine production and apoptosis of human eosinophils.

  Allergy and asthma proceedings 20070101

• Not all ACE inhibitor related angioedema is always evident: a case which is misdiagnosed as panic attack and speech disorder.

  Allergologia et immunopathologia 20070101

• Levocetirizine: The latest treatment option for allergic rhinitis and chronic idiopathic urticaria.

  Allergy and asthma proceedings 20070101

• [Visual evoked potentials in the in evaluation of the safety profile of levocetirizine].

  Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20070101

• [Does new antihistamines characterize tachyphylaxis phenomenon?].

  Otolaryngologia polska = The Polish otolaryngology 20070101

• Paederus dermatitis in Sierra Leone.

  Dermatology online journal 20061210

• Cellular adhesion molecules in chronic urticaria: modulation of serum levels occurs during levocetirizine treatment.

  The British journal of dermatology 20061201

• Comment on severe arrhythmia as a result of the interaction of cetirizine and pilsicainide in a patient with renal insufficiency.

  Clinical pharmacology and therapeutics 20061201

• Design, synthesis and pharmacological screening of a series of N1-(substituted) aryl-5,7-dimethyl-2-(substituted)pyrido(2,3-d)-pyrimidin-4(3H)-ones as potential histamine H1-receptor antagonists.

  Journal of enzyme inhibition and medicinal chemistry 20061201

• Long QT syndrome in a patient with allergic rhinoconjunctivitis and auto-immune diabetes: focus on the choice of anti-H1 drugs.

  European annals of allergy and clinical immunology 20061201

• New antihistamines: a critical view.

  Jornal de pediatria 20061101

• Montelukast with desloratadine or levocetirizine for the treatment of persistent allergic rhinitis.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20061101

• [Inhibition of histamine-induced wheel after a recommended single dose administration of 10 mg cetirizine, 5 mg desloratadine, 120 i 180 mg fexofenadine, 5 mg levocetirizine and 10 mg loratadine--a randomized, double-blind, placebo controlled trial].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20061101

• [The effect of 5-days of cetirizine, desloratadine, fexofenadine 120 and 180 mg, levocetirizine, loratadine treatment on the histamine-induced skin reaction and skin blood flow--a randomized, double-blind, placebo controlled trial].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20061101

• [Cetirizine and respiratory tract infections in opinion of Polish doctors].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20061101

• Levocetirizine improves health-related quality of life and health status in persistent allergic rhinitis.

  Respiratory medicine 20061001

• Histamine is released following aminolevulinic acid-photodynamic therapy of human skin and mediates an aminolevulinic acid dose-related immediate inflammatory response.

  The Journal of investigative dermatology 20061001

• False-positive serum tricyclic antidepressant concentrations using fluorescence polarization immunoassay due to the presence of hydroxyzine and cetirizine.

  Therapeutic drug monitoring 20061001

• Sensitive bioassay for the simultaneous determination of pseudoephedrine and cetirizine in human plasma by liquid-chromatography-ion trap spectrometry.

  Journal of pharmaceutical and biomedical analysis 20060918

• Stereoselective pharmacokinetics of cetirizine in the guinea pig: role of protein binding.

  Biopharmaceutics & drug disposition 20060901

• Levocetirizine in persistent allergic rhinitis and asthma: effects on symptoms, quality of life and inflammatory parameters.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20060901

• Impact of azelastine nasal spray on symptoms and quality of life compared with cetirizine oral tablets in patients with seasonal allergic rhinitis.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20060901

• Comparison of cetirizine-pseudoephedrine and placebo in patients with seasonal allergic rhinitis and concomitant mild-to-moderate asthma: randomized, double-blind study.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20060901

• Facial thermography is a sensitive tool to determine antihistaminic activity: comparison of levocetirizine and fexofenadine.

  British journal of clinical pharmacology 20060801

• Pathophysiology of nasal obstruction and meta-analysis of early and late effects of levocetirizine.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20060801

• Study of the enantiomeric separation of oxfendazole and cetirizine using subcritical fluid chromatography on an amylose-based column.

  Journal of chromatography. A 20060721

• Influence of cetirizine and loratadine on granulocyte-macrophage colony-stimulating factor and interleukin-8 release in A549 human airway epithelial cells stimulated with interleukin-1beta.

  Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 20060601

• Chiral separation of cetirizine by capillary electrophoresis.

  Electrophoresis 20060601

• Efficacy and central nervous system impairment of newer-generation prescription antihistamines in seasonal allergic rhinitis.

  Southern medical journal 20060601

• A comparison of levocetirizine and desloratadine in the histamine-induced wheal and flare response in human skin in vivo.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20060601

• Recurrent syncope and anaphylaxis as presentation of systemic mastocytosis in a pediatric patient: case report and literature review.

  Journal of the American Academy of Dermatology 20060501

• Effects of levocetirizine as add-on therapy to fluticasone in seasonal allergic rhinitis.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20060501

• A case of discoid lupus erythematosus of the eyelid.

  The Journal of dermatology 20060501

• Safe medication prescribing and monitoring in the outpatient setting.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20060425

• Severe arrhythmia as a result of the interaction of cetirizine and pilsicainide in a patient with renal insufficiency: first case presentation showing competition for excretion via renal multidrug resistance protein 1 and organic cation transporter 2.

  Clinical pharmacology and therapeutics 20060401

• Levocetirizine in patients with chronic idiopathic urticaria: results of a multicenter clinical practice study.

  International journal of clinical pharmacology and therapeutics 20060401

• Levocetirizine is an effective treatment in patients suffering from chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled, parallel, multicenter study.

  International journal of dermatology 20060401

• Levocetirizine in the treatment of chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled study.

  The British journal of dermatology 20060301

• Evaluation of product switching after a state Medicaid program began covering loratadine OTC 1 year after market availability.

  Journal of managed care pharmacy : JMCP 20060301

• Mastocytic enterocolitis: increased mucosal mast cells in chronic intractable diarrhea.

  Archives of pathology & laboratory medicine 20060301

• Brain distribution of cetirizine enantiomers: comparison of three different tissue-to-plasma partition coefficients: K(p), K(p,u), and K(p,uu).

  Drug metabolism and disposition: the biological fate of chemicals 20060201

• Randomized placebo-controlled trial comparing montelukast and cetirizine for treating perennial allergic rhinitis in children aged 2-6 yr.

