86347-14-0 | Medetomidine

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$163.00	$114.00
5g	95%	in stock	$446.00	$312.00
10g	95%	in stock	$775.00	$543.00
25g	95%	in stock	$1,536.00	$1,075.00

Description

• Catalog Number: AH82156
• Chemical Name: Medetomidine
• CAS Number: 86347-14-0
• Molecular Formula: C13H16N2
• Molecular Weight: 200.2795
• MDL Number: MFCD00864346
• SMILES: Cc1cccc(c1C)C(c1c[nH]cn1)C

Computed Properties

• Complexity: 205
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 15
• Hydrogen Bond Acceptor Count: 1
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 2
• Undefined Atom Stereocenter Count: 1
• XLogP3: 3.1

Literature

• Role of the equine CYP3A94, CYP3A95 and CYP3A97 in ketamine metabolism in presence of medetomidine, diazepam and methadone studied by enantioselective capillary electrophoresis.

  Toxicology in vitro : an international journal published in association with BIBRA 20180801

• α2C-Adrenoceptors modulate L-DOPA uptake in opossum kidney cells and in the mouse kidney.

  American journal of physiology. Renal physiology 20121001

• Central vagal activation by alpha(2) -adrenergic stimulation is impaired in spontaneously hypertensive rats.

  Acta physiologica (Oxford, England) 20120901

• Comparison of S(+)-ketamine and ketamine, with medetomidine, for field anaesthesia in the European brown hare (Lepus europaeus).

  Veterinary anaesthesia and analgesia 20120901

• Evaluation of effectiveness, safety and reliability of intramuscular medetomidine-ketamine for captive great apes.

  The Veterinary record 20120825

• Ephedrine accelerates psychomotor recovery from anesthesia in macaque monkeys.

  Journal of medical primatology 20120801

• Effects of intramuscular administration of tiletamine-zolazepam with and without sedative pretreatment on plasma and serum biochemical values and glucose tolerance test results in Japanese black bears (Ursus thibetanus japonicus).

  American journal of veterinary research 20120801

• Preliminary studies of chemical immobilization of captive juvenile estuarine (Crocodylus porosus) and Australian freshwater (C. johnstoni) crocodiles with medetomidine and reversal with atipamezole.

  Veterinary anaesthesia and analgesia 20120701

• Use of a medetomidine-ketamine combination for anesthesia in captive common hippopotami (Hippopotamus amphibius).

  Journal of the American Veterinary Medical Association 20120701

• Medetomidine immobilisation and atipamezole reversal in large estuarine crocodiles (Crocodylus porosus) using metabolically scaled dosages.

  Australian veterinary journal 20120601

• Long-term nose-only cigarette smoke exposure induces emphysema and mild skeletal muscle dysfunction in mice.

  Disease models & mechanisms 20120501

• Apoptotic neurodegeneration and spatial memory are not affected by sedative and anaesthetics doses of ketamine/medetomidine combinations in adult mice.

  British journal of anaesthesia 20120501

• Medetomidine continuous rate intravenous infusion in horses in which surgical anaesthesia is maintained with isoflurane and intravenous infusions of lidocaine and ketamine.

  Veterinary anaesthesia and analgesia 20120501

• Effect of medetomidine-butorphanol and dexmedetomidine-butorphanol combinations on intraocular pressure in healthy dogs.

  Veterinary anaesthesia and analgesia 20120501

• Cardiopulmonary and sedative effects of the peripheral α2-adrenoceptor antagonist MK 0467 administered intravenously or intramuscularly concurrently with medetomidine in dogs.

  American journal of veterinary research 20120501

• Comparison of the effects of xylazine bolus versus medetomidine constant rate infusion on cardiopulmonary function and depth of anesthesia in horses anesthetized with isoflurane.

  Journal of the American Veterinary Medical Association 20120415

• Comparison of the effects of xylazine bolus versus medetomidine constant rate infusion on the stress response, urine production, and anesthetic recovery characteristics in horses anesthetized with isoflurane.

  Journal of the American Veterinary Medical Association 20120415

• Effects of medetomidine and ketamine on the regional cerebral blood flow in cats: a SPECT study.

  Veterinary journal (London, England : 1997) 20120401

• The effect of repetitive intraperitoneal anesthesia by application of fentanyl-medetomidine and midazolam in laboratory rats.

  Journal of investigative surgery : the official journal of the Academy of Surgical Research 20120401

• Field immobilization of feral 'Judas' donkeys (Equus asinus) by remote injection of medetomidine and ketamine and antagonism with atipamezole.

  Journal of wildlife diseases 20120401

• Optimal medetomidine dose when combined with ketamine and tiletamine-zolazepam to immobilize white-tailed deer.

  Journal of wildlife diseases 20120401

• Pharmacological modulation of functional connectivity: α2-adrenergic receptor agonist alters synchrony but not neural activation.

  NeuroImage 20120301

• A comparison of two different ketamine and diazepam combinations with an alphaxalone and medetomidine combination for induction of anaesthesia in sheep.

  New Zealand veterinary journal 20120301

• Low frequency stimulation of the perforant pathway generates anesthesia-specific variations in neural activity and BOLD responses in the rat dentate gyrus.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20120201

• Developmental and behavioral effects of medetomidine following in ovo injection in chicks.

  Neurotoxicology and teratology 20120101

• Transplacental transfer of medetomidine and ketamine in pregnant ewes.

  Laboratory animals 20120101

• Medetomidine, an α(2)-adrenergic agonist, activates cardiac vagal nerve through modulation of baroreflex control.

  Circulation journal : official journal of the Japanese Circulation Society 20120101

• Pharmacokinetics and pharmacodynamics of intravenous medetomidine in the horse.

  Veterinary anaesthesia and analgesia 20120101

• Medetomidine-ketamine-isoflurane anaesthesia in pygmy hippopotami (Choeropsis liberiensis)--a case series.

  Veterinary anaesthesia and analgesia 20120101

• Chemical immobilization of raccoons (Procyon lotor) with ketamine-medetomidine mixture and reversal with atipamezole.

  Journal of wildlife diseases 20120101

• Inhibition of firefly luciferase by general anesthetics: effect on in vitro and in vivo bioluminescence imaging.

  PloS one 20120101

• Intravenous immunoglobulin prevents murine antibody-mediated acute lung injury at the level of neutrophil reactive oxygen species (ROS) production.

  PloS one 20120101

• Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling.

  PloS one 20120101

• Short-term effects of medetomidine on photosynthesis and protein synthesis in periphyton, epipsammon and plankton communities in relation to predicted environmental concentrations.

  Biofouling 20120101

• Capture, anesthesia, and disturbance of free-ranging brown bears (Ursus arctos) during hibernation.

  PloS one 20120101

• Analysis of uncoupling protein 2-deficient mice upon anaesthesia and sedation revealed a role for UCP2 in locomotion.

  PloS one 20120101

• Liquid chromatography tandem mass spectrometry for the simultaneous quantitative analysis of ketamine and medetomidine in ovine plasma.

  Biomedical chromatography : BMC 20111201

• Clinical evaluation of total intravenous anesthesia using a combination of propofol and medetomidine following anesthesia induction with medetomidine, guaifenesin and propofol for castration in Thoroughbred horses.

  The Journal of veterinary medical science 20111201

• Evaluation of medetomidine, ketamine and buprenorphine for neutering feral cats.

  Journal of feline medicine and surgery 20111201

• Evaluation of two sedation protocols for use before diagnostic intra-articular anaesthesia in lame dogs.

  The Journal of small animal practice 20111201

• A comparison of two field chemical immobilization techniques for bobcats (Lynx rufus).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20111201

• Evaluation of medetomidine-alfaxalone and medetomidine-ketamine in semi-free ranging Bennett's wallabies (Macropus rufogriseus).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20111201

• Evaluation of modified techniques for immobilization of wild ring-tailed lemurs (Lemur catta).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20111201

• Swept source optical coherence tomography as a tool for real time visualization and localization of electrodes used in electrophysiological studies of brain in vivo.

  Biomedical optics express 20111101

• Effects of early atipamezole reversal of medetomidine-ketamine anesthesia in mice.

  Journal of the American Association for Laboratory Animal Science : JAALAS 20111101

• Bleeding time in healthy dogs sedated with morphine and medetomidine.

  The Veterinary record 20111029

• Fractal analysis of spontaneous fluctuations of the BOLD signal in rat brain.

  NeuroImage 20111015

• Minimal driving of hippocampal theta by the supramammillary nucleus during water maze learning.

