856866-72-3 | Tedizolid

Packsize	Purity	Availability	Price	Discounted Price
250mg	95%	in stock	$24.00	$17.00
1g	95%	in stock	$59.00	$41.00
5g	95%	in stock	$272.00	$190.00

Description

• Catalog Number: AH51120
• Chemical Name: Tedizolid
• CAS Number: 856866-72-3
• Molecular Formula: C17H15FN6O3
• Molecular Weight: 370.3378
• MDL Number: MFCD19442562
• SMILES: OC[C@@H]1OC(=O)N(C1)c1ccc(c(c1)F)c1ccc(nc1)c1nnn(n1)C

Computed Properties

• Complexity: 543
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 27
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 4
• XLogP3: 1.4

Literature

• Recent development of potent analogues of oxazolidinone antibacterial agents.

  Bioorganic & medicinal chemistry 20130201

• Skin and soft tissue concentrations of tedizolid (formerly torezolid), a novel oxazolidinone, following a single oral dose in healthy volunteers.

  International journal of antimicrobial agents 20120701

• The chemistry of peptidyltransferase center-targeted antibiotics: enzymatic resistance and approaches to countering resistance.

  ACS chemical biology 20120120

• In vitro activity of tedizolid (TR-700) against linezolid-resistant staphylococci.

  The Journal of antimicrobial chemotherapy 20120101

• Exploiting adaptive laboratory evolution of Streptomyces clavuligerus for antibiotic discovery and overproduction.

  PloS one 20120101

• Discovery of torezolid as a novel 5-hydroxymethyl-oxazolidinone antibacterial agent.

  European journal of medicinal chemistry 20110401

• Whole genome analysis of linezolid resistance in Streptococcus pneumoniae reveals resistance and compensatory mutations.

  BMC genomics 20110101

• Cellular pharmacokinetics and intracellular activity of torezolid (TR-700): studies with human macrophage (THP-1) and endothelial (HUVEC) cell lines.

  The Journal of antimicrobial chemotherapy 20091101

• In vitro activities of DA-7157 and DA-7218 against Mycobacterium tuberculosis and Nocardia brasiliensis.

  Antimicrobial agents and chemotherapy 20060901