  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20060201

• Onset of action of a topical antihistamine as assessed by histamine challenge-induced plasma exudation responses.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20060201

• Effects of histamine H(1) receptor antagonists on depressive-like behavior in diabetic mice.

  Pharmacology, biochemistry, and behavior 20060201

• Cetirizine-induced dystonic movements.

  Neurology 20060110

• Potential clinical uses of cetirizine in dermatology.

  Medical hypotheses 20060101

• Familial aquagenic urticaria and bernard-soulier syndrome.

  Dermatology (Basel, Switzerland) 20060101

• Evaluation of the cognitive, psychomotor and pharmacokinetic profiles of rupatadine, hydroxyzine and cetirizine, in combination with alcohol, in healthy volunteers.

  Human psychopharmacology 20060101

• Repeated-dose effects of mequitazine, cetirizine and dexchlorpheniramine on driving and psychomotor performance.

  British journal of clinical pharmacology 20060101

• Theophylline as 'add-on' therapy to cetirizine in patients with chronic idiopathic urticaria. A randomized, double-blind, placebo-controlled pilot study.

  International archives of allergy and immunology 20060101

• A review of the evidence from comparative studies of levocetirizine and desloratadine for the symptoms of allergic rhinitis.

  Clinical therapeutics 20060101

• Maximum skin hyperaemia induced by local heating: possible mechanisms.

  Journal of vascular research 20060101

• Cetirizine as a novel weapon against reperfusion injury.

  Medical hypotheses 20060101

• The role of antihistamines in asthma management.

  Treatments in respiratory medicine 20060101

• Levocetirizine: a review of its use in the management of allergic rhinitis and skin allergies.

  Drugs 20060101

• Immunotherapy for patients with persistent allergic rhinitis unsatisfied with free chronic pharmacotherapy.

  Allergologia et immunopathologia 20060101

• In vivo pharmacological characterisation of bilastine, a potent and selective histamine H1 receptor antagonist.

  Drugs in R&D 20060101

• Levocetirizine for treatment of immediate and delayed mosquito bite reactions.

  Acta dermato-venereologica 20060101

• Oral montelukast monotherapy is ineffective in chronic idiopathic urticaria: a comparison with oral cetirizine.

  Indian journal of dermatology, venereology and leprology 20060101

• Levocetirizine as treatment for symptoms of seasonal allergic rhinitis.

  B-ENT 20060101

• Effect of levocetirizine on the contraction induced by histamine on isolated rabbit bronchioles from precision-cut lung slices.

  Pharmacology 20060101

• Comparison of the risk of drowsiness and sedation between levocetirizine and desloratadine: a prescription-event monitoring study in England.

  Drug safety 20060101

• Levocetirizine: an update.

  Current medicinal chemistry 20060101

• The histamine-induced enhanced expression of vascular cell adhesion molecule-1 by nasal polyp-derived fibroblasts is inhibited by levocetirizine.

  American journal of rhinology 20060101

• Clinicopathologic features of systemic contact dermatitis from ethylenediamine in cetirizine and levocetirizine.

  Dermatology (Basel, Switzerland) 20060101

• A randomized controlled trial of cetirizine plus pseudoephedrine versus loratadine plus pseudoephedrine for perennial allergic rhinitis.

  Asian Pacific journal of allergy and immunology 20060101

• Cost effectiveness of levocetirizine in chronic idiopathic urticaria : a pooled analysis of two randomised controlled trials.

  Clinical drug investigation 20060101

• Selecting the optimal oral antihistamine for patients with allergic rhinitis.

  Drugs 20060101

• Desloratadine and levocetirizine improve nasal symptoms, airflow, and allergic inflammation in patients with perennial allergic rhinitis: a pilot study.

  International immunopharmacology 20051201

• Skin lesions induced by bortezomib.

  Haematologica 20051201

• Cetirizine dihydrochloride interaction with some diclofenac complexes.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20051101

• Effects on symptoms and quality of life of hypertonic saline nasal spray added to antihistamine in persistent allergic rhinitis--a randomized controlled study.

  European annals of allergy and clinical immunology 20051101

• Effect of cetirizine dihydrochloride on the airway response to hypertonic saline aerosol in patients with chronic obstructive pulmonary disease (COPD).

  Respiratory medicine 20051001

• Oral allergy syndrome and contact urticaria to apples.

  Journal of the American Academy of Dermatology 20051001

• The various effects of four H1-antagonists on serum substance P levels in patients with atopic dermatitis.

  The Journal of dermatology 20051001

• A two-year course of specific immunotherapy or of continuous antihistamine treatment reverse eosinophilic inflammation in severe persistent allergic rhinitis.

  Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale 20051001

• Development and validation of a dissolution test for a once-a-day combination tablet of immediate-release cetirizine dihydrochloride and extended-release pseudoephedrine hydrochloride.

  Journal of pharmaceutical and biomedical analysis 20050915

• Fixed drug eruption: a novel side-effect of levocetirizine.

  International journal of dermatology 20050901

• [Effect of humectants on pharmaceutical availability and rheological properties of cetirizine-containing hydrogels].

  Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20050901

• Histamine H1 receptor occupancy and pharmacodynamics of second generation H1-antihistamines.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20050901

• Off-label prescribing to children: attitudes and experience of general practitioners.

  British journal of clinical pharmacology 20050801

• Management of seasonal allergic rhinitis: comparative efficacy of the newer-generation prescription antihistamines.

  Journal of the American Academy of Nurse Practitioners 20050801

• Levocetirizine: pharmacokinetics and pharmacodynamics in children age 6 to 11 years.

  The Journal of allergy and clinical immunology 20050801

• Assessing the therapeutic benefits of antihistamines for the treatment of chronic idiopathic urticaria--a requirement for well-designed comparative clinical studies.

  The Journal of dermatological treatment 20050801

• A new antihistamine levocetirizine inhibits eosinophil adhesion to vascular cell adhesion molecule-1 under flow conditions.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20050801

• Efficacy and safety of levocetirizine on symptoms and health-related quality of life of children with perennial allergic rhinitis: a double-blind, placebo-controlled randomized clinical trial.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20050801

• Levocetirizine has a longer duration of action on improving total nasal symptoms score than fexofenadine after single administration.