  Hippocampus 20111001

• α₂-Adrenoceptor-mediated inhibition of catecholamine release from the adrenal medulla of spontaneously hypertensive rats is preserved in the early stages of hypertension.

  Basic & clinical pharmacology & toxicology 20111001

• Subeffective doses of nitroparacetamol (NCX-701) enhance the antinociceptive activity of the α₂-adrenoceptor agonist medetomidine.

  Pharmacology, biochemistry, and behavior 20110901

• Physiology and mRNA expression in rainbow trout (Oncorhynchus mykiss) after long-term exposure to the new antifoulant medetomidine.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20110901

• Medetomidine/midazolam/ketamine anaesthesia in ferrets: effects on cardiorespiratory parameters and evaluation of plasma drug concentrations.

  Veterinary anaesthesia and analgesia 20110901

• Short term pharmacological immobilization in macaque monkeys.

  Veterinary anaesthesia and analgesia 20110901

• Comparison of the effects of racemic ketamine and S-ketamine for anesthesia in Rheem gazelles (Gazella subgutturosa marica) and Subgutturosa gazelles (Gazella subgutturosa subgutturosa).

  American journal of veterinary research 20110901

• Effect of sedation protocol on glomerular filtration rate in cats as determined by use of quantitative renal scintigraphy.

  American journal of veterinary research 20110901

• Comparison of carfentanil-xylazine and thiafentanil-medetomidine in electroejaculation of captive gaur (Bos gaurus).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20110901

• The effect of medetomidine on the regional cerebral blood flow in dogs measured using Technetium-99m-Ethyl Cysteinate Dimer SPECT.

  Research in veterinary science 20110801

• In vivo layer visualization of rat olfactory bulb by a swept source optical coherence tomography and its confirmation through electrocoagulation and anatomy.

  Biomedical optics express 20110801

• Cutaneous reaction after intravenous administration of medetomidine?

  Veterinary anaesthesia and analgesia 20110701

• Effective immobilizing doses of medetomidine-ketamine in free-ranging, wild Norwegian reindeer (Rangifer tarandus tarandus).

  Journal of wildlife diseases 20110701

• Determination of an optimal dose of medetomidine-ketamine-buprenorphine for anaesthesia in the Cape ground squirrel (Xerus inauris).

  Journal of the South African Veterinary Association 20110601

• Sedative effects of three doses of romifidine in comparison with medetomidine in cats.

  Veterinary anaesthesia and analgesia 20110501

• A clinical study on the effect in horses during medetomidine-isoflurane anaesthesia, of butorphanol constant rate infusion on isoflurane requirements, on cardiopulmonary function and on recovery characteristics.

  Veterinary anaesthesia and analgesia 20110501

• Evaluation of medetomidine-ketamine and dexmedetomidine-ketamine in Chinese water deer (Hydropotes inermis).

  Veterinary anaesthesia and analgesia 20110301

• Evaluation of the electroencephalogram in young cats.

  American journal of veterinary research 20110301

• Comparative evaluation of halothane anaesthesia in medetomidine-butorphanol and midazolam-butorphanol premedicated water buffaloes (Bubalus bubalis).

  Journal of the South African Veterinary Association 20110301

• Physiologic evaluation of capture and anesthesia with medetomidine-zolazepam-tiletamine in brown bears (Ursus arctos).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20110301

• Biochemical variables in free-ranging white-tailed deer (Odocoileus virginianus) after chemical immobilization in clover traps or via ground-darting.

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20110301

• Field anesthesia of wild ring-tailed lemurs (Lemur catta) using tiletamine-zolazepam, medetomidine, and butorphanol.

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20110301

• Sterilisation of hybrid Galapagos tortoises (Geochelone nigra) for island restoration. Part 1: endoscopic oophorectomy of females under ketamine-medetomidine anaesthesia.

  The Veterinary record 20110115

• Implant size and fixation mode strongly influence tissue reactions in the CNS.

  PloS one 20110101

• Neuromodulation by soy diets or equol: anti-depressive & anti-obesity-like influences, age- & hormone-dependent effects.

  BMC neuroscience 20110101

• Unexpected long-term protection of adult offspring born to high-fat fed dams against obesity induced by a sucrose-rich diet.

  PloS one 20110101

• Kinase activity profiling of pneumococcal pneumonia.

  PloS one 20110101

• Dynamic stereotypic responses of Basal Ganglia neurons to subthalamic nucleus high-frequency stimulation in the parkinsonian primate.

  Frontiers in systems neuroscience 20110101

• Cardiovascular and respiratory safety pharmacology in Göttingen minipigs: Pharmacological characterization.

  Journal of pharmacological and toxicological methods 20110101

• Treatment of major vein injury with the hemostatic fleece TachoSil by interposing a peritoneal patch to avoid vein thrombosis: A feasibility study in pigs.

  Journal of emergencies, trauma, and shock 20110101

• Thyroid hormone T3 counteracts STZ induced diabetes in mouse.

  PloS one 20110101

• Memory B cells and CD8⁺ lymphocytes do not control seasonal influenza A virus replication after homologous re-challenge of rhesus macaques.

  PloS one 20110101

• Stimulus-specific adaptation and deviance detection in the rat auditory cortex.

  PloS one 20110101

• Intravital two-photon microscopy of immune cell dynamics in corneal lymphatic vessels.

  PloS one 20110101

• Effect of three types of mixed anesthetic agents alternate to ketamine in mice.

  Experimental animals 20110101

• Comparison of intravenous medetomidine and medetomidine/ketamine for immobilization of free-ranging variable flying foxes (Pteropus hypomelanus).

  PloS one 20110101

• Development and optimization of oil-filled lipid nanoparticles containing docetaxel conjugates designed to control the drug release rate in vitro and in vivo.

  International journal of nanomedicine 20110101

• Ghrelin and its analogues, BIM-28131 and BIM-28125, improve body weight and regulate the expression of MuRF-1 and MAFbx in a rat heart failure model.

  PloS one 20110101

• Characterisation of a C1qtnf5 Ser163Arg knock-in mouse model of late-onset retinal macular degeneration.

  PloS one 20110101

• Culling-induced changes in badger (Meles meles) behaviour, social organisation and the epidemiology of bovine tuberculosis.

  PloS one 20110101

• Exogenous IFN-alpha administration reduces influenza A virus replication in the lower respiratory tract of rhesus macaques.

  PloS one 20110101

• A comparison of acepromazine-buprenorphine and medetomidine-buprenorphine for preanesthetic medication of dogs.

  Journal of the American Veterinary Medical Association 20101215

• Melody, an ENU mutation in Caspase 3, alters the catalytic cysteine residue and causes sensorineural hearing loss in mice.

  Mammalian genome : official journal of the International Mammalian Genome Society 20101201

• Effects of two fractions of inspired oxygen on lung aeration and gas exchange in cats under inhalant anaesthesia.

  Veterinary anaesthesia and analgesia 20101101

• Evaluation of butorphanol, medetomidine and midazolam as a reversible narcotic combination in free-ranging African lions (Panthera leo).

  Veterinary anaesthesia and analgesia 20101101

• Creating a population-averaged standard brain template for Japanese macaques (M. fuscata).

  NeuroImage 20101001

• Simultaneous fMRI and local field potential measurements during epileptic seizures in medetomidine-sedated rats using raser pulse sequence.

  Magnetic resonance in medicine 20101001

• Effects of medetomidine-midazolam-fentanyl IV bolus injections and its reversal by specific antagonists on cardiovascular function in rabbits.

  Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20101001

• Comparison of alpha-chloralose, medetomidine and isoflurane anesthesia for functional connectivity mapping in the rat.

  Magnetic resonance imaging 20100901

• Comparison of anaesthetic and cardiorespiratory effects of xylazine or medetomidine in combination with tiletamine/zolazepam in pigs.

  The Veterinary record 20100814

• Metabolic stability and determination of cytochrome P450 isoenzymes' contribution to the metabolism of medetomidine in dog liver microsomes.

  Biomedical chromatography : BMC 20100801

• Octopamine receptors from the barnacle balanus improvisus are activated by the alpha2-adrenoceptor agonist medetomidine.

  Molecular pharmacology 20100801

• Colour and melanophore function in rainbow trout after long term exposure to the new antifoulant medetomidine.

  Chemosphere 20100801

• Effects of synephrine and beta-phenethylamine on human alpha-adrenoceptor subtypes.

  Planta medica 20100701

• In vitro evaluation of fresh sperm quality in tomcats: a comparison of two collection techniques.

