839712-12-8 | Cariprazine

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$42.00	$29.00
5mg	95%	in stock	$179.00	$126.00
10mg	95%	in stock	$313.00	$219.00
100mg	95%	in stock	$558.00	$391.00
250mg	95%	in stock	$760.00	$532.00
1g	95%	in stock	$1,536.00	$1,075.00

Description

• Catalog Number: AH51047
• Chemical Name: Cariprazine
• CAS Number: 839712-12-8
• Molecular Formula: C21H32Cl2N4O
• Molecular Weight: 427.4109799999999
• MDL Number: MFCD19443701
• SMILES: O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl

Computed Properties

• Complexity: 491
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 28
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 5
• XLogP3: 4.3

Literature

• Dichlorophenyl piperazines, including a recently-approved atypical antipsychotic, are potent inhibitors of DHCR7, the last enzyme in cholesterol biosynthesis.

  Toxicology and applied pharmacology 20180615

• Cariprazine: First Global Approval.

  Drugs 20151101

• Cariprazine: chemistry, pharmacodynamics, pharmacokinetics, and metabolism, clinical efficacy, safety, and tolerability.

  Expert opinion on drug metabolism & toxicology 20130201

• Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors.

  Bioorganic & medicinal chemistry letters 20120515

• Occupancy of dopamine D₂ and D₃ and serotonin 5-HT₁A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography.

  Psychopharmacology 20111201

• Cariprazine (RGH-188), a potent D3/D2 dopamine receptor partial agonist, binds to dopamine D3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodents.

  Neurochemistry international 20111101

• In vitro pharmacology of aripiprazole, its metabolite and experimental dopamine partial agonists at human dopamine D2 and D3 receptors.

  European journal of pharmacology 20111015

• Pharmacokinetics and metabolism update for some recent antipsychotics.

  Expert opinion on drug metabolism & toxicology 20110701

• [The dopamin D3 receptor--the gray eminence of pharmacotherapy?].

  Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology 20100901

• Cariprazine, an orally active D2/D3 receptor antagonist, for the potential treatment of schizophrenia, bipolar mania and depression.

  Current opinion in investigational drugs (London, England : 2000) 20100701

• Cariprazine (RGH-188), a dopamine D(3) receptor-preferring, D(3)/D(2) dopamine receptor antagonist-partial agonist antipsychotic candidate: in vitro and neurochemical profile.

  The Journal of pharmacology and experimental therapeutics 20100401