  British journal of clinical pharmacology 20050701

• A treatment for allergic rhinitis: a view on the role of levocetirizine.

  Current medical research and opinion 20050701

• Successful treatment of refractory recurrent vaginal candidiasis with cetirizine plus fluconazole.

  Journal of lower genital tract disease 20050701

• A review of the evidence from comparative studies of levocetirizine and desloratadine for the symptoms of allergic rhinitis.

  Clinical therapeutics 20050701

• [Effect of cetirizine hydrochloride on the expression of substance P in IgE-mediated triphasic cutaneous reaction].

  Yao xue xue bao = Acta pharmaceutica Sinica 20050701

• [Case of interstitial cystitis accompanied by food allergy].

  Arerugi = [Allergy] 20050701

• Determination and quantification of cetirizine HCl in dosage formulations by RP-HPLC.

  Pakistan journal of pharmaceutical sciences 20050701

• Costs associated with persistent allergic rhinitis are reduced by levocetirizine.

  Allergy 20050601

• Evaluation of pharmacokinetic interaction between cetirizine and ritonavir, an HIV-1 protease inhibitor, in healthy male volunteers.

  European journal of clinical pharmacology 20050601

• Potential of levocetirizine in the relief of nasal congestion.

  International journal of clinical practice 20050601

• Psychopharmacology news.

  Journal of child and adolescent psychopharmacology 20050601

• Bacillus clausii effects in children with allergic rhinitis.

  Allergy 20050501

• [Circadian rhythms in the toxic effects of the histamine antagonist cetirizine in mice].

  Pathologie-biologie 20050501

• Levocetirizine in children: evidenced efficacy and safety in a 6-week randomized seasonal allergic rhinitis trial.

  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20050501

• Cetirizine.

  Nursing times 20050501

• Effectiveness of azelastine nasal spray compared with oral cetirizine in patients with seasonal allergic rhinitis.

  Clinical therapeutics 20050501

• [Intervention of cetirizine on monocyte chemoattractant protein-1 in cutaneous inflammation].

  Yao xue xue bao = Acta pharmaceutica Sinica 20050501

• Drug-drug interaction between diclofenac, cetirizine and ranitidine.

  Journal of pharmaceutical and biomedical analysis 20050401

• Persistent skin colonization with Staphylococcus aureus in atopic dermatitis: relationship to clinical and immunological parameters.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20050401

• The efficacy of short-term administration of 3 antihistamines vs placebo under natural exposure to Japanese cedar pollen.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20050401

• Levocetirizine in 1-2 year old children: pharmacokinetic and pharmacodynamic profile.

  International journal of clinical pharmacology and therapeutics 20050401

• Narrow-bore high performance liquid chromatographic method for the determination of cetirizine in human plasma using column switching.

  Journal of pharmaceutical and biomedical analysis 20050309

• Histamine receptors that influence blockage of the normal human nasal airway.

  British journal of pharmacology 20050301

• Population pharmacokinetics of levocetirizine in very young children: the pediatricians' perspective.

  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20050301

• Hydroxyzine- and cetirizine-loaded liposomes: effect of duration of thin film hydration, freeze-thawing, and changing buffer pH on encapsulation and stability.

  Drug development and industrial pharmacy 20050301

• Cetirizine: An effective agent in Kimura's disease.

  Arthritis and rheumatism 20050215

• [Torsades de pointes caused by cetirizine overdose].

  Archives des maladies du coeur et des vaisseaux 20050201

• Comparison of allergen immunotherapy and drug treatment in seasonal rhinoconjunctivitis: a 3-years study.

  European annals of allergy and clinical immunology 20050201

• Automated 96-well solid phase extraction and hydrophilic interaction liquid chromatography-tandem mass spectrometric method for the analysis of cetirizine (ZYRTEC) in human plasma--with emphasis on method ruggedness.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050105

• Retrospective population pharmacokinetics of levocetirizine in atopic children receiving cetirizine: the ETAC study.

  British journal of clinical pharmacology 20050101

• [Oral second generation antihistamines in allergic rhinitis].

  Laryngo- rhino- otologie 20050101

• Levocetirizine improves nasal symptoms and airflow in patients with persistent allergic rhinitis: a pilot study.

  European annals of allergy and clinical immunology 20050101

• Urticarial reaction to the antihistamine levocetirizine dihydrochloride.

  Dermatology (Basel, Switzerland) 20050101

• Double-blind, crossover comparison of olopatadine and cetirizine versus placebo: suppressive effects on skin response to histamine iontophoresis.

  The Journal of dermatology 20050101

• Liquid chromatographic determination of cetirizine in oral formulations.

  Journal of AOAC International 20050101

• Rupatadine 10 mg and cetirizine 10 mg in seasonal allergic rhinitis: a randomised, double-blind parallel study.

  Journal of investigational allergology & clinical immunology 20050101

• Quantitative determination of cetirizine enantiomers in guinea pig plasma, brain tissue and microdialysis samples using liquid chromatography/tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20050101

• The effect of cetirizine on IFN-gamma and IL-10 production in children with allergic rhinitis.

  The Turkish journal of pediatrics 20050101

• Efficacy and safety of an oral formulation of cetirizine and prolonged-release pseudoephedrine versus budesonide nasal spray in the management of nasal congestion in allergic rhinitis.

  Treatments in respiratory medicine 20050101

• Theophylline as 'add-on' therapy in patients with delayed pressure urticaria: a prospective self-controlled study.

  International journal of immunopathology and pharmacology 20050101

• Comparative efficacy of cetirizine and fexofenadine for seasonal allergic rhinitis, 5-12 hours postdose, in the environmental exposure unit.

  Allergy and asthma proceedings 20050101

• An unusual presentation of mastocytosis: unilateral swelling of the vulva.

  Pediatric dermatology 20050101

• Fixed drug eruption due to levocetirizine.

  Indian journal of dermatology, venereology and leprology 20050101

• [Patient report: allergic rhinitis].

  Krankenpflege Journal 20050101

• Similar rapid onset of action and magnitude of effect of fexofenadine and cetirizine as assessed by inhibition of histamine-induced wheal-and-flare reaction.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20041201

• Effects of cetirizine on substance P release in patients with perennial allergic rhinitis.

  The Annals of otology, rhinology, and laryngology 20041201

• Electrooxidation of cetirizine dihydrochloride with a glassy carbon electrode.