  Theriogenology 20100701

• Tissue restoration after implantation of polyglycolide, polydioxanone, polylevolactide, and metallic pins in cortical bone: an experimental study in rabbits.

  Calcified tissue international 20100701

• Cardiac troponin I concentrations following medetomidine-butorphanol sedation in dogs.

  Veterinary anaesthesia and analgesia 20100701

• Anesthesia with intraperitoneal propofol, medetomidine, and fentanyl in rats.

  Journal of the American Association for Laboratory Animal Science : JAALAS 20100701

• Adaptation to stimulus statistics in the perception and neural representation of auditory space.

  Neuron 20100624

• Sympathetic alpha(2)-adrenoceptors prevent cardiac hypertrophy and fibrosis in mice at baseline but not after chronic pressure overload.

  Cardiovascular research 20100601

• Experience with a naphthylmedetomidine-ketamine-hyaluronidase combination in inducing immobilization in anthropoid apes.

  Journal of medical primatology 20100601

• High field BOLD response to forepaw stimulation in the mouse.

  NeuroImage 20100601

• Epidermal neural crest stem cell (EPI-NCSC)--mediated recovery of sensory function in a mouse model of spinal cord injury.

  Stem cell reviews 20100601

• Use of thiafentanil-medetomidine for the induction of anesthesia in emus (Dromaius novaehollandiae) within a wild animal park.

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20100601

• Evaluation of medetomidine-ketamine-butorphanol anesthesia with atipamezole-naltrexone antagonism in captive male guanacos (Lama guanicoe).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20100601

• Reversible immobilization of giant otters (Pteronura brasiliensis) using medetomidine-ketamine and atipamezole.

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20100601

• The current functional state of local neuronal circuits controls the magnitude of a BOLD response to incoming stimuli.

  NeuroImage 20100501

• Brief sounds evoke prolonged responses in anesthetized ferret auditory cortex.

  Journal of neurophysiology 20100501

• Comparison of three anaesthetic protocols in Bennett's wallabies (Macropus rufogriseus).

  Veterinary anaesthesia and analgesia 20100501

• Anaesthesia with a combination of ketamine and medetomidine in the rabbit: effect of premedication with buprenorphine.

  Veterinary anaesthesia and analgesia 20100501

• The hemodynamic effects of medetomidine continuous rate infusions in the dog.

  Veterinary anaesthesia and analgesia 20100501

• Effective and safe anesthesia for Yorkshire and Yucatan swine with and without cardiovascular injury and intervention.

  Journal of the American Association for Laboratory Animal Science : JAALAS 20100501

• Intranasal naltrexone and atipamezole for reversal of white-tailed deer immobilized with carfentanil and medetomidine.

  The Canadian veterinary journal = La revue veterinaire canadienne 20100501

• Hemodynamics and bispectral index (BIS) of dogs anesthetized with midazolam and ketamine associated with medetomidine or dexmedetomidine and submitted to ovariohysterectomy.

  Acta cirurgica brasileira 20100401

• Comparison of cardiovascular function and quality of recovery in isoflurane-anaesthetised horses administered a constant rate infusion of lidocaine or lidocaine and medetomidine during elective surgery.

  Equine veterinary journal 20100401

• Immobilization of red fox (Vulpes vulpes) with medetomidine-ketamine or medetomidine-midazolam and antagonism with atipamezole.

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20100301

• Comparison of the anesthetic effects of oral transmucosal versus injectable medetomidine in combination with tiletamine-zolazepam for immobilization of chimpanzees (Pan troglodytes).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20100301

• Effects of serial anesthesia using ketamine or ketamine/medetomidine on hematology and serum biochemistry values in rhesus macaques (Macaca mulatta).

  Journal of medical primatology 20100201

• The effect of daily repeated sedation using ketamine or ketamine combined with medetomidine on physiology and anesthetic characteristics in rhesus macaques.

  Journal of medical primatology 20100201

• Cancer treatment dosing regimens of zoledronic acid result in near-complete suppression of mandible intracortical bone remodeling in beagle dogs.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100101

• Evaluation of three immobilization combinations in the capybara (Hydrochoerus hydrochaeris).

  Zoo biology 20100101

• The sedative effects of low-dose medetomidine and butorphanol alone and in combination intravenously in dogs.

  Veterinary anaesthesia and analgesia 20100101

• Alfaxalone induction dose following administration of medetomidine and butorphanol in the dog.

  Veterinary anaesthesia and analgesia 20100101

• Comparison of the effects of ketamine, ketamine-medetomidine, and ketamine-midazolam on physiologic parameters and anesthesia-induced stress in rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) macaques.

  Journal of the American Association for Laboratory Animal Science : JAALAS 20100101

• New class of monoclonal antibodies against severe influenza: prophylactic and therapeutic efficacy in ferrets.

  PloS one 20100101

• [Effect of dexmedetomidine on bispectral index and auditory evoked potential index during anesthesia with target controlled infusion of propofol and remifentanyl].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20100101

• Responses in fish exposed to medetomidine, a new antifouling agent.

  Marine environmental research 20100101

• Microscopic mammalian retinal pigment epithelium lesions induce widespread proliferation with differences in magnitude between center and periphery.

  Molecular vision 20100101

• Effects of anesthetic protocol on normal canine brain uptake of 18F-FDG assessed by PET/CT.

  Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association 20100101

• The effect of medetomidine-ketamine anesthesia on hemodynamic parameters during hemorrhagic shock in minipigs.

  Physiological research 20100101

• Lysophosphatidylcholine as an adjuvant for lentiviral vector mediated gene transfer to airway epithelium: effect of acyl chain length.

  Respiratory research 20100101

• Combined cardiopulmonary assessments with implantable telemetry device in conscious freely moving cynomolgus monkeys.

  Journal of pharmacological and toxicological methods 20100101

• Description of the type of chemical restraint used by French veterinarians to perform hip dysplasia screening radiographs. A retrospective study based on 3302 radiographs.

  Veterinary and comparative orthopaedics and traumatology : V.C.O.T 20100101

• The non-lemniscal auditory cortex in ferrets: convergence of corticotectal inputs in the superior colliculus.

  Frontiers in neuroanatomy 20100101

• Hemodynamic effects of an intravenous infusion of medetomidine at six different dose regimens in isoflurane-anesthetized dogs.

  Veterinary therapeutics : research in applied veterinary medicine 20100101

• Nitric oxide synthase enzymes in the airways of mice exposed to ovalbumin: NOS2 expression is NOS3 dependent.

  Mediators of inflammation 20100101

• Manufacturing and in vivo inner ear visualization of MRI traceable liposome nanoparticles encapsulating gadolinium.

  Journal of nanobiotechnology 20100101

• Evaluation of two short-term anesthetic protocols in captive juvenile pronghorn (Antilocapra americana).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20091201

• Partial intravenous anaesthesia in 5 horses using ketamine, lidocaine, medetomidine and halothane.

  Journal of the South African Veterinary Association 20091201

• Atipamezole changes the antinociceptive effects of butorphanol after medetomidine-ketamine anaesthesia in rats.

  Veterinary anaesthesia and analgesia 20091101

• Comparison of the effects of three different combinations of general anesthetics on the electroretinogram of dogs.

  Documenta ophthalmologica. Advances in ophthalmology 20091001

• Modulation of alpha2-adrenoceptor functions by heterotrimeric Galphai protein isoforms.

  The Journal of pharmacology and experimental therapeutics 20091001

• Antinociceptive effects of epidural buprenorphine or medetomidine, or the combination, in conscious cats.

  Journal of veterinary pharmacology and therapeutics 20091001

• Antagonistic effects of atipamezole and yohimbine on medetomidine-induced diuresis in healthy dogs.

  Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20091001

• Evaluation of the muscular relaxant effect of dexmedetomidine or medetomidine in cats.

  Veterinary research communications 20090901

• A study of cardiovascular function under controlled and spontaneous ventilation in isoflurane-medetomidine anaesthetized horses.

  Veterinary anaesthesia and analgesia 20090901

• Effects of sedative and hypnotic drug combinations on transcranial magnetic motor evoked potential, bispectral index and ARX-derived auditory evoked potential index in dogs.

  Veterinary journal (London, England : 1997) 20090801

• The effect of the novel partial alpha2-adrenoceptor agonist naphthylmedetomidine on the basic cardiorespiratory parameters and behavior in rhesus monkeys.

  Journal of medical primatology 20090801

• A protocol for use of medetomidine anesthesia in rats for extended studies using task-induced BOLD contrast and resting-state functional connectivity.

