865854-05-3 | Tideglusib

Packsize	Purity	Availability	Price	Discounted Price
10mg	98%	in stock	$36.00	$25.00
100mg	98%	in stock	$73.00	$51.00
250mg	98%	in stock	$117.00	$82.00

Description

• Catalog Number: AB47740
• Chemical Name: Tideglusib
• CAS Number: 865854-05-3
• Molecular Formula: C19H14N2O2S
• Molecular Weight: 334.3917
• MDL Number: MFCD18633296
• SMILES: O=c1sn(c(=O)n1Cc1ccccc1)c1cccc2c1cccc2

Computed Properties

• Complexity: 492
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 24
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• XLogP3: 4.3

Literature

• Promotion of natural tooth repair by small molecule GSK3 antagonists.

  Scientific reports 20170101

• Treatment of Alzheimer's disease with the GSK-3 inhibitor tideglusib: a pilot study.

  Journal of Alzheimer's disease : JAD 20130101

• Evidence for irreversible inhibition of glycogen synthase kinase-3β by tideglusib.

  The Journal of biological chemistry 20120106

• Exploring the binding sites of glycogen synthase kinase 3. Identification and characterization of allosteric modulation cavities.

  Journal of medicinal chemistry 20111222

• Switching reversibility to irreversibility in glycogen synthase kinase 3 inhibitors: clues for specific design of new compounds.

  Journal of medicinal chemistry 20110623

• Glycogen synthase kinase 3 inhibitors in the next horizon for Alzheimer's disease treatment.

  International journal of Alzheimer's disease 20110101

• A novel GSK-3beta inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo.

  Neurobiology of disease 20090901

• NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20070523