  Die Pharmazie 20041201

• Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity.

  Bioorganic & medicinal chemistry letters 20041115

• Participation of chemical mediators in the development of experimental allergic conjunctivitis in rats.

  International immunopharmacology 20041101

• Recurrent acute hepatitis associated with use of cetirizine.

  The Annals of pharmacotherapy 20041101

• Cetirizine from topical phosphatidylcholine liposomes: evaluation of peripheral antihistaminic activity and systemic absorption in a rabbit model.

  Biopharmaceutics & drug disposition 20041101

• H1 histamine receptor mediates inflammatory responses in human keratinocytes.

  The Journal of allergy and clinical immunology 20041101

• An evaluation of the ocular drying effects of 2 systemic antihistamines: loratadine and cetirizine hydrochloride.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20041101

• Determination of cetirizine dihydrochloride, related impurities and preservatives in oral solution and tablet dosage forms using HPLC.

  Journal of pharmaceutical and biomedical analysis 20041029

• Comparison of the effects in the nose and skin of a single dose of desloratadine and levocetirizine over 24 hours.

  International archives of allergy and immunology 20041001

• Failure of cetirizine to prevent nevirapine-associated rash: a double-blind placebo-controlled trial for the GESIDA 26/01 Study.

  Journal of acquired immune deficiency syndromes (1999) 20041001

• Levocetirizine improves quality of life and reduces costs in long-term management of persistent allergic rhinitis.

  The Journal of allergy and clinical immunology 20041001

• Effects of bepotastine, cetirizine, fexofenadine, and olopatadine on histamine-induced wheal-and flare-response, sedation, and psychomotor performance.

  Clinical and experimental dermatology 20040901

• Modern histamine H1-receptor antagonists in the unified airway.

  The Journal of allergy and clinical immunology 20040901

• [Allergy to formaldehyde].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20040901

• Cetirizine from topical phosphatidylcholine-hydrogenated liposomes: evaluation of peripheral antihistaminic activity and systemic absorption in a rabbit model.

  The AAPS journal 20040810

• Antihistamines: do they work? Further well-controlled trials involving larger samples are needed.

  Allergy 20040801

• Central effects of fexofenadine and cetirizine: measurement of psychomotor performance, subjective sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography.

  Journal of clinical pharmacology 20040801

• Interactions between eotaxin, histamine and mast cells in early microvascular events associated with eosinophil recruitment to the site of allergic skin reactions in humans.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040801

• Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans.

  Fundamental & clinical pharmacology 20040801

• Single and short-term dosing effects of levocetirizine on adenosine monophosphate bronchoprovocation in atopic asthma.

  British journal of clinical pharmacology 20040701

• Levocetirizine: the allergist's arsenal grows larger.

  Expert opinion on pharmacotherapy 20040701

• Adverse ocular drug reactions recently identified by the National Registry of Drug-Induced Ocular Side Effects.

  Ophthalmology 20040701

• Congenital cutaneous mastocytosis.

  The Journal of pediatrics 20040701

• Is it important to correct apparent drug tissue concentrations for blood contamination in the dog?

  Fundamental & clinical pharmacology 20040601

• Cutaneous drug eruption from cetirizine and hydroxyzine.

  Journal of the American Academy of Dermatology 20040601

• Levocetirizine improves nasal obstruction and modulates cytokine pattern in patients with seasonal allergic rhinitis: a pilot study.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040601

• A direct comparison of the efficacy of antihistamines in SAR and PAR: randomised, placebo-controlled studies with levocetirizine and loratadine using an environmental exposure unit - the Vienna Challenge Chamber (VCC).

  Current medical research and opinion 20040601

• Comparative activity of cetirizine and desloratadine on histamine-induced wheal-and-flare responses during 24 hours.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20040601

• Cetirizine reduces cytokines and inflammatory cells in children with perennial allergic rhinitis.

  European annals of allergy and clinical immunology 20040601

• Antipruritic effects of two different 5-HT3 receptor antagonists and an antihistamine in haemodialysis patients.

  Experimental dermatology 20040501

• Treatment of canine atopic dermatitis with cetirizine, a second generation antihistamine: a single-blinded, placebo-controlled study.

  The Canadian veterinary journal = La revue veterinaire canadienne 20040501

• Comparative efficacy of wheal-and-flare suppression among various non-sedating antihistamines and the pharmacologic insights to their efficacy.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20040501

• Levocetirizine: a new selective H1 receptor antagonist for use in allergic disorders.

  Drugs of today (Barcelona, Spain : 1998) 20040501

• Assessment of cetirizine, an antihistamine, to prevent cutaneous reactions to nevirapine therapy: results of the viramune-zyrtec double-blind, placebo-controlled trial.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040415

• New drugs and dosage forms.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040415

• Retrospective population pharmacokinetic analysis of cetirizine in children aged 6 months to 12 years.

  British journal of clinical pharmacology 20040401

• Comparative effects of desloratadine, fexofenadine, and levocetirizine on nasal adenosine monophosphate challenge in patients with perennial allergic rhinitis.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040401

• Levocetirizine better protects than desloratadine in a nasal provocation with allergen.

  The Journal of allergy and clinical immunology 20040401

• Combined mediator antagonism for allergic rhinitis.

  Allergy 20040301

• Montelukast plus cetirizine in the prophylactic treatment of seasonal allergic rhinitis: influence on clinical symptoms and nasal allergic inflammation.

  Allergy 20040301

• Role of histamine release in nonspecific vasodilatation during anodal and cathodal iontophoresis.

  Microvascular research 20040301

• Cetirizine and allopurinol as novel weapons against cellular autoimmune disorders.

  International immunopharmacology 20040301

• The histamine H(1)-receptor antagonist cetirizine does not interact with bradykinin B(1) or B(2)-receptors in vitro.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20040301

• [Study on the enantiomer separation of cetirizine dihydrochloride using proteinate- and amylose-based chiral stationary phase].

  Yao xue xue bao = Acta pharmaceutica Sinica 20040301

• Central nervous system side effects of first- and second-generation antihistamines in school children with perennial allergic rhinitis: a randomized, double-blind, placebo-controlled comparative study.

  Pediatrics 20040201

• Oculogyric crisis in patients taking cetirizine.