  NeuroImage 20090715

• Isoflurane attenuates pulmonary interleukin-1beta and systemic tumor necrosis factor-alpha following mechanical ventilation in healthy mice.

  Acta anaesthesiologica Scandinavica 20090701

• Bioaccumulation of the new antifoulant medetomidine in marine organisms.

  Marine environmental research 20090701

• A comparison of the efficacy and cardiorespiratory effects of four medetomidine-based anaesthetic protocols in the red fox (Vulpes vulpes).

  Veterinary anaesthesia and analgesia 20090701

• Evaluation of the anaesthetic effects of medetomidine and ketamine in rats and their reversal with atipamezole.

  Veterinary anaesthesia and analgesia 20090701

• Incorrect comments regarding the use of butorphanol-medetomidine as a premedicant in cats.

  The Journal of small animal practice 20090701

• Reversible immobilization of free-ranging Svalbard reindeer (Rangifer tarandus platyrhynchus) with medetomidine-ketamine and atipamezole.

  Journal of wildlife diseases 20090701

• Diuretic effects of medetomidine compared with xylazine in healthy dogs.

  Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20090701

• Evaluation of the effects of naloxone on recovery time and quality after ketamine-medetomidine-butorphanol anesthesia in servals (Leptailurus serval).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20090601

• The effects of different anesthetic agents on short electroretinography protocol in dogs.

  The Journal of veterinary medical science 20090601

• Visual and quantitative electroencephalographic analysis of healthy young and adult cats under medetomidine sedation.

  Veterinary journal (London, England : 1997) 20090501

• Seizures during medetomindine sedation and local anaesthesia in two dogs undergoing skin biopsy.

  Australian veterinary journal 20090501

• Urethral obstruction by seminal coagulum is associated with medetomidine-ketamine anesthesia in male mice on C57BL/6J and mixed genetic backgrounds.

  Journal of the American Association for Laboratory Animal Science : JAALAS 20090501

• Butorphanol-azaperone-medetomidine for immobilization of captive white-tailed deer.

  Journal of wildlife diseases 20090401

• Butorphanol, azaperone, and medetomidine anesthesia in free-ranging white-tailed deer (Odocoileus virginianus) using radiotransmitter darts.

  Journal of wildlife diseases 20090401

• The use of lingual venous blood to determine the acid-base and blood-gas status of dogs under anesthesia.

  Veterinary anaesthesia and analgesia 20090301

• The effect of the novel alpha-2-adrenoceptor agonist naphthylmedetomidine on pulse rate, arterial blood pressure and sedation in rabbits.

  Veterinary anaesthesia and analgesia 20090301

• Effects of medetomidine, L-methadone, and their combination on arterial blood gases in dogs.

  Veterinary anaesthesia and analgesia 20090301

• Investigating medetomidine-buprenorphine as preanaesthetic medication in cats.

  The Journal of small animal practice 20090201

• Behavioural and cardiorespiratory effects of a constant rate infusion of medetomidine and morphine for sedation during standing laparoscopy in horses.

  Equine veterinary journal 20090201

• Induction of anaesthesia in wild rabbits using a new alfaxalone formulation.

  The Veterinary record 20090124

• Retrograde adenoviral vector targeting of nociresponsive pontospinal noradrenergic neurons in the rat in vivo.

  The Journal of comparative neurology 20090110

• Intraperitoneal anaesthesia with propofol, medetomidine and fentanyl in mice.

  Laboratory animals 20090101

• Effect of bupivacaine on epidural analgesia produced by xylazine or medetomidine in buffaloes (Bubalus bubalis).

  Veterinary anaesthesia and analgesia 20090101

• Serotonin transporter genotype modulates social reward and punishment in rhesus macaques.

  PloS one 20090101

• Evaluation of medetomidine-midazolam-atropine (MeMiA) anesthesia maintained with propofol infusion in New Zealand White rabbits.

  Polish journal of veterinary sciences 20090101

• Late treatment with imatinib mesylate ameliorates radiation-induced lung fibrosis in a mouse model.

  Radiation oncology (London, England) 20090101

• Determination of a sedative protocol for use in California sea lions (Zalophus californianus) with neurologic abnormalities undergoing electroencephalographic examination.

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20081201

• Field anesthesia of golden jackals (Canis aureus) with the use of medetomidine-ketamine or medetomidine-midazolam with atipamezole reversal.

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20081201

• Anesthetic and cardiopulmonary effects of intramuscular morphine, medetomidine, ketamine injection in dogs.

  Veterinary anaesthesia and analgesia 20081101

• Effects of premedication with tiletamine/zolazepam/medetomidine during general anesthesia using sevoflurane/fentanyl in swine undergoing pancreas transplantation.

  Transplantation proceedings 20081101

• Efficacy and safety of five injectable anesthetic regimens for chronic blood collection from the anterior vena cava of Guinea pigs.

  Journal of the American Association for Laboratory Animal Science : JAALAS 20081101

• Evaluation of the efficacy and safety for use of two sedation and analgesia protocols to facilitate assisted ventilation of healthy dogs.

  American journal of veterinary research 20081001

• Immobilization of free-ranging Hoffmann's two-toed and brown-throated three-toed sloths using ketamine and medetomidine: a comparison of physiologic parameters.

  Journal of wildlife diseases 20081001

• EphrinB2 induces tyrosine phosphorylation of NR2B via Src-family kinases during inflammatory hyperalgesia.

  Neuroscience 20080922

• The effects of medetomidine on the action of vecuronium in dogs anaesthetized with halothane and nitrous oxide.

  Veterinary anaesthesia and analgesia 20080901

• Evaluation of intramuscular butorphanol, azaperone, and medetomidine and nasal oxygen insufflation for the chemical immobilization of white-tailed deer, Odocoileus virginianus.

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20080901

• Regio- and stereospecific N-glucuronidation of medetomidine: the differences between UDP glucuronosyltransferase (UGT) 1A4 and UGT2B10 account for the complex kinetics of human liver microsomes.

  Drug metabolism and disposition: the biological fate of chemicals 20080801

• Differences in hepatic cytochrome P450 activity correlate with the strain-specific biotransformation of medetomidine in AX/JU and IIIVO/JU inbred rabbits.

  Journal of veterinary pharmacology and therapeutics 20080801

• Immobilization of black bears (Ursus americanus) with a combination of butorphanol, azaperone, and medetomidine.

  Journal of wildlife diseases 20080701

• Effects of medetomidine and midazolam alone or in combination on the metabolic and neurohormonal responses in healthy cats.

  Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20080701

• Effects of a peripheral alpha2 adrenergic-receptor antagonist on the hemodynamic changes induced by medetomidine administration in conscious dogs.

  American journal of veterinary research 20080601

• The efficacy of orally dosed ketamine and ketamine/medetomidine compared with intramuscular ketamine in rhesus macaques (Macaca mulatta) and the effects of dosing route on haematological stress markers.

  Journal of medical primatology 20080601

• Caesarian section and neonatal care in the aardvark (Orycteropus afer).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20080601

• Inhibition of opioid release in the rat spinal cord by alpha2C adrenergic receptors.

  Neuropharmacology 20080501

• Cardiopulmonary effects of anesthetic induction with thiopental, propofol, or a combination of ketamine hydrochloride and diazepam in dogs sedated with a combination of medetomidine and hydromorphone.

  American journal of veterinary research 20080501

• Neurohormonal and metabolic effects of medetomidine compared with xylazine in healthy cats.

  Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20080401

• Quality and in vitro fertilizing ability of cryopreserved cat spermatozoa obtained by urethral catheterization after medetomidine administration.

  Theriogenology 20080301

• A comparison of ketamine-midazolam and ketamine-medetomidine combinations for induction of anaesthesia in rabbits.

  Veterinary anaesthesia and analgesia 20080301

• Sedative and cardiopulmonary effects of medetomidine hydrochloride and xylazine hydrochloride and their reversal with atipamezole hydrochloride in calves.

  American journal of veterinary research 20080301

• IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo.

  PLoS pathogens 20080301

• Effect of medetomidine infusion on the anaesthetic requirements of desflurane in dogs.

  Research in veterinary science 20080201

• Antagonistic effects of atipamezole, flumazenil and 4-aminopyridine against anaesthesia with medetomidine, midazolam and ketamine combination in cats.

  Journal of feline medicine and surgery 20080201

• Effects of medetomidine on Doppler variables of major abdominal arteries in normal dogs.

  Veterinary research communications 20080201

• Reversible medetomidine/ketamine anesthesia in captive capuchin monkeys (Cebus apella).

  Journal of medical primatology 20080201

• Vascular disrupting action of electroporation and electrochemotherapy with bleomycin in murine sarcoma.

  British journal of cancer 20080129

• Sedative and cardiorespiratory effects of three doses of romifidine in comparison with medetomidine in five cats.

  The Veterinary record 20080119

• The effects of medetomidine on radial nerve blockade with mepivacaine in dogs.

  Veterinary anaesthesia and analgesia 20080101

• Effects of medetomidine on hepatic EROD activity in three species of fish.

  Ecotoxicology and environmental safety 20080101

• BOLD study of stimulation-induced neural activity and resting-state connectivity in medetomidine-sedated rat.

  NeuroImage 20080101

• Capture and medetomidine-ketamine anesthesia of free-ranging wolverines (Gulo gulo).

  Journal of wildlife diseases 20080101

• [Clinical evaluation of three medetomidine--midazolam--ketamine combinations for neutering of ferrets (Mustela putorius furo)].

  Berliner und Munchener tierarztliche Wochenschrift 20080101

• Selective antiaggressive effect of an alpha-2 adrenoceptor agonist naphthylmedetomidine in mice.

  Aggressive behavior 20080101

• Changes in minimal alveolar concentration of isoflurane following treatment with medetomidine and tiletamine/zolazepam, epidural morphine or systemic buprenorphine in pigs.

  Laboratory animals 20080101

• The effects of medetomidine hydrochloride on the electroretinogram of normal dogs.

  Veterinary ophthalmology 20080101

• Estrogen sensitivity of target genes and expression of nuclear receptor co-regulators in rat prostate after pre- and postnatal exposure to the ultraviolet filter 4-methylbenzylidene camphor.

  Environmental health perspectives 20071201

• Evaluation of the anaesthetic effects of combinations of ketamine, medetomidine, romifidine and butorphanol in European badgers (Meles meles).

  Veterinary anaesthesia and analgesia 20071101

• Partial antagonization of midazolam-medetomidine-ketamine in cats--atipamezole versus combined atipamezole and flumazenil.

  Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20071101

• Comparison of subcutaneous and intramuscular ketamine-medetomidine with and without reversal by atipamezole in Dutch belted rabbits (Oryctolagus cuniculus).

  Journal of the American Association for Laboratory Animal Science : JAALAS 20071101

• Clinicophysiological effects of spinally administered ketamine and its combination with xylazine and medetomidine in healthy goats.

  Veterinary research communications 20071001

• A comparative clinical study of three different dosages of intramuscular midazolam-medetomidine-ketamine immobilization in cats.

  Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20071001

• Effects of ketamine or medetomidine administration on quality of electroejaculated sperm and on sperm flow in the domestic cat.

  Theriogenology 20070915

• Medetomidine as a candidate antifoulant: sublethal effects on juvenile turbot (Psetta maxima L.).

  Aquatic toxicology (Amsterdam, Netherlands) 20070720

• Field anaesthesia of leatherback sea turtles (Dermochelys coriacea).

  The Veterinary record 20070707

• A clinical comparison of two anaesthetic protocols using lidocaine or medetomidine in horses.

  Veterinary anaesthesia and analgesia 20070701

• Differences in response to anaesthetics and analgesics between inbred rat strains.

  Laboratory animals 20070701

• Evaluation of a medetomidine-midazolam combination for immobilizing and sedating Japanese monkeys (Macaca fuscata).

  Journal of the American Association for Laboratory Animal Science : JAALAS 20070701

• Survey of utilization of medetomidine and atipamezole in private veterinary practice in Quebec in 2002.

  The Canadian veterinary journal = La revue veterinaire canadienne 20070701

• Evaluation of the clinical efficacy and safety of intramuscular and intravenous doses of dexmedetomidine and medetomidine in dogs and their reversal with atipamezole.

  The Veterinary record 20070630

• Peri-operative body temperatures in isoflurane-anaesthetized rabbits following ketamine-midazolam or ketamine-medetomidine.

  Veterinary anaesthesia and analgesia 20070501

• Sevoflurane anaesthesia in Iberian lynx (Lynx pardinus).

  The Veterinary record 20070428

• Anaesthetic and cardiopulmonary effects of intramuscular morphine, medetomidine and ketamine administered to telemetered cats.

  Journal of feline medicine and surgery 20070401

• Impact of sedation method on the diagnosis of hip and elbow dysplasia in Swedish dogs.

  Preventive veterinary medicine 20070317

• Evaluation of cardiovascular effects of total intravenous anesthesia with propofol or a combination of ketamine-medetomidine-propofol in horses.

  American journal of veterinary research 20070201

• In vivo evaluation of alpha(2)-adrenoceptors in cats with idiopathic cystitis.

  American journal of veterinary research 20070201

• Total intravenous anaesthesia with propofol or propofol/ketamine in spontaneously breathing dogs premedicated with medetomidine.

  The Veterinary record 20070120

• Post-anesthetic hyperthermia in cats.

  Veterinary anaesthesia and analgesia 20070101

• Anesthetic and cardiopulmonary effects of total intravenous anesthesia using a midazolam, ketamine and medetomidine drug combination in horses.

  The Journal of veterinary medical science 20070101

• Oxygenation in medetomidine-sedated dogs with and without 100% oxygen insufflation.

  Veterinary therapeutics : research in applied veterinary medicine 20070101

• Effects of tribromoethanol-medetomidine combination on cycling and ovariectomized Sprague-Dawley rats.

  Lab animal 20070101

• A cardiovascular monitoring system used in conscious cynomolgus monkeys for regulatory safety pharmacology. Part 2: Pharmacological validation.

  Journal of pharmacological and toxicological methods 20070101

• Comparison of anesthetic and cardiorespiratory effects of tiletamine-zolazepam-butorphanol and tiletamine-zolazepam-butorphanol-medetomidine in dogs.

  Veterinary therapeutics : research in applied veterinary medicine 20070101

• Continuous infusion in adult females dogs submitted to ovariohysterectomy with midazolam-xylazine and/or medetomidine pre-treated with methotrimeprazine and buprenorphine.

  Acta cirurgica brasileira 20070101

• Degradable gelatin microspheres as an embolic agent: an experimental study in a rabbit renal model.

  Korean journal of radiology 20070101

• A comparison of anesthetic and cardiorespiratory effects of tiletamine-zolazepam-butorphanol and tiletamine-zolazepam-butorphanol- medetomidine in cats.

  Veterinary therapeutics : research in applied veterinary medicine 20070101

• Effects of a candidate antifouling compound (medetomidine) on pheromone induced mate search in the amphipod Corophium volutator.

  Marine pollution bulletin 20061201

• Effects of carprofen on renal function during medetomidine-propofol-isoflurane anesthesia in dogs.

  American journal of veterinary research 20061201

• Anesthesia of male axis deer (Axis axis): evaluation of thiafentanil, medetomidine, and ketamine versus medetomidine and ketamine.

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20061201

• Reversible anesthesia in wild marine otters (Lontra felina) using ketamine and medetomidine.

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20061201

• Reversible anesthesia of Southeast Asian primates with medetomidine, zolazepam, and tiletamine.

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20061201

• Cardiopulmonary effects of medetomidine or midazolam in combination with ketamine or tiletamine/zolazepam for the immobilisation of captive cheetahs (Acinonyx jubatus).

  Journal of the South African Veterinary Association 20061201

• Complexation chemistry for tuning release from polymer coatings.

  The journal of physical chemistry. B 20061102

• Tethered yohimbine analogs as selective human alpha2C-adrenergic receptor ligands.

  The Journal of pharmacology and experimental therapeutics 20061101

• GLC756 decreases TNF-alpha via an alpha2 and beta2 adrenoceptor related mechanism.

  Experimental eye research 20061101

• Comparison of romifidine and medetomidine pre-medication in propofol-isoflurane anaesthetised dogs.

  Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20061101

• Effects of medetomidine, a novel antifouling agent, on the burrowing bivalve Abra nitida (Müller).

  Chemosphere 20061001

• Cardiorespiratory effects of desflurane in dogs given romifidine or medetomidine before induction of anesthesia with propofol.

  Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20061001

• Effect of four sedative and anesthetic protocols on quantitative thyroid scintigraphy in euthyroid cats.

  American journal of veterinary research 20060801

• Evaluation of the clinical efficacy and safety of dexmedetomidine or medetomidine in cats and their reversal with atipamezole.