  American journal of ophthalmology 20040201

• A dose-ranging study of the effects of mequitazine on actual driving, memory and psychomotor performance as compared to dexchlorpheniramine, cetirizine and placebo.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040201

• Randomized placebo-controlled trial comparing fluticasone aqueous nasal spray in mono-therapy, fluticasone plus cetirizine, fluticasone plus montelukast and cetirizine plus montelukast for seasonal allergic rhinitis.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040201

• Assessing patient satisfaction with desloratadine after conversion from loratadine, fexofenadine, or cetirizine.

  Managed care interface 20040201

• Comparative clinical efficacy, onset and duration of action of levocetirizine and desloratadine for symptoms of seasonal allergic rhinitis in subjects evaluated in the Environmental Exposure Unit (EEU).

  International journal of clinical practice 20040201

• Antihistamines added to an antileukotriene in treating seasonal allergic rhinitis: histamine and leukotriene antagonism.

  European annals of allergy and clinical immunology 20040201

• [Respiratory allergies in the child and the adult].

  La Revue du praticien 20040131

• Review of cetirizine hydrochloride for the treatment of allergic disorders.

  Expert opinion on pharmacotherapy 20040101

• The addition of zafirlukast to cetirizine improves the treatment of chronic urticaria in patients with positive autologous serum skin test results.

  The Journal of allergy and clinical immunology 20040101

• Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040101

• Comparative efficacy of cetirizine and fexofenadine in the treatment of chronic idiopathic urticaria.

  The Journal of dermatological treatment 20040101

• Cetirizine: a review of its use in allergic disorders.

  Drugs 20040101

• Randomized double-blind comparison of cetirizine and fexofenadine after pollen challenge in the Environmental Exposure Unit: duration of effect in subjects with seasonal allergic rhinitis.

  Allergy and asthma proceedings 20040101

• Onset of action for the relief of allergic rhinitis symptoms with second-generation antihistamines.

  Allergy and asthma proceedings 20040101

• Two cases of gynaecomastia with cetirizine, a second-generation antihistamine.

  Therapie 20040101

• Direct injection of solid-phase extraction eluents onto silica columns for the analysis of polar compounds isoniazid and cetirizine in plasma using hydrophilic interaction chromatography with tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20040101

• [Fatal suicidal intoxication with cetirizine in patient with anorexia--a case report].

  Przeglad lekarski 20040101

• Clinical study of the therapeutic efficacy and safety of emedastine difumarate versus cetirizine in the treatment of seasonal allergic rhinitis.

  Arzneimittel-Forschung 20040101

• Cold urticaria and infectious mononucleosis in children.

  Allergologia et immunopathologia 20040101

• Chronic urticaria: clinical aspects and focus on a new antihistamine, levocetirizine.

  Journal of drugs in dermatology : JDD 20040101

• [Effects of changes in conformation and configuration of N-containing compounds on NMR spactra].

  Yao xue xue bao = Acta pharmaceutica Sinica 20031201

• Epileptogenic activity induced by histamine H(1) antagonists in amygdala-kindled rats.

  Brain research 20031121

• An analysis of the association between preoperative renal dysfunction and outcome in cardiac surgery: estimated creatinine clearance or plasma creatinine level as measures of renal function.

  Chest 20031101

• Twenty-four-hour activity and consistency of activity of levocetirizine and desloratadine in the skin.

  British journal of clinical pharmacology 20031001

• P-glycoprotein influences the brain concentrations of cetirizine (Zyrtec), a second-generation non-sedating antihistamine.

  Journal of pharmaceutical sciences 20031001

• Compared pharmacological characteristics in humans of racemic cetirizine and levocetirizine, two histamine H1-receptor antagonists.

  Biochemical pharmacology 20031001

• Treatment of acquired cold urticaria with cetirizine and zafirlukast in combination.

  Journal of the American Academy of Dermatology 20031001

• Comparison of the effects of desloratadine and levocetirizine on histamine-induced wheal, flare and itch in human skin.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20031001

• Elevated substance P levels in nasal lavage fluids from patients with chronic nonproductive cough and increased cough sensitivity to inhaled capsaicin.

  The Journal of allergy and clinical immunology 20031001

• Is 3-mm less drowsiness important?

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20031001

• Fexofenadine hydrochloride, 180 mg, exhibits equivalent efficacy to cetirizine, 10 mg, with less drowsiness in patients with moderate-to-severe seasonal allergic rhinitis.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20031001

• Levocetirizine: new preparation. Me-too: simply the active enantiomer of cetirizine.

  Prescrire international 20031001

• [NMR studies on cetirizine hydrochloride].

  Yao xue xue bao = Acta pharmaceutica Sinica 20031001

• Levocetirizine is effective for symptom relief including nasal congestion in adolescent and adult (PAR) sensitized to house dust mites.

  Allergy 20030901

• Driving ability after acute and sub-chronic administration of levocetirizine and diphenhydramine: a randomized, double-blind, placebo-controlled trial.

  Psychopharmacology 20030801

• Evaluation of the efficacy of antihistamines using human monocyte-derived dendritic cells stimulated with histamine.

  Journal of the American Academy of Dermatology 20030801

• H1-antihistaminic activity of cetirizine and fexofenadine in allergic children.

  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20030601

• Safety of cetirizine in infants 6 to 11 months of age: a randomized, double-blind, placebo-controlled study.

  The Journal of allergy and clinical immunology 20030601

• Long-term cetirizine treatment may reduce new sensitisations in allergic children: a pilot study.

  European annals of allergy and clinical immunology 20030601

• [Clinical aspects of anti-inflammatory action of antihistamines].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20030601

• Histamine H1 receptor antagonism by cetirizine in isolated guinea pig tissues: influence of receptor reserve and dissociation kinetics.

  European journal of pharmacology 20030530

• [Antihistaminics. Side effects also after raising dosage at the placebo level].

  MMW Fortschritte der Medizin 20030529

• [In seasonal and perennial rhinitis. Superiority to standard H1 blockers].

  MMW Fortschritte der Medizin 20030529

• High dose cetirizine: a case report.

  Cutis 20030501

• The role of chemical mediators in eosinophil infiltration in allergic rhinitis in mice.

  International immunopharmacology 20030401

• Investigation of an unexplained skin disorder in a prison clinic in the Netherlands in 2002.

  Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20030401

• [H1 histamine antagonists].