  Veterinary anaesthesia and analgesia 20060701

• Cerebral state monitoring in Beagle dogs sedated with medetomidine.

  Veterinary anaesthesia and analgesia 20060701

• Dexmedetomidine or medetomidine premedication before propofol-desflurane anaesthesia in dogs.

  Journal of veterinary pharmacology and therapeutics 20060601

• Effects of xylazine, medetomidine, detomidine, and diazepam on sedation, heart and respiratory rates, and cloacal temperature in rock partridges (Alectoris graeca).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20060601

• Anesthesia of captive African wild dogs (Lycaon pictus) using a medetomidine-ketamine-atropine combination.

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20060601

• Light stimulus frequency dependence of activity in the rat visual system as studied with high-resolution BOLD fMRI.

  Journal of neurophysiology 20060501

• Effect of medetomidine on respiration and minimum alveolar concentration in halothane- and isoflurane-anesthetized dogs.

  American journal of veterinary research 20060501

• Evaluation of total intravenous anesthesia with propofol or ketamine-medetomidine-propofol combination in horses.

  Journal of the American Veterinary Medical Association 20060415

• Training-induced plasticity of auditory localization in adult mammals.

  PLoS biology 20060401

• Reversible immobilization of free-ranging African lions (Panthera leo) with medetomidine-tiletamine-zolazepam and atipamezole.

  Journal of wildlife diseases 20060401

• Evaluation of medetomidine/ketamine for short-term immobilization of variable flying foxes (Pteropus hypomelanus).

  Journal of wildlife diseases 20060401

• The influence of the time course of inflammation and spinalization on the antinociceptive activity of the alpha2-adrenoceptor agonist medetomidine.

  European journal of pharmacology 20060217

• A fully noninvasive and robust experimental protocol for longitudinal fMRI studies in the rat.

  NeuroImage 20060215

• Comparative pharmacokinetics of medetomidine enantiomers in goats and sheep during sevoflurane anaesthesia.

  Journal of veterinary pharmacology and therapeutics 20060201

• Effects of intravenous diazepam or microdose medetomidine on propofol-induced sedation in dogs.

  Journal of the American Animal Hospital Association 20060101

• Effects of medetomidine and medetomidine-butorphanol combination on Schirmer tear test 1 readings in dogs.

  Veterinary ophthalmology 20060101

• Comparison of two pre-anaesthetic medetomidine doses in isoflurane anaesthetized sheep.

  Veterinary anaesthesia and analgesia 20060101

• Successful protocol of anaesthesia for measuring transepithelial nasal potential difference in spontaneously breathing mice.

  Laboratory animals 20060101

• Evaluation of sedation on electroencephalographic spectral edge frequency 95 in dogs sedated by acupuncture at GV20 or Yintang and sedative combination.

  Acupuncture & electro-therapeutics research 20060101

• Reversible anaesthesia of free-ranging lions (Panthera leo) in Zimbabwe.

  Journal of the South African Veterinary Association 20051201

• Perioperative normothermia depends on intraoperative warming procedure, extent of the surgical intervention and age of the experimental animal.

  Life sciences 20051104

• Total intravenous anaesthesia in horses using medetomidine and propofol.

  Veterinary anaesthesia and analgesia 20051101

• The use and assessment of ketamine-medetomidine-butorphanol combinations for field anaesthesia in wild European badgers (Meles meles).

  Veterinary anaesthesia and analgesia 20051101

• Romifidine or medetomidine premedication before propofol-sevoflurane anaesthesia in dogs.

  Journal of veterinary pharmacology and therapeutics 20051001

• Comparative study of three intramuscular anaesthetic combinations (medetomidine/ketamine, medetomidine/fentanyl/midazolam and xylazine/ketamine) in rabbits.

  Veterinary anaesthesia and analgesia 20050901

• Assessment of ketamine and medetomidine anaesthesia in the domestic rabbit.

  Veterinary anaesthesia and analgesia 20050901

• Determination of acepromazine, ketamine, medetomidine, and xylazine in serum: multi-residue screening by liquid chromatography-mass spectrometry.

  Journal of analytical toxicology 20050901

• Acute aortic rupture in a dog with spirocercosis following the administration of medetomidine.

  Journal of the South African Veterinary Association 20050901

• The use of a medetomidine, butorphanol and atropine combination to enable blood sampling in young pigs.

  New Zealand veterinary journal 20050801

• Evaluation of the cardiovascular effects of an anaesthetic protocol for immobilization and anaesthesia in grey wolves (Canis lupus L, 1758).

  Veterinary research communications 20050801

• Comparison of xylazine and medetomidine as premedicants for cats being anaesthetised with propofol-sevoflurane.

  The Veterinary record 20050730

• Yohimbine disrupts prepulse inhibition in rats via action at 5-HT1A receptors, not alpha2-adrenoceptors.

  Psychopharmacology 20050701

• Cardiopulmonary effects of fentanyl in conscious dogs and dogs sedated with a continuous rate infusion of medetomidine.

  American journal of veterinary research 20050701

• Evaluation of two combinations of Domitor, Zoletil 100, and Euthatal to obtain long-term nonrecovery anesthesia in Sprague-Dawley rats.

  Comparative medicine 20050601

• Medetomidine and dexmedetomidine: a review of cardiovascular effects and antinociceptive properties in the dog.

  Veterinary anaesthesia and analgesia 20050501

• Effect of medetomidine and its antagonism with atipamezole on stress-related hormones, metabolites, physiologic responses, sedation, and mechanical threshold in goats.

  Veterinary anaesthesia and analgesia 20050501

• Renal effects of medetomidine in isoflurane-anesthetized dogs with special reference to its diuretic action.

  The Journal of veterinary medical science 20050501

• Anesthetic and cardiovascular effects of balanced anesthesia using constant rate infusion of midazolam-ketamine-medetomidine with inhalation of oxygen-sevoflurane (MKM-OS anesthesia) in horses.

  The Journal of veterinary medical science 20050401

• Use of medetomidine-ketamine and atipamezole for reversible immobilization of free-ranging hog deer (Axis porcinus) captured in drive nets.

  Journal of wildlife diseases 20050401

• Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity.

  Journal of medicinal chemistry 20050324

• Results of 24-hour ambulatory electrocardiography in dogs undergoing ovariohysterectomy following premedication with medetomidine or acepromazine.

  Journal of the American Veterinary Medical Association 20050301

• Influence of medetomidine on stress-related neurohormonal and metabolic effects caused by butorphanol, fentanyl, and ketamine administration in dogs.

  American journal of veterinary research 20050301

• Anaesthesia of nyala (Tragelaphus angasi) with a combination of thiafentanil (A3080), medetomidine and ketamine.

  Journal of the South African Veterinary Association 20050301

• Ketamine-medetomidine anesthesia with atipamezole reversal: practical anesthesia for rodents under field conditions.

  Lab animal 20050201

• Preliminary comparison of four anaesthetic techniques in badgers (Meles meles).

  Veterinary anaesthesia and analgesia 20050101

• Tribromoethanol-medetomidine combination provides a safe and reversible anesthetic effect in Sprague-Dawley rats.

  Contemporary topics in laboratory animal science 20050101

• Medetomidine with ketamine and bupivacaine for epidural analgesia in buffaloes.

  Veterinary research communications 20050101

• Radiosensitising effect of electrochemotherapy with bleomycin in LPB sarcoma cells and tumors in mice.

  BMC cancer 20050101

• The effect of cartilage and bone density of mushroom-shaped, photooxidized, osteochondral transplants: an experimental study on graft performance in sheep using transplants originating from different species.

  BMC musculoskeletal disorders 20050101

• Sublethal effects of a new antifouling candidate on lumpfish (Cyclopterus lumpus L.) and Atlantic cod (Gadus morhua L.) larvae.

  Biofouling 20050101

• Four preanesthetic oral sedation protocols for rhesus macaques (Macaca mulatta).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20041201

• Reversal of medetomidine-ketamine combination anesthesia in rabbits by atipamezole.

  Experimental animals 20041001

• Immobilization of Chacoan peccaries (Catagonus wagneri) using medetomidine, Telazol, and ketamine.

  Journal of wildlife diseases 20041001

• Xylazine-midazolam-ketamine versus medetomidine-midazolam-ketamine anesthesia in captive Siberian tigers (Panthera tigris altaica).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20040901

• Evaluation of the effects of premedication on gastroduodenoscopy in cats.

  Journal of the American Veterinary Medical Association 20040815

• Intramuscular anesthesia of bonito and Pacific mackerel with ketamine and medetomidine and reversal of anesthesia with atipamezole.

  Journal of the American Veterinary Medical Association 20040801

• Comparative cardiovascular, analgesic, and sedative effects of medetomidine, medetomidine-hydromorphone, and medetomidine-butorphanol in dogs.

  American journal of veterinary research 20040701

• In-vitro contraction of the equine aortic valve.

  The Journal of heart valve disease 20040701

• Effect of medetomidine on breathing and inspiratory neuromuscular drive in conscious dogs.

  American journal of veterinary research 20040601

• Comparison of medetomidine-ketamine and dexmedetomidine-ketamine anesthesia in golden-headed lion tamarins.

  The Canadian veterinary journal = La revue veterinaire canadienne 20040601

• Anaesthesia with midazolam/medetomidine/fentanyl in chinchillas (Chinchilla lanigera) compared to anaesthesia with xylazine/ketamine and medetomidine/ketamine.

  Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20040601

• The effect of tiletamine/zolazepam (Zoletile) combination with xylazine or medetomidine on electroencephalograms in dogs.

  The Journal of veterinary medical science 20040501

• Impact of polymer surface affinity of novel antifouling agents.

  Biotechnology and bioengineering 20040405

• The effect of four anesthetic protocols on splenic size in dogs.

  Veterinary anaesthesia and analgesia 20040401

• Cardiopulmonary effects of medetomidine, oxymorphone, or butorphanol in selegiline-treated dogs.

  Veterinary anaesthesia and analgesia 20040401

• Experimental comparison of ketamine with a combination of ketamine, butorphanol and medetomidine for general anaesthesia of the Eurasian badger (Meles meles L.).

  Veterinary journal (London, England : 1997) 20040301

• Reversible anesthesia of captive California sea lions (Zalophus californianus) with medetomidine, midazolam, butorphanol, and isoflurane.

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20040301

• Immobilisation of impala (Aepyceros melampus) with a ketamine hydrochloride/medetomidine hydrochloride combination, and reversal with atipamezole hydrochloride.

  Journal of the South African Veterinary Association 20040301

• Medetomidine analogs as selective agonists for the human alpha2-adrenoceptors.

  Biochemical pharmacology 20040101

• Pentobarbital versus medetomidine-ketamine-fentanyl anaesthesia: effects on haemodynamics and the incidence of ischaemia-induced ventricular fibrillation in swine.

  Laboratory animals 20040101

• A comparison of xylazine and medetomidine in an anesthetic combination in New Zealand White Rabbits.

  Contemporary topics in laboratory animal science 20040101

• All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons.

  Naunyn-Schmiedeberg's archives of pharmacology 20031201

• Medetomidine-ketamine-butorphanol anesthetic combinations in binturongs (Arctictis binturong).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20031201

• The effect of intrathecal medetomidine on small bowel transit in the rat.

  European journal of anaesthesiology 20031101

• A review of the physiological effects of alpha2-agonists related to the clinical use of medetomidine in small animal practice.

  The Canadian veterinary journal = La revue veterinaire canadienne 20031101

• Effects of midazolam-butorphanol, acepromazine-butorphanol and medetomidine on an induction dose of propofol and their compatibility in dogs.

  The Journal of veterinary medical science 20031001

• Influence of yohimbine and atipamezole on haemodynamics and ECG after lumbosacral subarachnoid administration of medetomidine in goats.

  Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20031001

• Comparison of etorphine-detomidine and medetomidine-ketamine anesthesia in captive addax (Addax nasomaculatus).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20030901

• Anesthetic induction of captive tigers (Panthera tigris) using a medetomidine-ketamine combination.

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20030901

• Pharmacokinetics and sedative effects of intramuscular medetomidine in domestic sheep.

  Journal of veterinary pharmacology and therapeutics 20030801

• Comparison of ketamine versus combination of ketamine and medetomidine in injectable anesthetic protocols: chemical immobilization in macaques and tissue reaction in rats.

  Contemporary topics in laboratory animal science 20030701

• Evaluation of three combinations of anesthetics for use in free-ranging alpine marmots (Marmota marmota).

  Journal of wildlife diseases 20030701

• Evaluation of propofol and medetomidine-ketamine for short-term immobilization of Gulf of Mexico sturgeon (Acipenser oxyrinchus de soti).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20030601

• Comparison of the efficacy and cardiorespiratory effects of medetomidine-based anesthetic protocols in ring-tailed lemurs (Lemur catta).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20030601

• Immobilization of sun bears (Helarctos malayanus) with medetomidine-zolazepam-tiletamine.

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20030601

• [Domitor not to used in collies?].

  Tijdschrift voor diergeneeskunde 20030515

• Effects of anaesthesia and manual restraint on the plasma concentrations of pituitary and adrenocortical hormones in ferrets.

  The Veterinary record 20030510

• Medetomidine-ketamine anaesthesia induction followed by medetomidine-propofol in ponies: infusion rates and cardiopulmonary side effects.

  Equine veterinary journal 20030501

• Regulation of Cl- secretion by alpha2-adrenergic receptors in mouse colonic epithelium.

  The Journal of physiology 20030415

• Immobilization of free-ranging European mink (Mustela lutreola) an polecat (Mustela putorius) with medetomidine-ketamine and reversal by atipamezole.

  Journal of wildlife diseases 20030401

• Strain differences in response to propofol, ketamine and medetomidine in rabbits.

  The Veterinary record 20030308

• Effect of medetomidine administration on bispectral index measurements in dogs during anesthesia with isoflurane.

  American journal of veterinary research 20030301

• Comparison of the cardiorespiratory effects of medetomidine-butorphanol-ketamine and medetomidine-butorphanol-midazolam in patas monkeys (Erythrocebus patas).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20030301

• Postoperative analgesia in dogs receiving epidural morphine plus medetomidine.

  Journal of veterinary pharmacology and therapeutics 20030201

• Isoflurane to prolong medetomidine/ ketamine anaesthesia in six adult female chimpanzees (Pan troglodytes).

  The Veterinary record 20030104

• The antagonistic effects of atipamezole and yohimbine on stress-related neurohormonal and metabolic responses induced by medetomidine in dogs.

  Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20030101

• Effect of dorsal hip loading, sedation, and general anesthesia on the dorsolateral subluxation score in dogs.

  Veterinary surgery : VS 20030101

• Medetomidine a novel immobilizing agent for the elephant (Elephas maximus).

  Research in veterinary science 20021201

• Effects of medetomidine-midazolam, acepromazine-butorphanol, and midazolam-butorphanol on induction dose of thiopental and propofol and on cardiopulmonary changes in dogs.

  American journal of veterinary research 20021201

• Surgical implantation of radio transmitters in arctic foxes (Alopex lagopus) on Svalbard, Norway.

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20021201

• Medetomidine-ketamine in reindeer (Rangifer tarandus tarandus): effective immobilization by hand- and dart-administered injection.

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20021201

• Doppler echocardiographic effects of medetomidine on dynamic left ventricular outflow tract obstruction in cats.

  Journal of the American Veterinary Medical Association 20021101

• Reduced blood flow and oxygenation in SA-1 tumours after electrochemotherapy with cisplatin.

  British journal of cancer 20021021

• Clinical comparison of xylazine and medetomidine for premedication of horses.

  Journal of the American Veterinary Medical Association 20021015

• Infusion of guaifenesin, ketamine, and medetomidine in combination with inhalation of sevoflurane versus inhalation of sevoflurane alone for anesthesia of horses.

  Journal of the American Veterinary Medical Association 20021015

• Medetomidine, ketamine, and sevoflurane for anesthesia of injured loggerhead sea turtles: 13 cases (1996-2000).

  Journal of the American Veterinary Medical Association 20021001

• The cardiovascular and respiratory effects of medetomidine and thiopentone anaesthesia in dogs breathing at an altitude of 1486 m.

  Journal of the South African Veterinary Association 20020901

• Effect of medetomidine-butorphanol-ketamine anaesthesia and atipamezole on heart and respiratory rate and cloacal temperature of domestic pigeons.

  Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20020801

• Effects of medetomidine-midazolam, midazolambutorphanol, or acepromazine-butorphanol as premedicants for mask induction of anesthesia with sevoflurane in dogs.

  American journal of veterinary research 20020701

• Evaluation of the perioperative stress response in dogs administered medetomidine or acepromazine as part of the preanesthetic medication.

  American journal of veterinary research 20020701

• Reliability of goniometry in Labrador Retrievers.

  American journal of veterinary research 20020701

• Hemodynamics of anesthetized ventilated mouse models: aspects of anesthetics, fluid support, and strain.