  Revue medicale de Bruxelles 20030401

• Effects of second generation of histamine H1 antagonists, cetirizine and ebastine, on the antitussive and rewarding effects of dihydrocodeine in mice.

  Psychopharmacology 20030301

• P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists.

  Drug metabolism and disposition: the biological fate of chemicals 20030301

• The health-related quality of life effects of once-daily cetirizine HCl in patients with seasonal allergic rhinitis: a randomized double-blind, placebo-controlled trial.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20030301

• Acute and subchronic effects of levocetirizine and diphenhydramine on memory functioning, psychomotor performance, and mood.

  The Journal of allergy and clinical immunology 20030301

• Failure of cetirizine and fexofenadine to prevent motion sickness.

  The Annals of pharmacotherapy 20030201

• Comparative in vivo bioactivity of modern H1-antihistamines on AMP challenge in atopic asthma.

  The Journal of allergy and clinical immunology 20030201

• Plasma serotonin and histamine levels in hemodialysis-related pruritus are not significantly influenced by 5-HT3 receptor blocker and antihistaminic therapy.

  Clinical nephrology 20030201

• Comparative antiallergic effects of second-generation H1-antihistamines ebastine, cetirizine and loratadine in preclinical models.

  Arzneimittel-Forschung 20030101

• Cetirizine modulates adhesion molecule expression in a double-blind controlled study conducted in psoriatic patients.

  International journal of tissue reactions 20030101

• [Prevention of aspirin-induced angioedema with an association of leukotriene inhibitors and antihistamines].

  Annales de dermatologie et de venereologie 20030101

• Relationship between behavior and asthma in children with atopic dermatitis.

  Psychosomatic medicine 20030101

• Mast cell stabilization, lipoxygenase inhibition, hyaluronidase inhibition, antihistaminic and antispasmodic activities of Aller-7, a novel botanical formulation for allergic rhinitis.

  Drugs under experimental and clinical research 20030101

• [Efficacy of the medical treatment of adenoid hypertrophy in children with house dust mite allergy].

  Przeglad lekarski 20030101

• Roles of histamine in regulation of arousal and cognition: functional neuroimaging of histamine H1 receptors in human brain.

  Life sciences 20021220

• Facial swelling and eosinophilia in a 44-year-old woman.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20021201

• The comparison of the efficacy and safety of cetirizine, oxatomide, ketotifen, and a placebo for the treatment of childhood perennial allergic rhinitis.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20021201

• Blood distribution of levocetirizine, a new non-sedating histamine H1-receptor antagonist, in humans.

  Fundamental & clinical pharmacology 20021201

• The new antihistamines--desloratadine and levocetirizine: a review.

  Journal of drugs in dermatology : JDD 20021201

• Chronic urticaria and angioedema.

  The New England journal of medicine 20021121

• Multiple fixed drug eruptions due to cetirizine.

  The British journal of dermatology 20021101

• Possible role of histamine (H1- and H2-) receptors in the regulation of meningeal blood flow.

  British journal of pharmacology 20021101

• Publication bias with cetirizine in atopic dermatitis: safe but ineffective?

  The Journal of allergy and clinical immunology 20021101

• HLA-DR and ICAM-1 expression and modulation in epithelial cells from nasal polyps.

  The Laryngoscope 20021101

• Erythema gyratum repens responding to cetirizine hydrochloride.

  The Journal of dermatology 20021101

• [Cutaneous drug eruption with two antihistaminic drugs of a same chemical family: cetirizine and hydroxyzine].

  Annales de dermatologie et de venereologie 20021101

• Visual inspection of medications in preventing unexplained relapses.

  The Annals of pharmacotherapy 20021001

• Dermal objective pharmacodynamic profile of cetirizine and epinastine: two controlled, randomised, double-blind, crossover studies.

  International journal of clinical practice 20021001

• Anaphylactic reaction after cisatracurium administration.

  European journal of anaesthesiology 20020901

• Efficacy of ebastine, cetirizine, and loratadine in histamine cutaneous challenges.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20020901

• Participation of chemical mediators other than histamine in nasal allergy signs: a study using mice lacking histamine H(1) receptors.

  European journal of pharmacology 20020809

• Long-term evaluation of the impact of the h1-receptor antagonist cetirizine on the behavioral, cognitive, and psychomotor development of very young children with atopic dermatitis.

  Pediatric research 20020801

• Levetiracetam in autistic children: an open-label study.

  Journal of developmental and behavioral pediatrics : JDBP 20020801

• Cetirizine and levocetirizine inhibit eotaxin-induced eosinophil transendothelial migration through human dermal or lung microvascular endothelial cells.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20020801

• Long-term treatment with cetirizine of infants with atopic dermatitis: a multi-country, double-blind, randomized, placebo-controlled trial (the ETAC trial) over 18 months.

  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20020801

• Serum sickness and hepatitis B vaccine including review of the literature.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20020801

• Lack of effect of single and repeated doses of levocetirizine, a new antihistamine drug, on cognitive and psychomotor functions in healthy volunteers.

  British journal of clinical pharmacology 20020701

• Extractionless and sensitive method for high-throughput quantitation of cetirizine in human plasma samples by liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020625

• Comparison of cetirizine, ebastine and loratadine in the treatment of immediate mosquito-bite allergy.

  Allergy 20020601

• The Rx-to-OTC switch of Claritin, Allegra, and Zyrtec: an unprecedented FDA response to petitioners and the protection of public health.

  The American University law review 20020601

• Treating seasonal allergic rhinitis. Well designed experiments should have been used.

  BMJ (Clinical research ed.) 20020525

• Treating seasonal allergic rhinitis. Trial does not show that there is no difference between butterbur and cetirizine.

  BMJ (Clinical research ed.) 20020525

• Development and validation of a HPLC method for the determination of cetirizine in pharmaceutical dosage forms.

  Die Pharmazie 20020501

• Urticarial intolerance reaction to cetirizine.

  Clinical and experimental dermatology 20020501

• Acute hepatitis associated with cetirizine intake.

  Journal of clinical gastroenterology 20020401

• Binding characteristics of [3H]levocetirizine to cloned human H1-histamine-receptors expressed in CHO cells.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20020401

• Major role for the carboxylic function of cetirizine and levocetirizine in their binding characteristics to human H1-histamine-receptors.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20020401

• [The first case of lasting pigmented toxidermia induced by cetirizine (Zyrtec, Virlix) and ticlopidine].