  American journal of physiology. Heart and circulatory physiology 20020601

• Cardiorespiratory effects of medetomidine-butorphanol, medetomidine-butorphanol-diazepam, and medetomidine-butorphanol-ketamine in captive red wolves (Canis rufus).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20020601

• Cardiopulmonary effects of a medetomidine-ketamine combination administered intravenously in gopher tortoises.

  Journal of the American Veterinary Medical Association 20020515

• Quantitative electroencephalography of medetomidine, medetomidine-midazolam and medetomidine-midazolam-butorphanol in dogs.

  Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20020501

• Anesthesia of boma-captured Lichtenstein's hartebeest (Sigmoceros lichtensteinii) with a combination of thiafentanil, medetomidine, and ketamine.

  Journal of wildlife diseases 20020401

• N-Glucuronidation of some 4-arylalkyl-1H-imidazoles by rat, dog, and human liver microsomes.

  Drug metabolism and disposition: the biological fate of chemicals 20020301

• Infusion of alpha-2-adrenergic agents into the paraventricular and arcuate nuclei of the hypothalamus in the Siberian hamster: opposing effects on basal prolactin.

  Neuroendocrinology 20020301

• Use of medetomidine for capture and restraint of cassowaries (Casuarius casuaris).

  Australian veterinary journal 20020301

• Evaluation of medetomidine-ketamine anesthesia with atipamezole reversal in American alligators (Alligator mississippiensis).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20020301

• Chemical restraint of fishers (Martes pennanti) with ketamine and medetomidine-ketamine.

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20020301

• Some factors influencing the level of clinical sedation induced by medetomidine in rabbits.

  Journal of veterinary pharmacology and therapeutics 20020201

• Neurohormonal and metabolic effects of medetomidine compared with xylazine in beagle dogs.

  Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20020101

• Postoperative pain control in cats: clinical trials with medetomidine and butorphanol.

  Veterinary surgery : VS 20020101

• [Medetomidine-butorphanol combination anesthesia in the dog].

  Schweizer Archiv fur Tierheilkunde 20011201

• Cardiopulmonary evaluation of the use of medetomidine hydrochloride in cats.

  American journal of veterinary research 20011101

• Cardiopulmonary effects of three different anaesthesia protocols in cats.

  The Veterinary quarterly 20011101

• Effect of medetomidine on electroencephalography and use of a quantitative electroencephalograph for evaluating sedation levels in dogs.

  Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20011101

• Clinical comparison of preanaesthetic intramuscular medetomidine and dexmedetomidine in domestic sheep.

  DTW. Deutsche tierarztliche Wochenschrift 20011001

• Cardiopulmonary effects of prolonged anesthesia via propofol-medetomidine infusion in ponies.

  American journal of veterinary research 20010901

• Effects of medetomidine and buprenorphine administered for sedation in dogs.

  The Journal of small animal practice 20010901

• Procedure for successful interspecific embryo transfer from mouflon (Ovis gmelini musimon) to Spanish Merino sheep (Ovis aries).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20010901

• Comparison of medetomidine and dexmedetomidine as premedicants in dogs undergoing propofol-isoflurane anesthesia.

  American journal of veterinary research 20010701

• Reversible immobilization of eurasian otters with a combination of ketamine and medetomidine.

  Journal of wildlife diseases 20010701

• Use of medetomidine-zolazepam-tiletamine with and without atipamezole reversal to immobilize captive California sea lions.

  Journal of wildlife diseases 20010701

• Anaesthesia of gemsbok (Oryx gazella) with a combination of A3080, medetomidine and ketamine.

  Journal of the South African Veterinary Association 20010601

• Cardiopulmonary assessment of medetomidine, ketamine, and butorphanol anesthesia in captive Thomson's gazelles (Gazella thomsoni).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20010601

• High-performance liquid chromatographic method combining radiochemical and ultraviolet detection for determination of low activities of uridine 5'-diphosphate-glucuronosyltransferase.

  Analytical biochemistry 20010515

• Modulation of ligand responses by coupling of alpha(2A)-adrenoceptors to diverse G(alpha)-proteins.

  Biochemical pharmacology 20010501

• Medetomidine-ketamine anesthesia in red-eared slider turtles (Trachemys scripta elegans).

  Contemporary topics in laboratory animal science 20010501

• Comparison of medetomidine and dexmedetomidine as premedication in isoflurane anaesthesia for orthopaedic surgery in domestic sheep.

  Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20010501

• Acid-base status and blood gas arterial values in free-ranging sika deer hinds immobilized with medetomidine and ketamine.

  Journal of wildlife diseases 20010401

• Infusion of a combination of propofol and medetomidine for long-term anesthesia in ponies.

  American journal of veterinary research 20010401

• Sedative, analgesic, and cardiovascular effects of levomedetomidine alone and in combination with dexmedetomidine in dogs.

  American journal of veterinary research 20010401

• Minimal alveolar concentration of desflurane in combination with an infusion of medetomidine for the anaesthesia of ponies.

  The Veterinary record 20010303

• Clinical evaluation of established optimal immobilizing doses of medetomidine-ketamine in captive reindeer (Rangifer tarandus tarandus).

  American journal of veterinary research 20010301

• The effects of topical tropicamide and systemic medetomidine, followed by atipamezole reversal, on pupil size and intraocular pressure in normal dogs.

  Veterinary ophthalmology 20010301

• Anaesthesia of roan antelope (Hippotragus equinus) with a combination of A3080, medetomidine and ketamine.

  Journal of the South African Veterinary Association 20010301

• Alpha2-adrenoceptors modulating neuronal serotonin release: a study in alpha2-adrenoceptor subtype-deficient mice.

  British journal of pharmacology 20010201

• Results of cystometry and urethral pressure profilometry in dogs sedated with medetomidine or xylazine.

  American journal of veterinary research 20010201

• Use of medetomidine and ketamine for immobilization of free-ranging giraffes.

  Journal of the American Veterinary Medical Association 20010115

• Effects of preemptive atropine administration on incidence of medetomidine-induced bradycardia in dogs.

  Journal of the American Veterinary Medical Association 20010101

• Determination of optimal immobilizing doses of a medetomidine hydrochloride and ketamine hydrochloride combination in captive reindeer.

  American journal of veterinary research 20010101

• Anesthetic effects of ketamine or isoflurane induction prior to isoflurane anesthesia in medetomidine-premedicated dogs.

  Journal of the American Animal Hospital Association 20010101

• The effect of a combination of medetomidine-butorphanol and medetomidine, butorphanol, atropine on glomerular filtration rate in dogs.

  Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association 20010101

• Anesthetic and cardiopulmonary effects of propofol in dogs premedicated with atropine, butorphanol, and medetomidine.

  Veterinary therapeutics : research in applied veterinary medicine 20010101

• Dexmedetomidine as an anesthetic adjunct in coronary artery bypass grafting.

  Anesthesiology 19970201

• Beneficial effects of dexmedetomidine on ischaemic myocardium of anaesthetized dogs.

  British journal of anaesthesia 19960901

• Postoperative analgesic and cardiopulmonary effects in dogs of oxymorphone administered epidurally and intramuscularly, and medetomidine administered epidurally: a comparative clinical study.

  Veterinary surgery : VS 19960101

• Further characterization of the receptor mechanism involved in the antidysrhythmic effect of dexmedetomidine on halothane/epinephrine dysrhythmias in dogs.

  Anesthesiology 19951101

• Role of the vagus nerve in the antidysrhythmic effect of dexmedetomidine on halothane/epinephrine dysrhythmias in dogs.

  Anesthesiology 19951101

• Comparison of intramuscular dexmedetomidine and midazolam premedication for elective abdominal hysterectomy.

  Anesthesia and analgesia 19941001

• Comparison of neurologic responses to the use of medetomidine as a sole agent or preanesthetic in laboratory beagles.

  Acta veterinaria Scandinavica 19920101

• Effects of anticholinergic treatment on the cardiac and respiratory systems in dogs sedated with medetomidine.

  The Veterinary record 19911005

• Rapid reversal of alpha 2-adrenoceptor agonist effects by atipamezole in human volunteers.

  British journal of clinical pharmacology 19910201

• Dexmedetomidine, a selective alpha 2-agonist, does not potentiate the cardiorespiratory depression of alfentanil in the rat.

  Anesthesiology 19900501

• Dexmedetomidine, acting through central alpha-2 adrenoceptors, prevents opiate-induced muscle rigidity in the rat.

  Anesthesiology 19890801