  Annales de dermatologie et de venereologie 20020401

• [Already allergic to pollen in early childhood. Can future asthma still be prevented?].

  MMW Fortschritte der Medizin 20020307

• Comparative activity of cetirizine and mizolastine on histamine-induced skin wheal and flare responses at 24 h.

  British journal of clinical pharmacology 20020301

• Early treatment of perennial rhinitis with budesonide or cetirizine and its effect on long-term outcome.

  The Journal of allergy and clinical immunology 20020301

• Effects of emedastine and cetirizine, alone and with alcohol, on actual driving of males and females.

  Journal of psychopharmacology (Oxford, England) 20020301

• [Skin prick test results in snoring and sleep apnea patients].

  Laryngo- rhino- otologie 20020301

• Cardiotoxicity of new antihistamines and cisapride.

  Toxicology letters 20020227

• Binding characteristics of cetirizine and levocetirizine to human H(1) histamine receptors: contribution of Lys(191) and Thr(194).

  Molecular pharmacology 20020201

• A double-blind, randomized, single-dose, crossover comparison of levocetirizine with ebastine, fexofenadine, loratadine, mizolastine, and placebo: suppression of histamine-induced wheal-and-flare response during 24 hours in healthy male subjects.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20020201

• Are antihistamines useful in managing asthma?

  Current opinion in allergy and clinical immunology 20020201

• Randomised controlled trial of butterbur and cetirizine for treating seasonal allergic rhinitis.

  BMJ (Clinical research ed.) 20020119

• Cetirizine decreases interleukin-4, interleukin-5, and interferon-gamma gene expressions in nasal-associated lymphoid tissue of sensitized mice.

  American journal of rhinology 20020101

• Titrimetric and spectrophotometric assay of some antihistamines through the determination of the chloride of their hydrochlorides.

  Farmaco (Societa chimica italiana : 1989) 20020101

• Displacement of histamine from liver cells and cell components by ligands for cytochromes P450.

  Journal of cellular biochemistry 20020101

• [Comparative antihistamine and anti-allergic effects of various antihistamine preparations].

  Terapevticheskii arkhiv 20020101

• Applications of derivative UV spectrophotometry for the determinations of cetirizine dihydrochloride in pharmaceutical preparations.

  Acta poloniae pharmaceutica 20020101

• Pharmacokinetics of cetirizine in tear fluid after a single oral dose.

  Clinical pharmacokinetics 20020101

• Retrospective evaluation of cetirizine (zyrtec) ingestion.

  Journal of toxicology. Clinical toxicology 20020101

• Urticaria to cetirizine.

  Journal of investigational allergology & clinical immunology 20020101

• [Cold urticaria: review of 12 cases].

  Allergologia et immunopathologia 20020101

• The health-related quality of life effects of once-daily cetirizine HCl syrup in children with seasonal allergic rhinitis.

  Clinical pediatrics 20020101

• Comprehensive evaluation of cetirizine in the management of seasonal allergic rhinitis: impact on symptoms, quality of life, productivity, and activity impairment.

  Allergy and asthma proceedings 20020101

• Inhibition of the histamine wheal by ebastine compared with cetirizine, fexofenadine and loratadine at steady state.

  Drugs under experimental and clinical research 20020101

• A double-blinded, randomized, placebo-controlled trial of cetirizine in preventing the onset of asthma in children with atopic dermatitis: 18 months' treatment and 18 months' posttreatment follow-up.

  The Journal of allergy and clinical immunology 20011201

• Comparative onset of action and symptom relief with cetirizine, loratadine, or placebo in an environmental exposure unit in subjects with seasonal allergic rhinitis: confirmation of a test system.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20011201

• Inhibition of depolarization-induced [3H]noradrenaline release from SH-SY5Y human neuroblastoma cells by some second-generation H(1) receptor antagonists through blockade of store-operated Ca(2+) channels (SOCs).

  Biochemical pharmacology 20011101

• Efficacy and safety of an oral formulation of cetirizine and prolonged-release pseudoephedrine versus xylometazoline nasal spray in nasal congestion.

  Arzneimittel-Forschung 20011101

• Comparison of the effects of levocetirizine and loratadine on histamine-induced wheal, flare, and itch in human skin.

  Allergy 20011001

• Efficacy of leukotriene receptor antagonist in chronic urticaria. A double-blind, placebo-controlled comparison of treatment with montelukast and cetirizine in patients with chronic urticaria with intolerance to food additive and/or acetylsalicylic acid.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20011001

• The costs of nonsedating antihistamine therapy for allergic rhinitis in managed care: an updated analysis.

  The American journal of managed care 20011001

• Effects of topical corticosteroid and combined mediator blockade on domiciliary and laboratory measurements of nasal function in seasonal allergic rhinitis.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20011001

• Absorption, distribution, metabolism and excretion of [14C]levocetirizine, the R enantiomer of cetirizine, in healthy volunteers.

  European journal of clinical pharmacology 20011001

• Pharmacokinetics of cetirizine in chronic hemodialysis patients: multiple-dose study.

  Nephron 20010901

• Long-term cetirizine treatment reduces allergic symptoms and drug prescriptions in children with mite allergy.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20010901

• Cetirizine inhibits skin reactions but not mediator release in immediate and developing late-phase allergic cutaneous reactions. A double-blind, placebo-controlled study.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20010901

• Antiallergic/antiasthmatic effect of novel antiallergic hexapeptide-95/220 in various experimental models.

  Indian journal of experimental biology 20010901

• Absorption and disposition of levocetirizine, the eutomer of cetirizine, administered alone or as cetirizine to healthy volunteers.

  Fundamental & clinical pharmacology 20010801

• Severe hepatitis in a patient taking cetirizine.

  Annals of internal medicine 20010717

• Extractive spectrophotometric determination of ceterizine HCl in pharmaceutical preparations.

  Journal of pharmaceutical and biomedical analysis 20010701

• Double-blind multicenter study on the efficacy and tolerability of cetirizine compared with oxatomide in chronic idiopathic urticaria in preschool children.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20010701

• Distributions of results of cetirizine dihydrochloride assay in bulk material.

  International journal of pharmaceutics 20010619

• Stability indicating HPTLC method for the simultaneous determination of pseudoephedrine and cetirizine in pharmaceutical formulations.

  Journal of pharmaceutical and biomedical analysis 20010601

• Stanozolol in chronic urticaria: a double blind, placebo controlled trial.

  The Journal of dermatology 20010601

• Efficacy of nimesulide alone and in combination with cetirizine in acute allergic rhinitis.

  The Journal of the Association of Physicians of India 20010501

• Controlled comparison of the efficacy and safety of cetirizine 10 mg o.d. and fexofenadine 120 mg o.d. in reducing symptoms of seasonal allergic rhinitis.

  International archives of allergy and immunology 20010501

• A descriptive analysis of the use and cost of new-generation antihistamines in the treatment of allergic rhinitis: a retrospective database analysis.

  The American journal of managed care 20010501

• Acute urticaria with elevated circulating interleukin-6 is resistant to anti-histamine treatment.

  The Journal of dermatology 20010501

• Lipophilicity behaviour of the Zwitterionic antihistamine cetirizine in phosphatidylcholine liposomes/water systems.

  Pharmaceutical research 20010501

• Newer antihistamines.

  The Medical letter on drugs and therapeutics 20010430

• Effect of cetirizine, levocetirizine, and dextrocetirizine on histamine-induced nasal response in healthy adult volunteers.

  Allergy 20010401

• Prevention of acute urticaria in young children with atopic dermatitis.

  The Journal of allergy and clinical immunology 20010401

• Twenty-four hours of activity of cetirizine and fexofenadine in the skin.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20010401

• Do antihistamines have a role in asthma therapy?

  Pharmacotherapy 20010301

• An investigation into the effects of cetirizine on cognitive function and psychomotor performance in healthy volunteers.

  European journal of clinical pharmacology 20010301

• Sure outcomes of random events: a model for clinical trials.

  Statistics in medicine 20010227

• Effects of cetirizine and epinastine on the skin response to histamine iontophoresis.

  Journal of dermatological science 20010101

• Effect of cetirizine on bronchial hyperresponsiveness in patients with seasonal allergic rhinitis and asthma.

  Allergy 20010101

• A randomized, double-blind, crossover comparison among cetirizine, levocetirizine, and ucb 28557 on histamine-induced cutaneous responses in healthy adult volunteers.

  Allergy 20010101

• Urticaria induced by cetirizine.

  The British journal of dermatology 20010101

• Effects of monotherapy with intra-nasal corticosteroid or combined oral histamine and leukotriene receptor antagonists in seasonal allergic rhinitis.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20010101

• [Prednicarbate and cetirizin dihydrochloride in the treatment of atopic eczema in the acute phase in children].

  Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20010101

• A randomized trial of leukotriene receptor antagonist montelukast in moderate-to-severe atopic dermatitis of adults.

  European journal of dermatology : EJD 20010101

• Stability of cetirizine dihydrochloride in solid state.

  Acta poloniae pharmaceutica 20010101

• The comparison of the efficacy of fluticasone propionate with cetirizine in perennial allergic rhinitis.

  Allergologia et immunopathologia 20010101

• Burn wound itch control using H1 and H2 antagonists.

  The Journal of burn care & rehabilitation 20010101

• Cetirizine reduces the number of tryptase-positive mast cells in psoriatic patients: a double-blind controlled study.

  International journal of tissue reactions 20010101

• Dissociable effects of histamine H1 antagonists on reaction-time performance in rats.

  Pharmacology, biochemistry, and behavior 20010101

• Cetirizine/pseudoephedrine.

  Drugs 20010101

• Serum tryptase in allergic rhinitis: effect of cetirizine and fluticasone propionate treatment.

  La Clinica terapeutica 20010101

• [Efficacy and safety of fexofenadine and cetirizine in the treatment of allergic rhinitis].

  Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20010101

• Efficacy and safety of levocetirizine in seasonal allergic rhinitis.

  Acta oto-rhino-laryngologica Belgica 20010101

• The acute and sub-chronic effects of levocetirizine, cetirizine, loratadine, promethazine and placebo on cognitive function, psychomotor performance, and weal and flare.

  Current medical research and opinion 20010101

• Pharmacological blockade of ERG K(+) channels and Ca(2+) influx through store-operated channels exerts opposite effects on intracellular Ca(2+) oscillations in pituitary GH(3) cells.

  Molecular pharmacology 20001101

• Cetirizine-induce cholestasis.

  Journal of clinical gastroenterology 20001001

• Loratadine versus cetirizine: assessment of somnolence and motivation during the workday.

  Clinical therapeutics 20000501

• Sedation with 'non-sedating' antihistamines: four prescription-event monitoring studies in general practice.

  BMJ (Clinical research ed.) 20000429

• Antiallergic effects of H1-receptor antagonists.

  Allergy 20000101

• Risk of ventricular arrhythmias associated with nonsedating antihistamine drugs.

  British journal of clinical pharmacology 19990301

• Central nervous system effects of H1-receptor antagonists in the elderly.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 19990201

• Molecular basis for the lack of HERG K+ channel block-related cardiotoxicity by the H1 receptor blocker cetirizine compared with other second-generation antihistamines.

  Molecular pharmacology 19980701

• Comparative study between fluticasone propionate and cetirizine in the treatment of allergic rhinitis.

  Allergologia et immunopathologia 19980101

• The effect of cetirizine and loratadine on codeine-induced histamine release in human skin in vivo assessed by cutaneous microdialysis.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 19960901

• Inhibition of mediator release in RBL-2H3 cells by some H1-antagonist derived anti-allergic drugs: relation to lipophilicity and membrane effects.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 19950201

• The effect of antihistamines on the immediate allergic response: a comparative review.

  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 19930601

• Canine in vivo tracheal chemotaxis of eosinophils to antigen in sensitized dogs: inhibition by a steroid, a systemic lazaroid U-78517F, and several topical H1 antihistamines.

  The American review of respiratory disease 19920901

• Direct measurement of daytime sleepiness after administration of cetirizine and hydroxyzine with a standardized electroencephalographic assessment.

  The Journal of allergy and clinical immunology 19901201

• Cetirizine vs astemizole in the treatment of chronic idiopathic urticaria.

  The Journal of international medical research 19900101

• [Therapy of acute and chronic urticaria and of Quincke's edema].

  Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis 19890516